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                      RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                      IMMULOGIC PHARMACEUTICAL CORPORATION,
                             a Delaware corporation


                           Incorporated March 27, 1987

                         Pursuant to Section 245 of the
                General Corporation Law of the State of Delaware


              The undersigned, Richard E. Bagley and Janet C. Bush are President
         and Chief Executive Officer, and Secretary and Treasurer, respectively,
         of ImmuLogic Pharmaceutical Corporation, a corporation organized and
         existing under the General Corporation Law of the State of Delaware
         (the "Corporation"). The Corporation's Certificate of Incorporation was
         initially filed in the Office of the Secretary of State of the State of
         Delaware on March 27, 1987. Certificates of Amendment to the
         Certificate of Incorporation were filed with the Office of the
         Secretary of State of the State of Delaware on April 2, 1987, May 26,
         1987 and December 9, 1987. The Corporation's Amended and Restated
         Certificate of Incorporation was initially filed in the Office of the
         Secretary of State of the State of Delaware on July 11, 1988. A
         Certificate of Amendment to the Amended and Restated Certificate of
         Incorporation was filed with the Office of the Secretary of State of
         the State of Delaware on October 4, 1989. The Corporation's current
         Amended and Restated Certificate of Incorporation was filed in the
         Office of the Secretary of the State of Delaware on March 27, 1991. A
         Certificate of Amendment to the Amended and Restated Certificate of
         Incorporation was filed with the Office of the Secretary of State of
         the State of Delaware on May 20, 1991. The undersigned, as President
         and Secretary of the Corporation, do hereby certify that (a) by
         unanimous vote the Board of Directors at a meeting held on November 14,
         1991 and in accordance with Section 245 of the General Corporation law
         of Delaware, the Board of Directors adopted a resolution setting forth
         the proposed Restated Certificate of Incorporation of the Corporation;
         and (b) this Restated Certificate of Incorporation only restates and
         integrates and does not further amend the provisions of the
         Corporation's Amended and Restated Certificate of Incorporation and
         there is no discrepancy between such provisions and the provisions of
         this Restated Certificate of Incorporation.

              The Restated Certificate of Incorporation is as follows:

              FIRST:    The name of the Corporation is:  ImmuLogic 
         Pharmaceutical Corporation.



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              SECOND:   The address of the Corporation's registered office in 
         the State of Delaware is Corporation Trust Center, 1209 Orange Street 
         in the City of Wilmington, County of New Castle. The name of the
         registered agent of the Corporation at such address is The Corporation
         Trust Company.

              THIRD:    The purpose of the Corporation is to engage in any
         lawful act or activity for which corporations may be organized
         under the General Corporation Law of Delaware.

              FOURTH:   The total number of shares of all classes of stock which
         the Corporation shall have authority to issue is sixteen million
         (16,000,000) shares, consisting of fifteen million (15,000,000) shares
         of Common Stock, $.01 par value per share ("Common Stock"), and one
         million (1,000,000) shares of undesignated Preferred Stock, $.01 par
         value per share (Undesignated Preferred Stock").

         A.   Common Stock.
              -------------
 
              1.   GENERAL.  The voting, dividend and liquidation rights of
         the holders of the Common Stock are subject to and qualified by
         the rights of the holders of the Preferred Stock.

              2.   DIVIDENDS.  Dividends may be declared and paid on the
         Common Stock from funds lawfully available therefor as and when
         determined by the Board of Directors and subject to any
         preferential dividend rights of any then outstanding Preferred
         Stock.

              3.   LIQUIDATION.  In the event of liquidation, dissolution or
         winding up of the affairs of the Corporation, whether voluntary or
         involuntary, each issued and outstanding share of Common Stock shall
         entitle the holder thereof to receive an equal portion of the net
         assets of the Corporation available for distribution to holders of
         Common Stock, subject to any preferential rights of any then
         outstanding Preferred Stock.

              4.   VOTING RIGHTS.  Each issued and outstanding share of Common
         Stock shall entitle the holder thereof to one vote for each share held
         at all meetings of stockholders. Except as otherwise required by law or
         as otherwise provided herein, holders of Common Stock will vote
         together with holders of the Preferred Stock as a single class, subject
         to any preferential voting rights of any then outstanding Preferred
         Stock. There shall be no cumulative voting.

         B.   Undesignated Preferred Stock.
              -----------------------------
   
              Undesignated Preferred Stock may be issued from time to time in
         one or more series, each of such series to have such terms as stated or
         expressed herein and in the resolution or resolutions



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         providing for the issue of such series adopted by the Board of
         Directors of the Corporation as hereinafter provided. Different series
         of Preferred Stock shall not be construed to constitute different
         classes of shares for the purposes of voting by classes unless
         expressly provided.

