EXHIBIT 32

                                  ARQULE, INC.

                 CERTIFICATE OF THE CHIEF EXECUTIVE OFFICER AND
                             CHIEF FINANCIAL OFFICER

The undersigned, Stephen A. Hill, President and Chief Executive Officer of
ArQule, Inc. (the "Company") Louise A. Mawhinney, Principal Financial and
Accounting Officer of the Company, both duly elected currently serving, do each
hereby certify that, to the best of his/her knowledge:

         1.       The annual report on Form 10-K for the period ending December
                  31, 2004, filed on behalf of the Company pursuant to the
                  Securities Exchange Act of 1934 (the "Exchange Act") and
                  containing the financial statements of the Company, fully
                  complies with the requirements of section 13(a) of the
                  Exchange Act; and

         2.       the information contained in such annual report fairly
                  presents, in all material respects, the financial condition
                  and results of operations of the Company for the dates and
                  periods covered by such annual report.


This certification accompanies the Company's Annual Report on Form 10-K for the
year ended December 31, 2004 pursuant to Section 906 of the Sarbanes-Oxley Act
of 2002 (the "2002 Act") and shall not be deemed filed by the Company for
purposes of Section 18 of the Exchange Act.

This certification is being made for the exclusive purpose of compliance by the
Chief Executive Officer and Acting Principal Accounting and Financial Officer of
the Company with the requirements of Section 906 of the 2002 Act, and may not be
disclosed, distributed or used by any person for any reason other than as
specifically required by law.

IN WITNESS WHEREOF, the undersigned have executed this Certificate as of the
16th day of March 2005.

/s/ Stephen A. Hill
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Name:    Stephen A. Hill
Title:   President and Chief Executive Officer

/s/ Louise A. Mawhinney
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Name:    Louise A. Mawhinney
Title:   Vice President and Chief Financial Officer
         (Principal Accounting and Financial Officer)