1 EXHIBIT 11.1 ARONEX PHARMACEUTICALS, INC. AND SUBSIDIARIES STATEMENT REGARDING COMPUTATION OF PER SHARE EARNINGS The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Statements of Operations. INCOME AVERAGE (LOSS) DAYS SHARES INCOME PER SHARES OUTSTANDING SHARES X DAYS OUTSTANDING (LOSS) SHARE NINE MONTHS ENDED SEPTEMBER 30, 1999: 16,379,309 3 49,137,927 16,415,664 50 820,783,200 22,415,664 14 313,819,296 22,463,211 21 471,727,431 22,474,987 1 22,474,987 22,494,671 1 22,494,671 22,495,050 64 1,439,683,200 22,496,505 26 584,909,130 22,555,435 1 22,555,435 22,555,977 8 180,447,816 22,560,179 27 609,124,833 22,697,866 20 453,957,320 22,719,999 6 136,319,994 22,723,765 3 68,171,295 22,723,927 13 294,411,051 22,773,927 5 113,869,635 22,775,753 9 204,981,777 22,788,071 1 22,788,071 273 5,832,657,069 /273 21,365,044 (7,305,000) (0.34) NINE MONTHS ENDED SEPTEMBER 30, 2000: 22,853,782 21 479,929,422 22,873,782 3 68,621,346 22,876,765 4 91,507,060 22,877,930 12 274,535,160 22,879,230 23 526,222,290 22,888,646 6 137,331,876 22,905,144 14 320,672,016 22,922,078 54 1,237,792,212 25,854,652 44 1,137,604,688 25,890,127 1 25,890,127 25,890,127 74 1,915,869,398 25,890,567 1 25,890,567 25,900,901 5 129,504,505 25,913,022 2 51,826,044 25,918,209 7 181,427,463 25,918,417 2 51,836,834 25,932,005 1 25,932,005 274 6,682,393,013 /274 24,477,630 (12,049,000) (0.49) QUARTER ENDED SEPTEMBER 30, 1999: 22,555,977 8 180,447,816 22,560,179 27 609,124,833 22,697,866 20 453,957,320 22,719,999 6 136,319,994 22,723,765 3 68,171,295 22,723,927 13 295,411,051 22,723,927 5 113,869,635 22,775,753 9 204,981,777 22,788,071 1 22,788,071 92 2,085,071,792 /92 22,663,824 (5,399,000) (0.24) QUARTER ENDED SEPTEMBER 30, 2000: 25,890,127 74 1,915,869,398 25,890,567 1 25,890,567 25,900,901 5 129,504,505 25,913,022 2 51,826,044 25,918,209 7 181,427,463 25,918,417 2 51,836,834 25,932,005 1 25,932,005 92 /92 25,894,422 (4,131,000) (0.16) - 14 -