Filed by Genomica Corporation

                                Pursuant to Rule 425 under the Securities Act of
                                                                            1933

                                          Subject Company:  Genomica Corporation
                                                  Commission File No:  000-31637


[E-mail to All Genomica Employees]

To the employees of Genomica Corporation:

For those who are considering exercising options in conjunction with the tender
offer, Cherry is placing packages in your mail boxes this afternoon with the
materials and information regarding the tender offer and how to tender shares.

Important points about your option exercises and tendering shares:

1) If you are doing a cashless exercise and sale when the tender offer closes,
you will be exercising and trading Genomica shares. You will not have any shares
to tender so portion of this message relating to the tender of shares does not
pertain to you.

2) You may also exercise your option(s) and retain Genomica shares, if desired.
In this case you may trade those Genomica shares in the future, or they are
expected to be automatically exchanged for Exelixis shares when the merger
occurs, if the transaction is consummated as currently expected.

3) For those exercising options who are not immediately selling and who wish to
tender their Genomica shares: --the tender of your shares will be effected by
completing the green folder in your package, page 3, "Instructions with Respect
to the Offer". This completed document needs to be given Greg Weiss at First
Union Securities, AND --you will need to complete the pink folder in your
package, pages 2 and 3 "Notice of Guaranteed Delivery" and give that document to
Brian Selby, at Genomica.

The shares covered by #3 above will be tendered to the exchange agent as a group
on your behalf, and the exchange agent will issue shares of Exelixis stock
directly to your account at First Union. You should receive your Exelixis shares
at First Union approximately 4 business days after the tender offer closes
(scheduled for December 28th) but you will be able to trade the exchanged
Exelixis shares approximately 3 days after the tender offer closes.

Again, if you would like additional information regarding Genomica and Exelixis,
you may access publicly filed documents at www.sec.gov or at a number of
commercially available websites which compile documents filed with the
Securities and Exchange Commission. In addition, information regarding
Genomica's and Exelixis' current trading prices on the Nasdaq National Market is
available at www.nasdaq.com. Please note that Exelixis' offer to exchange shares
of its common stock for shares of Genomica stock and the subsequent merger are
subject to a number of conditions, many of which are set forth in Exelixis'
Preliminary Prospectus, as well as in Genomica's Solicitation/ Recommendation
Statement on form 14D-9. You should have already received each of these
documents, as well as others relating to the tender offer. If you have not
received these documents, please contact me at the number below immediately. In
addition, you should consult your personal financial and tax advisor to
determine how your exercise or non-exercise of your stock option will affect
you.


Brian Selby
Corporate Controller
Genomica Corporation