EXHIBIT 32.2

                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

      In connection with the Quarterly Report on Form 10-Q of Critical
Therapeutics, Inc. (the "Company") for the period ended June 30, 2005 as filed
with the Securities and Exchange Commission on the date hereof (the "Report"),
I, Frank E. Thomas, Senior Vice President of Finance, Chief Financial Officer
and Treasurer of the Company, hereby certify, pursuant to 18 U.S.C. Section
1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002,
that:

      (1)   The Report fully complies with the requirements of Section 13(a) or
            15(d) of the Securities Exchange Act of 1934; and

      (2)   The information contained in the Report fairly presents, in all
            material respects, the financial condition and results of operations
            of the Company.

Dated: August 12, 2005                     /s/ Frank E. Thomas
                                           -------------------------------------
                                           Frank E. Thomas
                                           Senior Vice President of Finance,
                                           Chief Financial Officer and Treasurer