              Authority is hereby expressly granted to the Board of Directors
         from time to time to issue the Undesignated Preferred Stock in one or
         more series, and in connection with the creation of any such series, by
         resolution or resolutions providing for the issue of the share thereof,
         to determine and fix such voting powers, full or limited, or no voting
         powers, and such designations, preferences, relative participating,
         optional or other special rights, and qualifications, limitations or
         restrictions thereof, including without limitation thereof, dividend
         rights, conversion rights, redemption privileges and liquidation
         preferences, as shall be stated and expressed in such resolutions, all
         to the full extent now or hereafter permitted by the General
         Corporation Law of the State of Delaware. Without limiting the
         generality of the foregoing, the resolutions providing for issuance of
         any series of Undesignated Preferred Stock may provide that such series
         shall be superior or rank equally or be junior to the Undesignated
         Preferred Stock of any other series or any Designated Preferred Stock
         to the extent permitted by law and subject to the terms of previously
         issued and then outstanding series of Undesignated Preferred Stock or
         Designated Preferred Stock. Except as otherwise provided in this
         Restated Certificate of Incorporation, no vote of the holders of the
         Undesignated Preferred Stock or Common Stock shall be a prerequisite to
         the designation or issuance of any shares of any series of the
         Undesignated Preferred Stock authorized by and complying with the
         conditions of this Restated Certificate of Incorporation, the right to
         have such vote being expressly waived by all present and future holders
         of the capital stock of the Corporation.

              FIFTH:    The name and mailing address of the incorporator is
         Sandra Ward, c/o Weil, Gotshal & Manges, 767 Fifth Avenue, New
         York, New York 10153.

              SIXTH:    The Corporation is to have perpetual existence.

              SEVENTH:  In furtherance and not in limitation of the powers
         conferred by statute, the Board of Directors is expressly
         authorized to make, alter or repeal the bylaws of the Corporation.

              EIGHTH:   This Article is inserted for indemnification of
         officers and directors.

              Section 1.  ACTIONS, SUITS AND PROCEEDINGS OTHER THAN BY OR
         IN THE RIGHT OF THE CORPORATION. The Corporation shall indemnify
         each person who was or is a party or is threatened to be made a



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         party to any threatened, pending or completed action, suit or
         proceeding, whether civil, criminal, administrative or investigative
         (other than an action by or in the right of the Corporation), by reason
         of the fact that he is or was, or has agreed to become, a director or
         officer of the Corporation, or is or was serving, or has agreed to
         serve, at the request of the Corporation, as a director, officer or
         trustee of, or in a similar capacity with, another corporation,
         partnership, joint venture, trust or other enterprise (including any
         employee benefit plan) (all such persons being referred to hereafter as
         an "Indemnitee"), or by reason of any action alleged to have been taken
         or omitted in such capacity, against all expenses (including attorneys'
         fees), judgments, fines and amounts paid in settlement actually and
         reasonably incurred by him or on his behalf in connection with such
         action, suit or proceeding and any appeal therefrom, if he acted in
         good faith and in a manner he reasonably believed to be in, or not
         opposed to, the best interests of the Corporation, and, with respect to
         any criminal action or proceeding, had no reasonable cause to believe
         his conduct was unlawful. The termination of any action, suit or
         proceeding by judgment, order, settlement, conviction or upon a please
         of NOLO CONTENDERE or its equivalent, shall not, of itself, create a
         presumption that the person did not act in good faith and in a manner
         which he reasonably believed to be in, or not opposed to, the best
         interests of the Corporation, and, with respect to any criminal action
         or proceeding, had reasonable cause to believe that his conduct was
         unlawful. Notwithstanding anything to the contrary in this Article,
         except as set forth in Section 6 below, the Corporation shall not
         indemnify an Indemnitee seeking indemnification in connection with a
         proceeding (or part thereof) initiated by the Indemnitee unless the
         initiation thereof was approved by the Board of Directors of the
         Corporation.

              Section 2. ACTIONS OR SUITS BY OR IN THE RIGHT OF THE CORPORATION.
         The Corporation shall indemnify any Indemnitee who was or is a party or
         is threatened to be made a party to any threatened, pending or
         completed action or suit by or in the right of the Corporation to
         procure a judgment in its favor by reason of the fact that he is or
         was, or has agreed to become, a director or officer of the Corporation,
         or is or was serving, or has agreed to serve, at the request of the
         Corporation, as a director, officer or trustee of, or in a similar
         capacity with, another corporation, partnership, joint venture, trust
         or other enterprise (including any employee benefit plan), or by reason
         of any action alleged to have been taken or omitted in such capacity,
         against all expenses (including attorneys' fees) and amounts paid in
         settlement actually and reasonably incurred by him or on his behalf in
         connection with such action, suit or proceeding and any appeal
         therefrom, if he acted in good faith and in a manner he reasonably
         believed to be in, or not opposed to, the best interests of the
         Corporation, except that no indemnification shall be made in respect of
         any claim, issue or matter as to which such person



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         shall have been adjudged to be liable to the Corporation unless and
         only to the extent that the Court of Chancery of Delaware or the court
         in which such action or suit was brought shall determine upon
         application that, despite the adjudication of such liability but in
         view of all the circumstances of the case, such person is fairly and
         reasonably entitled to indemnity for such expenses (including
         attorneys' fees) which the Court of Chancery of Delaware or such other
         court shall deem proper.

