Exhibit 32.1 MACKINAC FINANCIAL CORPORATION CERTIFICATION PERSUANT TO 18 U.S.C. SECTION 1350 AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 This certification is provided pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, 18 U.S.C Section 1350, and accompanies the quarterly report on Form 10-Q for the quarter ended September 30, 2006, (the "Form 10-Q") of Mackinac Financial Corporation (the "Issuer"). I, Paul D. Tobias, Chairman and Chief Executive Officer of the Issuer, certify that: (1) The Form 10-Q fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m(a) or 78o(d)); and (2) The information contained in the Form 10-Q fairly presents, in all material respects, the financial condition and results of operation of the Issuer. /s/ Paul D. Tobias - ------------------------------------- Paul D. Tobias Chairman and Chief Executive Officer (chief executive officer) November 14, 2006 37.