EXHIBIT 4.2

                              OFFICERS' CERTIFICATE

                                       OF

                                   AMGEN INC.

Dated as of November 18, 2004

                  The undersigned officers of the Company certify, pursuant to
resolutions duly adopted by the Board of Directors of the Company at a meeting
duly held on October 5, 2004, and the unanimous written consent of the Offering
Committee of the Board of Directors, dated as of November 15, 2004
(collectively, the "RESOLUTIONS"), and in accordance with Sections 2.1, 2.2 and
2.3 of the Indenture, dated as of August 4, 2003 (the "INDENTURE"; capitalized
terms used herein and not otherwise defined shall have the meanings given to
them in the Indenture), between Amgen Inc., a Delaware corporation (the
"COMPANY"), and JPMorgan Chase Bank, N.A., as trustee, (the "TRUSTEE") the
following matters related to the issuance of the Company's 4.00% Senior Notes
due 2009 (the "2009 NOTES") and the Company's 4.85% Senior Notes due 2014 (the
"2014 NOTES"):

            1.    Attached hereto as Annex A is a true and correct copy of a
      specimen note (the "FORM OF 2009 NOTE") representing the 2009 Notes and
      attached hereto as Annex B is a true and correct copy of a specimen note
      (the "FORM OF 2014 NOTE") representing the 2014 Notes. The Form of 2009
      Note and the Form of 2014 Note are herein collectively referred to as the
      "FORMS OF NOTES." The Forms of Notes set forth certain of the terms
      required to be set forth in this Certificate pursuant to Section 2.2 of
      the Indenture, and said terms are incorporated herein by reference. The
      2009 Notes and the 2014 Notes are each a separate series of Securities
      under the Indenture and are referred to herein collectively as the
      "NOTES." The term "Notes" shall also include any exchange notes issued in
      exchange for the 2009 Notes and 2014 Notes, respectively, pursuant to the
      transactions contemplated by that certain Registration Rights Agreement,
      dated as of November 18, 2004 (the "REGISTRATION RIGHTS AGREEMENT"), by
      and among the Company and the initial purchasers named therein (the
      "EXCHANGE SECURITIES").

            2.    The title of the 2009 Notes shall be the "4.00% Senior Notes
      due 2009" and the title of the 2014 Notes shall be the "4.85% Senior Notes
      due 2014."

            3.    The 2009 Notes shall be issued at the initial offering price
      of 99.803% of the principal amount and the 2014 Notes shall be issued at
      the initial offering price of 99.984% of the principal amount.

            4.    The Company will initially issue $1.0 billion aggregate
      principal amount of 2009 Notes (except for 2009 Notes authenticated and
      delivered upon registration of transfer of, in exchange for, or in lieu
      of, other 2009 Notes pursuant to Sections 2.7, 2.8, 2.11, 3.6 or 9.6 of
      the Indenture) and the $1.0 billion aggregate principal amount of 2014
      Notes (except for 2014 Notes authenticated and delivered upon registration
      of transfer of, in exchange for, or in lieu of, other 2014 Notes pursuant
      to Sections 2.7, 2.8, 2.11, 3.6 or



      9.6 of the Indenture). The Company may issue additional 2009 Notes and/or
      2014 Notes from time to time after the date hereof, and such Notes will be
      treated as part of the respective series of Notes for all purposes under
      the Indenture.

            5.    The Notes and the Exchange Securities shall be issued as
      Global Securities only and will be exchangeable for certificated notes
      ("CERTIFICATED NOTES") only if:

                  (a)   DTC (x) notifies the Company that it is unwilling or
                        unable to continue as depository for the Global
                        Securities or (y) at any time has ceased to be a
                        clearing agency registered under the Exchange Act and,
                        in either case, the Company fails to appoint a successor
                        depository registered as a clearing agency under the
                        Exchange Act within 90 days of such event;

                  (b)   the Company, at its option, notifies the Trustee in
                        writing to the effect that the Company elects to cause
                        the issuance of the Certificated Notes; or

                  (c)   there has occurred and is continuing an Event of Default
                        with respect to the Notes.

                  Certificated Notes delivered in exchange for any Global
      Security or beneficial interests in Global Securities will be registered
      in the names, and issued in any approved denominations, requested by or on
      behalf of the depository (in accordance with its customary procedures).

            6.    The Global Securities and the Certificated Notes will bear the
      following restrictive legend unless the legend is not required by
      applicable law, or as set forth in Item 7 below:

                  "THIS NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
      1933, AS AMENDED (THE "SECURITIES ACT"), AND ACCORDINGLY, MAY NOT BE
      OFFERED OR SOLD WITHIN THE UNITED STATES OR TO, OR FOR THE ACCOUNT OR
      BENEFIT OF, U.S. PERSONS EXCEPT AS SET FORTH IN THE FOLLOWING SENTENCE. BY
      ITS ACQUISITION HEREOF, THE HOLDER (I) REPRESENTS THAT (A) IT IS A
      "QUALIFIED INSTITUTIONAL BUYER" (AS DEFINED IN RULE 144A UNDER THE
      SECURITIES ACT) OR (B) IT IS AN INSTITUTIONAL "ACCREDITED INVESTOR" (AS
      DEFINED IN RULE 501(a)(1), (2), (3) OR (7) OF REGULATION D UNDER THE
      SECURITIES ACT) (AN "INSTITUTIONAL ACCREDITED INVESTOR") OR (C) IT IS NOT
      A U.S. PERSON AND IS ACQUIRING THIS NOTE IN AN OFFSHORE TRANSACTION (AS
      DEFINED IN REGULATION S UNDER THE SECURITIES ACT) IN COMPLIANCE WITH
      REGULATION S UNDER THE SECURITIES ACT, (2) AGREES THAT IT WILL NOT, WITHIN
      THE TIME PERIOD REFERRED TO IN RULE 144(k) UNDER THE SECURITIES ACT AS IN
      EFFECT ON THE DATE OF THE TRANSFER OF THIS NOTE, RESELL OR OTHERWISE



      TRANSFER THIS NOTE EXCEPT (A) TO THE ISSUER OR ANY SUBSIDIARY THEREOF, (B)
      TO A QUALIFIED INSTITUTIONAL BUYER IN COMPLIANCE WITH RULE 144A UNDER THE
      SECURITIES ACT, (C) INSIDE THE UNITED STATES TO AN INSTITUTIONAL
      ACCREDITED INVESTOR THAT, PRIOR TO SUCH TRANSFER, FURNISHES TO THE TRUSTEE
      A SIGNED LETTER CONTAINING CERTAIN REPRESENTATIONS AND AGREEMENTS RELATING
      TO THE RESTRICTIONS ON TRANSFER OF THIS NOTE (THE FORM OF WHICH LETTER CAN
      BE OBTAINED FROM THE TRUSTEE) AND IF SUCH TRANSFER IS IN RESPECT OF AN
      AGGREGATE PRINCIPAL AMOUNT OF NOTES OF LESS THAN $100,000, AN OPINION OF
      COUNSEL ACCEPTABLE TO THE ISSUER THAT SUCH TRANSFER IS IN COMPLIANCE WITH
      THE SECURITIES ACT, (D) OUTSIDE THE UNITED STATES IN AN OFFSHORE
      TRANSACTION IN COMPLIANCE WITH RULE 904 UNDER THE SECURITIES ACT, (E)
      PURSUANT TO THE EXEMPTION FROM REGISTRATION PROVIDED UNDER THE SECURITIES
      ACT (IF AVAILABLE) OR (F) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT
      UNDER THE SECURITIES ACT AND IN EACH CASE IN ACCORDANCE WITH ANY
      APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES. PRIOR TO ANY
      TRANSFER, THE HOLDER OF THIS SECURITY AGREES THAT IT WILL DELIVER TO EACH
      PERSON TO WHOM THIS NOTE IS TRANSFERRED A NOTICE SUBSTANTIALLY TO THE
      EFFECT OF THIS LEGEND. IN CONNECTION WITH ANY TRANSFER OF THIS NOTE WITHIN
      THE TIME PERIOD REFERRED TO IN RULE 144(k) UNDER THE SECURITIES ACT AFTER
      THE ORIGINAL ISSUANCE OF THE NOTES, THE HOLDER MUST CHECK THE APPROPRIATE
      BOX SET FORTH ON THE REVERSE HEREOF RELATING TO THE MANNER OF SUCH
      TRANSFER AND SUBMIT THIS CERTIFICATE TO THE TRUSTEE. IF THE PROPOSED
      TRANSFEREE IS AN INSTITUTIONAL ACCREDITED INVESTOR OR A NON-U.S. PERSON,
      THE HOLDER MUST, PRIOR TO SUCH TRANSFER, FURNISH TO THE TRUSTEE AND THE
      COMPANY SUCH CERTIFICATIONS, LEGAL OPINIONS OR OTHER INFORMATION AS EITHER
      OF THEM MAY REASONABLY REQUIRE TO CONFIRM THAT SUCH TRANSFER IS BEING MADE
      PURSUANT TO AN EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE
      REGISTRATION REQUIREMENTS OF THE SECURITIES ACT. AS USED HEREIN, THE TERMS
      "OFFSHORE TRANSACTION." "UNITED STATES" AND "U.S. PERSON" HAVE THE
      MEANINGS GIVEN TO THEM BY REGULATION S UNDER THE SECURITIES ACT. THE
      INDENTURE CONTAINS A PROVISION REQUIRING THE TRUSTEE TO REFUSE TO REGISTER
      ANY TRANSFER OF THIS NOTE IN VIOLATION OF THE FOREGOING RESTRICTION."



