As Filed with the Securities and Exchange Commission on August 1, 1995.
                           Registration No. 33-61467

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                       POST-EFFECTIVE AMENDMENT NO. 1 TO

                                    FORM S-3

                             REGISTRATION STATEMENT
                                     Under
                           THE SECURITIES ACT OF 1933

                          FIRST MIDWEST BANCORP, INC.
             (Exact name of registrant as specified in its charter)

          Delaware                                     36-3161078
(State or other jurisdiction                        (I.R.S. Employer
of incorporation or organization)                  Identification No.)

   300 Park Boulevard, Suite 405, Itasca, Illinois 60143-0459, (708) 875-7450
    (Address, including zip code, and telephone number, including area code,
                  of registrant's principal executive offices)

                              Donald J. Swistowicz
                            Executive Vice President
                          First Midwest Bancorp, Inc.
           300 Park Boulevard, Suite 405, Itasca, Illinois 60143-0459
                                 (708) 875-7450
           (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

     APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as
practicable after the effective date of the Registration Statement.

     If the only securities being registered on this form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box. [_]

     If any of the securities being registered on this form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. [_]

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First Midwest Bancorp, Inc.
Post-Effective Amendment No. 1 to Form S-3



On August 1, 1995, First Midwest Bancorp, Inc. ("First Midwest") filed with the
Securities and Exchange Commission (the "Commission") a Registration Statement
on Form S-3 (No. 33-61467) for the issuance of 75,000 to 125,000 shares of First
Midwest Common Stock.  The Commission notified First Midwest on August 11, 1995,
that such Registration Statement was effective as of August 14, 1995.

On August 6, 1995, First Midwest filed a form of Prospectus pursuant to Rule
424(b)-1 of Regulation C of the Securities Act of 1933, as amended.  Such
424(b)-1 filing contained changes to the August 1, 1995 Registration Statement
including 1) a final price per share to the public, 2) final proceeds to the
company, 3) a revision to the Plan of Distribution to indicate that the licensed
broker/dealer selling all or a portion of the shares offered under the
Prospectus may retain a portion of such shares for investment for its own
account, and 4) certain other minor non-substantive changes.

Pursuant to the filing of the Prospectus, 100,000 shares of First Midwest Common
Stock were issued to the public through a licensed broker/dealer at a price per
share of $27.25.  Proceeds to First Midwest amounted to $27.00 per share, after
deducting selling costs.

Accordingly, First Midwest is filing this Post-Effective Amendment No. 1 to the
Registration Statement to deregister 25,000 shares of First Midwest Common
Stock, representing the difference between the maximum 125,000 shares of common
stock covered by the Registration Statement and the 100,000 shares issued.  This
Post-Effective Amendment No. 1 contains an executed copy of a representation
letter by First Midwest to the broker/dealer regarding the sale of such Common
Stock.

                                       2

 
                                   SIGNATURES

     Pursuant to the requirements of the Securities Act, the registrant has duly
caused this post-effective amendment to be signed on its behalf by the
undersigned, thereunto duly authorized, in the Village of Itasca, State of
Illinois on August 23, 1995.


                             FIRST MIDWEST BANCORP, INC.



                             By:  ROBERT P. O'MEARA
                                  --------------------------------------
                                  Robert P. O'Meara
                                  President and Chief Executive Officer





                               POWER OF ATTORNEY

   Pursuant to the requirements of the Securities Act of 1933, this post-
effective amendment has been signed below by the following persons in their
capacities indicated on August 23, 1995.

            Signature                                    Capacity
----------------------------------           ----------------------------------

     CLARENCE D. OBERWORTMANN *              Chairman of the Board of Directors 
----------------------------------           and Principal Executive Officer 
     Clarence D. Oberwortmann                


        ANDREW B. BARBER *                   Vice Chairman of the Board
----------------------------------           of Directors
        Andrew B. Barber


        ROBERT P. O'MEARA *                  President, Principal Executive 
----------------------------------           Officer and Director
        Robert P. O'Meara



----------------------------------           Executive Vice President, 
         John M. O'Meara                     Principal Operating Officer
                                             and Director

       DONALD J. SWISTOWICZ                  Executive Vice President, 
----------------------------------           Principal Financial and
       Donald J. Swistowicz                  Accounting Officer



----------------------------------           Director
        Bruce S. Chelberg

                                       3

             
            Signature                                   Capacity
----------------------------------          ----------------------------------




----------------------------------          Director
         O. Ralph Edwards


        JOSEPH W. ENGLAND *                 Director
----------------------------------
        Joseph W. England


        THOMAS M. GARVIN *                  Director
----------------------------------
        Thomas M. Garvin


         ALAN M. HALLENE *                  Director
----------------------------------
         Alan M. Hallene


  SISTER NORMA JANSSEN, O.S.F. *            Director
----------------------------------
  Sister Norma Janssen, O.S.F.


        ROBERT E. JOYCE *                   Director
----------------------------------
        Robert E. Joyce


      FRANK J. TURK, SR. *                  Director
----------------------------------
      Frank J. Turk, Sr. 


     J. STEPHEN VANDERWOUDE *               Director
----------------------------------
     J. Stephen Vanderwoude

    
* By Donald J. Swistowicz, Attorney-in-Fact

                                       4

 
                                 EXHIBIT INDEX


                                                                      Sequential
Exhibits                          Description                          Page No.
--------  ----------------------------------------------------------  ---------

99        Representation letter between First Midwest and Keefe           6
          Bruyette & Woods, Inc. regarding the sale of First Midwest 
          Common Stock. 

                                       5