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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 14C

      INFORMATION STATEMENT PURSUANT TO SECTION 14(c) OF THE SECURITIES
                   EXCHANGE ACT OF 1934 (AMENDMENT NO.   )


Check the appropriate box:

/ / Preliminary Information Statement    / / Confidential,
                                             for Use of the Commission Only
/X/ Definitive Information Statement         (as permitted by Rule 14c-5(d)(2)).

                        MANHATTAN PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)

Payment of Filing Fee (Check the appropriate box):

     /X/ No fee required

     / / Fee computed on table below per Exchange Act Rules 14c-5(g) and 0-11

     (1) Title of each class of securities to which transaction applies:

- --------------------------------------------------------------------------------

     (2) Aggregate number of securities to which transaction applies:

- --------------------------------------------------------------------------------

     (3) Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee
is calculated and state how it was determined):

- --------------------------------------------------------------------------------

     (4) Proposed maximum aggregate value of transaction:

- --------------------------------------------------------------------------------

     (5) Total fee paid:

- --------------------------------------------------------------------------------

     / / Fee paid previously with preliminary materials.

     / / Check box if any part of the fee is offset as provided by Exchange Act
Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid
previously. Identify the previous filing by registration statement number, or
the Form or Schedule and the date of its filing.

     (1) Amount Previously Paid:

- --------------------------------------------------------------------------------

     (2) Form, Schedule or Registration Statement No.:

- --------------------------------------------------------------------------------

     (3) Filing Party:

- --------------------------------------------------------------------------------

     (4) Date Filed:

- --------------------------------------------------------------------------------





                         MANHATTAN PHARMACEUTICALS, INC.
                         787 SEVENTH AVENUE, 48TH FLOOR
                            NEW YORK, NEW YORK 10019

                                 August 28, 2003


Dear Stockholder:

         This Information Statement is being furnished to the stockholders of
Manhattan Pharmaceuticals, Inc. (formerly Atlantic Technology Ventures, Inc.), a
Delaware corporation (the "Company"), in connection with the proposed
combination of the Company's common stock on a 1-for-5 basis, which was approved
by the Company's Board of Directors on July 17, 2003. Although the approval of
the holders of a majority of the Company's outstanding common stock is required
to effect a stock combination, a resolution authorizing the proposed stock
combination has been consented to in writing by the holders of more than 57
percent of our outstanding common stock. Accordingly, it is not necessary for
the Company to call a special meeting of stockholders to consider the proposed
stock combination and your approval is not required and is not being sought.

         We are proposing the combination of our common stock in order to allow
us to have a sufficient number of authorized but unissued shares to be able to
issue in connection with financing transactions. Our certificate of
incorporation authorizes us to issue up to 150,000,000 shares of common stock.
We currently have 116,811,980 shares of common stock outstanding, and another
20,559,674 shares of common stock reserved for issuance pursuant to outstanding
stock options and warrants, leaving only 12,628,346 shares available for
issuance. Although we obtained stockholder authorization to effect a 2-for-3
reverse stock split in May 2003, our board of directors determined to abandon
that proposed split and seek approval to effect a larger split. Accordingly,
based on our current capitalization, after the proposed 1-for-5 stock
combination is effected, we will have approximately 23,362,396 shares of common
stock outstanding and approximately 4,111,935 additional shares reserved for
issuance pursuant to outstanding options and warrants.

         This Information Statement enclosed herewith provides further
information about the Company and the proposed stock combination. Please
carefully read the document in its entirety. You may also obtain other
information about the Company from publicly available documents that have been
filed with the Securities and Exchange Commission.

