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                                                                    Exhibit 23.1

                       CONSENT OF INDEPENDENT ACCOUNTANTS

We hereby consent to the incorporation by reference in this Registration
Statement on Form S-3 (No. 333-54796) of our report dated January 11, 2001,
except as to Footnote 14, which is as of March 14, 2001 relating to the
financial statements, which appears in ArQule, Inc.'s Annual Report on Form 10-K
for the year ended December 31, 2000. We also consent to the references to us
under the headings "Experts" in such Registration Statement.


PricewaterhouseCoopers LLP

Boston, Massachusetts
March 22, 2001