UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                            Washington, D.C.   20549

                                   FORM 8-K

                                 CURRENT REPORT

                        PURSUANT TO SECTION 13 or 15(d)

                     OF THE SECURITIES EXCHANGE ACT OF 1934



      Date of report (Date of earliest event reported):  NOVEMBER 15, 1995
                                                         -----------------


                            FIRST BANK SYSTEM, INC.
                            -----------------------
             (Exact name of registrant as specified in its charter)


          DELAWARE                  1-6880                    41-0255900
          --------                  ------                    ----------
(State or other jurisdiction      (Commission             (I.R.S. Employer
     of Incorporation)            File Number)           Identification No.)
 

601 SECOND AVENUE SOUTH, MINNEAPOLIS, MINNESOTA                 55402
- -----------------------------------------------                 -----
   (Address of principal executive offices)                   (Zip Code)


      Registrant's telephone number, including area code:    612-973-1111
                                                             ------------


                                 NOT APPLICABLE
                                 --------------
         (Former name or former address, if changed since last report)

 
Item 5.  Other Events.
         -------------

             On November 5, 1995, First Bank System, Inc., a Delaware
         corporation ("FBS"), and First Interstate Bancorp, a Delaware
         corporation ("FI"), entered into an Agreement and Plan of Merger,
         pursuant to which a wholly owned acquisition subsidiary of FBS will be
         merged with and into First Interstate.

             In connection therewith, FBS hereby files as exhibits to this Form
         8-K, which exhibits are incorporated herein by reference, certain
         historical financial statements of FI and subsidiaries and pro forma
         financial information. The information included in such exhibits is as
         follows:

         99.1 Financial Statements of First Interstate Bancorp and Subsidiaries:

                    Consolidated Balance Sheet as of December 31, 1994 and
                    December 31, 1993

                    Consolidated Statement of Operations for the years ended
                    December 31, 1994, 1993 and 1992

                    Consolidated Statement of Cash Flows for the years ended
                    December 31, 1994, 1993 and 1992

                    Statement of Shareholders' Equity for the years ended
                    December 31, 1994, 1993 and 1992

                    Notes to Financial Statements for the years ended December
                    31, 1994, 1993 and 1992

                    Report of Independent Auditors

                    Consolidated Balance Sheet - September 30, 1995 (unaudited)

                    Consolidated Statement of Income - Nine months ended
                    September 30, 1995 and 1994 (unaudited)

                    Consolidated Statement of Cash Flows - Nine months ended
                    September 30, 1995 and 1994 (unaudited)

                    Consolidated Statement of Shareholders' Equity - Nine 
                    months ended September 30, 1995 (unaudited)

                    Notes to Consolidated Financial Statements - September 30,
                    1995 (unaudited)

         99.2 Pro Forma Financial Information

                    Unaudited Pro Forma Condensed Combined Balance Sheet at 
                    September 30, 1995

                    Unaudited Pro Forma Condensed Combined Statements of 
                    Income - Nine months Ended September 30, 1995 and Years 
                    Ended December 31, 1994, 1993 and 1992

                    Notes to Unaudited Pro Forma Condensed Combined Financial 
                    Statements

Item 7.  Financial Statements, Pro Forma Financial Statements and Exhibits
         -----------------------------------------------------------------
    (c)  Exhibits

         23.1 Consent of Ernst & Young LLP

         99.1 Financial Statements of First Interstate Bancorp and Subsidiaries

         99.2 Pro Forma Financial Information



 
                                   SIGNATURE



Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                              FIRST BANK SYSTEM, INC.



                              By /s/ David J. Parrin
                                 -------------------
                                 David J. Parrin
                                 Senior Vice President and Controller


  
DATE:  November 15, 1995

 
                               INDEX TO EXHIBITS
 
                                                                          PAGE
                                                                          ----
23.1  Consent of Ernst & Young LLP

99.1  Financial Statements of First Interstate Bancorp and 
      Subsidiaries

99.2  Pro Forma Financial Information