              Section 3. INDEMNIFICATION FOR EXPENSES OF SUCCESSFUL PARTY.
         Notwithstanding the other provisions of this Article, to the extent
         that an Indemnitee has been successful, on the merits or otherwise, in
         defense of any action, suit or proceeding referred to in Sections 1 and
         2 of this Article, or in defense of any claim, issue or matter therein,
         or on appeal from any such action, suit or proceeding, he shall be
         indemnified against all expenses (including attorneys' fees) actually
         and reasonably incurred by him or on his behalf in connection
         therewith. Without limiting the foregoing, if any action, suit or
         proceeding is disposed of, on the merits or otherwise (including a
         disposition without prejudice), without (i) the disposition being
         adverse to the Indemnitee, (ii) an adjudication that the Indemnitee was
         liable to the Corporation, (iii) a plea of guilty or NOLO CONTENDERE by
         the Indemnitee, (iv) an adjudication that the Indemnitee did not act in
         good faith and in a manner he reasonably believed to be in or not
         opposed to the best interests of the Corporation, (v) with respect to
         any criminal proceeding, an adjudication that the Indemnitee had
         reasonable cause to believe his conduct was unlawful, the Indemnitee
         shall be considered for the purposes hereof to have been wholly
         successful with respect thereto.

              Section 4. NOTIFICATION AND DEFENSE OF CLAIM. As a condition
         precedent to his right to be indemnified, the Indemnitee must notify
         the Corporation in writing as soon as practicable of any action, suit,
         proceeding or investigation involving him for which indemnity will or
         could be sought. With respect to any action, suit, proceeding or
         investigation of which the Corporation is so notified, the Corporation
         will be entitled to participate therein at its own expense and/or to
         assume the defense, thereof at its own expense, with legal counsel
         reasonably acceptable to the Indemnitee. After notice from the
         Corporation to the Indemnitee of its election so to assume such
         defense, the Corporation shall not be liable to the Indemnitee for any
         legal or other expenses subsequently incurred by the Indemnitee in
         connection with such claim, other than as provided below in this
         Section 4. The Indemnitee shall have the right to employ his own
         counsel in connection with such claim, but the fees and expenses of
         such counsel incurred after notice from the Corporation of its
         assumption of the defense thereof shall be at the expense of the
         Indemnitee unless (i) the employment of counsel by the Indemnitee has
         been authorized by the Corporation, (ii) counsel to the Indemnitee
         shall have reasonably concluded that there may be a



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         conflict of interest or position on any significant issue between the
         Corporation and the Indemnitee in the conduct of the defense of such
         action or (iii) the Corporation shall not in fact have employed counsel
         to assume the defense of such action, in each of which cases the fees
         and expenses of counsel for the Indemnitee shall be at the expense of
         the Corporation, except as otherwise expressly provided by this
         Article. The Corporation shall not be entitled, without the consent of
         the Indemnitee, to assume the defense of any claim brought by or in the
         right of the Corporation or as to which counsel for the Indemnitee
         shall have reasonably made the conclusion provided for in clause (ii)
         above.

              Section 5.  ADVANCE OF EXPENSES. Subject to the provisions of
         Section 6 below, in the event that the Corporation does not assume the
         defense pursuant to Section 4 of this Article of any action, suit,
         proceeding or investigation of which the Corporation receives notice
         under this Article, any expenses (including attorneys' fees) incurred
         by an Indemnitee in defending a civil or criminal action, suit,
         proceeding or investigation or any appeal therefrom shall be paid by
         the Corporation in advance of the final disposition of such matter,
         PROVIDED, HOWEVER, that the payment of such expenses incurred by an
         Indemnitee in advance of the final disposition of such matter shall be
         made only upon receipt of an undertaking by or on behalf of the
         Indemnitee to repay all amounts so advanced in the event that it shall
         ultimately be determined that the Indemnitee is not entitled to be
         indemnified by the Corporation as authorized in this Article. Such
         undertaking may be accepted without reference to the financial ability
         of such person to make such repayment.

              Section 6.  PROCEDURE FOR INDEMNIFICATION. In order to obtain
         indemnification or advancement of expenses pursuant to Section 1, 2, 3
         or 5 of this Article, the Indemnitee shall submit to the Corporation a
         written request, including in such request to such documentation and
         information as is reasonably available to the Indemnitee and is
         reasonably necessary to determine whether and to what extent the
         Indemnitee is entitled to indemnification or advancement of expenses.
         Any such indemnification or advancement of expenses shall be made
         promptly, and in any event within 60 days after receipt by the
         Corporation of the written request of the Indemnitee, unless with
         respect to requests under Section 1, 2 or 5 the Corporation determines,
         by clear and convincing evidence, within such 60-day period that the
         Indemnitee did not meet the applicable standard of conduct set forth in
         Section 1 or 2, as the case may be. Such determination shall be made in
         each instance by (a) a majority vote of a quorum of the director so the
         Corporation consisting of persons who are not at that time parties to
         the action, suit or proceeding in question ("disinterested directors"),
         (b) if no such quorum is obtainable, a majority vote of a committee of
         two or more disinterested directors, (c) a majority vote of a quorum of
         the outstanding shares of stock of all classes entitled to vote for
         directors,



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         voting as a single class, which quorum shall consist of stockholders
         who are not at that time parties to the action, suit or proceeding in
         questions, (d) independent legal counsel (who may be regular legal
         counsel to the Corporation), or (e) a court of competent jurisdiction.

