1 EXHIBIT 10.31 2 Exhibit 10.31 DEPARTMENT OF HEALTH AND HUMAN SERVICES PUBLIC HEALTH SERVICE National Institutes of Health Natl. Inst. of Arthritis and Musculoskeletal and Skin Diseases NOTICE OF GRANT AWARD AUTHORIZATION (Legislation/Regulation) 42 USC 241 42 CFR 52 RESEARCH 1. DATE ISSUED (Mo./Day/Yr.): 09/30/94 2. CFDA NO.: 93.846 3. SUPERSEDES AWARD NOTICE dated __________ except that any additions or restrictions previously imposed remain in effect unless specifically rescinded. 4. GRANT NO.: 1 R01 AR41450-01A2 Formerly: 5. ADMINISTRATIVE CODES: 2 6. PROJECT PERIOD Mo./Day/Yr.: From 09/30/94 Through 08/31/97 7. BUDGET PERIOD Mo./Day/Yr.: From 09/30/94 Through 08/31/95 8. TITLE OF PROJECT (OR PROGRAM) (Limit to 56 spaces): Cloning the gene responsible for FSH Muscular Dystrophy MEDB 9. GRANTEE NAME AND ADDRESS: Collaborative Research, Inc. 1365 Main Street Waltham, MA 02154 10. DIRECTOR OF PROJECT (PROGRAM DIRECTOR/PRINCIPAL INVESTIGATOR) (LAST NAME FIRST AND ADDRESS): WEIFFENBACH, BARBARA PHD Collaborative Research Inc. 1365 Main Street Waltham, MA 02154 3 11. APPROVED BUDGET (Excludes PHS Direct Assistance) I PHS Grant Funds Only _____ I _____ II Total project costs including grant funds and all other financial participation (SELECT ONE AND PLACE NUMERAL IN BOX.) a. Salaries and Wages . . . . . . . . . . . . . . . . . . . . . . . $103,470 b. Fringe Benefits. . . . . . . . . . . . . . . . . . . . . . . . . $ 35,181 c. Total Personnel Costs . . . . . . . . . . . . . . . . . . . $138,651 d. Consultant Costs . . . . . . . . . . . . . . . . . . . . . . . . 0 e. Equipment. . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 f. Supplies . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30,000 g. Travel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,200 h. Patient Care--Inpatient. . . . . . . . . . . . . . . . . . . . . 0 i. --Outpatient. . . . . . . . . . . . . . . . . . . . 0 j. Alterations and Renovations. . . . . . . . . . . . . . . . . . . 0 k. Other. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,750 l. Consortium/Contractual Costs . . . . . . . . . . . . . . . . . . 0 m. Trainee Related Expenses . . . . . . . . . . . . . . . . . . . . n. Trainee Stipends . . . . . . . . . . . . . . . . . . . . . . . . 0 o. Trainee Tuition and Fees . . . . . . . . . . . . . . . . . . . . 0 p. Trainee Travel . . . . . . . . . . . . . . . . . . . . . . . . . 0 q. TOTAL DIRECT COSTS [ARROW] . . . . . . . . . . . . . . . . $171,601 r. INDIRECT COSTS (Rate* % of S&W/TADC) . . . . . . . . . . . . . $154,441 s. TOTAL APPROVED BUDGET. . . . . . . . . . . . . . . . . . . . . . $326,042 t. SBIR Fee . . . . . . . . . . . . . . . . . . . . . . . . . . . . $ 0 u. Federal Share. . . . . . . . . . . . . . . . . . . . . . . . . . $326,042 v. Non-Federal Share. . . . . . . . . . . . . . . . . . . . . . . . $ 12. AWARD COMPUTATION FOR FINANCIAL ASSISTANCE a. Amount of PHS Financial Assistance (from Item 11.u.) . . . . . . $326,042 b. Less Unobligated Balance From Prior Budge Periods. . . . . . . . $0 c. Less Cumulative Prior Award(s) This Budget Period. . . . . . . . $0 d. AMOUNT OF FINANCIAL ASSISTANCE THIS ACTION . . . . . . . . . . . $326,042 13. RECOMMENDED FUTURE SUPPORT (SUBJECT TO THE AVAILABILITY OF FUNDS AND SATISFACTORY PROGRESS OF THE