[IRELL & MANELLA LLP LETTERHEAD]

                                                             WRITER'S DIRECT
                                                        TELEPHONE (310) 203-7139
                                                            AMUKHEY@IRELL.COM

                                February 1, 2005


VIA EDGAR AND OVERNIGHT COURIER

David Ritenour, Esq.
Special Counsel
U.S. Securities and Exchange Commission
Mail Stop 0306
450 Fifth Street, N.W.
Washington, D.C.  20549

   Re:      Cygnus, Inc.
            Preliminary Proxy Statement on Schedule 14A filed January 24, 2005
            Commission File No. 0-18962

Dear Mr. Ritenour:

         On behalf of Cygnus, Inc., a Delaware corporation, and in connection
with its Preliminary Proxy Statement on Schedule 14A of the Securities Exchange
Act of 1934, we hereby file a revised Preliminary Proxy Statement and respond to
the comment letter of the Securities and Exchange Commission dated January 28,
2005. In our letter, we refer to Cygnus, Inc. as "Cygnus" or the "Company," to
the Staff of the Securities and Exchange Commission as the "Staff," and to the
revised Preliminary Proxy Statement as the "Proxy Statement." Comment numbering
used for each response set forth below corresponds to the comment numbering used
in the Staff's letter.

PROPOSAL NO. 2: APPROVAL OF PLAN OF COMPLETE LIQUIDATION AND DISSOLUTION - PAGES
35 TO 49

ARBITRATION MATTER - PAGE 36

1.       WE NOTE YOUR RESPONSE TO PRIOR COMMENT 7 AND REISSUE THE COMMENT.
         PLEASE DESCRIBE THE CIRCUMSTANCES UNDER WHICH THE BOARD MAY ELECT NOT
         TO PURSUE ITS CLAIMS IN THE ARBITRATION MATTER. FOR EXAMPLE, MIGHT THE
         BOARD ELECT NOT TO PURSUE ITS CLAIMS IF IT DETERMINED THAT THE COMPANY
         WAS UNLIKELY TO SUCCEED IN THE ARBITRATION?

Response:

         The Company has revised the Proxy Statement in accordance with the
Staff's comment by stating that the Board of Directors might elect not to pursue
its claims in the

David Ritenour, Esq.
February 1, 2005
Page 2


Arbitration Matter if it determined, in its judgment, that it
was not in the Company's best financial interests to do so.

LIQUIDATING DISTRIBUTIONS: NATURE; AMOUNT: TIMING - PAGES 39 TO 43

         ESTIMATED DISTRIBUTIONS TO STOCKHOLDERS.... - PAGES 40 TO 43

2.       PLEASE REVISE YOUR ESTIMATED DISTRIBUTIONS TABLE AS FOLLOWS:

         -        PLEASE QUANTIFY AND LIST SEPARATELY THE AMOUNTS TO BE USED TO
                  DISCHARGE OUTSTANDING INDEBTEDNESS AND THE AMOUNTS ALLOCATED
                  TO PAY OR ACCRUE FOR ACCOUNTS PAYABLE.

         Response:

                  The Company notes that the table currently quantifies and
         lists separately the amounts to be used to discharge outstanding
         indebtedness and the amounts allocated to pay or accrue for accounts
         payable. The Company's only outstanding indebtedness is the arbitration
         obligation owing to Sanofi-Aventis, which, as described in the Proxy
         Statement, has been reduced to $10 million if payment of $10 million is
         made prior to February 28, 2006. Please note that the table now lists
         separately (both for the January-March 2005 period and the April-
         December 2005 period) line items for "Other operating expenses." In the
         January-March 2005 period, "Payments of accounts payable/accruals as of
         December 31, 2004" are also listed separately. The Company anticipates
         having no accounts payable/accruals in the April-December 2005 period
         that are not otherwise reflected in "Other operating expenses."

                  Please note that the Company has also revised the Estimated
         Distribution to Stockholders table to separate the expenses occurring
         in first quarter 2005 prior to the consummation of the Asset Sale from
         those expenses that will occur in the second, third and fourth quarters
         of 2005 after the Company has vacated its facility and after the Asset
         Sale has closed.

         -        PLEASE QUANTIFY AND LIST SEPARATELY THE $175,000 PER QUARTER
                  IN SALARY AND DIRECTORS' FEES THAT IS EXPECTED TO BE INCURRED,
                  AS WELL AS ANY OTHER COMPENSATION EXPENSES (OTHER THAN THE
                  SEVERANCE COSTS THAT ARE ALREADY SEPARATELY DISCLOSED). IN
                  ADDITION, IF THE TABLE INCLUDES AMOUNTS ALLOCATED FOR THE
                  POTENTIAL PAYMENT OF THE INCENTIVE COMPENSATION REFERENCED IN
                  YOUR RESPONSE TO PRIOR COMMENT 9, PLEASE QUANTIFY AND LIST
                  SEPARATELY THOSE AMOUNTS, OR, ALTERNATIVELY, PROVIDE
                  APPROPRIATE FOOTNOTE DISCLOSURE INDICATING, IF TRUE, THAT THE
                  TABLE HAS BEEN PREPARED ASSUMING THAT NO SUCH INCENTIVE
                  COMPENSATION WILL BE PAID.