              Section 7.  REMEDIES. The right to indemnification or advances as
         granted by this Article shall be enforceable by the Indemnitee in any
         court of competent jurisdiction if the Corporation denies such request,
         in whole or in part, or if no disposition thereof is made within the
         60-day period referred to above in Section 6. Unless otherwise provided
         by law, the burden of proving that the Indemnitee is not entitled to
         indemnification or advancement of expenses under this Article shall be
         on the Corporation. Neither the failure of the Corporation to have made
         a determination prior to the commencement of such action that
         indemnification is proper in the circumstances because the Indemnitee
         has met the applicable standard of conduct, nor an actual determination
         by the Corporation pursuant to Section 6 that the Indemnitee has not
         met such applicable standard of conduct, shall be a defense to the
         action or create a presumption that the Indemnitee has not met the
         applicable standard of conduct. The Indemnitee's expenses (including
         attorneys' fees) incurred in connection with successfully establishing
         his right to indemnification, in whole or in part, in any such
         proceeding shall also be indemnified by the Corporation.

              Section 8.  SUBSEQUENT AMENDMENT. No amendment, termination of
         repeal of this Article or of the relevant provisions of the General
         Corporation Law of Delaware or any other applicable laws shall affect
         or diminish in any way the rights of any Indemnitee to indemnification
         under the provisions hereof with respect to any action, suit,
         proceeding or investigation arising out of or relating to any actions,
         transactions or facts occurring prior to the final adoption of such
         amendment, termination or repeal.

              Section 9.  OTHER RIGHTS. The indemnification and advancement of
         expenses provided by this Article shall not be deemed exclusive of any
         other rights to which an Indemnitee seeking indemnification or
         advancement of expenses may be entitled under any law (common or
         statutory), agreement or vote of stockholders or disinterested
         directors or otherwise, both as to action in this official capacity and
         as to action in any other capacity while holding office for the
         Corporation, and shall continue as to an Indemnitee who has ceased to
         be a director or officer, and shall inure to the benefit of the estate,
         heirs, executors and administrators of the Indemnitee. Nothing
         contained in this Article shall be deemed to prohibit, and the
         Corporation is specifically authorized to enter into, agreements with
         officers and directors providing indemnification rights and procedures
         different from those set forth in this Article. In addition, the
         Corporation may, to the extent authorized from time to time by its



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         Board of Directors, grant indemnification rights to other employees or
         agents of the Corporation or other persons serving the Corporation and
         such rights may be equivalent to, or greater or less than, those set
         forth in this Article.

              Section 10.  PARTIAL INDEMNIFICATION. If an Indemnitee is entitled
         under any provision of this Article to indemnification by the
         Corporation for some or a portion of the expenses (including attorneys'
         fees), judgments, fees or amounts paid in settlement actually and
         reasonably incurred by him or on his behalf in connection with any
         action, suit, proceeding or investigation and any appeal therefrom but
         not, however, for the total amount thereof, the Corporation shall
         nevertheless indemnify the Indemnitee for the portion of such expenses
         (including attorneys' fees), judgments, fines or amounts paid in
         settlement to which the Indemnitee is entitled.

              Section 11.  INSURANCE. The Corporation may purchase and maintain
         insurance, at its expense, to protect itself and any director, officer,
         employee or agent of the Corporation or another corporation,
         partnership, joint venture, trust or other enterprise (including any
         employee benefit plan) against any expense, liability or loss incurred
         by him in any such capacity, or arising out of his status as such,
         whether or not the Corporation would have the power to indemnify such
         person against such expense, liability or loss under the General
         Corporation Law of Delaware.

              Section 12.  MERGER OR CONSOLIDATION. If the Corporation is merged
         into consolidated with another corporation and the Corporation is not
         the surviving corporation, the surviving corporation shall assume the
         obligations of the Corporation under this Article with respect to any
         action, suit, proceeding or investigation arising out of or relating to
         any actions, transactions or facts occurring prior to the date of such
         merger or consolidation.

              Section 13.  SAVINGS CLAUSE. If this Article or any portion hereof
         shall be invalidated on any ground by any court of competent
         jurisdiction, then the Corporation shall nevertheless indemnify each
         Indemnitee as to any expenses (including attorneys' fees), judgments,
         fines and amounts paid in settlement in connection with any action,
         suit, proceeding or investigation, whether civil, criminal or
         administrative, including an action by or in the right of the
         Corporation, to the fullest extent permitted by any applicable portion
         of this Article that shall not have been invalidated and to the fullest
         extent permitted by applicable law.

              Section 14.  DEFINITIONS. Terms used herein and defined in Section
         145(h) and Section 145(i) of the General Corporation Law of Delaware
         shall have the respective meanings assigned to such terms in such
         Section 145(h) and Section 145(i).



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              Section 15.  SUBSEQUENT LEGISLATION. If the General Corporation 
         Law of Delaware is amended after adoption of this Article to expand 
         further the indemnification permitted to Indemnitees, then the 
         Corporation shall indemnify such person sot the fullest extent 
         permitted by the General Corporation Law of Delaware, as so amended.

