EXHIBIT 23.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (No.333-129633, 333-129634, 333-129637 and 333-131024) of Clinical Data, Inc. of our report dated March 28, 2005 relating to the financial statements of Icoria, Inc., which appears in the Current Report on Form 8-K/A of Clinical Data, Inc. dated December 20, 2005. /s/ PricewaterhouseCoopers LLP PricewaterhouseCoopers LLP Raleigh, North Carolina MARCH 8, 2006