1 ARONEX PHARMACEUTICALS, INC. AND SUBSIDIARIES EXHIBIT 11.1 Statement Regarding Computation of Per Share Earnings The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Consolidated Statements of Operations. AVERAGE LOSS DAYS SHARES SHARES PER SHARES OUTSTANDING X DAYS OUTSTANDING LOSS SHARE Year Ended December 31, 2000: 22,853,782 21 479, 22,873,782 3 68,621,346 22,876,765 4 91,507,060 22,877,930 12 274,535,160 22,879,230 23 526,222,290 22,888,646 6 137,331,876 22,905,144 14 320,672,016 22,922,078 54 1,237,792,212 25,854,652 44 1,137,604,688 25,890,127 75 1,941,759,525 25,890,567 1 25,890,567 25,900,901 5 129,504,505 25,913,022 2 51,826,044 25,918,209 7 181,427,463 25,918,417 2 51,836,834 25,932,005 10 259,320,050 25,937,583 38 985,628,154 25,938,719 5 129,693,595 25,950,578 17 441,159,826 25,954,893 22 571,007,646 25,973,674 1 25,973,674 366 9,069,243,953 /366 24,847,244 (13,502,000) (0.54) 24,847,244 (17,957,000) (0.72) Page 1 of 3 2 AVERAGE LOSS DAYS SHARES SHARES PER SHARES OUTSTANDING X DAYS OUTSTANDING LOSS SHARE Year Ended December 31, 1999: 16,379,309 3 49,137,927 16,415,664 50 820,783,200 22,415,664 14 313,819,296 22,463,211 21 471,727,431 22,474,987 1 22,474,987 22,494,671 1 22,494,671 22,495,050 64 1,439,683,200 22,496,505 26 584,909,130 22,555,435 1 22,555,435 22,555,977 8 180,447,816 22,560,179 27 609,124,833 22,697,866 20 453,957,320 22,719,999 6 136,319,994 22,723,765 3 68,171,295 22,723,927 13 295,411,051 22,773,927 5 113,869,635 22,775,753 9 204,981,777 22,788,071 54 1,230,555,834 22,815,293 21 479,121,153 22,815,793 1 22,815,793 22,830,369 16 365,285,904 22,853,783 1 22,853,783 365 7,930,501,465 /365 21,727,401 (14,094,000) (0.65) Page 2 of 3 3 AVERAGE LOSS DAYS SHARES SHARES PER SHARES OUTSTANDING X DAYS OUTSTANDING LOSS SHARE Year Ended December 31, 1998: 15,459,166 11 170,050,826 15,460,684 71 1,097,708,564 15,465,729 1 15,465,729 15,467,281 97 1,500,326,257 15,497,443 92 1,425,764,756 15,503,745 1 15,503,745 15,503,745 40 620,149,800 15,508,745 9 139,578,705 15,509,301 5 77,546,505 16,347,290 23 375,987,670 16,349,706 6 98,098,236 16,352,277 6 98,113,662 16,352,763 2 32,705,526 16,379,309 1 16,379,309 365 5,683,379,290 /365 15,570,902 18,231,000 (1.17) Page 3 of 3