                                         Very truly yours,

                                         /s/ Leonard Firestone

                                         Leonard Firestone
                                         President & Chief Executive Officer



                         MANHATTAN PHARMACEUTICALS, INC.
                         787 SEVENTH AVENUE, 48TH FLOOR
                            NEW YORK, NEW YORK 10019

                        ---------------------------------
                         NOTICE OF ACTION TO BE TAKEN BY
          WRITTEN CONSENT OF STOCKHOLDERS IN LIEU OF A SPECIAL MEETING
                           AND INFORMATION STATEMENT
                        ---------------------------------


         This Information Statement is being mailed to stockholders of Manhattan
Pharmaceuticals, Inc. (formerly Atlantic Technology Ventures, Inc.), a Delaware
corporation (the "Company," "we," "us" or "our"), in connection with the
approval by the holders of a majority of the Company's outstanding common stock
of a resolution approving the combination, or "reverse stock split," of the
Company's common stock on a 1-for-5 basis. In order to effect a reverse stock
split, it is necessary for the Company to obtain the approval of its
stockholders. However, stockholders holding an aggregate of more than 57 percent
of our outstanding common stock have already consented in writing to a
resolution authorizing the Company to effect a 1-for-5 reverse split.
Accordingly, pursuant to our bylaws and the General Corporation Law of Delaware,
the Company will not call a special meeting of stockholders to consider the
proposed stock combination and your vote is not being solicited. This Notice of
Action to be Taken by Stockholders in Lieu of a Special Meeting and Information
Statement is furnished to you solely for the purpose of informing stockholders
of this corporate action before it takes effect, in the manner required under
the Securities Exchange Act of 1934, as amended.

         The written consents that we have received from holders of more than 57
percent of our outstanding common stock authorize us to effect a 1-for-5 reverse
stock split at any time after 20 days from the date of this Information
Statement. This Information Statement was first sent or provided to holders
(other than the stockholders who have already provided their written consent
authorizing the reverse split) of our outstanding common stock on or about
August 28, 2003. Other than common stock, we have no other shares of any other
class of our capital stock outstanding.


                      WE ARE NOT ASKING YOU FOR A PROXY AND
                    YOU ARE REQUESTED NOT TO SEND US A PROXY.

GENERAL; PURPOSE

         As of August 26, 2003, we had 116,811,980 shares of common stock
outstanding and an additional 20,559,674 shares of common stock reserved for
issuance upon the exercise of outstanding options and warrants. Our certificate
of incorporation authorizes us to issue only up to 150,000,000 shares of capital
stock, meaning that we are only authorized to issue an additional 12,628,346
shares of common stock. In light of the current market price of our common
stock, the number of remaining shares that we are authorized to issue limits our
flexibility to raise additional capital through equity financings. In order to
increase the number of shares of common stock that we are authorized to issue,
our Board of Directors has unanimously adopted a resolution seeking stockholder
approval authorizing the Board of Directors to amend our Certificate of
Incorporation to effect a reverse split of our common stock. The ratio of the
reverse stock split that the Board of Directors approved and deemed advisable
and to which the holders of a majority of our outstanding common stock have
consented is 1-for-5. This means that, when effected, every 5 shares of common
stock outstanding prior to the stock combination will represent only 1 share of
common stock after the combination. Accordingly, the proposed 1-for-5 reverse
stock split will provide us with greater flexibility in raising additional
capital by making approximately 109,897,323 additional shares of common stock
available for issuance.

         We are currently offering for sale a minimum of 300,000 shares and a
maximum of 750,000 shares (subject to an additional 250,000 share
over-allotment) of a class of newly-designated convertible preferred stock at a
price of $10.00 per share and have engaged a placement agent to assist us in the
offering. The current offering is being conducted in accordance with applicable
exemptions from the registration requirements of the Securities Act of 1933, as
amended (the "Securities Act"), and the preferred shares will not be and have
not been registered under the Securities Act and may not be offered or sold in
the United States absent registration or an applicable exemption from
registration requirements. In accordance with the terms of the offering,
however, we intend to register the resale of the shares of common stock issuable
upon conversion of the preferred stock. The terms of the preferred stock will
provide, among other things, for conversion at the holder's election into a
number of shares of our common stock based on a conversion price equal to the
lesser of (i) $0.30 per share (as adjusted for stock splits, combinations, etc.)
and (ii) 90 percent of the volume weighted average price of our common stock
during the 5 days preceding any closing of the sale of such preferred stock. We
intend to use the proceeds from this offering for working capital and general
corporate purposes, including pre-clinical and clinical research and development
of our licensed technologies. There can be no assurance that the preferred stock
offering will be completed, however, in which case we not receive any proceeds
in connection with the offering. We intend to effect the 1-for-5 reverse stock
split prior to a closing of the current offering, but neither the offering nor
the reverse split are contingent upon one another. We intend to complete the
reverse stock split even if it we are unable to complete the current offering.

