1
ARONEX PHARMACEUTICALS, INC. AND SUBSIDIARIES

                                                                    EXHIBIT 11.1

              Statement Regarding Computation of Per Share Earnings

The following reflects the information used in calculating the number of shares
in the computation of net loss per share for each of the periods set forth in
the Consolidated Statements of Operations.



                                                                                              AVERAGE                    LOSS
                                                       DAYS            SHARES                 SHARES                      PER
                                       SHARES       OUTSTANDING        X DAYS               OUTSTANDING       LOSS       SHARE

                                                                                                    
Year Ended December 31, 2000:                        22,853,782               21     479,
                                     22,873,782               3       68,621,346
                                     22,876,765               4       91,507,060
                                     22,877,930              12      274,535,160
                                     22,879,230              23      526,222,290
                                     22,888,646               6      137,331,876
                                     22,905,144              14      320,672,016
                                     22,922,078              54    1,237,792,212
                                     25,854,652              44    1,137,604,688
                                     25,890,127              75    1,941,759,525
                                     25,890,567               1       25,890,567
                                     25,900,901               5      129,504,505
                                     25,913,022               2       51,826,044
                                     25,918,209               7      181,427,463
                                     25,918,417               2       51,836,834
                                     25,932,005              10      259,320,050
                                     25,937,583              38      985,628,154
                                     25,938,719               5      129,693,595
                                     25,950,578              17      441,159,826
                                     25,954,893              22      571,007,646
                                     25,973,674               1       25,973,674
                                                            366    9,069,243,953    /366    24,847,244    (13,502,000)   (0.54)
                                                                                            24,847,244    (17,957,000)   (0.72)



                                  Page 1 of 3
   2




                                                                                              AVERAGE                    LOSS
                                                       DAYS            SHARES                 SHARES                      PER
                                       SHARES       OUTSTANDING        X DAYS               OUTSTANDING       LOSS       SHARE

                                                                                                    
Year Ended December 31, 1999:        16,379,309               3       49,137,927
                                     16,415,664              50      820,783,200
                                     22,415,664              14      313,819,296
                                     22,463,211              21      471,727,431
                                     22,474,987               1       22,474,987
                                     22,494,671               1       22,494,671
                                     22,495,050              64    1,439,683,200
                                     22,496,505              26      584,909,130
                                     22,555,435               1       22,555,435
                                     22,555,977               8      180,447,816
                                     22,560,179              27      609,124,833
                                     22,697,866              20      453,957,320
                                     22,719,999               6      136,319,994
                                     22,723,765               3       68,171,295
                                     22,723,927              13      295,411,051
                                     22,773,927               5      113,869,635
                                     22,775,753               9      204,981,777
                                     22,788,071              54    1,230,555,834
                                     22,815,293              21      479,121,153
                                     22,815,793               1       22,815,793
                                     22,830,369              16      365,285,904
                                     22,853,783               1       22,853,783
                                                            365    7,930,501,465     /365   21,727,401    (14,094,000)   (0.65)



                                  Page 2 of 3
   3




                                                                                              AVERAGE                    LOSS
                                                       DAYS            SHARES                 SHARES                      PER
                                       SHARES       OUTSTANDING        X DAYS               OUTSTANDING       LOSS       SHARE

                                                                                                    
Year Ended December 31, 1998:        15,459,166              11      170,050,826
                                     15,460,684              71    1,097,708,564
                                     15,465,729               1       15,465,729
                                     15,467,281              97    1,500,326,257
                                     15,497,443              92    1,425,764,756
                                     15,503,745               1       15,503,745
                                     15,503,745              40      620,149,800
                                     15,508,745               9      139,578,705
                                     15,509,301               5       77,546,505
                                     16,347,290              23      375,987,670
                                     16,349,706               6       98,098,236
                                     16,352,277               6       98,113,662
                                     16,352,763               2       32,705,526
                                     16,379,309               1       16,379,309
                                                            365    5,683,379,290     /365   15,570,902    18,231,000     (1.17)



                                  Page 3 of 3