PROJECT): - ----------------------------------------------------------------------------------- YEAR TOTAL DIRECT COSTS/STIPENDS YEAR TOTAL DIRECT COSTS/STIPENDS - ----------------------------------------------------------------------------------- a. 02 178,465 d. - ----------------------------------------------------------------------------------- b. 03 185,604 e. - ----------------------------------------------------------------------------------- c. f. - ----------------------------------------------------------------------------------- 2 4 14. APPROVED DIRECT ASSISTANCE BUDGET (IN LIEU OF CASH): a. Amount of PHS Direct Assistance. . . . . . . . . . . . $ b. Less Unobligated Balance From Prior Budget Periods . . $ c. Less Cumulative Prior Award(s) This Budget Period. . . $ d. AMOUNT OF DIRECT ASSISTANCE THIS ACTION. . . . . . . . $ 15. PROGRAM INCOME SUBJECT TO 45 CFR PART 74, SUBPART F, OR 45 CFR 92.25, SHALL BE USED IN ACCORD WITH ONE OF THE FOLLOWING ALTERNATIVES: (Select One and Place LETTER in box.) a. DEDUCTION b. ADDITIONAL COSTS --- c. MATCHING B d. OTHER RESEARCH (Add/Deduct Option) --- e. OTHER (See REMARKS) 16. THIS AWARD IS BASED ON AN APPLICATION SUBMITTED TO, AND AS APPROVED BY, THE PHS ON THE ABOVE TITLED PROJECT AND IS SUBJECT TO THE TERMS AND CONDITIONS INCORPORATED EITHER DIRECTLY OR BY REFERENCE IN THE FOLLOWING: a. The grant program legislation cited above. b. The grant program regulation cited above. c. This award notice including terms and conditions, if any, noted below under REMARKS. d. PHS Grants Policy Statement including addenda in effect as of the beginning date of the budget period. e. 45 CFR part 74 or 45 CFR Part 92 as applicable. IN THE EVENT THERE ARE CONFLICTING OR OTHERWISE INCONSISTENT POLICIES APPLICABLE TO THE GRANT, THE ABOVE ORDER OF PRECEDENCE SHALL PREVAIL. ACCEPTANCE OF THE GRANT TERMS AND CONDITIONS IS ACKNOWLEDGED BY THE GRANTEE WHEN FUNDS ARE DRAWN OR OTHERWISE OBTAINED FROM THE GRANT PAYMENT SYSTEM. - -------------------------------------------------------------------------------- REMARKS: (Other Terms and Conditions Attached -- /X/ Yes / / No) Grant Specialist: G. Carol Fitzpatrick (301) 594-9973 Program Official: Richard W. Lymn, Ph.D. (301) 594-9959 * Base X Rate ($171,601 x 90.00) This Grant is included under expanded authorities. - -------------------------------------------------------------------------------- PHS GRANTS MANAGEMENT OFFICER: (Signature) /S/ Mara H. DeKemper (Name-Typed/Print) (Title) Mrs. Mara H. Dekemper Grants Management Officer 17. OBJ. CLASS: 41.4A 18. CRS - EIN: 1042297484A1 3 5 19. LIST NO.: - -------------------------------------------------------------------------------------------- FY-CAN DOCUMENT NO. ADMINISTRATIVE AMT. ACTION FIN. AMT. ACTION DIR. CODE ASST. ASST. - -------------------------------------------------------------------------------------------- 20.a. 94 8425014 b. R1AR41450A c. d. e. 21.a. b. c. d. e. 22.a. b. c. d. e. - ------------------------------------------------------------------------------------------- PHS-5152-5 (Rev. 7/92): 940927 1409 (Note: See reverse for payment information.) KC 4 6 FOOTNOTES PAGE 2 1 RO1 AR41450-01A2 TERMS AND CONDITIONS o PURSUANT TO THE NIH REVITALIZATION ACT (P.L. 103-43, JUNE 10, 1993), SECTION 2004, WHEN PURCHASING EQUIPMENT