EXHIBIT 32.2


  CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO 18 U.S.C. SECTION 1350,
      AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

     In connection with the Quarterly Report on Form 10-Q of Hybridon, Inc. (the
"Company") for the three months ended March 31, 2004 as filed with the
Securities and Exchange Commission on the date hereof (the "Report"), the
undersigned, Robert G. Andersen, Chief Financial Officer of the Company, hereby
certifies, pursuant to 18 U.S.C. Section 1350, that:

          (1) the Report fully complies with the requirements of Section 13(a)
     or 15(d) of the Securities Exchange Act of 1934; and

          (2) the information contained in the Report fairly presents, in all
     material respects, the financial condition and results of operations of the
     Company.



                                            /s/ ROBERT G. ANDERSEN
                                            ------------------------------------
                                                  Robert G. Andersen
                                                 Chief Financial Officer

Date: May 14, 2004