         Although we have no current plans to offer or sell shares of our stock
other than in the current offering, we may in the future seek to raise
additional capital by selling shares of our stock or other securities
convertible into shares of our stock. The currently proposed 1-for-5 reverse
stock split should provide the Company with the necessary flexibility to
complete the current offering and any other offerings for the foreseeable
future. Any such offerings, including the current offering, will generally have
the effect of diluting the interests of existing stockholders.

         Holders of more than 57 percent of our outstanding common stock have
consented in writing to the proposed stock combination. The resolution consented
to by these stockholders authorizes us to effect the combination any time after
20 days from the date of this Information Statement. Accordingly, after that
time, we will file a Certificate of Amendment to our Certificate of
Incorporation with the Secretary of State of the State of Delaware (as described
below) which will effect a combination of the shares of our common stock then
issued and outstanding at a ratio of 1-for-5. The reverse split will not change
the number of authorized shares of common stock or preferred stock or the par
value of our common stock or


                                       2

preferred stock. Except for any changes resulting from the treatment of
fractional shares, each stockholder will hold the same percentage of common
stock outstanding immediately after the combination as such stockholder did
immediately prior to the combination. We may abandon the proposed stock split if
our board of directors deems it advisable.

ABANDONED 2-FOR-3 STOCK COMBINATION PLAN

         In June 2003, we informed our stockholders that we had obtained the
written consent of the holders of more than 57 percent of our common stock to
effect a 2-for-3 reverse stock split any time after 20 days from June 20, 2003.
After obtaining that stockholder approval and informing our stockholders of our
intention to effect the split, our board of directors determined that it was in
the Company's best interests to effect a larger stock combination than the
2-for-3 split that had been approved. In particular, as we were able to more
accurately determine the terms of a private placement of a newly-designated
class of convertible preferred stock, it became evident that a 2-for-3 split
might be inadequate to provide the Company with sufficient capital in connection
with our current private placement, as well as any equity financings that the
Company may determine to undertake in the future. Accordingly, we abandoned the
proposed 2-for-3 split and sought the written consents of the holders of a
majority of our outstanding shares of common stock to combine the outstanding
shares of common stock on a 1-for-5 basis.

CERTAIN RISKS ASSOCIATED WITH THE STOCK COMBINATION

THERE CAN BE NO ASSURANCE THAT THE TOTAL MARKET CAPITALIZATION OF OUR COMMON
STOCK AFTER THE PROPOSED STOCK COMBINATION WILL BE EQUAL TO OR GREATER THAN THE
TOTAL MARKET CAPITALIZATION BEFORE THE PROPOSED STOCK COMBINATION OR THAT THE
PER SHARE MARKET PRICE OF OUR COMMON STOCK FOLLOWING THE COMBINATION WILL EITHER
EXCEED OR REMAIN HIGHER THAN THE CURRENT PER SHARE MARKET PRICE.

         There can be no assurance that the market price per new share of our
common stock (the "New Shares") after the stock combination will rise or remain
constant in proportion to the reduction in the number of old shares of our
common stock (the "Old Shares") outstanding before the stock combination. For
example, based on the market price of our common stock on August 26, 2003 of
$0.28 per share, following a 1-for-5 reverse split there can be no assurance
that the post-split market price of our common stock would be $1.40 per share or
greater. Accordingly, the total market capitalization of our common stock after
the proposed reverse stock split may be lower than the total market
capitalization before the proposed reverse stock split and, in the future, the
market price of our common stock following the reverse stock split may not
exceed or remain higher than the market price prior to the proposed reverse
stock split. In many cases, the total market capitalization of a company
following a reverse stock split is lower than the total market capitalization
before the reverse stock split.