OR PRODUCTS UNDER THIS ASSISTANCE AWARD, THE RECIPIENT SHOULD, WHENEVER POSSIBLE, PURCHASE ONLY AMERICAN-MADE ITEMS. -5- 7 DEPARTMENT OF HEALTH AND HUMAN SERVICES PUBLIC HEALTH SERVICE National Institutes of Health Natl. Inst. of Arthritis and Musculoskeletal and Skin Diseases NOTICE OF GRANT AWARD AUTHORIZATION (Legislation/Regulation) 42 USC 241 42 CFR 52 RESEARCH REVISED 1. DATE ISSUED (Mo./Day/Yr.): 01/24/95 2. CFDA NO.: 93.846 3. SUPERSEDES AWARD NOTICE dated 09/30/94 except that any additions or restrictions previously imposed remain in effect unless specifically rescinded. 4. GRANT NO.: 1 R01 AR41450-01A2 Formerly: 5. ADMINISTRATIVE CODES: 2 6. PROJECT PERIOD Mo./Day/Yr.: From 09/30/94 Through 08/31/97 7. BUDGET PERIOD Mo./Day/Yr.: From 09/30/94 Through 08/31/95 8. TITLE OF PROJECT (OR PROGRAM) (Limit to 56 spaces): Cloning the gene responsible for FSH Muscular Dystrophy MEDB 9. GRANTEE NAME AND ADDRESS: Genome Therapeutics Corp. 100 Beaver Street Waltham, MA 02154 10. DIRECTOR OF PROJECT (PROGRAM DIRECTOR/PRINCIPAL INVESTIGATOR) (LAST NAME FIRST AND ADDRESS): WEIFFENBACH, BARBARA PHD Genome Therapeutics Corp., 1365 Main Street Waltham, MA 02154 8 11. APPROVED BUDGET (Excludes PHS Direct Assistance) I PHS Grant Funds Only --- I --- II Total project costs including grant funds and all other financial participation (SELECT ONE AND PLACE NUMERAL IN BOX.) a. Salaries and Wages . . . . . . . . . . . . . . . . . . . . . . . $103,470 b. Fringe Benefits. . . . . . . . . . . . . . . . . . . . . . . . . $ 35,181 c. Total Personnel Costs . . . . . . . . . . . . . . . . . . . $138,651 d. Consultant Costs . . . . . . . . . . . . . . . . . . . . . . . . 0 e. Equipment. . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 f. Supplies . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30,000 g. Travel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,200 h. Patient Care--Inpatient. . . . . . . . . . . . . . . . . . . . . 0 i. --Outpatient . . . . . . . . . . . . . . . . . . . . 0 j. Alterations and Renovations. . . . . . . . . . . . . . . . . . . 0 k. Other. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,750 l. Consortium/Contractual Costs . . . . . . . . . . . . . . . . . . 0 m. Trainee Related Expenses . . . . . . . . . . . . . . . . . . . . n. Trainee Stipends . . . . . . . . . . . . . . . . . . . . . . . . 0 o. Trainee Tuition and Fees . . . . . . . . . . . . . . . . . . . . 0 p. Trainee Travel . . . . . . . . . . . . . . . . . . . . . . . . . 0 q. TOTAL DIRECT COSTS [ARROW] . . . . . . . . . . . . . . . . $171,601 r. INDIRECT COSTS (Rate* % of S&W/TADC) . . . . . . . . . . . . $154,441 s. TOTAL APPROVED BUDGET. . . . . . . . . . . . . . . . . . . . . . $326,042 t. SBIR Fee . . . . . . . . . . . . . . . . . . . . . . . . . . . . $ 0 u. Federal Share. . . . . . . . . . . . . . . . . . . . . . . . . . $326,042 v. Non-Federal Share. . . . . . . . . . . . . . . . . . . . . . . . $ 12. AWARD COMPUTATION FOR FINANCIAL ASSISTANCE a. Amount of PHS Financial Assistance (from Item 11.u.) . . . . . . $326,042 b. Less Unobligated Balance From Prior Budge Periods. . . . . . . . $0 c. Less Cumulative Prior Award(s) This Budget Period. . . . . . . . $326,042 d. AMOUNT OF FINANCIAL ASSISTANCE THIS ACTION . . . . . . . . . . . $0 13. RECOMMENDED