.
                                                                               .
                                                                               .

                                                                      EXHIBIT 21

                         SUBSIDIARIES OF THE REGISTRANT


                                                        STATE OF
NAME OF SUBSIDIARY                                    INCORPORATION
- ------------------                                    -------------
                                                     
Acumed Pharmaceuticals, Inc.                            Delaware
Ara Pharmaceuticals, Inc.                               Delaware
Boston Life Sciences International, Inc.                Delaware
Coda Pharmaceuticals, Inc.                              Delaware
Neurobiologics, Inc.                                    Delaware
ProCell Pharmaceuticals, Inc.                           Delaware