1 EXHIBIT 11.1 ARONEX PHARMACEUTICALS, INC. AND SUBSIDIARIES STATEMENT REGARDING COMPUTATION OF PER SHARE EARNINGS The following reflects the information used in calculating the number of shares in the computation of net loss per share for each of the periods set forth in the Statements of Operations. INCOME AVERAGE (LOSS) DAYS SHARES INCOME PER SHARES OUTSTANDING SHARES X DAYS OUTSTANDING (LOSS) SHARE NINE MONTHS ENDED SEPTEMBER 30, 1998: 15,459,166 11 170,050,826 15,460,684 71 1,097,708,564 15,465,729 1 15,465,729 15,467,281 98 1,515,793,538 15,497,443 92 1,425,764,756 15,503,745 1 15,503,745 274 4,240,287,158 /274 15,475,501 (16,546,000) (1.07) NINE MONTHS ENDED SEPTEMBER 30, 1999: 16,379,309 3 49,137,927 16,415,664 50 820,783,200 22,415,664 14 313,819,296 22,463,211 21 471,727,431 22,474,987 1 22,474,987 22,494,671 1 22,494,671 22,495,050 64 1,439,683,200 22,496,505 26 584,909,130 22,555,435 1 22,555,435 22,555,977 8 180,447,816 22,560,179 27 609,124,833 22,697,866 20 453,957,320 22,719,999 6 136,319,994 22,723,765 3 68,171,295 22,723,927 13 294,411,051 22,773,927 5 113,869,635 22,775,753 9 204,981,777 22,788,071 1 22,788,071 273 5,832,657,069 /273 21,365,044 (7,305,000) (0.34) QUARTER ENDED SEPTEMBER 30, 1998: 15,497,443 91 1,410,267,313 15,503,745 1 15,503,745 92 1,425,771,058 /92 15,497,512 (6,059,000) (0.39) QUARTER ENDED SEPTEMBER 30, 1999: 22,555,977 8 180,447,816 22,560,179 27 609,124,833 22,697,866 20 453,957,320 22,719,999 6 136,319,994 22,723,765 3 68,171,295 22,723,927 13 295,411,051 22,723,927 5 113,869,635 22,775,753 9 204,981,777 22,788,071 1 22,788,071 92 2,085,071,792 /92 22,663,824 (5,399,000) (0.24)