EXHIBIT 21 MERCK & CO., INC. SUBSIDIARIES AS OF 12/31/97 Each of the subsidiaries set forth below does business under the name stated. A subsidiary of a subsidiary is indicated by indentation under the immediate parent. All voting securities of the subsidiaries named are owned directly or indirectly by the Company, except where otherwise indicated. COUNTRY OR STATE NAME OF INCORPORATION - ---- ---------------- Chibret A/S Denmark Hangzhou MSD Pharmaceutical Company Limited/1/ China International Indemnity Ltd. Bermuda Istituto Gentili S.p.A. Italy/Delaware Johnson & Johnson--Merck Consumer Pharmaceuticals Company/1/ New Jersey Laboratorios Prosalud S.A. Peru MCM Vaccine Co./1/ Pennsylvania Merck and Company, Incorporated Delaware Merck SH Inc. Delaware Merck Capital Investment, Inc. Delaware Merck Capital Resources, Inc. Delaware MSD Technology, L.P./1/ Bermuda Merck Finance Co., Inc. Delaware Merck de Puerto Rico, Inc. Delaware Merck Enterprises Canada, Ltd. Canada Merck Foreign Sales Corporation Ltd. Bermuda Merck Holdings, Inc. Delaware Astra Merck, Inc./1/ Delaware Chugai MSD Co., Ltd./1/ Japan Frosst Laboratories, Inc. Delaware Frosst Portuguesa--Produtos Farmaceuticos, Lda. Portugal Merck-Medco Holdings II Corp. Delaware Cloverleaf International Holdings S.A. Luxembourg Coordinated Patient Care Scandinavia AS Norway Medidoc AB Sweden Coordination Medicale et Pharmaceutique, S.A. France Merck Frosst Canada, Inc. Canada Merck Sharp & Dohme (Australia) Pty. Limited Australia AMRAD Pharmaceuticals Pty. Ltd./1/ Australia Merck Sharp & Dohme B.V. Netherlands Abello Farmacia, S.L./1/ Spain Financiere MSD S.A.S. France Chibret Pharmazeutische GmbH Germany Laboratoires Jean-Paul Martin S.A.S./1/ France Laboratoires Merck Sharp & Dohme Chibret SNC France Pasteur Merieux MSD Gestion S.A./1/ France Pasteur Merieux MSD S.N.C./1/ France Pasteur Merieux MSD A/S Denmark Pasteur Merieux MSD GmbH Germany Pasteur Merieux MSD Ltd. (UK) Great Britain Pasteur Merieux MSD Ltd. (Ireland) Ireland COUNTRY OR STATE NAME OF INCORPORATION - ---- ---------------- Pasteur Merieux MSD N.V. Belgium Pasteur Merieux MSD S.A. Spain Pasteur Merieux MSD S.p.A. Italy Pasteur Vaccins S.A. France Laboratorios Chibret, S.A. Spain Merck Sharp & Dohme GmbH Austria Merck Sharp & Dohme (Italia) S.p.A. Italy Abiogen Farma S.p.A. Italy Istituto Di Richerche Di Biologia Molecolare S.p.A./1/ Italy MSD (Proprietary) Limited South Africa MSD Sharp & Dohme GmbH Germany Dieckmann Arzneimittel GmbH Germany Woelm Pharma GmbH & Co./1/ Germany MSD Chibropharm GmbH Germany MSD Unterstutzungskasse GmbH Germany Varipharm Arzneimittel GmbH Germany Merck Sharp & Dohme Chibret A.G. Switzerland Merck Sharp & Dohme (Holdings) Limited Great Britain Charles E. Frosst (U.K.) Limited Great Britain Merck Sharp & Dohme Limited Great Britain Johnson & Johnson MSD Consumer Pharmaceuticals/1/ Great Britian Merck Sharp & Dohme Finance Europe Great Britain Thomas Morson & Son Limited Great Britain Merck Sharp & Dohme IDEA, Inc. Switzerland Merck Sharp & Dohme (Sweden) A.B. Sweden Merck Sharp & Dohme (Israel--1996) Company Ltd. Israel Merck Sharp & Dohme Trading & Service Limited Liability Company Hungary MSD Ireland (Holdings) S.A. Luxembourg Fabrica de Productos Quimicos y Farmaceuticos Abello, S.A. Spain Fregenal Holdings S.A. Panama Frosst Iberica, S.A. Spain Laboratorios Quimico-Farmaceuticos Chibret, Lda. Portugal Merck Sharp & Dohme de Espana, S.A. Spain Merck Sharp & Dohme, Limitada Portugal MSD Finance, B.V. Netherlands MSD Overseas Manufacturing Co. Bermuda Blue Jay Investments C.V. Netherlands Merck Sharp & Dohme (Singapore) Ltd. Bermuda MSD Ireland (Investment) Ltd. Bermuda MSD Overseas Manufacturing Co. (Ireland) Ireland Crosswinds B.V. Netherlands Merck Sharp & Dohme (Ireland) Ltd. Bermuda Neopharmed S.p.A. Italy Ruskin Limited Bermuda MSD (Norge) A/S Norway Suomen MSD Oy Finland Kiinteisto Oy Irmelinpesa/1/ Finland Kiinteisto Oy Viistotie 11 Finland Merck