FUTURE SUPPORT (SUBJECT TO THE AVAILABILITY OF FUNDS AND SATISFACTORY PROGRESS OF THE PROJECT): - ----------------------------------------------------------------------------------- YEAR TOTAL DIRECT COSTS/STIPENDS YEAR TOTAL DIRECT COSTS/STIPENDS - ----------------------------------------------------------------------------------- a. 02 178,465 d. - ----------------------------------------------------------------------------------- b. 03 185,604 e. - ----------------------------------------------------------------------------------- c. f. - ----------------------------------------------------------------------------------- -2- 9 14. APPROVED DIRECT ASSISTANCE BUDGET (IN LIEU OF CASH): a. Amount of PHS Direct Assistance. . . . . . . . . . . . $ b. Less Unobligated Balance From Prior Budget Periods . . $ c. Less Cumulative Prior Award(s) This Budget Period. . . $ d. AMOUNT OF DIRECT ASSISTANCE THIS ACTION. . . . . . . . $ 15. PROGRAM INCOME SUBJECT TO 45 CFR PART 74, SUBPART F, OR 45 CFR 92.25, SHALL BE USED IN ACCORD WITH ONE OF THE FOLLOWING ALTERNATIVES: (Select One and Place LETTER in box.) a. DEDUCTION b. ADDITIONAL COSTS --- c. MATCHING B d. OTHER RESEARCH (Add/Deduct Option) --- e. OTHER (See REMARKS) 16. THIS AWARD IS BASED ON AN APPLICATION SUBMITTED TO, AND AS APPROVED BY, THE PHS ON THE ABOVE TITLED PROJECT AND IS SUBJECT TO THE TERMS AND CONDITIONS INCORPORATED EITHER DIRECTLY OR BY REFERENCE IN THE FOLLOWING: a. The grant program legislation cited above. b. The grant program regulation cited above. c. This award notice including terms and conditions, if any, noted below under REMARKS. d. PHS Grants Policy Statement including addenda in effect as of the beginning date of the budget period. e. 45 CFR part 74 or 45 CFR Part 92 as applicable. IN THE EVENT THERE ARE CONFLICTING OR OTHERWISE INCONSISTENT POLICIES APPLICABLE TO THE GRANT, THE ABOVE ORDER OF PRECEDENCE SHALL PREVAIL. ACCEPTANCE OF THE GRANT TERMS AND CONDITIONS IS ACKNOWLEDGED BY THE GRANTEE WHEN FUNDS ARE DRAWN OR OTHERWISE OBTAINED FROM THE GRANT PAYMENT SYSTEM. - -------------------------------------------------------------------------------- REMARKS: (Other Terms and Conditions Attached -- /X/ Yes / / No) Grant Specialist: G. Carol Fitzpatrick (301) 594-3506 Program Official: Richard W. Lymn, Ph.D. (301) 594-5128 * Base X Rate ($171,601 x 90.00) This Grant is included under expanded authorities. - -------------------------------------------------------------------------------- PHS GRANTS MANAGEMENT OFFICER: (Signature) /S/ Mary L. Graham (Name-Typed/Print) (Title) Mrs. Mary L. Graham Grants Management Officer 17. OBJ. CLASS: 41.4A 18. CRS - EIN: 1042297484A1 -3- 10 19. LIST NO.: - -------------------------------------------------------------------------------------------- FY-CAN DOCUMENT NO. ADMINISTRATIVE AMT. ACTION FIN. AMT. ACTION DIR. CODE ASST. ASST. - -------------------------------------------------------------------------------------------- 20.a. 94 8425014 b. R1AR41450A c. d. e. 21.a. b. c. d. e. 22.a. b. c. d. e. - -------------------------------------------------------------------------------------------- PHS-5152-5 (Rev. 7/92): 950119 1027 (Note: See reverse for payment information.) KC 01 -4- 11 FOOTNOTES PAGE 2 1 ROI AR41450-01A2 TERMS AND CONDITIONS o AWARD