Exhibit 10.6

                      Eli Lilly and Company EVA Bonus Plan

               (As amended and restated effective January 1, 1999)


                                    ARTICLE I

                   Bonus Plan Statement of Purpose and Summary

1.1      The purpose of the Plan is to provide a system of bonus compensation
         for selected employees of Eli Lilly and Company and subsidiaries which
         will promote the maximization of shareholder value over the long term,
         by linking performance incentives to increases in shareholder value.
         The Plan ties bonus compensation to Economic Value Added ("EVA"), and
         thereby rewards employees for long-term, sustained improvement in
         shareholder value. The Plan is intended to satisfy the requirements for
         providing "performance-based" compensation under Section 162(m) of the
         Internal Revenue Code.

1.2      EVA will be used as the performance measure of value creation. EVA
         reflects the benefits and costs of capital employment. Employees create
         economic value when the operating profits from a business exceed the
         cost of the capital employed.


                                   ARTICLE II

                          Definitions of Certain Terms

Unless the context requires a different meaning, the following terms shall have
the following meanings:

2.1      "Company" means Eli Lilly and Company and its subsidiaries.

2.2      "Committee" means the Compensation and Management Development
         Committee, the members of which shall be selected by the Board of
         Directors from among its members. Each Committee member shall, at all
         times while serving, satisfy the requirements of an "outside director"
         within the meaning of Section 162(m).

2.3      "Participant" means any employee of the Company designated by the
         Committee as a participant in the Plan with respect to any Plan Year.
         In its discretion, the Committee may designate Participants either on
         an individual basis or by determining that all employees in specified
         job categories, classifications or levels shall be Participants.

2.4      "Plan" means this Eli Lilly and Company EVA Bonus Plan.

2.5      "Plan Year" means the applicable calendar year.

 
2.6      "Retirement" means the cessation of employment upon the attainment of
         at least eighty age and benefit years of service points, as determined
         by the provisions of The Lilly Retirement Plan as amended from time to
         time, assuming eligibility to participate in that plan.

2.7      "Disability" means the time at which a Participant becomes eligible for
         a payment under The Lilly Extended Disability Plan, assuming
         eligibility to participate in that plan.

2.8      "Section 162(m)" means Section 162(m) of the Internal Revenue Code of
         1986, as amended.

2.9      "Section 162(m) Participant" means a Participant who, in the
         determination of the Committee, is or may in the future become a
         "covered employee" under Section 162(m).


                                   ARTICLE III

                        Definition and Components of EVA

The following terms set forth the calculation of EVA and the components of
calculating EVA. The calculation of EVA for a Plan Year is used in determining
the bonuses earned by Participants under the Plan, as set forth in Article IV.

3.1      "Economic Value Added" or "EVA" means the excess NOPAT that remains
         after subtracting the Capital Charge.

3.2      "Net Operating Profit After Tax" or "NOPAT" means the after tax
         operating earnings of the Company for the Plan Year. NOPAT is
         determined by adding net sales plus other net income (excluding
         interest income from operating cash) and subtracting the following:
         cost of goods sold, selling, general and administrative expenses
         (excluding goodwill amortization and interest expense), amortization of
         research and development, taxes (excluding the tax benefit of interest
         expense) and amounts associated with discontinued operations.

3.3      "Capital Charge" means the deemed opportunity cost of employing Capital
         for the Company. The Capital Charge is calculated by multiplying
         Capital times Cost of Capital (C*).

3.4      "Capital" means the net investment employed in the operations of the
         Company produced by operations and financing activities. Capital is
         calculated by adding together current assets (excluding operating
         cash), net property, plant and equipment, gross goodwill, net
         intangibles, other assets, and capitalized research and development,
         and the present value of operating leases, and subtracting the
         following: non-interest bearing liabilities and capital associated with
         discontinued operations.

