EXHIBIT 23.1

                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

         We consent to the reference to our firm under the caption "Experts" in
the Registration Statement (Form S-3) and related Prospectus of Lexicon Genetics
Incorporated for the registration of 3,500,000 shares of its common stock and to
the incorporation by reference therein of our report dated February 13, 2003,
with respect to the consolidated financial statements of Lexicon Genetics
Incorporated included in its Annual Report (Form 10-K) for the year ended
December 31, 2002, filed with the Securities and Exchange Commission.

                                        /s/ ERNST & YOUNG LLP

Houston, Texas
January 7, 2004