            7.    In accordance with the terms of the Exchange Offer (as defined
in the Registration Rights Agreement), the Company will issue, and upon receipt
of a written order in accordance with Section 2.3 of the Indenture, the Trustee
will authenticate:

                  a.    One or more Global Securities in an aggregate principal
                        amount equal to the principal amount of the beneficial
                        interests in the Global Securities tendered into the
                        Exchange Offer pursuant to the terms of the Registration
                        Rights Agreement; and

                  b.    Certificated Notes in an aggregate principal amount
                        equal to the principal amount of the Certificated Notes
                        tendered into the Exchange Offer pursuant to the terms
                        of the Registration Rights Agreement.

            Such Global Securities and Certificated Notes shall will not contain
the restrictive legend set forth in Item 7 above. Concurrently with the issuance
of such Exchange Securities, the Company will instruct the Trustee to cause the
aggregate principal amount of the applicable Global Securities and Certificated
Notes to be reduced accordingly.

            8.    The Notes shall be denominated in Dollars and payments of
principal and interest shall be made in Dollars.

            9.    In addition to the covenants set forth in Article IV of the
Indenture, the following additional covenants shall apply to the 2009 Notes and
the 2014 Notes and shall be incorporated into the Indenture with respect to the
2009 Notes and the 2014 Notes, such additional covenants to be subject to
covenant defeasance pursuant to Section 8.4 of the Indenture:

            "Section 4.5 LIMITATION ON LIENS.

            (a)   The Company shall not, nor shall it permit any of its
Subsidiaries to, create or incur any Lien on any of their respective Properties,
whether now owned or hereafter acquired, or upon any income or profits
therefrom, in order to secure any Indebtedness of the Company, without
effectively providing that such series of Notes shall be equally and ratably
secured until such time as such Indebtedness is no longer secured by such Lien,
except:

                  (1)   Liens existing as of November 18, 2004 (the "CLOSING
DATE");

                  (2)   Liens granted after the Closing Date on any of the
Company or any of its Subsidiaries' Properties securing Indebtedness of the
Company created in favor of the Holders of the Notes;

                  (3)   Liens securing Indebtedness of the Company which are
incurred to extend, renew or refinance Indebtedness which is secured by Liens
permitted to be incurred under the Indenture; provided that those Liens do not
extend to or cover any of the Company or any of its Subsidiaries' Property other
than the Property securing the Indebtedness being refinanced and that the
principal amount of such Indebtedness does not exceed the principal amount of
the Indebtedness being refinanced;



                  (4)   Liens created in substitution of or as replacements for
any Liens permitted by the preceding clauses (1) through (3) directly above,
provided that, based on a good faith determination of an Officer of the Company,
the Property encumbered under any such substitute or replacement Lien is
substantially similar in nature to the Property encumbered by the otherwise
permitted Lien which is being replaced; and

                  (5)   Permitted Liens.

            (b)   Notwithstanding the foregoing, the Company and any of its
Subsidiaries may, without securing either series of Notes, create or incur Liens
which would otherwise be subject to the restrictions set forth in the preceding
paragraph, if after giving effect thereto, Exempted Debt does not exceed the
greater of (x) 35% of Consolidated Net Worth calculated as of the date of the
creation or incurrence of the Lien or (y) 35% of Consolidated Net Worth
calculated as of the Closing Date.

            Section 4.6 LIMITATION ON SALE AND LEASE-BACK TRANSACTIONS.

            (a)   The Company shall not and shall not permit its Subsidiaries
to, enter into any sale and lease-back transaction for the sale and leasing back
of any Property, whether now owned or hereafter acquired, of the Company or any
Subsidiary of the Company, unless:

                  (1)   such transaction was entered into prior to the Closing
Date;

                  (2)   such transaction was for the sale and leasing back of
any Property by a Subsidiary of the Company to the Company;

                  (3)   such transaction involves a lease for less than three
years;

                  (4)   the Company would be entitled to incur Indebtedness
secured by a mortgage on the property to be leased in an amount equal to the
Attributable Liens with respect to such sale and lease-back transaction without
equally and ratably securing the Notes pursuant to Section 4.5; or

                  (5)   the Company applies an amount equal to the fair value of
the proceeds of the Property sold to the purchase of Property or to the
retirement of long-term Indebtedness of the Company or any of its Subsidiaries
within 120 days of the effective date of any such sale and lease-back
transaction. In lieu of applying such amount to such retirement, the Company
may, or may cause any of its Subsidiaries to, deliver debt securities to the
Trustee therefor for cancellation, such debt securities to be credited at the
cost thereof to the Company.

            (b)   Notwithstanding the foregoing, the Company and any of its
Subsidiaries may enter into any sale lease-back transaction which would
otherwise be subject to the foregoing restrictions if after giving effect
thereto and at the time of determination, Exempted Debt does not exceed the
greater of (a) 35% of Consolidated Net Worth calculated as of the closing date
of the sale-leaseback transaction or (b) 35% of Consolidated Net Worth
calculated as of the Closing Date.



            10.   In addition to the definitions set forth in Article I of the
      Indenture, each of the Notes shall include the following additional
      definitions, which, in the event of a conflict with the definition of
      terms in the Indenture, shall control:

            As used in this section, the following terms have the meanings set
forth below.

            "Attributable Liens" means in connection with a sale and lease-back
transaction the lesser of:

            (1) the fair market value of the assets subject to such transaction;
and

            (2) the present value (discounted at a rate per annum equal to the
average interest borne by all outstanding debt securities issued under the
indenture (which may include debt securities in addition to the Notes)
determined on a weighted average basis and compounded semi-annually) of the
obligations of the lessee for rental payments during the term of the related
lease.

            "Capital Lease" means any Indebtedness represented by a lease
obligation of a Person incurred with respect to real property or equipment
acquired or leased by such Person and used in its business that is required to
be recorded as a capital lease in accordance with GAAP.

            "Consolidated Net Worth" means, as of any date of determination, the
Stockholders' Equity of the Company and its Consolidated Subsidiaries on that
date.

            "Consolidated Subsidiary" means, as of any date of determination and
with respect to any Person, any Subsidiary of that Person whose financial data
is, in accordance with GAAP, reflected in that Person's consolidated financial
statements.

            "Credit Agreement" means the Credit Agreement, dated as of July 16,
2004, by and among the company, Citicorp USA, Inc., Barclays Bank PLC and each
other financial institution party thereto, Citibank, N.A., as issuing bank,
Citicorp USA, Inc., as administrative agent, and Barclays Bank PLC, as
Syndication Agent, as such agreement may be amended (including any amendment,
restatement, refinancing and successors thereof), supplemented or otherwise
modified from time to time, including any increase in the principal amount of
the obligations thereunder.

