1 As filed with the Securities and Exchange Commission on November 4, 1998. REGISTRATION NO. 33-92152 ================================================================================ SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 TEXAS BIOTECHNOLOGY CORPORATION (Exact name of registrant as specified in its charter) DELAWARE 13-3532643 (State or other jurisdiction (I.R.S. Employer of incorporation or organization) Identification Number) 7000 FANNIN, SUITE 1920 HOUSTON, TEXAS 77030 (713) 796-8822 (Address, including zip code, and telephone number, including area code, of registrant's principal executive offices) STEPHEN L. MUELLER TEXAS BIOTECHNOLOGY CORPORATION 7000 FANNIN, SUITE 1920 HOUSTON, TEXAS 77030 (713) 796-8822 (Name and address, including zip code, and telephone number, including area code, of agent for service) With copies to: PORTER & HEDGES, L.L.P. 700 LOUISIANA, 35TH FLOOR HOUSTON, TEXAS 77002-2764 ATTN: ROBERT G. REEDY (713) 226-0600 Approximate date of commencement of proposed sale to the public: As soon as practicable after the Registration Statement became effective. If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. [ ] If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with a dividend or interest reinvestment plan, please check the following box.[X] If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [ ] ______________ If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [ ] _____________ If delivery of the prospectus is expected to be made pursuant to Rule 434, please check the following box. [ ] 2 DEREGISTRATION OF UNSOLD SHARES OF COMMON STOCK Pursuant to its Registration Statement on Form S-3 (No. 33-92152), Texas Biotechnology Corporation, a Delaware corporation (the "Company"), registered 4,087,485 shares of its common stock, par value $.005 per share (the "Common Stock"). As of November 4, 1998, 2,999,604 shares of Common Stock had been sold pursuant to the Registration Statement. The Company hereby deregisters the remaining 1,087,881 shares of Common Stock registered hereby. 2 3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this Post-Effective Amendment No. 1 to the Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Houston, State of Texas, on November 4, 1998. TEXAS BIOTECHNOLOGY CORPORATION By: /s/ ---------------------------------- Stephen L. Mueller Vice President, Finance and Administration, Treasurer and Secretary Pursuant to the requirements of the Securities Act of 1933, this Post-Effective Amendment No. 1 to the Registration Statement has been signed by the following persons in the capacities indicated on November 4, 1998. SIGNATURE TITLE --------- ----- * Director, Chairman of the Board of Directors - ------------------------------ John M. Pietruski * Director, President and Chief Executive Officer - ----------------------------- (Principal Executive Officer) David B. McWilliams * Director, Vice President of Research - ----------------------------- Richard A. F. Dixon, Ph.D. /s/ Vice President, Finance and Administration, - ----------------------------- Treasurer and Secretary (Principal Financial Stephen L. Mueller and Accounting Officer) * Director and Chairman of the - ----------------------------- Scientific Advisory Board James T. Willerson, M.D. 3 4 SIGNATURE TITLE --------- ----- Director - ----------------------------- Ron J. Anderson, M.D. * Director - ----------------------------- Frank C. Carlucci * Director - ----------------------------- Robert J. Cruikshank * Director - ----------------------------- James A. Thomson, Ph.D. *By: /s/ ------------------------- Stephen L. Mueller, Individually and as attorney-in-fact