A DECLINE IN THE MARKET PRICE FOR OUR COMMON STOCK AFTER THE REVERSE STOCK SPLIT
MAY RESULT IN A GREATER PERCENTAGE DECLINE THAN WOULD OCCUR IN THE ABSENCE OF A
REVERSE STOCK SPLIT, AND THE LIQUIDITY OF OUR COMMON STOCK COULD BE ADVERSELY
AFFECTED FOLLOWING A REVERSE STOCK SPLIT.

          The market price of our common stock will also be based on our
performance and other factors, some of which are unrelated to the number of
shares outstanding. If the reverse stock split is effected and the market price
of our common stock declines, the percentage decline as an absolute number and
as a percentage of our overall market capitalization may be greater than would
occur in the absence of a reverse stock split. In many cases, both the total
market capitalization of a company and the market price of a share of such
company's common stock following a reverse stock split are lower than they were
before the reverse stock split. Furthermore, the liquidity of our common stock
could be adversely affected by the reduced number of shares that would be
outstanding after the reverse stock split.


                                       3

PRINCIPAL EFFECTS OF THE REVERSE STOCK SPLIT

          CORPORATE MATTERS. If effected, the reverse stock split would have the
following effects:

              -   every 5 Old Shares owned by a stockholder would be exchanged
                  for 1 New Share;

              -   the number of shares of our common stock issued and
                  outstanding will be reduced proportionately based on the
                  1-for-5 split ratio;

              -   based on the 1-for-5 ratio, proportionate adjustments will be
                  made to the per share exercise price and the number of shares
                  issuable upon the exercise of all outstanding options and
                  warrants entitling the holders thereof to purchase shares of
                  our common stock, which will result in approximately the same
                  aggregate price being required to be paid for such options or
                  warrants upon exercise of such options or warrants immediately
                  preceding the reverse stock split; and

              -   the number of shares reserved for issuance under our existing
                  stock option plans will be reduced proportionately based on
                  the 1-for-5 split ratio.

         When effected, the reverse stock split will be effected simultaneously
for all of our common stock and the ratio will be the same for all of our common
stock. The reverse stock split will affect all of our stockholders uniformly and
will not affect any stockholder's percentage ownership interests in our company,
except to the extent that the reverse stock split results in any of our
stockholders owning a fractional share. As described below, stockholders holding
fractional shares will be entitled to cash payments in lieu of such fractional
shares. Such cash payments would reduce the number of post-split stockholders to
the extent there are stockholders presently holding fewer than 5 shares. This,
however, is not the purpose for which we are effecting the reverse stock split.
Common stock issued pursuant to the reverse stock split will remain fully paid
and non-assessable. We will continue to be subject to the periodic reporting
requirements of the Securities Exchange Act of 1934, as amended.

         FRACTIONAL SHARES. No scrip or fractional certificates will be issued
in connection with the reverse stock split. Stockholders who otherwise would be
entitled to receive fractional shares because they hold a number of Old Shares
not evenly divisible by the number selected by the Board of Directors for the
reverse stock split ratio will be entitled, upon surrender of certificate(s)
representing such shares, to a cash payment in lieu thereof. The cash payment
will equal the product obtained by multiplying (a) the fraction to which the
stockholder would otherwise be entitled by (b) the per share closing sales price
of our common stock on the day immediately prior to the effective time of the
reverse stock split, as reported on the Over-the-Counter Bulletin Board. The
ownership of a fractional interest will not give the holder thereof any voting,
dividend or other rights except to receive payment therefor as described herein.

         Stockholders should be aware that, under the escheat laws of the
various jurisdictions where our stockholders reside, where we are domiciled and
where the funds will be deposited, sums due for fractional interests that are
not timely claimed after the effective time may be required to be paid to the
designated agent for each such jurisdiction. Thereafter, stockholders otherwise
entitled to receive such funds may have to seek to obtain them directly from the
state to which they were paid.

         If approved and effected, the reverse stock split will result in some
stockholders owning "odd lots" of less than 100 shares of our common stock.
Brokerage commissions and other costs of transactions in odd lots are generally
somewhat higher than the costs of transactions in "round lots" of even multiples
of 100 shares.