            "Credit Facilities" means, one or more debt facilities (including,
without limitation, the Credit Agreement) or commercial paper facilities, in
each case, with banks or other institutional lenders providing for revolving
credit loans, term loans, receivables financing (including through the sale of
receivables to such lenders or to special purpose entities formed to borrow from
such lenders against such receivables) or letters of credit, in each case, as
amended, restated, modified, renewed, refunded, replaced (whether upon or after
termination or otherwise) or refinanced (including by means of sales of debt
securities to institutional investors) in whole or in part from time to time.



            "Exempted Debt" means the sum of the following as of the date of
determination:

            (1) Indebtedness of the Company incurred after the Closing Date and
secured by Liens not permitted by Section 4.5(a) above; and

            (2) Attributable Liens of the Company and any of its Subsidiaries in
respect of sale and lease-back transactions entered into after the Closing Date
pursuant to Section 4.6(b) above.

            "Governmental Agency" means:

            (1) any foreign, federal, state, county or municipal government, or
political subdivision thereof;

            (2) any governmental or quasi-governmental agency, authority, board,
bureau, commission, department, instrumentality or public body;

            (3) any court or administrative tribunal;

            (4) with respect to any Person, any arbitration tribunal or other
nongovernmental authority to whose jurisdiction that Person has consented.

            "Hedging Obligations" means, with respect to any specified Person,
the obligations of such Person under:

            (1) interest rate swap agreements (whether from fixed to floating or
from floating to fixed), interest rate cap agreements and interest rate collar
agreements;

            (2) other agreements or arrangements designed to manage interest
rates or interest rate risk; and

            (3) other agreements or arrangements designed to protect such Person
against fluctuations in currency exchange rates or commodity prices.

            "Indebtedness" of any Person means, without duplication, any
indebtedness, whether or not contingent, in respect of borrowed money or
evidenced by bonds, notes, debentures or similar instruments or letters of
credit (or reimbursement agreements with respect thereto) or representing the
balance deferred and unpaid of the purchase price of any Property (including
pursuant to Capital Leases), except any such balance that constitutes an accrued
expense or trade payable, if and to the extent any of the foregoing indebtedness
would appear as a liability upon a balance sheet of such Person prepared on a
consolidated basis in accordance with GAAP (but does not include contingent
liabilities which appear only in a footnote to a balance sheet), and shall also
include, to the extent not otherwise included, the guaranty of items which would
be included within this definition.

            "Laws" means, collectively, all foreign, federal, state and local
statutes, treaties, rules, regulations, ordinances, codes and administrative or
controlling precedents of any Governmental Agency.



            "Lien" means any lien, security interest, charge or encumbrance of
any kind (including any conditional sale or other title retention agreement, any
lease in the nature thereof, and any agreement to give any security interest).

            "Make-Whole Amount" means the excess of (1) the aggregate present
value, on the redemption date, of the principal being redeemed or paid and the
amount of interest (exclusive of interest accrued to the date of redemption or
accelerated payment) that would have been payable if such redemption or
accelerated payment had not been made, over (2) the aggregate principal amount
of the Notes being redeemed or paid. Net present value shall be determined by
discounting, on a semi-annual basis, such principal and interest at the
Reinvestment Rate (as defined below and as determined on the third business day
preceding the date such notice of redemption is given or declaration of
acceleration is made) from the respective dates on which such principal and
interest would have been payable if such redemption or accelerated payment had
not been made.

            "Permitted Liens" means:

            (1) Liens securing Indebtedness under Credit Facilities;

            (2) Liens on accounts receivable, merchandise inventory, equipment,
and patents, trademarks, trade names and other intangibles, securing
Indebtedness of the Company;

            (3) Liens on any assets of the Company, any of its Subsidiaries'
assets, or the assets of any joint venture to which the Company or any of its
Subsidiaries is a party, created solely to secure obligations incurred to
finance the refurbishment, improvement or construction of such asset, which
obligations are incurred no later than 24 months after completion of such
refurbishment, improvement or construction, and all renewals, extensions,
refinancings, replacements or refundings of such obligations;

            (4) (a) Liens given to secure the payment of the purchase price
incurred in connection with the acquisition (including acquisition through
merger or consolidation) of Property (including shares of stock), including
Capital Lease transactions in connection with any such acquisition, and (b)
Liens existing on Property at the time of acquisition thereof or at the time of
acquisition by the Company or one of its Subsidiaries of any Person then owning
such Property whether or not such existing Liens were given to secure the
payment of the purchase price of the Property to which they attach; provided
that, with respect to clause (a), the Liens shall be given within 24 months
after such acquisition and shall attach solely to the Property acquired or
purchased and any improvements then or thereafter placed thereon;

            (5) Liens in favor of customs and revenue authorities arising as a
matter of law to secure payment of customs duties in connection with the
importation of goods;

            (6) Liens upon specific items of inventory or other goods and
proceeds of any Person securing such Person's obligations in respect of bankers'
acceptances issued or created for the account of such Person to facilitate the
purchase, shipment or storage of such inventory or other goods;



            (7) Liens securing reimbursement obligations with respect to letters
of credit that encumber documents and other Property relating to such letters of
credit and the products and proceeds thereof;

            (8) Liens on key-man life insurance policies granted to secure
Indebtedness of the Company against the cash surrender value thereof;

            (9) Liens encumbering customary initial deposits and margin deposits
and other Liens in the ordinary course of business, in each case securing
Hedging Obligations and forward contract, option, futures contracts, futures
options or similar agreements or arrangements designed to protect the Company or
any of its Subsidiaries from fluctuations in interest rates, currencies or the
price of commodities;

            (10) Liens arising out of conditional sale, title retention,
consignment or similar arrangements for the sale of goods entered into by
Company or any of its Subsidiaries in the ordinary course of business;

            (11) pre-existing Liens on assets acquired by the Company or any of
its Subsidiaries after the Closing Date of the offering of the Notes;

            (12) Liens in favor of the Company or in favor of any of its
Subsidiaries;

            (13) inchoate Liens incident to construction or maintenance of real
property, or Liens incident to construction or maintenance of real property, now
or hereafter filed of record for sums not yet delinquent or being contested in
good faith, if reserves or other appropriate provisions, if any, as shall be
required by GAAP shall have been made therefore;

            (14) statutory Liens arising in the ordinary course of business with
respect to obligations which are not delinquent or are being contested in good
faith, if reserves or other appropriate provisions, if any, as shall be required
by GAAP shall have been made therefore;

            (15) Liens consisting of pledges or deposits to secure obligations
under workers' compensation laws or similar legislation, including Liens of
judgments thereunder which are not currently dischargeable;

            (16) Liens consisting of pledges or deposits of Property to secure
performance in connection with operating leases made in the ordinary course of
business to which Company or any of its Subsidiaries is a party as lessee,
provided the aggregate value of all such pledges and deposits in connection with
any such lease does not at any time exceed 16-2/3% of the annual fixed rentals
payable under such lease;

            (17) Liens consisting of deposits of Property to secure statutory
obligations of the Company or statutory obligations of any of its Subsidiaries
in the ordinary course of its business;

            (18) Liens consisting of deposits of Property to secure (or in lieu
of) surety, appeal or customs bonds in proceedings to which Company or any of
its Subsidiaries is a party in the ordinary course of its business, but not in
excess of $25,000,000;



            (19) purchase money Liens or purchase money security interests upon
or in any Property acquired or held by Company or any of its Subsidiaries in the
ordinary course of business to secure the purchase price of such Property or to
secure indebtedness incurred solely for the purpose of financing the acquisition
of such Property;

            (20) Liens on an asset created in connection with the acquisition,
construction or development of additions, extensions or improvements to such
asset which shall be financed by obligations described in Sections 142, 144(a)
or 144(c) of the Internal Revenue Code of 1986, as amended, or by obligations
entitled to substantially similar tax benefits under other legislation or
regulations in effect from time to time; and

            (21) Liens on Property subject to escrow or similar arrangements
established in connection with litigation settlements.

            "Property" means any property or asset, whether real, personal or
mixed, or tangible or intangible.

