.
                                                                               .
                                                                               .

                                                                      EXHIBIT 21

                         SUBSIDIARIES OF THE REGISTRANT




                                                 STATE OF
NAME OF SUBSIDIARY                            INCORPORATION
- ----------------------------------------      -------------
                                           
Acumed Pharmaceuticals, Inc.                      Delaware
Ara Pharmaceuticals, Inc.                         Delaware
Boston Life Sciences International, Inc.          Delaware
Coda Pharmaceuticals, Inc.                        Delaware
Neurobiologics, Inc.                              Delaware
ProCell Pharmaceuticals, Inc.                     Delaware