1 ARONEX PHARMACEUTICALS, INC. AND SUBSIDIARIES Exhibit 11.1 Statement Regarding Computation of Per Share Earnings The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Consolidated Statements of Operations. Average Loss Days Shares Shares Per Shares Outstanding X Days Outstanding Loss Share ------ ----------- ------ ----------- ---- ----- Year Ended December 31, 1999: 16,379,309 3 49,137,927 16,415,664 50 820,783,200 22,415,664 14 313,819,296 22,463,211 21 471,727,431 22,474,987 1 22,474,987 22,494,671 1 22,494,671 22,495,050 64 1,439,683,200 22,496,505 26 584,909,130 22,555,435 1 22,555,435 22,555,977 8 180,447,816 22,560,179 27 609,124,833 22,697,866 20 453,957,320 22,719,999 6 136,319,994 22,723,765 3 68,171,295 22,723,927 13 295,411,051 22,773,927 5 113,869,635 22,775,753 9 204,981,777 22,788,071 54 1,230,555,834 22,815,293 21 479,121,153 22,815,793 1 22,815,793 22,830,369 16 365,285,904 22,853,783 1 22,853,783 365 7,930,501,465 /365 21,727,401 (14,094,000) (0.65) Page 1 of 3 2 Average Loss Days Shares Shares Per Shares Outstanding X Days Outstanding Loss Share Year Ended December 31, 1998: 15,459,166 11 170,050,826 15,460,684 71 1,097,708,564 15,465,729 1 15,465,729 15,467,281 97 1,500,326,257 15,497,443 92 1,425,764,756 15,503,745 1 15,503,745 15,503,745 40 620,149,800 15,508,745 9 139,578,705 15,509,301 5 77,546,505 16,347,290 23 375,987,670 16,349,706 6 98,098,236 16,352,277 6 98,113,662 16,352,763 2 32,705,526 16,379,309 1 16,379,309 365 5,683,379,290 /365 15,570,902 (18,231,000) (1.17) Page 2 of 3 3 Average Loss Days Shares Shares Per Shares Outstanding X Days Outstanding Loss Share Year Ended December 31, 1997: 14,597,247 8 116,777,976 14,606,972 12 175,283,664 14,612,023 4 58,448,092 14,612,499 21 306,862,479 14,615,983 6 87,695,898 14,616,981 1 14,616,981 14,624,239 5 73,121,195 14,625,111 2 29,250,222 14,627,695 7 102,393,865 14,628,567 6 87,771,402 14,640,311 6 87,841,866 14,643,658 6 87,861,948 14,644,672 1 14,644,672 14,644,816 7 102,513,712 14,644,982 2 29,289,964 14,645,277 4 58,581,108 14,665,277 22 322,636,094 14,665,665 9 131,990,985 14,674,453 19 278,814,607 14,678,042 6 88,068,252 14,680,055 7 102,760,385 14,680,344 19 278,926,536 14,687,394 31 455,309,214 14,710,122 9 132,391,098 14,712,069 5 73,560,345 14,712,575 12 176,550,900 14,712,699 6 88,276,194 14,714,018 2 29,428,036 14,719,923 9 132,479,307 15,406,372 15 231,095,580 15,408,872 3 46,226,616 15,421,809 9 138,796,281 15,423,809 2 30,847,618 15,427,540 24 370,260,960 15,444,824 57 880,354,968 15,459,166 1 15,459,166 365 5,437,188,186 /365 14,896,406 (16,991,000) (1.14) Page 3 of 3