            "Reinvestment Rate" means for the 2009 Notes, 0.10% and for the 2014
Notes, means 0.15%, in each case plus the arithmetic mean of the yields under
the respective heading "Week Ending" published in the most recent Statistical
Release (as defined below) under the caption "Treasury Constant Maturities" for
the maturity (rounded to the nearest month) corresponding to the remaining life
to maturity, as of the payment date of the principal being redeemed or paid. If
no maturity exactly corresponds to such maturity, yields for the two published
maturities most closely corresponding to such maturity shall be calculated
pursuant to the immediately preceding sentence and the Reinvestment Rate shall
be interpolated or extrapolated from such yields on a straight-line basis,
rounding in each of such relevant periods to the nearest month. For the purpose
of calculating the Reinvestment Rate, the most recent Statistical Release
published prior to the date of determination of the Make-Whole Amount shall be
used.

            "Statistical Release" means the statistical release designated
"H.15(519)" or any successor publication which is published weekly by the
Federal Reserve System and which establishes yields on actively traded United
States government securities adjusted to constant maturities, or, if such
Statistical Release is not published at the time of any determination under the
indenture, then such other reasonably comparable index which shall be designated
by us.

            "Stockholders' Equity" means, as of any date of determination,
stockholders' equity as of that date determined in accordance with GAAP;
provided that there shall be excluded from Stockholders' Equity any amount
attributable to capital stock that is, directly or indirectly, required to be
redeemed or repurchased by the issuer thereof at a specified date or upon the
occurrence of specified events or at the election of the holder thereof.



            11. The Depository for the Notes shall be The Depository Trust
Company ("DTC").

            12. Each of the undersigned is authorized to approve the form, terms
and conditions of the Notes.

            13. Attached hereto as Annex C are true and correct copies of the
Resolutions.

            14. Each of the undersigned has read the provisions of the
Indenture, including the covenants and conditions precedent, pertaining to the
issuance of the Notes.

            15. In connection with this Certificate, each of the undersigned has
examined the documents, corporate records and certificates and has made such
inquiries of the other officers of the Company, which he has deemed necessary to
enable him to express an informed opinion as to whether or not such comments and
conditions have been complied with.

            16. In the opinion of each of the undersigned, all of the conditions
and covenants related to the issuance of the Notes have been complied with.



            IN WITNESS WHEREOF, the undersigned have executed this Officers'
Certificate as of the date first set forth above.

                                       By:    /s/ Richard D. Nanula
                                          -------------------------------------
                                          Name:  Richard D. Nanula
                                          Title: Executive Vice President and
                                                 Chief Financial Officer

                                       By:       Steven J. Schoch
                                          -------------------------------------
                                          Name:  Steven J. Schoch
                                          Title: Vice President, Finance and
                                                 Controller


                                     Annex A Form of 4.00% Senior Notes due 2009

                                 [Face of Note]

                                                          CUSIP/CINS ___________

                           4.00% Senior Notes due 2009

No. ___                                                            $____________

                                   AMGEN INC.

promises to pay to CEDE & CO. or registered assigns,

the principal sum of _____________________ on November 18, 2009.

Interest Payment Dates: May 18 and November 18

Record Dates: 15th day prior to May 18 and November 18

Dated: November 18, 2004

                                              AMGEN INC.

                                              By: ______________________________
                                                  Name:
                                                  Title:

                                              By: ______________________________
                                                  Name:
                                                  Title:

This is one of the Notes referred to
in the within-mentioned Indenture:

JPMorgan Chase Bank, N.A.,
  as Trustee

By: ________________________________
          Authorized Officer

                                       1


                                 [Back of Note]
                           4.00% SENIOR NOTES DUE 2009

[GLOBAL LEGEND]

      THIS  SECURITY  IS  A GLOBAL SECURITY WITHIN THE MEANING OF THE  INDENTURE
HEREINAFTER  REFERRED  TO  AND IS REGISTERED IN THE NAME OF THE DEPOSITORY OR  A
NOMINEE  OF  THE  DEPOSITORY.  THIS  SECURITY  IS  EXCHANGEABLE  FOR  SECURITIES
REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY
IN  THE  LIMITED  CIRCUMSTANCES  DESCRIBED  IN  THE  INDENTURE,  AND MAY NOT  BE
TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE  DEPOSITORY,
BY  A  NOMINEE  OF  THE  DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF  THE
DEPOSITORY OR BY THE DEPOSITORY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITORY OR
A NOMINEE OF SUCH A SUCCESSOR DEPOSITORY.

[TRANSFER RESTRICTED LEGEND]

      THIS  NOTE  HAS  NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,  AS
AMENDED  (THE  "SECURITIES  ACT"),  AND ACCORDINGLY, MAY NOT BE OFFERED OR  SOLD
WITHIN  THE UNITED STATES OR TO, OR FOR THE ACCOUNT OR BENEFIT OF, U.S.  PERSONS
EXCEPT  AS  SET FORTH IN THE FOLLOWING SENTENCE. BY ITS ACQUISITION HEREOF,  THE
HOLDER  (I)  REPRESENTS  THAT  (A)  IT IS A "QUALIFIED INSTITUTIONAL BUYER"  (AS
DEFINED  IN  RULE  144A UNDER THE SECURITIES ACT) OR (B) IT IS AN  INSTITUTIONAL
"ACCREDITED  INVESTOR"  (AS  DEFINED  IN  RULE  501(A)(1),  (2),  (3) OR (7)  OF
REGULATION D UNDER THE SECURITIES ACT) (AN "INSTITUTIONAL ACCREDITED  INVESTOR")
OR  (C)  IT  IS  NOT  A  U.S.  PERSON AND IS ACQUIRING THIS NOTE IN AN  OFFSHORE
TRANSACTION (AS DEFINED IN REGULATION S UNDER THE SECURITIES ACT) IN  COMPLIANCE
WITH REGULATION S UNDER THE SECURITIES ACT, (2) AGREES THAT IT WILL NOT,  WITHIN
THE TIME PERIOD REFERRED TO IN RULE 144(K) UNDER THE SECURITIES ACT AS IN EFFECT
ON THE DATE OF THE TRANSFER OF THIS NOTE, RESELL OR OTHERWISE TRANSFER THIS NOTE
EXCEPT  (A)  TO  THE  ISSUER  OR  ANY  SUBSIDIARY  THEREOF,  (B) TO A  QUALIFIED
INSTITUTIONAL  BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT,  (C)
INSIDE THE UNITED STATES TO AN INSTITUTIONAL ACCREDITED INVESTOR THAT, PRIOR  TO
SUCH  TRANSFER,  FURNISHES  TO  THE  TRUSTEE A SIGNED LETTER CONTAINING  CERTAIN
REPRESENTATIONS AND AGREEMENTS RELATING TO THE RESTRICTIONS ON TRANSFER OF  THIS
NOTE  (THE  FORM  OF WHICH LETTER CAN BE OBTAINED FROM THE TRUSTEE) AND IF  SUCH
TRANSFER  IS  IN RESPECT OF AN AGGREGATE PRINCIPAL AMOUNT OF NOTES OF LESS  THAN
$100,000,  AN OPINION OF COUNSEL ACCEPTABLE TO THE ISSUER THAT SUCH TRANSFER  IS
IN  COMPLIANCE  WITH  THE  SECURITIES  ACT, (D) OUTSIDE THE UNITED STATES IN  AN
OFFSHORE  TRANSACTION IN COMPLIANCE WITH RULE 904 UNDER THE SECURITIES ACT,  (E)
PURSUANT  TO  THE EXEMPTION FROM REGISTRATION PROVIDED UNDER THE SECURITIES  ACT
(IF AVAILABLE) OR (F) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER  THE
SECURITIES  ACT  AND  IN EACH CASE IN ACCORDANCE WITH ANY APPLICABLE  SECURITIES
LAWS  OF  ANY  STATE OF THE UNITED STATES. PRIOR TO ANY TRANSFER, THE HOLDER  OF
THIS  SECURITY  AGREES THAT IT WILL DELIVER TO EACH PERSON TO WHOM THIS NOTE  IS
TRANSFERRED A NOTICE SUBSTANTIALLY TO THE EFFECT OF THIS