3.5      "Cost of Capital" or "C*" is the percentage calculated from the
         weighted average of Cost of Debt and Cost of Equity. Cost of Capital
         for each Plan Year is determined by reference to the percentage
         calculated at the end of October of the prior Plan Year.

3.6      "Cost of Debt" capital is the marginal long-term borrowing rate of the
          Company times (one minus the tax rate).

 
3.7      "Cost of Equity" capital is the risk-free rate plus (beta times the
         market risk premium). For this purpose, (i) "risk free rate" is the
         30-year U.S. Treasury Bond rate, (ii) "beta" represents the 5 year
         historical average variation of the Company's earnings versus the S&P
         500, and (iii) "market risk premium" represents the average risk of an
         equity return versus a bond return.


                                   ARTICLE IV

                   Definition and Computation of the EVA Bonus

Bonuses earned under the Plan for a Plan Year are determined based on a
comparison of actual EVA to the "Target EVA" for the year, which is established
as described below to ensure improvement in EVA from year to year. The result of
this comparison is adjusted by a "Leverage Factor" measuring the volatility of
industry returns. The factor produced is referred to as the "Bonus Multiple,"
which is multiplied by the Participant's "Target Bonus" amount established for
the year to produce the actual bonus earned. This amount, referred to as the
"Declared Bonus," is credited to the Participant's "Bonus Bank" balance and paid
out in the manner provided below.

4.1      Target Bonus. The Target Bonus Awards will be determined by the
         Committee on a basis that takes into consideration a Participant's
         salary grade level, job responsibilities as well as past and expected
         future job performance. Target Bonus Awards are expressed as a
         percentage of annual base salary as in effect on the first day of the
         Plan Year. If a Participant moves from any salary grade level to a G-6
         or above salary grade level during a Plan Year, he/she will receive an
         award that is pro-rated according to time based on the Target Bonus
         percentage and base salary applicable to each such salary grade. The
         Target Bonus will be based on the currency in which the highest portion
         of base pay is regularly paid. The Committee shall determine the
         appropriate foreign exchange conversion methodology in its discretion.

4.2      Declared Bonus.  A Declared Bonus is the Target Bonus times the Bonus
         Multiple.

4.3      Bonus Multiple. The Bonus Multiple is the difference (positive or
         negative) between Actual EVA and Target EVA, divided by the Leverage
         Factor, plus one.

4.4      Bonus Bank. All bonus payments are made from the Bonus Bank. Each
         Participant's beginning Bonus Bank balance in his/her first year of
         participation is zero. The Bonus Bank is increased or decreased for any
         plan year by the amount of Declared Bonus. If the available Bonus Bank
         balance is positive, the Participant will be paid from such balance up
         to the Target Bonus amount, plus one third of any such balance that
         remains after subtracting the Target Bonus from the available Bonus
         Bank balance. If the available Bonus Bank balance is negative, no
         payment will occur.

4.5      Target EVA. The Target EVA for each year will be calculated as follows:

         Target EVA = Prior Year's Actual EVA + Expected Improvement

 
4.6      Expected Improvement. The Expected Improvement is the additional EVA
         amount determined by the Committee that is used to assure that a
         minimum level of improvement is achieved in order to earn target
         awards.

4.7      Leverage Factor. The Leverage Factor determines the rate of change in
         bonuses as EVA surpasses or falls short of Target EVA, determined by
         the Committee from an evaluation of the long term volatility of
         industry returns.

4.8      Section 162(m) Requirements, Bonus Maximum. In the case of Section
         162(m) Participants, all determinations necessary for computing
         Declared Bonuses for a Plan Year, including establishment of all
         components of the EVA calculation and of the Target Bonus percentages,
         shall be made by the Committee not later than 90 days after the
         commencement of the Plan Year. As and to the extent required by Section
         162(m), the terms of a Declared Bonus for a Section 162(m) Participant
         must state, in terms of an objective formula or standard, the method of
         computing the amount of compensation payable to the Section 162(m)
         Participant, and must preclude discretion to increase the amount of
         compensation payable that would otherwise be due under the terms of the
         award. Notwithstanding anything elsewhere in the Plan to the contrary,
         the maximum amount of the Declared Bonus that may be paid from the
         Bonus Bank to a Section 162(m) Participant during any one calendar year
         shall be $5 million.