              NINTH: Except to the extent that the General Corporation Law of
         Delaware prohibits the elimination or limitation of liability of
         directors for breaches of fiduciary duty, no director of the
         Corporation shall be personally liable to the Corporation or its
         stockholders for monetary damages for any breach of fiduciary duty as a
         director, notwithstanding any provision of law imposing such liability.
         No amendment to or repeal of this provision shall apply to or have any
         effect on the liability or alleged liability of any director of the
         Corporation for or with respect to any actions or omissions of such
         director occurring prior to such amendment.

              TENTH: The Corporation reserves the right to amend, alter, change
         or repeal any provision contained in this Certificate of Incorporation,
         in the manner now or hereinafter prescribed by statute, and all rights
         conferred by the stockholders herein are granted subject to this
         reservation.

              ELEVENTH: Whenever a compromise or arrangement is proposed between
         the Corporation and its creditors or any class of them and/or between
         the Corporation and its stockholders or any class of them, any court of
         equitable jurisdiction within the State of Delaware may, on the
         application in a summary way of the Corporation or of any creditor or
         stockholder thereof, or on the application of any receiver or receivers
         appointed for the Corporation under the provisions of Section 291 of
         Title 8 of the Delaware Code or on the application of trustees in
         dissolution or of any receiver of receivers appointed for the
         Corporation under the provisions of Section 279 of Title 8 of the
         Delaware Code order a meeting of the creditors of class of creditors,
         and/or of the stockholders or class of stockholders of the Corporation,
         as the case may be, to be summoned in such manner as the said court
         directs. If a majority in number representing three-fourths in value of
         the creditors or class or creditors, and/or of the stockholders or
         class of stockholders of the Corporation, as the case may be, agree to
         any compromise or arrangement and to any reorganization of the
         Corporation as consequence of such compromise or arrangement, the said
         compromise or arrangement and the said reorganization shall, if
         sanctioned by the court to which the said application has been made, be
         binding on all the creditors or class of creditors, and/or on all the
         stockholders or class of stockholders, of the Corporation, as the case
         may be, and also on the Corporation.





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              This Restated Certificate of Incorporation supersedes and takes
         the place of the heretofore existing Amended and Restated Certificate
         of Incorporation and all amendments, certificates and supplements
         thereto.

              EXECUTED at Cambridge, Massachusetts, as of the 13th day of
         December, 1991.


                                       /s/ Richard E. Bagley
                                       ------------------------------ 
                                       Richard E. Bagley
                                       President


         ATTEST:


         /s/ Janet C. Bush
         -----------------------
         Janet C. Bush
         Secretary



































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                            CERTIFICATE OF AMENDMENT
                                     OF THE
                                    RESTATED
                          CERTIFICATE OF INCORPORATION
                                       OF
                      IMMULOGIC PHARMACEUTICAL CORPORATION


              IMMULOGIC PHARMACEUTICAL CORPORATION, a corporation organized

         and existing under and by virtue of the General Corporation Law of

         the State of Delaware (the "corporation"), does hereby certify as

         follows:

              1.   The Board of Directors duly adopted a resolution pursuant

         to Section 242 of the General Corporation Law of the State of 
  
         Delaware, proposing that an amendment to the Restated Certificate of 

         Incorporation of the Corporation be approved and declaring said 

         amendment to be advisable; and

              2.   The stockholders of the Corporation duly approved this

         Certificate of Amendment in accordance with Sections 222 and 242 of

         the General Corporation Law of the State of Delaware.

              The resolution setting forth the amendment is as follows:

              RESOLVED:      That Article Fourth of the Restated
                             Certificate of Incorporation be and hereby is
                             amended to read as follows:

                                  1.  The total number of shares of all classes
                             of stock which the Corporation shall have authority
                             to issue is twenty-one million (21,000,000) shares,
                             consisting of twenty million (20,000,000) shares of
                             Common Stock, $.01 par value per share ("Common
                             Stock"), and one million (1,000,000) shares of
                             undesignated Preferred Stock, $.01 par value per
                             share ("Undesignated Preferred Stock").









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              Executed at Cambridge, Massachusetts, as of the 7th day of August,
         1992.



                                             /s/ Richard E. Bagley
                                            --------------------------------
                                            Richard E. Bagley
                                            President




         ATTEST:



          /s/ Janet C. Bush
         ------------------------ 
         Janet C. Bush
         Secretary





































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                            CERTIFICATE OF AMENDMENT

                                       OF

                        RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                      IMMULOGIC PHARMACEUTICAL CORPORATION

              ImmuLogic Pharmaceutical Corporation, a corporation organized

         and existing under and by virture of the General Corporation Law

         of the State of Delaware (the "Corporation"), DOES HEREBY CERTIFY:

              FIRST:  That the Board of Directors of said Corporation, in a

         Written Action of Directors in Lieu of Meeting, dated as of March

         22, 1994, as filed with the minutes of the Board, duly adopted a

         resolution pursuant to Section 242 of the General Corporation Law

         of the State of Delaware ("Delaware Law") proposing and declaring

         advisable the following amendment to the Restated Certificate of

         Incorporation of the Corporation:

              RESOLVED:      That the first paragraph of Article FOURTH of
                             the Restated Certificate of Incorporation be
                             amended to read in its entirety as follows:

                             FOURTH:  The total number of shares of all classes
                             of stock which the Corporation has authority to
                             issue is thirty-one million (31,000,000) shares
                             consisting of thirty million (30,000,000) shares of
                             common stock, $.01 par value per share ("Common
                             Stock"), and one million (1,000,000) shares of
                             undesignated Preferred Stock, $.01 par value per
                             share ("Undesignated Preferred Stock").