                                       2


LEGEND.  IN  CONNECTION  WITH  ANY TRANSFER OF THIS NOTE WITHIN THE TIME  PERIOD
REFERRED TO IN RULE 144(K) UNDER THE SECURITIES ACT AFTER THE ORIGINAL  ISSUANCE
OF THE NOTES, THE HOLDER MUST CHECK THE APPROPRIATE BOX SET FORTH ON THE REVERSE
HEREOF  RELATING  TO THE MANNER OF SUCH TRANSFER AND SUBMIT THIS CERTIFICATE  TO
THE TRUSTEE. IF THE PROPOSED TRANSFEREE IS AN INSTITUTIONAL ACCREDITED  INVESTOR
OR  A  NON-U.S. PERSON, THE HOLDER MUST, PRIOR TO SUCH TRANSFER, FURNISH TO  THE
TRUSTEE AND THE COMPANY SUCH CERTIFICATIONS, LEGAL OPINIONS OR OTHER INFORMATION
AS EITHER OF THEM MAY REASONABLY REQUIRE TO CONFIRM THAT SUCH TRANSFER IS  BEING
MADE  PURSUANT  TO  AN  EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO,  THE
REGISTRATION  REQUIREMENTS  OF  THE  SECURITIES  ACT. AS USED HEREIN, THE  TERMS
"OFFSHORE  TRANSACTION."  "UNITED  STATES"  AND "U.S. PERSON" HAVE THE  MEANINGS
GIVEN TO THEM BY REGULATION S UNDER THE SECURITIES ACT. THE INDENTURE CONTAINS A
PROVISION REQUIRING THE TRUSTEE TO REFUSE TO REGISTER ANY TRANSFER OF THIS  NOTE
IN VIOLATION OF THE FOREGOING RESTRICTION.

      Capitalized  terms  used herein have the meanings assigned to them in  the
Indenture referred to below unless otherwise indicated.

            (1)  INTEREST.  Amgen Inc., a Delaware corporation (the  "Company"),
      promises to pay interest on the principal amount of this Note at 4.00% per
      annum  from  November  18,  2004 until maturity and shall pay the  Special
      Interest  (as  defined  in  the  Registration  Rights Agreement), if  any,
      payable  pursuant  to  Section  4  of  the  Registration Rights  Agreement
      referred to below. The Company will pay interest and Special Interest,  if
      any,  semi-annually in arrears on May 18 and November 18 of each year,  or
      if any such day is not a Business Day, on the next succeeding Business Day
      (each, an "Interest Payment Date"). Interest on the Notes will accrue from
      the  most  recent date to which interest has been paid or, if no  interest
      has been paid, from the date of issuance; provided that the first Interest
      Payment  Date  shall be May 18, 2005; provided further that after May  18,
      2005,  if there is no existing Default in the payment of interest, and  if
      this  Note is authenticated between a record date referred to on the  face
      hereof  and  the  next  succeeding  Interest Payment Date, interest  shall
      accrue from such next succeeding Interest Payment Date.

            (2)  METHOD  OF PAYMENT. The Company will pay interest on the  Notes
      (except  defaulted interest) and Special Interest, if any, to the  Persons
      who  are  registered Holders of Notes at the close of business on the  day
      that  is  15  days  prior  to  the  next succeeding Interest Payment  Date
      (whether  or  not  such  day  is  a Business Day), even if such Notes  are
      canceled  after  such  record date and on or before such Interest  Payment
      Date, except as provided in Section 2.13 of the Indenture with respect  to
      defaulted  interest.  The Notes will be payable as to principal,  interest
      and  Special  Interest,  if  any,  at the office or agency of the  Company
      maintained  for  such  purpose  in the Borough of Manhattan, the City  and
      State  of  New  York (or, if the Company fails to maintain such office  or
      agency, at the corporate trust office of the trustee in New York, New York
      or  if the trustee does not maintain an office in New York, at the  office
      of a paying agent in New York), or, at the option of the Company,  payment
      of  interest and Special Interest, if any, may be made by check mailed  to
      the  Holders  at  their  addresses  set forth in the register of  Holders;
      provided that payment by wire transfer of immediately available funds will
      be  required  with  respect  to  principal  of  and  interest and  Special
      Interest,  if  any,  on,  all  Global  Securities and all other Notes  the
      Holders  of  which  will  have provided wire transfer instructions to  the
      Company  or the Paying Agent. Such payment will be in the currency of  the
      United States of America.

                                       3


            (3)  PAYING  AGENT  AND  REGISTRAR. Initially, JPMorgan Chase  Bank,
      N.A.,  the  Trustee  under  the  Indenture,  will act as Paying Agent  and
      Registrar.  The  Company may change any Paying Agent or Registrar  without
      notice  to  any Holder. The Company or any of its Subsidiaries may act  in
      any such capacity.

            (4)  INDENTURE.  The terms of the Notes include those stated in  the
      Indenture  and  those  made  part  of  the  Indenture  by  the   Officers'
      Certificate  dated  November  18,  2004  delivered  pursuant thereto  (the
      "Officers'  Certificate")  and the TIA. The Notes are subject to all  such
      terms,  and  the  Holders are referred to the Indenture and the TIA for  a
      statement of them.

            (5) OPTIONAL REDEMPTION. At any time prior to maturity, the  Company
      will  have  the option to redeem all or a part of the Notes upon not  less
      than 30 nor more than 60 days' notice, at a redemption price equal to  the
      sum  of (1) 100% of the principal amount of any notes being redeemed  plus
      accrued  and  unpaid interest to, but not including, the redemption  date,
      and (2) the Make-Whole Amount. Unless the Company defaults in the  payment
      of  the  redemption  price, interest will cease to accrue on the Notes  or
      portions thereof called for redemption on the applicable redemption  date.

            (6)  MANDATORY  REDEMPTION.  The  Company  is  not required to  make
      mandatory  redemption or sinking fund payments with respect to the  Notes.

            (7)  NOTICE  OF  REDEMPTION. Notice of redemption will be mailed  at
      least 30 days but not more than 60 days before the redemption date to each
      Holder  whose  Notes are to be redeemed at its registered address,  except
      that  redemption  notices  may  be  mailed  more  than 60 days prior to  a
      redemption date if the notice is issued in connection with a defeasance of
      the  Notes  or  a  satisfaction  or  discharge of the Indenture. Notes  in
      denominations larger than $1,000 may be redeemed in part but only in whole
      multiples  of  $1,000, unless all of the Notes held by a Holder are to  be
      redeemed.

            (8) DEFEASANCE PRIOR TO MATURITY. The Indenture contains  provisions
      for defeasance of (i) the entire indebtedness of the Notes or (ii) certain
      covenants  and  Events of Default with respect to the Notes, in each  case
      upon compliance with certain conditions set forth therein.

            (9)   RESTRICTIVE   COVENANTS.  The  Indenture  and  the   Officers'
      Certificate   impose   certain  limitations  on  the  Company's  and   its
      Subsidiaries', including limitations on the Company's and its subsidiaries
      ability  to  create  or  incur  certain  Liens on any of their  respective
      properties  or  assets  and  to  enter  into  certain sale and  lease-back
      transactions  and  on  the  Company's  ability  to  engage  in mergers  or
      consolidations   or   the   conveyance,  transfer  or  lease  of  all   or
      substantially  all  of  its  properties and assets. These limitations  are
      subject  to  a  number  of  important  qualifications  and exceptions  and
      reference  is  made  to the Indenture and the Officers' Certificate for  a
      description thereof.

            (10) DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in  registered
      form without coupons in denominations of $1,000 and integral multiples  of
      $1,000. The transfer of Notes may be registered and Notes may be exchanged
      as provided in the Indenture. The Registrar and the Trustee may require  a
      Holder,  among  other  things,  to  furnish  appropriate endorsements  and
      transfer  documents and the Company may require a Holder to pay any  taxes
      and  fees required by law or permitted by the Indenture. The Company  need
      not  exchange  or  register the transfer of any Note or portion of a  Note
      selected  for  redemption,  except for the unredeemed portion of any  Note
      being  redeemed  in part. Also, the Company need not exchange or  register
      the transfer of

                                       4


      any  Notes  for  a  period  of  15 days before a selection of Notes to  be
      redeemed or during the period between a record date and the  corresponding
      Interest Payment Date.

