1


                                                                       Exhibit 4



                                 [DEMEGEN LOGO]



February 8, 2000


James Colker
CEO Venture Fund
2000 Technology Drive, Suite 160
Pittsburgh, PA 15219-3451


Re: Demegen Warrant No. 1 (the "Warrant") held by CEO Venture Fund (the "Fund")


Dear Jim:

         This letter will confirm the agreement that has been reached between
Demegen, Inc. (the "Company") and the Fund concerning certain provisions of the
Warrant as follows (all capitalized terms not otherwise defined in this letter
will have the meaning given to them in the Warrant):

         1.       The Company will permit the warrant to be transferred without
                  an accompanying transfer of the Preferred Stock held by the
                  Fund;

         2.       In the event the Company shall exercise its rights under
                  Section 2.3 of the Warrant to call the Warrant and the Fund
                  shall subsequently exercise the Warrant in accordance with
                  Section 2.3(b) of the Warrant, the Company shall extend the
                  time that the Fund shall have to pay the Exercise Price for a
                  period of twenty-four (24) months;

         3.       The Company will file a Form SB-2 registration statement with
                  the Securities Exchange Commission seeking registration of the
                  4,965,556 shares of its Common Stock issuable upon the
                  exercise of the Warrant on or before March 31, 2001; and

         4.       In consideration of the Company's covenants set forth in items
                  1-3 above, the Fund has agreed to purchase Two Hundred
                  Thousand dollars ($200,000) of the Units offered for sale by
                  the Company in the upcoming offering to accredited investors.

If the foregoing accurately reflects the terms of the agreement we have
reached, please so indicate in the space provide below on the additional
enclosed copy of the letter and return it to me.


Very Truly Yours,

/s/ Richard D. Ekstrom
- ----------------------------
Richard D. Ekstrom
President


Acknowledged and Agreed:

CEO Venture Fund III

By /s/ James Colker
- ----------------------------
Title: Managing General Partner



            Demegen, Inc. o 1051 Brinton Road, Pittsburgh, PA 15221
                       o 412-241-2150 o Fax 412-241-2161