              SECOND:   That the foregoing Amendment to the Corporation's

         Restated Certificate of Incorporation was adopted by the holders

         of a majority of the outstanding shares of Common Stock at the

         Corporation's Annual Meeting of Stockholders held on May 26, 1994

         pursuant to notice duly given.



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              IN WITNESS WHEREOF, ImmuLogic Pharmaceutical Corporation has

         caused this Certificate to be signed by Richard N. Small, its Vice

         President, Chief Financial Officer and attested by Stacey L.

         Channing, its Secretary, this 7th day of June, 1994.


                                                 IMMULOGIC PHARMACEUTICAL
                                                   CORPORATION


                                                 By: /s/ Richard N. Small
                                                     ---------------------
                                                     Richard N. Small
                                                Its: Vice President, Chief
                                                     Financial Officer


         ATTEST:


         By:  /s/ Stacey L. Channing
             -----------------------------  
             Stacey L. Channing

































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                                      FORM

                                       of

                           CERTIFICATE OF DESIGNATIONS

                                       of

                      IMMULOGIC PHARMACEUTICAL CORPORATION

                         (Pursuant to Section 151 of the
                        Delaware General Corporation Law)


                        ---------------------------------



              ImmuLogic Pharmaceutical Corporation, a corporation organized and
         existing under the General Corporation Law of the State of Delaware
         (hereinafter called the "Corporation"), hereby certifies that the
         following resolution was adopted by the Board of Directors of the
         Corporation as required by Section 151 of the General Corporation Law
         at a meeting duly called and held on July 11, 1995:

              RESOLVED: That pursuant to the authority granted to and vested in
         the Board of Directors of this Corporation (hereinafter called the
         "Board of Directors" or the "Board") in accordance with the provisions
         of the Restated Certificate of Incorporation, as amended, the Board of
         Directors hereby creates a series of Preferred Stock, $.01 par value
         (the "Preferred Stock"), of the Corporation and hereby states the
         designation and number of shares, and fixes the relative rights,
         preferences and limitations thereof as follows:

              Series A Junior Participating Preferred Stock:

              Section 1. DESIGNATION AND AMOUNT. The shares of such series shall
         be designated as "Series A Junior Participating Preferred Stock" (the
         "Series A Preferred Stock") and the number of shares constituting the
         Series A Preferred Stock shall be twenty-five thousand (25,000). Such
         number of shares may be increased or decreased by resolution of the
         Board of Directors; PROVIDED, that no decrease shall reduce the number
         of shares of Series A Preferred Stock to a number less than the number
         of




   16


         shares then outstanding plus the number of shares reserved for issuance
         upon the exercise of outstanding options, rights or warrants or upon
         the conversion of any outstanding securities issued by the Corporation
         convertible into Series A Preferred Stock.

              Section 2.  DIVIDENDS AND DISTRIBUTIONS.

                        (A) Subject to the rights of the holders of any shares
                   of any series of Preferred Stock (or any similar stock)
                   ranking prior and superior to the Series A Preferred Stock
                   with respect to dividends, the holders of shares of Series A
                   Preferred Stock, in preference to the holders of Common
                   Stock, par value $.01 per share (the "Common Stock"), of the
                   Corporation, and of any other junior stock, shall be entitled
                   to receive, when, as and if declared by the Board of
                   Directors out of funds of the Corporation legally available
                   for the payment of dividends, quarterly dividends payable in
                   cash on March 31, June 30, September 30 and December 31 in
                   each year (each such date being referred to herein as a
                   "Quarterly Dividend Payment Date"), commencing on the first
                   Quarterly Dividend Payment Date after the first issuance of a
                   share or fraction of a share of Series A Preferred Stock, in
                   an amount per share (rounded to the nearest cent) equal to
                   the greater of (a) $10 or (b) subject to the provision for
                   adjustment hereinafter set forth, 1,000 times the aggregate
                   per share amount of all cash dividends, and 1,000 times the
                   aggregate per share amount (payable in kind) of all non-cash
                   dividends or other distributions, other than a dividend
                   payable in shares of Common Stock or a subdivision of the
                   outstanding shares of Common Stock (by reclassification or
                   otherwise), declared on the Common Stock since the
                   immediately preceding Quarterly Dividend Payment Date or,
                   with respect to the first Quarterly Dividend Payment Date,
                   since the first issuance of any share or fraction of a share
                   of Series A Preferred Stock. In the event the Corporation
                   shall at any time declare or pay any dividend on the Common
                   Stock payable in shares of Common Stock, or effect a
                   subdivision, combination or consolidation of the outstanding
                   shares of Common Stock (by reclassification or otherwise than
                   by payment of a dividend in shares of Common Stock) into a
                   greater or lesser number of shares of Common Stock, then in
                   each such case the amount to which holders of shares of