                                       4

         AUTHORIZED SHARES. Upon the effectiveness of the reverse stock split,
the number of authorized shares of common stock that are not issued or
outstanding would increase due to the reduction in the number of shares of our
common stock issued and outstanding based on the 1-for-5 reverse stock split
ratio. As of August 26, 2003, we had 150,000,000 shares of common stock
authorized for issuance, 116,811,980 shares of common stock issued and
outstanding and an additional 20,559,674 shares authorized for issuance upon
exercise of outstanding options and warrants. Accordingly, after giving effect
to the proposed reverse stock split, we will have only approximately 23,362,396
shares of common stock outstanding and 4,111,935 shares authorizes for issuance
under out outstanding options and warrants. We will continue to have 10,000,000
authorized shares of preferred stock. Authorized but unissued shares will be
available for issuance, and we may issue such shares in financings, including
the currently preferred stock offering, or otherwise. If we issue additional
shares, the ownership interest of holders of our common stock may also be
diluted. Also, the issued shares may have rights, preferences or privileges
senior to those of our common stock.

         ACCOUNTING MATTERS. The reverse stock split will not affect the par
value of our common stock, which is $.001 per share. As a result, as of the
effective time of the reverse stock split, the stated capital on our balance
sheet attributable to our common stock will be reduced proportionately based on
the 1-for-5 split ratio, and the additional paid-in capital account will be
credited with the amount by which the stated capital is reduced. The per share
net income or loss and net book value of our common stock will be restated
because there will be fewer shares of common stock outstanding.

         POTENTIAL ANTI-TAKEOVER EFFECT. Although the increased proportion of
unissued authorized shares to issued shares could, under certain circumstances,
have an anti-takeover effect (for example, by permitting issuances that would
dilute the stock ownership of a person seeking to effect a change in the
composition of our Board of Directors or contemplating a tender offer or other
transaction for the combination of us with another company), the reverse stock
split is not being proposed in response to any effort of which we are aware to
accumulate shares of our common stock or obtain control of our company, nor is
it part of a plan by management to recommend a series of similar amendments to
our Board of Directors and stockholders. Other than the reverse stock split
proposal, we do not currently contemplate recommending the adoption of any other
amendments to our Certificate of Incorporation that could be construed to affect
the ability of third parties to take over or change the control of our company.

PROCEDURE FOR EFFECTING REVERSE STOCK SPLIT AND EXCHANGE OF STOCK CERTIFICATES

      In order to effect the 1-for-5 reverse split, we will file a Certificate
of Amendment to our Certificate of Incorporation ("Amendment") with the
Secretary of State of the State of Delaware to amend our existing Certificate of
Incorporation. The reverse stock split will become effective at the time
specified in the Amendment, which is referred to below as the "effective time."
Beginning at the effective time, each certificate representing Old Shares will
be deemed for all corporate purposes to evidence ownership of New Shares. The
text of the Amendment to effect the reverse stock split will be in substantially
the form attached hereto as APPENDIX A; provided, however, that the text of the
form of Amendment attached hereto is subject to modification to include such
changes as may be required by the office of the Secretary of State of the State
of Delaware and as the Board of Directors deems necessary and advisable to
effect the reverse stock split, including the insertion of the effective time
determined by the Board of Directors.

         As soon as practicable after the effective time, stockholders will be
notified that the reverse stock split has been effected. We expect that our
transfer agent, Continental Stock Transfer and Trust Company, will act as
exchange agent for purposes of implementing the exchange of stock certificates.
Holders of Old Shares will be asked to surrender to the exchange agent
certificates representing Old Shares in exchange for certificates representing
New Shares in accordance with the procedures to be set forth in the letter of
transmittal that we send to our stockholders. No new certificates will be issued
to a stockholder until such stockholder has surrendered such stockholder's
outstanding certificate(s), together with the


                                       5

properly completed and executed letter of transmittal, to the exchange agent.
Any Old Shares submitted for transfer, whether pursuant to a sale, other
disposition or otherwise, will automatically be exchanged for New Shares.
STOCKHOLDERS SHOULD NOT DESTROY ANY STOCK CERTIFICATE(S) AND SHOULD NOT SUBMIT
ANY CERTIFICATE(S) UNTIL REQUESTED TO DO SO.

