EXHIBIT 32.1

  CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO 18 U.S.C. SECTION 1350,
      AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Cardiac Science Corporation (the
Company) on Form 10-Q for the quarter ended March 31, 2006 as filed with the
Securities and Exchange Commission on the date hereof (the Report), I, John R.
Hinson, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C.
Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
2002, that:

(1) The Report fully complies with the requirements of Section 13(a) or 15(d) of
the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material
respects, the financial condition and result of operations of the Company.

                                                   /s/ JOHN R. HINSON
                                               ---------------------------------
                                              John R. Hinson
                                              Chief Executive Officer

Date:  May 10, 2006