                                    ARTICLE V

                               Plan Administration

5.1      Time of Payment.  Payment from the Bonus Bank will be made before March
         1 of the year following the Plan Year.

5.2      Certification of Results. Before any amount is paid under the Plan, the
         Committee shall certify in writing the calculation of EVA for the Plan
         Year and the satisfaction of all other material terms of the
         calculation of the Declared Bonus.

5.3      New Hires, Promotions. New hires or individuals promoted who are first
         selected for participation by the Committee effective on a date other
         than January 1 will participate on a pro-rata basis in their first year
         of participation, based on the Declared Bonus determined for the Plan
         Year, pro-rated for that period of the year during which the
         Participant was selected for participation in the Plan. Any such
         Participant's Target Bonus Award will be determined based on his or her
         annual base salary as in effect on the date of hire or promotion, as
         applicable Notwithstanding the foregoing, in the case of any Section
         162(m) Participant who first becomes eligible to participate in the
         Plan after January 1 of a Plan Year, such Participant's Declared Bonus
         may be determined, at the discretion of the Committee exercised at the
         time such participation begins, in a manner that complies with the
         requirements for "performance-based compensation" under Section 162(m).

5.4      Termination of Employment, Demotions. If a Participant ceases
         employment with the Company before the end of a Plan Year for reasons
         other than Retirement, Disability or death, or is demoted to a
         non-global job level with the Company during a Plan Year, the
         Participant shall receive no Declared Bonus for that Plan Year, and
         his/her Bank Balance

 
         shall be forfeited. The Committee may make complete or partial
         exceptions to this rule, in its sole discretion, and, with respect to
         employees other than executive officers, may delegate to the vice
         president responsible for human resources the authority to make such
         exceptions. Notwithstanding the foregoing, with respect to the Declared
         Bonus for a Section 162(m) Participant, any such termination of
         employment or demotion shall result in payment of a bonus based on the
         Declared Bonus determined for the Plan Year but pro-rated for the
         period of the year prior to such event, subject to the Committee's
         discretion to forfeit all or any portion of such bonus.

5.5      Leave of Absence. If a Participant takes an approved leave of absence
         from employment during a Plan Year, the Participant will not be
         eligible for the Declared Bonus for the Plan Year. The Committee may
         make complete or partial exceptions to this rule, in whatever manner it
         deems appropriate, and, with respect to employees other than executive
         officers, may delegate to the vice president responsible for human
         resources the authority to make such exceptions. The Participant will
         retain his Bonus Bank balance if he returns to employment following the
         period of leave of absence. Notwithstanding the foregoing, with respect
         to the Declared Bonus for a Section 162(m) Participant, any such leave
         of absence shall result in payment of a bonus based on the Declared
         Bonus determined for the Plan Year but pro-rated for the period of the
         year that the Participant was actively employed by the Company, subject
         to the Committee's discretion to forfeit all or any portion of such
         bonus.

5.6      Retirement, Disability or Death. If a Participant ceases employment
         with the Company because of Retirement, Disability or death, the
         Participant or personal representative, as the case may be, shall
         receive full payment of his/her Bank Balance and a bonus based on the
         Declared Bonus determined for the Plan Year but pro-rated for that
         period of the Plan Year during which the Participant was an active
         employee of the Company.

5.7      Plan Participation. A Participant may not participate in this Plan for
         any portion of a Plan Year for which he/she is entitled to receive
         payment under the Eli Lilly and Company Contingent Compensation Plan,
         and shall be treated in accordance with 5.3.

