Ex. 99.2

                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,

                             AS ADOPTED PURSUANT TO

                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

         In connection the Quarterly Report on Form 10-Q of Hybridon, Inc. (the
"Company") for the period ended March 31, 2003 as filed with the Securities and
Exchange Commission on the date hereof (the "Report"), the undersigned, Robert
G. Andersen, Chief Financial Officer of the Company, hereby certifies, pursuant
to 18 U.S.C. Section 1350, that:

         (1) The Report fully complies with the requirements of Section 13(a) or
15(d) of the Securities Exchange Act of 1934; and

         (2) The information contained in the Report fairly presents, in all
material respects, the financial condition and results of operations of the
Company.

         A signed original of this written statement has been provided to the
Company and will be retained by the Company and furnished to the Securities and
Exchange Commission or its staff upon request.

                                                          /s/ Robert G. Andersen
Dated: May 14, 2003                                       ----------------------
                                                              Robert G. Andersen
                                                         Chief Financial Officer

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