NO DISSENTERS' RIGHTS

      Under the Delaware General Corporation Law, our stockholders are not
entitled to dissenters' rights with respect to the reverse stock split, and we
will not independently provide stockholders with any such right.

FEDERAL INCOME TAX CONSEQUENCES OF THE REVERSE STOCK SPLIT

          The following is a summary of certain material federal income tax
consequences of the reverse stock split, does not purport to be a complete
discussion of all of the possible federal income tax consequences of the reverse
stock split and is included for general information only. Further, it does not
address any state, local or foreign income or other tax consequences. Also, it
does not address the tax consequences to holders that are subject to special tax
rules, such as banks, insurance companies, regulated investment companies,
personal holding companies, foreign entities, nonresident alien individuals,
broker-dealers and tax-exempt entities. The discussion is based on the
provisions of the United States federal income tax law as of the date hereof,
which is subject to change retroactively as well as prospectively. This summary
also assumes that the Old Shares were, and the New Shares will be, held as a
"capital asset," as defined in the Internal Revenue Code of 1986, as amended
(i.e., generally, property held for investment). The tax treatment of a
stockholder may vary depending upon the particular facts and circumstances of
such stockholder. Each stockholder is urged to consult with such stockholder's
own tax advisor with respect to the tax consequences of the reverse stock split.

      Other than the cash payments for fractional shares discussed below, no
gain or loss should be recognized by a stockholder upon such stockholder's
exchange of Old Shares for New Shares pursuant to the reverse stock split. The
aggregate tax basis of the New Shares received in the reverse stock split
(including any fraction of a New Share deemed to have been received) will be the
same as the stockholder's aggregate tax basis in the Old Shares exchanged
therefor. In general, stockholders who receive cash in exchange for their
fractional share interests in the New Shares as a result of the reverse stock
split will recognize gain or loss based on their adjusted basis in the
fractional share interests redeemed. The stockholder's holding period for the
New Shares will include the period during which the stockholder held the Old
Shares surrendered in the reverse stock split.

      Our view regarding the tax consequences of the reverse stock split is not
binding on the Internal Revenue Service or the courts. ACCORDINGLY, EACH
STOCKHOLDER SHOULD CONSULT WITH HIS OR HER OWN TAX ADVISOR WITH RESPECT TO ALL
OF THE POTENTIAL TAX CONSEQUENCES TO HIM OR HER OF THE REVERSE STOCK SPLIT.

VOTE REQUIRED

      The affirmative vote of the holders of a majority of all outstanding
shares of our common stock entitled to vote on this proposal was required for
approval of this proposal. As of August 12, 2003, we had obtained written
consents authorizing the 1-for-5 reverse split from holders of more than 57
percent of our outstanding common stock.


                                       6

                              SECURITY OWNERSHIP OF
                    CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The following table sets forth certain information regarding beneficial
ownership of the our common stock as of August 26, 2003, by (i) each person
known by us to be the beneficial owner of more than 5 percent of the outstanding
common stock, (ii) each director, (iii) each executive officer, and (iv) all
executive officers and directors as a group. The number of shares beneficially
owned is determined under rules promulgated by the SEC, and the information is
not necessarily indicative of beneficial ownership for any other purpose. Under
those rules, beneficial ownership includes any shares as to which the individual
has sole or shared voting power or investment power and also any shares which
the individual has the right to acquire within 60 days of the date hereof,
through the exercise or conversion of any stock option, convertible security,
warrant or other right. Including those shares in the tables does not, however,
constitute an admission that the named stockholder is a direct or indirect
beneficial owner of those shares. Unless otherwise indicated, each person or
entity named in the table has sole voting power and investment power (or shares
that power with that person's spouse) with respect to all shares of capital
stock listed as owned by that person or entity. Unless otherwise indicated, the
address of each of the following persons is 787 Seventh Avenue, 48th Floor, New
York, New York 10019.