                                        -2-


   17



                   Series A Preferred Stock were entitled immediately prior to
                   such event under clause (b) of the preceding sentence shall
                   be adjusted by multiplying such amount by a fraction, the
                   numerator of which is the number of shares of Common Stock
                   outstanding immediately after such event and the denominator
                   of which is the number of shares of Common Stock that were
                   outstanding immediately prior to such event. In the event the
                   Corporation shall at any time declare or pay any dividend on
                   the Series A Preferred Stock payable in shares of Series A
                   Preferred Stock, or effect a subdivision, combination or
                   consolidation of the outstanding shares of Series A Preferred
                   Stock (by reclassification or otherwise than by payment of a
                   dividend in shares of Series A Preferred Stock) into a
                   greater or lesser number of shares of Series A Preferred
                   Stock, then in each such case the amount to which holders of
                   shares of Series A Preferred Stock were entitled immediately
                   prior to such event under clause (b) of the first sentence of
                   this Section 2(A) shall be adjusted by multiplying such
                   amount by a fraction, the numerator of which is the number of
                   shares of Series A Preferred Stock that were outstanding
                   immediately prior to such event and the denominator of which
                   is the number of shares of Series A Preferred Stock
                   outstanding immediately after such event.

                        (B) The Corporation shall declare a dividend or
                   distribution on the Series A Preferred Stock as provided in
                   paragraph (A) of this Section immediately after it declares a
                   dividend or distribution on the Common Stock (other than a
                   dividend payable in shares of Common Stock) and the
                   Corporation shall pay such dividend or distribution on the
                   Series A Preferred Stock before the dividend or distribution
                   declared on the Common Stock is paid or set apart; provided
                   that, in the event no dividend or distribution shall have
                   been declared on the Common Stock during the period between
                   any Quarterly Dividend Payment Date and the next subsequent
                   Quarterly Dividend Payment Date, a dividend of $10 per share
                   on the Series A Preferred Stock shall nevertheless be payable
                   on such subsequent Quarterly Dividend Payment Date.







                                        -3-


   18




                        (C) Dividends shall begin to accrue and be cumulative on
                   outstanding shares of Series A Preferred Stock from the
                   Quarterly Dividend Payment Date next preceding the date of
                   issue of such shares, unless the date of issue of such shares
                   is prior to the record date for the first Quarterly Dividend
                   Payment Date, in which case dividends on such shares shall
                   begin to accrue from the date of issue of such shares, or
                   unless the date of issue is a Quarterly Dividend Payment Date
                   or is a date after the record date for the determination of
                   holders of shares of Series A Preferred Stock entitled to
                   receive a quarterly dividend and before such Quarterly
                   Dividend Payment Date, in either of which events such
                   dividends shall begin to accrue and be cumulative from such
                   Quarterly Dividend Payment Date. Accrued but unpaid dividends
                   shall not bear interest. Dividends paid on the shares of
                   Series A Preferred Stock in an amount less than the total
                   amount of such dividends at the time accrued and payable on
                   such shares shall be allocated pro rata on a share-by-share
                   basis among all such shares at the time outstanding. The
                   Board of Directors may fix a record date for the
                   determination of holders of shares of Series A Preferred
                   Stock entitled to receive payment of a dividend or
                   distribution declared thereon, which record date shall be not
                   more than 60 days prior to the date fixed for the payment
                   thereof.

              Section 3.  VOTING RIGHTS.  The holders of shares of Series A
         Preferred Stock shall have the following voting rights:

                        (A) Subject to the provision for adjustment hereinafter
                   set forth, each share of Series A Preferred Stock shall
                   entitle the holder thereof to 1,000 votes on all matters
                   submitted to a vote of the stockholders of the Corporation.
                   In the event the Corporation shall at any time declare or pay
                   any dividend on the Common Stock payable in shares of Common
                   Stock, or effect a subdivision, combination or consolidation
                   of the outstanding shares of Common Stock (by
                   reclassification or otherwise than by payment of a dividend
                   in shares of Common Stock) into a greater or lesser number of
                   shares of Common Stock, then in each such case the number of
                   votes per share to which holders of shares of Series A
                   Preferred Stock were entitled immediately prior to such event
                   shall be adjusted by multiplying such number by a



                                        -4-


   19




                   fraction, the numerator of which is the number of shares of
                   Common Stock outstanding immediately after such event and the
                   denominator of which is the number of shares of Common Stock
                   that were outstanding immediately prior to such event. In the
                   event the Corporation shall at any time declare or pay any
                   dividend on the Series A Preferred Stock payable in shares of
                   Series A Preferred Stock, or effect a subdivision,
                   combination or consolidation of the outstanding shares of
                   Series A Preferred Stock (by reclassification or otherwise
                   than by payment of a dividend in shares of Series A Preferred
                   Stock) into a greater or lesser number of shares of Series A
                   Preferred Stock, then in each such case the number of votes
                   per share to which holders of shares of Series A Preferred
                   Stock were entitled immediately prior to such event shall be
                   adjusted by multiplying such amount by a fraction, the
                   numerator of which is the number of shares of Series A
                   Preferred Stock that were outstanding immediately prior to
                   such event and the denominator of which is the number of
                   shares of Series A Preferred Stock outstanding immediately
                   after such event.