ISSUED IN ACCORDANCE WITH SUCCESSOR IN INTEREST AGREEMENT DATED JANUARY 1, 1995. -5- 12 DEPARTMENT OF HEALTH AND HUMAN SERVICES PUBLIC HEALTH SERVICE National Institutes of Health Natl. Inst. of Arthritis and Musculoskeletal and Skin Diseases NOTICE OF GRANT AWARD AUTHORIZATION (Legislation/Regulation) 42 USC 241 42 CFR 52 RESEARCH 20. DATE ISSUED (Mo./Day/Yr.): 08/08/95 21. CFDA NO.: 93.846 22. SUPERSEDES AWARD NOTICE dated __________________ except that any additions or restrictions previously imposed remain in effect unless specifically rescinded. 23. GRANT NO.: 5 R01 AR41450-02 Formerly: 24. ADMINISTRATIVE CODES: 2 25. PROJECT PERIOD Mo./Day/Yr.: From 09/30/94 Through 08/31/97 26. BUDGET PERIOD Mo./Day/Yr.: From 09/01/95 Through 08/31/96 27. TITLE OF PROJECT (OR PROGRAM) (Limit to 56 spaces): Cloning the Gene responsible for FSH Muscular Dystrophy MEDB 28. GRANTEE NAME AND ADDRESS: Genome Therapeutics Corp. 100 Beaver Street Waltham, MA 02154 29. DIRECTOR OF PROJECT (PROGRAM DIRECTOR/PRINCIPAL INVESTIGATOR) (LAST NAME FIRST AND ADDRESS): Weiffenbach, Barbara PHD Genome Therapeutics Corp. 1365 Main Street Waltham, MA 02154 13 30. APPROVED BUDGET (Excludes PHS Direct Assistance) I PHS Grant Funds Only --- I --- II Total project costs including grant funds and all other financial participation (Select one and place NUMERAL in box.) a. Salaries and Wages . . . . . . . . . . . . . . . . . . . $144,197 b. Fringe Benefits. . . . . . . . . . . . . . . . . . . . . $0 c. Total Personnel Costs . . . . . . . . . . . . . . . $144,197 d. Consultant Costs . . . . . . . . . . . . . . . . . . . . 0 e. Equipment. . . . . . . . . . . . . . . . . . . . . . . . 0 f. Supplies . . . . . . . . . . . . . . . . . . . . . . . . 31,200 g. Travel . . . . . . . . . . . . . . . . . . . . . . . . . 1,248 h. Patient Care--Inpatient. . . . . . . . . . . . . . . . . 0 i. --Outpatient . . . . . . . . . . . . . . . . 0 j. Alterations and Renovations. . . . . . . . . . . . . . . 0 k. Other. . . . . . . . . . . . . . . . . . . . . . . . . . 1,820 l. Consortium/Contractual Costs . . . . . . . . . . . . . . 0 m. Trainee Related Expenses . . . . . . . . . . . . . . . . n. Trainee Stipends . . . . . . . . . . . . . . . . . . . . 0 o. Trainee Tuition and Fees . . . . . . . . . . . . . . . . 0 p. Trainee Travel . . . . . . . . . . . . . . . . . . . . . 0 q. TOTAL DIRECT COSTS [ARROW]. . . . . . . . . . . . . $178,465 r. INDIRECT COSTS (Rate* % of S&W/TADC) . . . . . . . . $160,619 s. TOTAL APPROVED BUDGET. . . . . . . . . . . . . . . . . . $339,084 t. SBIR Fee . . . . . . . . . . . . . . . . . . . . . . . . $ 0 u. Federal Share. . . . . . . . . . . . . . . . . . . . . . $339,084 v. Non-Federal Share. . . . . . . . . . . . . . . . . . . . $ 31. AWARD COMPUTATION FOR FINANCIAL ASSISTANCE a. Amount of PHS Financial Assistance (from Item 11.u.). . . $339,084 b. Less Unobligated Balance From Prior Budge Periods . . . . $0 c. Less Cumulative Prior Award(s) This Budget Period . . . . $0 d. AMOUNT OF FINANCIAL ASSISTANCE THIS ACTION . . . . . . . $339,084 32. RECOMMENDED FUTURE SUPPORT (SUBJECT TO THE AVAILABILITY OF FUNDS AND SATISFACTORY PROGRESS OF THE PROJECT): - ----------------------------------------------------------------------------------- YEAR TOTAL DIRECT COSTS/STIPENDS YEAR TOTAL