                                                                          SHARES
        NAME                                                        BENEFICIALLY OWNED       PERCENT OF CLASS
        ----                                                        ------------------       ----------------

                                                                                       
        Leonard Firestone.......................................                  0                   *
        Nicholas J. Rossettos(1)................................            287,500                   *
        Joshua Kazam............................................          1,220,129                  1.0
        Michael Weiser..........................................          6,837,806                  5.9
        Joan Pons(2)............................................                  0                   *
        David M. Tanen(3).......................................          1,871,236                  1.6
        All directors and officers as a group(4)................         10,216,671                  8.7

        Lindsay A. Rosenwald(5).................................         13,569,320                 11.6
        Oleoylestrone Developments, SL(6).......................         20,785,188                 17.8
            Josep Samitier 1-5, Barcelona Science Park
            08028 Barcelona Spain
        Jay Lobell(7)...........................................         18,848,450                 16.1
            365 West End Avenue
            New York, New York 10024


         ------------------------
         *   Less than 1.0%

(1)  Represents shares issuable upon the exercise of options that are currently
     exercisable or will become exercisable within 60 days.
(2)  Does not include any shares beneficially owned by Oleoylestrone
     Developments, SL, of which Mr. Pons is chief executive officer.
(3)  Includes 28,333 shares issuable upon the exercise of options that are
     currently exercisable or will become exercisable within 60 days.
(4)  Includes 165,833 shares issuance upon the exercise of options. Does not
     include any shares held by Oleoylestrone Developments, SL, of which Mr.
     Pons is chief executive officer.
(5)  Includes 190 shares of common stock held by Huntington Street Corporation
     and 190 shares of common stock held by June Street Corporation. Dr.
     Rosenwald is the sole owner of both Huntington Street Corporation and June
     Street Corporation.
(6)  Mr. Pons is the chief executive officer of Oleoylestrone Developments, SL.
(7)  Includes 18,721,353 shares of common stock held by eight separate trusts
     with respect to which Mr. Lobell is either trustee or manager and in either
     case has investment and voting power.


                                       7

                       WHERE YOU CAN FIND MORE INFORMATION

         We file annual, quarterly and current reports, proxy statements and
other information with the SEC. You may read and copy any reports, statements or
other information we file at the SEC's public reference rooms in Washington,
D.C., and Chicago, Illinois. Please call the SEC at 1-800-SEC-0330 for further
information on the public reference rooms. Our SEC filings are also available to
the public from commercial document retrieval services and at the internet
website maintained by the SEC at: http://www.sec.gov.

- --------------------------------------------------------------------------------
YOU SHOULD RELY ONLY ON THE INFORMATION CONTAINED IN THIS INFORMATION STATEMENT.
WE HAVE NOT AUTHORIZED ANYONE TO PROVIDE YOU WITH INFORMATION THAT IS DIFFERENT
FROM WHAT IS CONTAINED IN THIS INFORMATION STATEMENT. THIS INFORMATION STATEMENT
IS DATED AUGUST 28, 2003. YOU SHOULD NOT ASSUME THAT THE INFORMATION CONTAINED
IN THIS INFORMATION STATEMENT IS ACCURATE AS OF ANY DATE OTHER THAN SUCH DATE,
AND THE MAILING OF THIS INFORMATION STATEMENT TO SHAREHOLDERS SHALL NOT CREATE
ANY IMPLICATION TO THE CONTRARY.
- --------------------------------------------------------------------------------


                                       8

                                                                      APPENDIX A

                            CERTIFICATE OF AMENDMENT
                                     OF THE
                          CERTIFICATE OF INCORPORATION
                                       OF
                         MANHATTAN PHARMACEUTICALS, INC.

                     Pursuant to Section 242 of the General
                    Corporation Law of the State of Delaware

         It is hereby certified that:

         1. Manhattan Pharmaceuticals, Inc. (formerly known as Atlantic
Technology Ventures, Inc.) is a corporation formed under the laws of the State
of Delaware, and its certificate of incorporation was filed in the office of the
Secretary of State on May 18, 1993.