            (11)  PERSONS DEEMED OWNERS. The registered Holder of a Note may  be
      treated as its owner for all purposes.

            (12)   AMENDMENT,   SUPPLEMENT   AND  WAIVER.  Subject  to   certain
      exceptions, the Indenture or the Notes may be amended or supplemented with
      the  consent of the Holders of at least a majority in aggregate  principal
      amount  of  the  then outstanding Notes voting as a single class, and  any
      existing  Default or Event or Default or compliance with any provision  of
      the  Indenture or the Notes may be waived with the consent of the  Holders
      of a majority in aggregate principal amount of the then outstanding  Notes
      voting as a single class. Without the consent of any Holder of a Note, the
      Indenture  or  the  Notes  may  be  amended  or  supplemented to cure  any
      ambiguity, defect or inconsistency, to provide for uncertificated Notes in
      addition  to  or  in place of certificated Notes, to make any change  that
      would  not  adversely  affect the legal rights under the Indenture of  any
      such  Holder,  to  provide  for  the  issuance of any additional notes  as
      permitted by the Indenture, to appoint a successor trustee with respect to
      the  notes and to add to or change any of the provisions of the  Indenture
      necessary to provide for the administration of the trusts in the indenture
      by more than one trustee, or to comply with the requirements of the SEC in
      order  to effect or maintain the qualification of the Indenture under  the
      TIA.

            (13)  DEFAULTS AND REMEDIES. If an Event of Default shall occur  and
      be continuing, the principal of the Notes may be declared (or, in  certain
      cases, shall ipso facto become) due and payable in the manner and with the
      effect provided in the Indenture.

            (14) TRUSTEE DEALINGS WITH COMPANY. The Trustee under the Indenture,
      in  its individual or any other capacity, may deal with the Company or  an
      Affiliate of the Company with the same rights it would have if it were not
      Trustee.

            (15)  NO  RECOURSE AGAINST OTHERS. A director, officer, employee  or
      stockholder  of  the  Company  shall  not  have  any  liability  for   any
      obligations  of  the  Company under the Notes or the Indenture or for  any
      claim based on, in respect of, or by reason of, such obligations or  their
      creation.  Each  Holder  by accepting a Note waives and releases all  such
      liability.  The  waiver and release are part of the consideration for  the
      issuance of the Notes.

            (16) AUTHENTICATION. This Note will not be valid until authenticated
      by the manual signature of the Trustee or an authenticating agent.

            (17) ABBREVIATIONS. Customary abbreviations may be used in the  name
      of  a  Holder or an assignee, such as: TEN COM (= tenants in common),  TEN
      ENT  (= tenants by the entireties), JT TEN (= joint tenants with right  of
      survivorship  and  not  as  tenants  in  common), CUST (= Custodian),  and
      U/G/M/A (= Uniform Gifts to Minors Act).

            (18)  REGISTRATION  RIGHTS  OF  HOLDERS.  In addition to the  rights
      provided  to  Holders of Notes under the Indenture, Holders of  restricted
      Notes  will  have  all  the  rights  set forth in the Registration  Rights
      Agreement,  dated  as  of  November 18, 2004, between the Company and  the
      other  parties  named  on  the signature pages thereof (the  "Registration
      Rights Agreement").

            (19) CUSIP NUMBERS. Pursuant to a recommendation promulgated by  the
      Committee  on Uniform Security Identification Procedures, the Company  has
      caused  CUSIP numbers to be printed on the Notes, and the Trustee may  use
      CUSIP numbers in notices of redemption as a

                                       5


      convenience  to  Holders. No representation is made as to the accuracy  of
      such numbers either as printed on the Notes or as contained in any  notice
      of redemption, and reliance may be placed only on the other identification
      numbers placed thereon.

            (20)  GOVERNING LAW. THE INTERNAL LAW OF THE STATE OF NEW YORK  WILL
      GOVERN AND BE USED TO CONSTRUE THE INDENTURE AND THIS NOTE WITHOUT  GIVING
      EFFECT TO APPLICABLE PRINCIPLES OF CONFLICTS OF LAW TO THE EXTENT THAT THE
      APPLICATION OF THE LAWS OF ANOTHER JURISDICTION WOULD BE REQUIRED THEREBY.

      The  Company  will furnish to any Holder upon written request and  without
charge  a  copy  of  the  Indenture  and/or  the Registration Rights  Agreement.
Requests may be made to:

                                   Amgen Inc.
                             One Amgen Center Drive
                          Thousand Oaks, CA 91320-1799
                          Attention: Investor Relations

                                       6


                                 ASSIGNMENT FORM

      To assign this Note, fill in the form below:

(I) or (we) assign and transfer this Note to: __________________________________
                                                (Insert assignee's legal name)

_______________________________________________________________________________
                  (Insert assignee's soc. sec. or tax I.D. no.)

_______________________________________________________________________________

_______________________________________________________________________________

_______________________________________________________________________________

_______________________________________________________________________________
              (Print or type assignee's name, address and zip code)

and irrevocably appoint ________________________________________________________
to transfer this Note on the books of the Company. The agent may substitute
another to act for him.

Date: _______________

                                    Your Signature: ___________________________
                                             (Sign exactly as your name appears
                                              on the face of this Note)

Signature Guarantee*: _________________________

* Participant in a recognized Signature Guarantee Medallion Program (or other
signature guarantor acceptable to the Trustee).

                                       7


                                     Annex B Form of 4.85% Senior Notes due 2014

                                 [Face of Note]

                                                          CUSIP/CINS ___________

                           4.85% Senior Notes due 2014

No. ___                                                            $____________

                                   AMGEN INC.

promises to pay to CEDE & CO. or registered assigns,

the principal sum of _____________________ on November 18, 2014.

Interest Payment Dates: May 18 and November 18

Record Dates: 15th day prior to May 18 and November 18

Dated: November 18, 2004

                                               AMGEN INC.

                                               By:
                                                   -----------------------------
                                                   Name:
                                                   Title:

                                               By:
                                                   -----------------------------
                                                   Name:
                                                   Title:

This is one of the Notes referred to
in the within-mentioned Indenture:

JPMorgan Chase Bank, N.A.,
  as Trustee

By:
    -----------------------------
         Authorized Officer

                                       1


                                 [Back of Note]
                           4.85% SENIOR NOTES DUE 2014

[GLOBAL LEGEND]

      THIS  SECURITY  IS  A GLOBAL SECURITY WITHIN THE MEANING OF THE  INDENTURE
HEREINAFTER  REFERRED  TO  AND IS REGISTERED IN THE NAME OF THE DEPOSITORY OR  A
NOMINEE  OF  THE  DEPOSITORY.  THIS  SECURITY  IS  EXCHANGEABLE  FOR  SECURITIES
REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY
IN  THE  LIMITED  CIRCUMSTANCES  DESCRIBED  IN  THE  INDENTURE,  AND MAY NOT  BE
TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE  DEPOSITORY,
BY  A  NOMINEE  OF  THE  DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF  THE
DEPOSITORY OR BY THE DEPOSITORY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITORY OR
A NOMINEE OF SUCH A SUCCESSOR DEPOSITORY.

