Exhibit 32.1



                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                       AS ADOPTED PURSUANT TO SECTION 906
                        OF THE SARBANES-OXLEY ACT OF 2002


     In connection with the Annual Report of Encysive Pharmaceuticals Inc. (the
"Company") on Form 10-K/A for the period ending December 31, 2002 (the
"Report"), as filed with the Securities and Exchange Commission on the date
hereof, I, Bruce D. Given, M.D., President and Chief Executive Officer of the
Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to
Section 906 of the Sarbanes-Oxley Act of 2002, that:

     1. The Report fully complies with the requirements of section 13(a) or
15(d) of the Securities Exchange Act of 1934, as amended; and

     2. The information contained in the Report fairly presents, in all material
respects, the financial condition and results of operations of the Company.



/s/ BRUCE D. GIVEN, M.D.
- -------------------------------------
Bruce D. Given, M.D.
President and Chief Executive Officer

November 14, 2003

A signed original of this written statement required by Section 906 has been
provided to Encysive Pharmaceuticals Inc. and will be retained by Encysive
Pharmaceuticals Inc. and furnished to the Securities and Exchange Commission or
its staff upon request.