         2. The certificate of incorporation is hereby amended by deleting the
text of Article FOURTH in its entirety and replacing it with the following:

                  FOURTH: A. The corporation is authorized to issue two classes
         of stock designated "Common Stock" and "Preferred Stock," respectively.
         The total number of shares of Common Stock authorized to be issued is
         150,000,000, and each such share will have a par value of $0.001. The
         total number of shares of Preferred Stock authorized to be issued is
         10,000,000, and each such share will have a par value of $0.001.

                  B. Effective 12:01 a.m. on             , 2003 (the "Effective
         Time") every five (5) shares of Common Stock of the Corporation issued
         and outstanding immediately prior to the Effective Time ("Old Common
         Stock") shall automatically be combined, without any action on the part
         of the holder thereof, into one (1) share of fully paid and
         nonassessable Common Stock of the Corporation ("New Common Stock"),
         subject to the treatment of fractional shares interests described
         below.

                  C. Following the Effective Time, each holder of Old Common
         Stock shall be entitled to receive upon surrender of such holder's
         certificate(s) representing Old Common Stock (whether one or more, "Old
         Certificates") for cancellation pursuant to procedures adopted by the
         Corporation, a certificate(s) representing the number of whole shares
         of New Common Stock (whether one or more, "New Certificates") into
         which and for which the shares of Old Common Stock formerly represented
         by such Old Certificates so surrendered are reclassified under the
         terms hereof. From and after the Effective Time, Old Certificates shall
         represent only the right to receive New Certificates and, where
         applicable, cash in lieu of fractional shares, as provided below.

                  D. No fractional shares of Common Stock of the Corporation
         shall be issued. No stockholder of the Corporation shall transfer any
         fractional shares of Common Stock of the Corporation. The Corporation
         shall not recognize on its stock record books any purported transfer of
         any fractional share of Common Stock of the Corporation. A holder of
         Old Certificates at the Effective Time who would otherwise be entitled
         to a fraction of a share of New Common Stock shall, in lieu thereof, be
         entitled to receive a cash payment in an amount equal to the fraction
         to which the stockholder would otherwise be entitled multiplied by the
         last reported per share sale price of the Common Stock on the day
         immediately prior to the Effective Time, as reported on



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         the Over-the-Counter Bulletin Board (or if such price is not available,
         then such other price as determined by the Board of Directors).

                  E. Shares of Preferred Stock may be issued from time to time
         in one or more series. The Board of Directors is hereby authorized, by
         adopting appropriate resolutions and causing one or more certificates
         of amendment to be signed, verified and delivered in accordance with
         the General Corporation Law, to establish from time to time the number
         of shares to be included in such series, and to fix the designations,
         relative rights, preferences and limitations of the shares of each such
         series. Such designations, relative rights, preferences and limitations
         may include, but are not limited to, the fixing or alteration of the
         dividend rights, dividend rate, conversion rights, exchange rights,
         voting rights, rights and terms of redemption (including sinking fund
         provisions), the redemption price or prices, and the liquidation
         preferences of any wholly unissued series of shares of Preferred Stock,
         or any of them. In accordance with the authority hereby granted, the
         Board of Directors may increase or decrease the number of shares of any
         series subsequent to the issue of shares of that series, but not above
         the total number of authorized shares of Preferred Stock and not below
         the number of shares of such series then outstanding. In case the
         number of shares of any series shall be so decreased, the shares
         constituting such decrease shall resume the status that they had prior
         to the adoption of the resolution originally fixing the number of
         shares of such series. Except as may otherwise be required by law or
         this Certificate of Incorporation, the terms of any series of Preferred
         Stock may be amended without the consent of the holders of any other
         series of Preferred Stock, or Common Stock.

         3. This amendment to the certificate of incorporation has been duly
adopted in accordance with Section 242 of the General Corporation Law of the
State of Delaware.

         The undersigned is signing this certificate on ________, 2003.



                                   _______________________________________
                                   Leonard Firestone
                                   President and Chief Executive Officer






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