EXHIBIT 32

                                  ARQULE, INC.

                CERTIFICATE OF THE CHIEF EXECUTIVE OFFICER AND
                            CHIEF FINANCIAL OFFICER

The undersigned, Stephen A. Hill, President and Chief Executive Officer of
ArQule, Inc. (the "Company") and Louise A. Mawhinney, Vice President, Chief
Financial Officer and Treasurer, and Principal Financial and Accounting Officer
of the Company, both duly elected and currently serving, do each hereby certify
that, to the best of his or her knowledge:

         1.       The quarterly report on Form 10-Q for the period ending March
                  31, 2004, filed on behalf of the Company pursuant to the
                  Securities Exchange Act of 1934 (the "Exchange Act") and
                  containing the financial statements of the Company, fully
                  complies with the requirements of section 13(a) of the
                  Exchange Act; and

         2.       the information contained in such quarterly report fairly
                  presents, in all material respects, the financial condition
                  and results of operations of the Company for the dates and
                  periods covered by such quarterly report.

This certification accompanies the Company's Quarterly Report on Form 10-Q for
the period ended March 31, 2004, pursuant to Section 906 of the Sarbanes-Oxley
Act of 2002 (the "2002 Act") and shall not be deemed filed by the Company for
purposes of Section 18 of the Exchange Act.

This certification is being made for the exclusive purpose of compliance by the
Chief Executive Officer and Acting Principal Accounting and Financial Officer
of the Company with the requirements of Section 906 of the 2002 Act, and may
not be disclosed, distributed or used by any person for any reason other than
as specifically required by law.

IN WITNESS WHEREOF, the undersigned have executed this Certificate as of the
7th day of May 2004.

/s/ Stephen A. Hill
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Name:  Stephen A. Hill
Title: President and Chief Executive Officer


/s/ Louise A. Mawhinney
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Louise A. Mawhinney
Title: Vice President, Chief Financial Officer and Treasurer