EXHIBIT 32.2

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

     This certification is provided pursuant to Section 906 of the
Sarbanes-Oxley Act of 2002,18 U.S.C. Section 1350, and accompanies the quarterly
report on Form 10-Q for the quarter ended March 31, 2006 (the "Form 10-Q") of
Mercantile Bank Corporation (the "Issuer").

     I, Charles E. Christmas, Senior Vice President, Chief Financial Officer and
Treasurer of the Issuer, certify that:

(i) the Form 10-Q fully complies with the requirements of Section 13(a) or
Section 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m(a) or
78o(d)); and

(ii) the information contained in the Form 10-Q fairly presents, in all material
respects, the financial condition and results of operations of the Issuer.

Dated: May 8, 2006


                                        /s/ Charles E. Christmas
                                        ----------------------------------------
                                        Charles E. Christmas
                                        Senior Vice President, Chief
                                        Financial Officer and Treasurer