[TRANSFER RESTRICTED LEGEND]

      THIS  NOTE  HAS  NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,  AS
AMENDED  (THE  "SECURITIES  ACT"),  AND ACCORDINGLY, MAY NOT BE OFFERED OR  SOLD
WITHIN  THE UNITED STATES OR TO, OR FOR THE ACCOUNT OR BENEFIT OF, U.S.  PERSONS
EXCEPT  AS  SET FORTH IN THE FOLLOWING SENTENCE. BY ITS ACQUISITION HEREOF,  THE
HOLDER  (I)  REPRESENTS  THAT  (A)  IT IS A "QUALIFIED INSTITUTIONAL BUYER"  (AS
DEFINED  IN  RULE  144A UNDER THE SECURITIES ACT) OR (B) IT IS AN  INSTITUTIONAL
"ACCREDITED  INVESTOR"  (AS  DEFINED  IN  RULE  501(A)(1),  (2),  (3) OR (7)  OF
REGULATION D UNDER THE SECURITIES ACT) (AN "INSTITUTIONAL ACCREDITED  INVESTOR")
OR  (C)  IT  IS  NOT  A  U.S.  PERSON AND IS ACQUIRING THIS NOTE IN AN  OFFSHORE
TRANSACTION (AS DEFINED IN REGULATION S UNDER THE SECURITIES ACT) IN  COMPLIANCE
WITH REGULATION S UNDER THE SECURITIES ACT, (2) AGREES THAT IT WILL NOT,  WITHIN
THE TIME PERIOD REFERRED TO IN RULE 144(K) UNDER THE SECURITIES ACT AS IN EFFECT
ON THE DATE OF THE TRANSFER OF THIS NOTE, RESELL OR OTHERWISE TRANSFER THIS NOTE
EXCEPT  (A)  TO  THE  ISSUER  OR  ANY  SUBSIDIARY  THEREOF,  (B) TO A  QUALIFIED
INSTITUTIONAL  BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT,  (C)
INSIDE THE UNITED STATES TO AN INSTITUTIONAL ACCREDITED INVESTOR THAT, PRIOR  TO
SUCH  TRANSFER,  FURNISHES  TO  THE  TRUSTEE A SIGNED LETTER CONTAINING  CERTAIN
REPRESENTATIONS AND AGREEMENTS RELATING TO THE RESTRICTIONS ON TRANSFER OF  THIS
NOTE  (THE  FORM  OF WHICH LETTER CAN BE OBTAINED FROM THE TRUSTEE) AND IF  SUCH
TRANSFER  IS  IN RESPECT OF AN AGGREGATE PRINCIPAL AMOUNT OF NOTES OF LESS  THAN
$100,000,  AN OPINION OF COUNSEL ACCEPTABLE TO THE ISSUER THAT SUCH TRANSFER  IS
IN  COMPLIANCE  WITH  THE  SECURITIES  ACT, (D) OUTSIDE THE UNITED STATES IN  AN
OFFSHORE  TRANSACTION IN COMPLIANCE WITH RULE 904 UNDER THE SECURITIES ACT,  (E)
PURSUANT  TO  THE EXEMPTION FROM REGISTRATION PROVIDED UNDER THE SECURITIES  ACT
(IF AVAILABLE) OR (F) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER  THE
SECURITIES  ACT  AND  IN EACH CASE IN ACCORDANCE WITH ANY APPLICABLE  SECURITIES
LAWS  OF  ANY  STATE OF THE UNITED STATES. PRIOR TO ANY TRANSFER, THE HOLDER  OF
THIS  SECURITY  AGREES THAT IT WILL DELIVER TO EACH PERSON TO WHOM THIS NOTE  IS
TRANSFERRED A NOTICE SUBSTANTIALLY TO THE EFFECT OF THIS

                                       2


LEGEND.  IN  CONNECTION  WITH  ANY TRANSFER OF THIS NOTE WITHIN THE TIME  PERIOD
REFERRED TO IN RULE 144(K) UNDER THE SECURITIES ACT AFTER THE ORIGINAL  ISSUANCE
OF THE NOTES, THE HOLDER MUST CHECK THE APPROPRIATE BOX SET FORTH ON THE REVERSE
HEREOF  RELATING  TO THE MANNER OF SUCH TRANSFER AND SUBMIT THIS CERTIFICATE  TO
THE TRUSTEE. IF THE PROPOSED TRANSFEREE IS AN INSTITUTIONAL ACCREDITED  INVESTOR
OR  A  NON-U.S. PERSON, THE HOLDER MUST, PRIOR TO SUCH TRANSFER, FURNISH TO  THE
TRUSTEE AND THE COMPANY SUCH CERTIFICATIONS, LEGAL OPINIONS OR OTHER INFORMATION
AS EITHER OF THEM MAY REASONABLY REQUIRE TO CONFIRM THAT SUCH TRANSFER IS  BEING
MADE  PURSUANT  TO  AN  EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO,  THE
REGISTRATION  REQUIREMENTS  OF  THE  SECURITIES  ACT. AS USED HEREIN, THE  TERMS
"OFFSHORE  TRANSACTION."  "UNITED  STATES"  AND "U.S. PERSON" HAVE THE  MEANINGS
GIVEN TO THEM BY REGULATION S UNDER THE SECURITIES ACT. THE INDENTURE CONTAINS A
PROVISION REQUIRING THE TRUSTEE TO REFUSE TO REGISTER ANY TRANSFER OF THIS  NOTE
IN VIOLATION OF THE FOREGOING RESTRICTION.

      Capitalized  terms  used herein have the meanings assigned to them in  the
Indenture referred to below unless otherwise indicated.

            (1)  INTEREST.  Amgen Inc., a Delaware corporation (the  "Company"),
      promises to pay interest on the principal amount of this Note at 4.85% per
      annum  from  November  18,  2004 until maturity and shall pay the  Special
      Interest  (as  defined  in  the  Registration  Rights Agreement), if  any,
      payable  pursuant  to  Section  4  of  the  Registration Rights  Agreement
      referred to below. The Company will pay interest and Special Interest,  if
      any,  semi-annually in arrears on May 18 and November 18 of each year,  or
      if any such day is not a Business Day, on the next succeeding Business Day
      (each, an "Interest Payment Date"). Interest on the Notes will accrue from
      the  most  recent date to which interest has been paid or, if no  interest
      has been paid, from the date of issuance; provided that the first Interest
      Payment  Date  shall be May 18, 2005; provided further that after May  18,
      2005,  if there is no existing Default in the payment of interest, and  if
      this  Note is authenticated between a record date referred to on the  face
      hereof  and  the  next  succeeding  Interest Payment Date, interest  shall
      accrue from such next succeeding Interest Payment Date.

            (2)  METHOD  OF PAYMENT. The Company will pay interest on the  Notes
      (except  defaulted interest) and Special Interest, if any, to the  Persons
      who  are  registered Holders of Notes at the close of business on the  day
      that  is  15  days  prior  to  the  next succeeding Interest Payment  Date
      (whether  or  not  such  day  is  a Business Day), even if such Notes  are
      canceled  after  such  record date and on or before such Interest  Payment
      Date, except as provided in Section 2.13 of the Indenture with respect  to
      defaulted  interest.  The Notes will be payable as to principal,  interest
      and  Special  Interest,  if  any,  at the office or agency of the  Company
      maintained  for  such  purpose  in the Borough of Manhattan, the City  and
      State  of  New  York (or, if the Company fails to maintain such office  or
      agency, at the corporate trust office of the trustee in New York, New York
      or  if the trustee does not maintain an office in New York, at the  office
      of a paying agent in New York), or, at the option of the Company,  payment
      of  interest and Special Interest, if any, may be made by check mailed  to
      the  Holders  at  their  addresses  set forth in the register of  Holders;
      provided that payment by wire transfer of immediately available funds will
      be  required  with  respect  to  principal  of  and  interest and  Special
      Interest,  if  any,  on,  all  Global  Securities and all other Notes  the
      Holders  of  which  will  have provided wire transfer instructions to  the
      Company  or the Paying Agent. Such payment will be in the currency of  the
      United States of America.

                                       3


            (3)  PAYING  AGENT  AND  REGISTRAR. Initially, JPMorgan Chase  Bank,
      N.A.,  the  Trustee  under  the  Indenture,  will act as Paying Agent  and
      Registrar.  The  Company may change any Paying Agent or Registrar  without
      notice  to  any Holder. The Company or any of its Subsidiaries may act  in
      any such capacity.

            (4)  INDENTURE.  The terms of the Notes include those stated in  the
      Indenture  and  those  made  part  of  the  Indenture  by  the   Officers'
      Certificate  dated  November  18,  2004  delivered  pursuant thereto  (the
      "Officers'  Certificate")  and the TIA. The Notes are subject to all  such
      terms,  and  the  Holders are referred to the Indenture and the TIA for  a
      statement of them.

            (5) OPTIONAL REDEMPTION. At any time prior to maturity, the  Company
      will  have  the option to redeem all or a part of the Notes upon not  less
      than 30 nor more than 60 days' notice, at a redemption price equal to  the
      sum  of (1) 100% of the principal amount of any notes being redeemed  plus
      accrued  and  unpaid interest to, but not including, the redemption  date,
      and (2) the Make-Whole Amount. Unless the Company defaults in the  payment
      of  the  redemption  price, interest will cease to accrue on the Notes  or
      portions thereof called for redemption on the applicable redemption  date.

