Exhibit 32.2

                    CERTIFICATION OF CHIEF FINANCIAL OFFICER

    PURSUANT TO RULE 13a-14(a) OR RULE 15d-14(a) AND 18 U.S.C. SECTION 1350,

                             AS ADOPTED PURSUANT TO

                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

         In connection with the quarterly report on Form 10-Q of Hybridon, Inc.
(the "Company") for the period ended September 30, 2003 as filed with the
Securities and Exchange Commission on the date hereof (the "Report"), the
undersigned, Robert G. Andersen, Chief Financial Officer of the Company, hereby
certifies, pursuant to 18 U.S.C. Section 1350, that:

         (1) The Report fully complies with the requirements of Section 13(a) or
15(d) of the Securities Exchange Act of 1934; and

         (2) The information contained in the Report fairly presents, in all
material respects, the financial condition and results of operations of the
Company.

         A signed original of this written statement has been provided to the
Company and will be retained by the Company and furnished to the Securities and
Exchange Commission or its staff upon request.

                                           /s/ Robert G. Andersen
                                           -------------------------------------
Dated: November 14, 2003                   Robert. G. Andersen
                                           Chief Financial Officer