EXHIBIT 32.1

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

IN CONNECTION WITH THE QUARTERLY REPORT OF CELL ROBOTICS INTERNATIONAL, INC.
(THE "COMPANY") ON FORM 10-QSB FOR THE PERIOD ENDING SEPTEMBER 30, 2004 AS FILED
WITH THE SECURITIES AND EXCHANGE COMMISSION ON THE DATE HEREOF (THE "REPORT"),
I, EUTIMIO SENA, CHIEF EXECUTIVE OFFICER OF THE COMPANY, CERTIFY, TO THE BEST
OF MY KNOWLEDGE AND BELIEF, PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED
PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002, BASED UPON A REVIEW
OF THE REPORT, THAT:

      (1)   THE REPORT FULLY COMPLIES WITH THE REQUIREMENTS OF SECTION 13(a) OR
            15(d) OF THE SECURITIES EXCHANGE ACT OF 1934; AND

      (2)   THE INFORMATION CONTAINED IN THE REPORT FAIRLY PRESENTS, IN ALL
            MATERIAL RESPECTS, THE FINANCIAL CONDITION AND RESULTS OF OPERATIONS
            OF THE COMPANY.

A signed original of this written statement required by Section 906 has been
provided to the Company and will be retained by the Company and furnished to the
Securities and Exchange Commission or its staff upon request.

                                               /S/ EUTIMIO L. SENA
                                               ---------------------------------
                                               EUTIMIO SENA
                                               CHIEF EXECUTIVE OFFICER
                                               CELL ROBOTICS INTERNATIONAL, INC.
                                               NOVEMBER 19, 2004


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