         Response:

                  The Company has revised the Proxy Statement in accordance with
         the Staff's comment by listing separately under the line item entitled
         "Salary and directors' fees" the salary and directors' fees expected to
         be incurred in 2005, which includes $175,000 per quarter beginning in
         the second quarter after the estimated Asset Sale closing date of March
         31, 2005 and the Company's departure from its premises on or before the
         same date. The $175,000 per quarter after the closing of the Asset Sale
         consists of the potential estimated salaries of Mr. Hodgman
         and Ms.

David Ritenour, Esq.
February 1, 2005
Page 3


         McClung for the balance of 2005 if retention agreements can be reached,
         as disclosed elsewhere in the Proxy Statement, and directors' fees. The
         Company has added a footnote to the table explaining this proposed
         arrangement.

              In addition to salary payments, the Company is discussing with Mr.
         Hodgman and Ms. McClung whether those arrangements would include
         incentive compensation to Mr. Hodgman and Ms. McClung based on the
         recovery in the Arbitration Matter. No agreements have yet been reached
         with Mr. Hodgman or Ms. McClung, but in accordance with the Staff's
         comment, the Company has included a separate line item entitled
         "Estimated incentive compensation" to show this potential payment. In
         addition, this proposed arrangement is also described in "Interests of
         Certain Persons in the Asset Sale and the Plan of Dissolution."

               As noted in the response to the previous comment, the Company has
          revised the Estimated Distribution to Stockholders table to show the
          estimated 2005 cash uses before and after the consummation of the
          Asset Sale. This also will give greater clarity to the ongoing
          expenses following the Asset Sale, including the salaries and
          directors' fees.

         -        PLEASE QUANTIFY AND LIST SEPARATELY ANY AMOUNTS THAT ARE
                  EXPECTED TO BE RECEIVED IN CONNECTION WITH THE DISPOSAL OF THE
                  ASSETS EXCLUDED FROM THE ASSET SALE OR DISCLOSE WHY NO SUCH
                  AMOUNTS HAVE NOT BEEN INCLUDED IN THE TABLE.

         Response:

                  The Company notes that, other than the Arbitration Matter, no
         amounts are expected to be received in connection with the disposal of
         assets excluded from the Asset Sale. As described on page 16 of the
         Proxy Statement, trade fixtures and personal property (including office
         furniture) will be transferred to the landlord at the time the Company
         vacates its facilities on or before March 31, 2005 in accordance with
         the lease termination agreement entered into with the landlord. The
         Company's only other remaining assets would be office supplies which
         the Company intends to donate following the closing of the Asset Sale.
         The Company has added a paragraph after the footnotes to the estimated
         distribution table explaining these points.

         -        PLEASE QUANTIFY AND LIST SEPARATELY ANY AMOUNTS THAT ARE
                  EXPECTED TO BE PAID IN CONNECTION WITH THE TERMINATION OF THE
                  COMPANY'S FACILITIES LEASE OR IN CONNECTION WITH THE
                  TERMINATION OF ANY OTHER RETAINED CONTRACTS.

         Response:

                  As described on page 16 of the Proxy Statement, in December
         2004, the Company agreed to terminate the lease as of March 31, 2005 by
         making a $500,000 payment and prepaying rent through March 31, 2005. No
         additional cash payments are required to be made to the landlord in
         connection with the termination of the facilities lease. In addition,
         the Company has no retained contracts. The Company has added a
         paragraph after the footnotes to the estimated distribution table
         explaining these points.


                                   * * * * * *


         The Company notes that, in accordance with the Staff's request in the
initial comment letter, the Company has previously submitted a written statement
making the acknowledgments referenced at the end of the comment letter. The
Company intended that

David Ritenour, Esq.
February 1, 2005
Page 4


written statement to apply to its responses to all Staff comments in the review
of all versions of the Proxy Statement filed with the Securities and Exchange
Commission, including the initial comment letter, the comment letter to which
this letter responds and any future comment letters of the Staff. If you wish to
have a current letter, please so advise us or the Company and the Company will
provide an additional, more recently dated, letter.

         If you have any questions concerning the foregoing, please contact
Barbara G. McClung at (650) 599-2527, the undersigned at (310) 203-7139 or Ben
Orlanski at (310) 203-7068. We would appreciate it if you could direct your
response to this submission to Barbara G. McClung at Cygnus, Inc. as you did
with the last comment letter. Ms. McClung's fax number is (650) 599-3913.

                                                     Very truly yours,

                                                     /s/ Ashok W. Mukhey

                                                     Ashok W. Mukhey

AM:kbj

cc:   Adelaja K. Heyliger, Esq.
      Barbara McClung, Esq.
      Ben D. Orlanski, Esq.