1 EXHBIT 12.1 Ratio of Earnings to Fixed Charges Year Ended December 31, -------------------------------------------------------------------- 2000 1999 1998 1997 1996 ---- ---- ---- ---- ---- Fixed Charges: Interest expense on indebtedness (including amortization of debt expense and discount) $ 36,082 $ 14,146 $ 191 $ 446 $ 422 Interest expense on portion of rent expense representative of interest 3,251 2,951 1,299 1,072 843 ---------- ---------- ---------- ----------- ----------- Total Fixed Charges $ 39,333 $ 17,097 $ 1,490 $ 1,518 $ 1,265 ========== ========== ========== =========== =========== Earnings (Loss): Net loss before provision for income taxes and cumulative effect of change in accounting principle $ (235,331) $ (41,944) $ (22,957) $ (21,148) $ (7,559) Fixed charges per above 39,333 17,097 1,490 1,518 1,265 ---------- ---------- ---------- ----------- ----------- Total Earnings (Loss) $ (195,998) $ (24,847) $ (21,467) $(19,630) $ (6,294) ========== ========== ========== =========== =========== Ratio of Earnings to Fixed Charges (4.98) (1.45) (14.41) (12.93) (4.98) ========== ========== ========== =========== =========== Coverage deficiency (1) $(235,331) $ (41,944) $ (22,957) $(21,148) $ (7,559) ========== ========== ========== =========== =========== (1) The Company's Coverage deficiency for 2000 includes non-recurring charges aggregating $184,868 arising from purchased in-process research and development and debt conversion expenses of $134,050 and $50,818, respectively.