5.8      Forfeiture Events. Notwithstanding any other provision of this Plan to
         the contrary, the Committee may, in its sole discretion, upon the
         occurrence of a Forfeiture Event (as defined below), forfeit all or any
         portion of a Participant's Declared Bonus and Bonus Bank balance and
         terminate such Participant's future participation in the Plan. For
         purposes hereof, a "Forfeiture Event" shall mean the occurrence of one
         or more of the following events with respect to a Participant: (i) the
         termination or forced resignation from employment of the Participant
         for "misconduct" (as defined in the Company's Employee Information
         Handbook), (ii) any violation by the Participant of the Guidelines of
         Company Policy (the "Redbook") that is detrimental to the Company,
         (iii) any breach of a noncompetition, nonsolicitation, nondisclosure or
         other restrictive covenant that may apply by written agreement between
         the Company and the Participant or (iv) Participant's having engaged in
         any other activity that, in the judgment of the Committee, is
         detrimental to the business, affairs or reputation of the Company
         (including, without limitation, engaging in any criminal activity).
         Except with respect to executive officers, the Committee may delegate
         the authority granted under this section to the vice president
         responsible for human resources.

 
                                   ARTICLE VI

                               General Provisions

6.1      Withholding of Taxes. The Company shall have the right to withhold the
         amount of taxes which in the sole determination of the Company are
         required to be withheld under law with respect to any amount due or
         payable under the Plan.

6.2      Expenses. All expenses and costs in connection with the adoption and
         administration of the Plan shall be borne by the Company.

6.3      No Prior Right or Offer, No Right to Future Participation.
         Participation in the Plan for Plan Years is determined from
         year-to-year by the Committee in its sole discretion. Except and until
         expressly granted pursuant to the Plan, nothing in the Plan shall be
         deemed to give any employee any contractual or other right to
         participate in the benefits of the Plan. No award to any such
         Participant in any Plan Year shall be deemed to create a right to
         receive any award or to participate in the benefits of the Plan in any
         subsequent Plan Year.

6.4      Rights Personal to Employee. Any rights provided to an employee under
         the Plan shall be personal to such employee, shall not be transferable,
         except by will or pursuant to the laws of descent or distribution, and
         shall be exercisable during his/her lifetime, only by such employee, or
         a court-appointed guardian for the employee.

6.5      Non-Allocation of Award. In the event of a suspension of the Plan in
         any Plan Year, as described in Section 11.1, no awards under the Plan
         for the Plan Year during which such suspension occurs shall affect the
         calculation of awards for any subsequent period in which the Plan is
         continued.


                                   ARTICLE VII

                                   Limitations

7.1      No Continued Employment. Neither the establishment of the Plan nor the
         grant of an award thereunder shall be deemed to constitute an express
         or implied contract of employment of any Participant for any period of
         time or in any way abridge the rights of the Company to determine the
         terms and conditions of employment or to terminate the employment of
         any employee with or without notice or cause at any time.

7.2      No Vested Rights. Except as expressly provided herein, no employee or
         other person shall have any claim of right (legal, equitable, or
         otherwise) to any award, allocation, or distribution or any right,
         title, or vested interest in any amounts in his/her Bonus Bank and no
         officer or employee of the Company or any other person shall have any
         authority to make representations or agreements to the contrary. No
         interest conferred herein to a Participant shall be assignable or
         subject to claim by a Participant's creditors.

7.3      Non-alienation. Except as provided in Subsection 5.1, no Participant or
         other person shall have any right or power, by draft, assignment, or
         otherwise, to mortgage, pledge or

 
         otherwise encumber in advance any payment under the Plan, and every
         attempted draft, assignment, or other disposition thereof shall be
         absolutely void.


