EXHIBIT 4.4 DEED OF ACCESSION dated 7 December 1998 CHIREX AMERICA INC as Guarantor CHIREX (HOLDINGS) LIMITED as Borrower BANKERS TRUST COMPANY as Agent LINKLATERS & PAINES One Silk Street London EC2Y 8HQ Tel: (-44) 171 456 2000 Ref. RL? 2 THIS DEED is made this 7th day of December 1998 by ChiRex America Inc, as Guarantor, IN FAVOUR OF: (1) CHIREX (HOLDINGS) LIMITED (the "Borrower") (2) BANKERS TRUST INTERNATIONAL PLC AND MIDLAND BANK PLC as Joint Arrangers; (3) BANKERS TRUST COMPANY, as Agent (the "Agent") (4) BANKERS TRUST COMPANY, as Security Agent; (5) THE LENDERS PARTY TO THE FACILITIES AGREEMENT DESCRIBED BELOW; and (6) THE OBLIGORS PARTY TO THE FACILITIES AGREEMENT DESCRIBED BELOW. WHEREAS A This Deed is supplemental to a facilities agreement dated 30 October, 1997 made among the parties referred to in paragraphs (1) to (6) above as amended by the First and Second Amendments dated 30 July 1998 and 16 November 1998 respectively, (the "Facilities Agreement" which expression includes any amendments or supplements thereto or restatements thereof). B It is a term of the Second Amendment that each of the Borrower and the Guarantors procure that ChiRex America Inc accede to the Facilities Agreement as a Guarantor. C ChiRex America Inc wishes to accede to the Facilities Agreement as a Guarantor. NOW THIS DEED WITNESSETH AS FOLLOWS: 1 Words and expressions defined in the Facilities Agreement shall have the same meanings when used herein. 2 ChiRex America Inc hereby: (a) agrees to be bound by all the terms and conditions of the Facilities Agreement insofar as they relate to a Guarantor (including without limitation Clause 15 (Guarantee) and Clause 30 (Jurisdiction) of the Facilities Agreement) as if it were a party to the Facilities Agreement in such capacity; and (b) represents and warrants to the Agent and the other Finance Parties in the terms of the Facilities Agreement. 3 3 The undersigned Guarantor agrees to be bound by all the terms and conditions of the Facilities Agreement insofar as they relate to an Obligor as if it were a party to the Facilities Agreement in such capacity. 4 The undersigned Guarantor confirms that its address for the purposes of Clause 27 (Notices) of the Facilities Agreement is set out under its name as follows: ChiRex America Inc 300 Atlantic Street Suite 402 Stamford CT 06901 USA Attention: M A Griffith Facsimile: 001 203 425 9996 5 Each of the undersigned hereby agrees that ChiRex America Inc shall, from the date of the later of (i) the execution by the Agent of this Deed and (ii) the execution by Borrower of this Deed, accede to the Facilities Agreement as if it were a Guarantor and an Obligor named therein and a party thereto. 6 This Deed may be executed in any number of counterparts and all of such counterparts taken together shall be deemed to constitute one and the same instrument. 7 This Deed shall be governed by and constructed in accordance with the laws of England. IN WITNESS WHEREOF the undersigned have caused this Deed to be duly executed and delivered the day and year first above written. EXECUTED and DELIVERED ) as a deed ) for and on behalf of ) ChiRex America Inc ) by ) in the presence of ) EXECUTED and DELIVERED ) as a deed ) for and on behalf of ) ChiRex (Holdings) Limited ) as Borrower ) by ) in the presence of ) 4 SIGNED by for and on behalf of BANKERS TRUST COMPANY, as Agent Date: DEED OF ACCESSION dated 7 December 1998 CHIREX TECHNOLOGY CENTRE INC as Guarantor CHIREX (HOLDINGS) LIMITED as Borrower BANKERS TRUST COMPANY as Agent LINKLATERS & PAINES One Silk Street London EC2Y 8HQ Tel: (-44) 171 456 2000 2 THIS DEED is made this 7th day of December 1998 by ChiRex Technology Centre Inc, as Guarantor, IN FAVOR OF: (1) CHIREX (HOLDINGS) LIMITED (the "Borrower") (2) BANKERS TRUST INTERNATIONAL PLC AND MIDLAND BANK PLC as Joint Arrangers; (3) BANKERS TRUST COMPANY, as Agent (the "Agent") (4) BANKERS TRUST COMPANY, as Security Agent; (5) THE LENDERS PARTY TO THE FACILITIES AGREEMENT DESCRIBED BELOW; and (6) THE OBLIGORS PARTY TO THE FACILITIES AGREEMENT DESCRIBED BELOW. WHEREAS A This Deed is supplemental to a facilities agreement dated 30 October, 1997 made among the parties referred to in paragraph (1) to (6) above as amended by the First and Second Amendments dated 30 July 1998 and 16 November 1998 respectively (the "Facilities Agreement" which expression includes any amendments or supplements thereto or restatements thereof). B It is a term of the Second Amendment that each of the Borrower and the Guarantors procure that ChiRex Technology Centre Inc accede to the Facilities Agreement as a Guarantor. C ChiRex Technology Centre Inc wishes to accede to the Facilities Agreement as a Guarantor. NOW THIS DEED WITNESSETH AS FOLLOWS: 1 Words and expressions defined in the Facilities Agreement shall have the same meanings when used herein. 2 ChiRex Technology Centre Inc hereby: (a) agrees to be bound by all the terms and conditions of the Facilities Agreement insofar as they relate to a Guarantor (including without limitation Clause 15 (Guarantee) and Clause 30 (Jurisdiction) of the Facilities Agreement) as if it were a party to the Facilities Agreement in such capacity, and (b) represents and warrants to the Agent and the other Finance Parties in the terms of the Facilities Agreement. 3 3 The undersigned Guarantor agrees to be bound by all the terms and conditions of the Facilities Agreement insofar as they relate to an Obligor as if it were a party to the Facilities Agreement in such capacity. 4 The undersigned Guarantor confirms that its address for the purposes of Clause 21 (Notices) of the Facilities Agreement is set out under its name as follows: ChiRex Technology Centre Inc 300 Atlantic Street Suite 402 Stamford CT 06901 USA Attention: M A Griffith Facsimile: 001 203 425 9996 5 Each of the undersigned hereby agrees that ChiRex Technology Centre Inc shall, from the date of the later of (i) the execution by the Agent of this Deed and (ii) the execution by Borrower of this Deed, accede to the Facilities Agreement as if it were a Guarantor and an Obligor named therein and a party thereto. 6 This Deed may be executed in any number of counterparts and all of such counterparts taken together shall be deemed to constitute one and the same instrument. 7 This Deed shall be governed by and constructed in accordance with the laws of England. IN WITNESS WHEREOF the undersigned have caused this Deed to be duly executed and delivered the day and year first above written. EXECUTED and DELIVERED ) as a deed ) for and on behalf of ) ChiRex Technology Centre Inc ) By ) in the presence of ) EXECUTED and DELIVERED ) as a deed ) for and on behalf of ) ChiRex (Holdings) Limited ) as Borrower ) by ) in the presence of ) 4 SIGNED by for and on behalf of BANKERS TRUST COMPANY, as Agent Date: