SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                       Pursuant to Section 13 or 15 (d) of
                       the Securities Exchange Act of 1934

  Date of Report (Date of earliest event reported): June 7, 2004 (June 4, 2004)


                          ENCYSIVE PHARMACEUTICALS INC.
             (Exact name of registrant as specified in its charter)


                                                    
       DELAWARE                       0-20117                       13-3532643
(State of Incorporation)      (Commission File Number)    (IRS Employer Identification No.)



                            6700 WEST LOOP, 4TH FLOOR
                              BELLAIRE, TEXAS 77401
              (Address of Registrant's principal executive offices)

                                 (713) 796-8822
              (Registrant's telephone number, including area code)


                                 Not Applicable
          (Former name or former address, if changed since last report)

ITEM 5. OTHER EVENTS AND REGULATION FD DISCLOSURE

      On June 7, 2004, Encysive Pharmaceuticals Inc. issued a press release
announcing that it has filed a universal shelf registration statement on Form
S-3 with the Securities and Exchange Commission. The full text of the press
release is furnished herewith as Exhibit 99.1 and is incorporated herein by
reference.

ITEM 7. FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

      (c) Exhibits.

          99.1 Press Release.




                            [SIGNATURE PAGE FOLLOWS]

                                    SIGNATURE

      Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                  Encysive Pharmaceuticals Inc.

Date: June 7, 2004                By: /s/ Stephen L. Mueller
                                      ------------------------------------------
                                      Stephen L. Mueller
                                      Vice-President, Finance and Administration
                                      Secretary and Treasurer


                                INDEX TO EXHIBITS

EXHIBIT NO.           DESCRIPTION
- -----------           -----------

   99.1               Press Release