DIRECT COSTS/STIPENDS - ----------------------------------------------------------------------------------- a. 03 185,604 d. - ----------------------------------------------------------------------------------- b. e. - ----------------------------------------------------------------------------------- c. f. - ----------------------------------------------------------------------------------- -2- 14 33. APPROVED DIRECT ASSISTANCE BUDGET (IN LIEU OF CASH): a. Amount of PHS Direct Assistance. . . . . . . . . . . . . $ b. Less Unobligated Balance From Prior Budget Periods . . . $ c. Less Cumulative Prior Award(s) This Budget Period. . . . $ d. AMOUNT OF DIRECT ASSISTANCE THIS ACTION. . . . . . . . . $ 34. PROGRAM INCOME SUBJECT TO 45 CFR PART 74, SUBPART F, OR 45 CFR 92.25, SHALL BE USED IN ACCORD WITH ONE OF THE FOLLOWING ALTERNATIVES: (Select One and Place LETTER in box.) a. DEDUCTION b. ADDITIONAL COSTS c. MATCHING --- d. OTHER RESEARCH (Add/Deduct Option) B e. OTHER (See REMARKS) --- 35. THIS AWARD IS BASED ON AN APPLICATION SUBMITTED TO, AND AS APPROVED BY, THE PHS ON THE ABOVE TITLED PROJECT AND IS SUBJECT TO THE TERMS AND CONDITIONS INCORPORATED EITHER DIRECTLY OR BY REFERENCE IN THE FOLLOWING: a. The grant program legislation cited above. b. The grant program regulation cited above. c. This award notice including terms and conditions, if any, noted below under REMARKS. d. PHS Grants Policy Statement including addenda in effect as of the beginning date of the budget period. e. 45 CFR part 74 or 45 CFR Part 92 as applicable. IN THE EVENT THERE ARE CONFLICTING OR OTHERWISE INCONSISTENT POLICIES APPLICABLE TO THE GRANT, THE ABOVE ORDER OF PRECEDENCE SHALL PREVAIL. ACCEPTANCE OF THE GRANT TERMS AND CONDITIONS IS ACKNOWLEDGED BY THE GRANTEE WHEN FUNDS ARE DRAWN OR OTHERWISE OBTAINED FROM THE GRANT PAYMENT SYSTEM. - -------------------------------------------------------------------------------- REMARKS: (Other Terms and Conditions Attached -- /X/ Yes / / No) Grant Specialist: G. Carol Fitzpatrick (301) 594-3506 Program Official: Richard W. Lymn, Ph.D. (301) 594-5128 * Base X Rate ($178,465 x 90.00) This Grant is included under expanded authorities. - -------------------------------------------------------------------------------- PHS GRANTS MANAGEMENT OFFICER: (Signature) /S/ G. Carol Fitzpatrick (Name-Typed/Print) (Title) G. Carol Fitzpatrick Grants Management Officer 36. OBJ. CLASS: 41.4E -3- 15 37. CRS-EIN: 1042297484A1 38. lIST NO.: - -------------------------------------------------------------------------------------------- FY-CAN DOCUMENT NO. ADMINISTRATIVE AMT. ACTION FIN. AMT. ACTION DIR. CODE ASST. ASST. - -------------------------------------------------------------------------------------------- 20.a. 95 8425014 b. R1AR41450A c. d. e. 21.a. b. c. d. e. 22.a. b. c. d. e. - -------------------------------------------------------------------------------------------- PHS-5152-5 (Rev. 7/94) 950804 1433 (Note: See reverse for payment information.) WBG -4- 16 FOOTNOTES PAGE 2 5 R01 AR41450-02 TERMS AND CONDITIONS o PURSUANT TO THE NIH REVITALIZATION ACT (P.L. 103-43, JUNE 10, 1993), SECTION 2004, WHEN PURCHASING EQUIPMENT OR PRODUCTS UNDER THIS ASSISTANCE AWARD, THE RECIPIENT SHOULD, WHENEVER POSSIBLE, PURCHASE ONLY AMERICAN-MADE ITEMS. -5-