                                  ARTICLE VIII

                               Committee Authority

8.1      Authority to Interpret and Administer. Except as otherwise expressly
         provided herein, full power and authority to interpret and administer
         this Plan shall be vested in the Committee. The Committee may from time
         to time make such decisions and adopt such rules and regulations for
         implementing the Plan as it deems appropriate for any Participant under
         the Plan. Except as to Participants who are treated by the Company as
         executive officers of the Company for federal securities law reporting
         purposes (including any Section 162(m) Participant), the Committee may
         delegate in writing to officers or employees of the Company the power
         and authority granted by this Section 8.1 to interpret and administer
         this Plan. Any decision taken by the Committee or officer or employee
         to whom authority has been delegated, arising out of or in connection
         with the construction, administration, interpretation and effect of the
         Plan shall be final, conclusive and binding upon all Participants and
         any person claiming under or through Participants.

8.2      Adjustments for Significant Events. Prior to the beginning of a Plan
         Year, the Committee may specify with respect to Declared Bonuses for
         the Plan Year that EVA will be determined before the effects of
         acquisitions, divestitures, restructurings or changes in corporate
         capitalization, accounting changes, and/or events that are treated as
         extraordinary items for accounting purposes; provided that such
         adjustments shall be made only to the extent permitted by Section
         162(m) in the case of Section 162(m) Participants.

8.3      Financial And Accounting Terms. Except as otherwise provided, financial
         and accounting terms, including terms defined herein, shall be
         determined by the Committee in accordance with generally accepted
         accounting principles and as derived from the audited consolidated
         financial statements of the Company, prepared in the ordinary course of
         business.

8.4      Section 162(m) Deferrals. To the extent that, notwithstanding the terms
         of the Plan, the Company's tax deduction for remuneration in respect of
         the payment of bonuses under the Plan to a Section 162(m) Participant
         would be disallowed under Section 162(m) by reason of the fact that
         such Participant's applicable employee remuneration, as defined in
         Section 162(m), either exceeds or, if such bonus were paid, would
         exceed the $1,000,000 limitation in Section 162(m), any such excess (as
         determined by the Committee in its sole discretion) shall be
         automatically deferred under the terms of The Lilly Deferred
         Compensation Plan. Payment of any deferred amounts shall be made to the
         Participant in the first year thereafter that the Company's tax
         deduction in respect of the payment would not be disallowed under
         Section 162(m).

 
                                   ARTICLE IX

                                     Notice

9.1      Any notice to be given to the Company or Committee pursuant to the
         provisions of the Plan shall be in writing and directed to Secretary,
         Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285.


                                    ARTICLE X

                                 Effective Date

10.1     This Plan, as amended and restated herein, shall be effective for the
         Plan Year commencing January 1, 1999, subject to the approval of the
         Plan at the Company's 1998 annual meeting of stockholders. The terms of
         this restated plan shall apply to Declared Bonuses earned in 1999 and
         future years. All Declared Bonuses earned in years prior to 1999 shall
         be payable in accordance with the terms of the Plan as in effect for
         the year to which the Declared Bonus relates. The final Plan Year of
         this Plan, unless amended by the Board (or the Committee) and approved
         by the stockholders as provided in Article XI, shall be the 2002 Plan
         Year.


                                   ARTICLE XI

                           Amendments and Termination

11.1     This Plan may be amended, suspended or terminated at any time at the
         discretion of the Board of Directors of Eli Lilly and Company, and may,
         except for this Section 11.1, be amended at any time by the Committee.
         Solely to the extent deemed necessary or advisable by the Board (or the
         Committee) for purposes of complying with Section 162(m), the Board (or
         the Committee) may seek the approval of any such amendment by the
         Company's stockholders. Any such approval shall be by the affirmative
         votes of the stockholders of the Company present, or represented, and
         entitled to vote at a meeting duly held in accordance with applicable
         state law and the Articles of Incorporation and By-Laws of the Company.
         The material terms of EVA must be disclosed to and reapproved by the
         stockholders of the Company no later than the Company's annual meeting
         of stockholders that occurs in the year 2003.


                                   ARTICLE XII

                                 Applicable Law

12.1     This Plan shall be governed by and construed in accordance with the
         provisions of the laws of the State of Indiana without regard to the
         conflicts-of-law principles of Indiana.