EXHIBIT 32.2

                           CALIPER LIFE SCIENCES, INC.
                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

      In connection with the Quarterly Report of Caliper Life Sciences, Inc.
(the "Company") on Form 10-Q for the quarter ended June 30, 2005 as filed with
the Securities and Exchange Commission on the date hereof (the "Report"), I,
Thomas T. Higgins, Executive Vice President and Chief Financial Officer of the
Company certify, pursuant to the requirement set forth in Rule 13a-14(b) of the
Securities Exchange Act of 1934, as amended (the "Exchange Act") and 18 U.S.C.
Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
2002, to the best of my knowledge that:

            (1) The Report fully complies with the requirements of section 13(a)
      or 15(d) of the Exchange Act; and

            (2) The information contained in the Report fairly presents, in all
      material respects, the financial condition and result of operations of the
      Company.

                                           /s/ THOMAS T. HIGGINS
                                           -----------------------------
                                           Thomas T. Higgins
                                           Executive Vice President and
                                           Chief Financial Officer
Date: August 9, 2005