            (6)  MANDATORY  REDEMPTION.  The  Company  is  not required to  make
      mandatory  redemption or sinking fund payments with respect to the  Notes.

            (7)  NOTICE  OF  REDEMPTION. Notice of redemption will be mailed  at
      least 30 days but not more than 60 days before the redemption date to each
      Holder  whose  Notes are to be redeemed at its registered address,  except
      that  redemption  notices  may  be  mailed  more  than 60 days prior to  a
      redemption date if the notice is issued in connection with a defeasance of
      the  Notes  or  a  satisfaction  or  discharge of the Indenture. Notes  in
      denominations larger than $1,000 may be redeemed in part but only in whole
      multiples  of  $1,000, unless all of the Notes held by a Holder are to  be
      redeemed.

            (8) DEFEASANCE PRIOR TO MATURITY. The Indenture contains  provisions
      for defeasance of (i) the entire indebtedness of the Notes or (ii) certain
      covenants  and  Events of Default with respect to the Notes, in each  case
      upon compliance with certain conditions set forth therein.

            (9)   RESTRICTIVE   COVENANTS.  The  Indenture  and  the   Officers'
      Certificate   impose   certain  limitations  on  the  Company's  and   its
      Subsidiaries', including limitations on the Company's and its subsidiaries
      ability  to  create  or  incur  certain  Liens on any of their  respective
      properties  or  assets  and  to  enter  into  certain sale and  lease-back
      transactions  and  on  the  Company's  ability  to  engage  in mergers  or
      consolidations   or   the   conveyance,  transfer  or  lease  of  all   or
      substantially  all  of  its  properties and assets. These limitations  are
      subject  to  a  number  of  important  qualifications  and exceptions  and
      reference  is  made  to the Indenture and the Officers' Certificate for  a
      description thereof.

            (10) DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in  registered
      form without coupons in denominations of $1,000 and integral multiples  of
      $1,000. The transfer of Notes may be registered and Notes may be exchanged
      as provided in the Indenture. The Registrar and the Trustee may require  a
      Holder,  among  other  things,  to  furnish  appropriate endorsements  and
      transfer  documents and the Company may require a Holder to pay any  taxes
      and  fees required by law or permitted by the Indenture. The Company  need
      not  exchange  or  register the transfer of any Note or portion of a  Note
      selected  for  redemption,  except for the unredeemed portion of any  Note
      being  redeemed  in part. Also, the Company need not exchange or  register
      the transfer of

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      any  Notes  for  a  period  of  15 days before a selection of Notes to  be
      redeemed or during the period between a record date and the  corresponding
      Interest Payment Date.

            (11)  PERSONS DEEMED OWNERS. The registered Holder of a Note may  be
      treated as its owner for all purposes.

            (12)   AMENDMENT,   SUPPLEMENT   AND  WAIVER.  Subject  to   certain
      exceptions, the Indenture or the Notes may be amended or supplemented with
      the  consent of the Holders of at least a majority in aggregate  principal
      amount  of  the  then outstanding Notes voting as a single class, and  any
      existing  Default or Event or Default or compliance with any provision  of
      the  Indenture or the Notes may be waived with the consent of the  Holders
      of a majority in aggregate principal amount of the then outstanding  Notes
      voting as a single class. Without the consent of any Holder of a Note, the
      Indenture  or  the  Notes  may  be  amended  or  supplemented to cure  any
      ambiguity, defect or inconsistency, to provide for uncertificated Notes in
      addition  to  or  in place of certificated Notes, to make any change  that
      would  not  adversely  affect the legal rights under the Indenture of  any
      such  Holder,  to  provide  for  the  issuance of any additional notes  as
      permitted by the Indenture, to appoint a successor trustee with respect to
      the  notes and to add to or change any of the provisions of the  Indenture
      necessary to provide for the administration of the trusts in the indenture
      by more than one trustee, or to comply with the requirements of the SEC in
      order  to effect or maintain the qualification of the Indenture under  the
      TIA.

            (13)  DEFAULTS AND REMEDIES. If an Event of Default shall occur  and
      be continuing, the principal of the Notes may be declared (or, in  certain
      cases, shall ipso facto become) due and payable in the manner and with the
      effect provided in the Indenture.

            (14) TRUSTEE DEALINGS WITH COMPANY. The Trustee under the Indenture,
      in  its individual or any other capacity, may deal with the Company or  an
      Affiliate of the Company with the same rights it would have if it were not
      Trustee.

            (15)  NO  RECOURSE AGAINST OTHERS. A director, officer, employee  or
      stockholder  of  the  Company  shall  not  have  any  liability  for   any
      obligations  of  the  Company under the Notes or the Indenture or for  any
      claim based on, in respect of, or by reason of, such obligations or  their
      creation.  Each  Holder  by accepting a Note waives and releases all  such
      liability.  The  waiver and release are part of the consideration for  the
      issuance of the Notes.

            (16) AUTHENTICATION. This Note will not be valid until authenticated
      by the manual signature of the Trustee or an authenticating agent.

            (17) ABBREVIATIONS. Customary abbreviations may be used in the  name
      of  a  Holder or an assignee, such as: TEN COM (= tenants in common),  TEN
      ENT  (= tenants by the entireties), JT TEN (= joint tenants with right  of
      survivorship  and  not  as  tenants  in  common), CUST (= Custodian),  and
      U/G/M/A (= Uniform Gifts to Minors Act).

            (18)  REGISTRATION  RIGHTS  OF  HOLDERS.  In addition to the  rights
      provided  to  Holders of Notes under the Indenture, Holders of  restricted
      Notes  will  have  all  the  rights  set forth in the Registration  Rights
      Agreement,  dated  as  of  November 18, 2004, between the Company and  the
      other  parties  named  on  the signature pages thereof (the  "Registration
      Rights Agreement").

            (19) CUSIP NUMBERS. Pursuant to a recommendation promulgated by  the
      Committee  on Uniform Security Identification Procedures, the Company  has
      caused  CUSIP numbers to be printed on the Notes, and the Trustee may  use
      CUSIP numbers in notices of redemption as a

                                       5


      convenience  to  Holders. No representation is made as to the accuracy  of
      such numbers either as printed on the Notes or as contained in any  notice
      of redemption, and reliance may be placed only on the other identification
      numbers placed thereon.

            (20)  GOVERNING LAW. THE INTERNAL LAW OF THE STATE OF NEW YORK  WILL
      GOVERN AND BE USED TO CONSTRUE THE INDENTURE AND THIS NOTE WITHOUT  GIVING
      EFFECT TO APPLICABLE PRINCIPLES OF CONFLICTS OF LAW TO THE EXTENT THAT THE
      APPLICATION OF THE LAWS OF ANOTHER JURISDICTION WOULD BE REQUIRED THEREBY.

      The  Company  will furnish to any Holder upon written request and  without
charge  a  copy  of  the  Indenture  and/or  the Registration Rights  Agreement.
Requests may be made to:

                                   Amgen Inc.
                             One Amgen Center Drive
                          Thousand Oaks, CA 91320-1799
                          Attention: Investor Relations

                                       6


                                 ASSIGNMENT FORM

      To assign this Note, fill in the form below:

(I) or (we) assign and transfer this Note to: _________________________________
                                               (Insert assignee's legal name)

_______________________________________________________________________________
                  (Insert assignee's soc. sec. or tax I.D. no.)

_______________________________________________________________________________

_______________________________________________________________________________

_______________________________________________________________________________

_______________________________________________________________________________
              (Print or type assignee's name, address and zip code)

and irrevocably appoint ________________________________________________________
to transfer this Note on the books of the Company. The agent may substitute
another to act for him.

Date:  _______________

                               Your Signature: ________________________________
                                          (Sign exactly as your name appears on
                                           the face of this Note)

Signature Guarantee*: _________________________

* Participant in a recognized Signature Guarantee Medallion Program (or other
signature guarantor acceptable to the Trustee).

                                       7