Sharp & Dohme de Venezuela, C.A. Venezuela Merck Sharp & Dohme Holdings de Mexico, S.A. de C.V. Mexico 2 COUNTRY OR STATE NAME OF INCORPORATION - ---- ------------------ Merck Sharp & Dohme de Mexico, S.A. de C.V. Mexico Merck Sharp & Dohme (I.A.) Corp. Delaware Merck Sharp & Dohme (Argentina) Inc. Delaware MSD Korea Ltd. Korea/Delaware Merck Sharp Dohme Ilaclari Limited Sirketi Turkey Merck Sharp & Dohme Industrial e Exportadora Ltda. Brazil Merck Sharp & Dohme Farmaceutica e Veterinaria Ltda. Brazil Prodome Quimica e Farmaceutica Ltda.1 Brazil Merck Sharp & Dohme (International) Limited Bermuda Merck Sharp & Dohme (Asia) Limited Hong Kong Merck Sharp & Dohme (China) Limited Hong Kong Merck Sharp & Dohme S.A. France Merck Sharp & Dohme International Services B.V. Netherlands Merck Sharp & Dohme--Lebanon S.A.L. Lebanon Merck Sharp & Dohme L.L.C. Russian Federation Merck Sharp & Dohme (Middle East) Limited Cyprus Merck Sharp & Dohme of Pakistan Limited Pakistan Merck Sharp & Dohme Quimica de Puerto Rico, Inc. Delaware Merck Sharp & Dohme S.A.R.L. Morocco Merck Ventures, Inc. Delaware MSD Chimie S.A France MSD Lakemedel (Scandinavia) Aktiebolog Sweden Prosalud Peruana S.A. Peru TELERx Marketing Inc. Pennsylvania Merck Investment Co., Inc. Delaware Merck-Medco Managed Care, L.L.C. Delaware CM Delaware Corporation Delaware DM-MG, L.L.C. Delaware MCCO Corp. New Jersey MCCO, L.L.C. New Jersey Medco Containment Insurance Company of New Jersey New Jersey Medco Containment Insurance Company of New York New York Medco Containment Life Insurance Company Pennsylvania Medco MM Corp. New Jersey Merck-Medco Managed Care of California, Inc. California Merck-Medco Rx Services of Florida No. 2, L.C. Florida Merck-Medco Rx Services of Florida, L.C. Florida Merck-Medco Rx Services of Massachusetts, L.L.C. Massachusetts Merck-Medco Rx Services of Nevada, Inc. Nevada Merck-Medco Rx Services of New Jersey, L.L.C. New Jersey Merck-Medco Rx Services of New York, L.L.C. New York Merck-Medco Rx Services of Ohio, Ltd. Ohio Merck-Medco Rx Services of Ohio No. 2, Ltd. Ohio Merck-Medco Rx Services of Oklahoma, L.L.C. Oklahoma Merck-Medco Rx Services of Pennsylvania, L.L.C. Pennsylvania Merck-Medco Rx Services of Pennsylvania No. 2, L.L.C. Pennsylvania Merck-Medco Rx Services of Texas, L.L.C. Texas Merck-Medco Rx Services of Virginia, L.L.C. Virginia Merck-Medco Rx Services of Washington, Inc. Washington Mergerco Delaware No. 7, L.L.C. Delaware Mergerco Delaware No. 10, L.L.C. Delaware 3 COUNTRY OR STATE NAME OF INCORPORATION - ---- ---------------- MW Holdings, L.L.C. Delaware NJRE, L.L.C. New Jersey NRx Federal Corp. Delaware National Rx Services, Inc. California National Rx Services, Inc. of Missouri Missouri National Rx Services No. 3, Inc. of Ohio Ohio New York PAID Independent Practice Association, L.L.C. New York Paid Direct, Inc. Delaware PAID Prescriptions, L.L.C. Nevada Replacement Distribution Center, Inc. Ohio Systemed, L.L.C. Delaware American Medical Outcomes Repository, Inc. Delaware Systemed Pharmacy of Iowa, L.L.C. Delaware Systemed Pharmacy of Ohio, Ltd. Ohio Merck Resource Management, Inc. Delaware Merck Sharp & Dohme (Europe) Inc. Delaware Merck Sharp & Dohme Industria Quimica e Veterinaria Limitada Brazil Merck Sharp & Dohme (New Zealand) Limited New Zealand Merck Sharp & Dohme Overseas Finance N.V. Neth. Antilles Merck Sharp & Dohme (Panama) S.A. Panama Merck Sharp & Dohme Peru S.C. Peru Merck Sharp & Dohme (Philippines) Inc. Philippines Merial Limited/LLC/1/ Great Britain/Delaware British United Turkeys Limited/1/ Great Britain Turkey Research & Development Limited/1/ Great Britain MI (FDL) Holdings, Inc. Delaware MSD International Holdings, Inc. Delaware Banyu Pharmaceutical Company, Ltd./1/ Japan Banyu-A.S.C. Co., Ltd. Japan Nippon Merck-Banyu Co., Ltd. Japan MSD (Japan) Co., Ltd. Japan The Du Pont Merck Pharmaceutical Company/1/ Delaware The O'Hare Group, Inc./1/ Delaware - -------- /1/ own less than 100% 4