                        (B) Except as otherwise provided herein, in the Restated
                   Certificate of Incorporation or by law, the holders of shares
                   of Series A Preferred Stock and the holders of shares of
                   Common Stock and any other capital stock of the Corporation
                   having general voting rights shall vote together as one class
                   on all matters submitted to a vote of stockholders of the
                   Corporation.

                        (C)(i) If at any time dividends on any Series A
                   Preferred Stock shall be in arrears in an amount equal to six
                   quarterly dividends thereon, the holders of the Series A
                   Preferred Stock, voting as a separate series from all other
                   series of Preferred Stock and classes of capital stock, shall
                   be entitled to elect two members of the Board of Directors in
                   addition to any Directors elected by any other series, class
                   or classes of securities and the authorized number of
                   Directors will automatically be increased by two. Promptly
                   thereafter, the Board of Directors of this Corporation shall,
                   as soon as may be practicable, call a special meeting of
                   holders of Series A Preferred Stock for the purpose of





                                        -5-


   20





                   electing such members of the Board of Directors. Said special
                   meeting shall in any event be held within 45 days of the
                   occurrence of such arrearage.

                          (ii) During any period when the holders of Series A
                   Preferred Stock, voting as a separate series, shall be
                   entitled and shall have exercised their right to elect two
                   Directors, then and during such time as such right continues
                   (a) the then authorized number of Directors shall be
                   increased by two, and the holders of Series A Preferred
                   Stock, voting as a separate series, shall be entitled to
                   elect the additional Directors so provided for, and (b) each
                   such additional Director shall not be a member of any
                   existing class of the Board of Directors, but shall serve
                   until the next annual meeting of stockholders for the
                   election of Directors, or until his successor shall be
                   elected and shall qualify, or until his right to hold such
                   office terminates pursuant to the provisions of this Section
                   3(C).

                         (iii) A Director elected pursuant to the terms hereof
                   may be removed with or without cause by the holders of Series
                   A Preferred Stock entitled to vote in an election of such
                   Director.

                          (iv) If, during any interval between annual meetings
                   of stockholders for the election of Directors and while the
                   holders of Series A Preferred Stock shall be entitled to
                   elect two Directors, there is no such Director in office by
                   reason of resignation, death or removal, then, promptly
                   thereafter, the Board of Directors shall call a special
                   meeting of the holders of Series A Preferred Stock for the
                   purpose of filling such vacancy and such vacancy shall be
                   filled at such special meeting. Such special meeting shall in
                   any event be held within 45 days of the occurrence of such
                   vacancy.

                           (v) At such time as the arrearage is fully cured, and
                   all dividends accumulated and unpaid on any shares of Series
                   A Preferred Stock outstanding are paid, and, in addition
                   thereto, at least one regular dividend has been paid
                   subsequent to curing such arrearage, the term of office of
                   any Director elected pursuant to this Section 3(C), or his
                   successor, shall automatically terminate, and the authorized
                   number of Directors shall



                                        -6-


   21



                   automatically decrease by two, the rights of the holders of
                   the shares of the Series A Preferred Stock to vote as
                   provided in this Section 3(C) shall cease, subject to renewal
                   from time to time upon the same terms and conditions, and the
                   holders of shares of the Series A Preferred Stock shall have
                   only the limited voting rights elsewhere herein set forth.

                        (D) Except as set forth herein, or as otherwise provided
                   by law, holders of Series A Preferred Stock shall have no
                   special voting rights and their consent shall not be required
                   (except to the extent they are entitled to vote with holders
                   of Common Stock as set forth herein) for taking any corporate
                   action.

              Section 4.  CERTAIN RESTRICTIONS.

                        (A) Whenever quarterly dividends or other dividends or
                   distributions payable on the Series A Preferred Stock as
                   provided in Section 2 are in arrears, thereafter and until
                   all accrued and unpaid dividends and distributions, whether
                   or not declared, on shares of Series A Preferred Stock
                   outstanding shall have been paid in full, the Corporation
                   shall not:

                            (i) declare or pay dividends, or make any other
                   distributions, on any shares of stock ranking junior (either
                   as to dividends or upon liquidation, dissolution or winding
                   up) to the Series A Preferred Stock;

                           (ii) declare or pay dividends, or make any other
                   distributions, on any shares of stock ranking on a parity
                   (either as to dividends or upon liquidation, dissolution or
                   winding up) with the Series A Preferred Stock, except
                   dividends paid ratably on the Series A Preferred Stock and
                   all such parity stock on which dividends are payable or in
                   arrears in proportion to the total amounts to which the
                   holders of all such shares are then entitled;

                          (iii) redeem or purchase or otherwise acquire for
                   consideration shares of any stock ranking junior (either as
                   to dividends or upon liquidation, dissolution or winding up)
                   to the Series A Preferred Stock, provided that the
                   Corporation may at any time redeem, purchase or



                                        -7-


   22









                   otherwise acquire shares of any such junior stock in exchange
                   for shares of any stock of the Corporation ranking junior
                   (either as to dividends or upon dissolution, liquidation or
                   winding up) to the Series A Preferred Stock; or

                           (iv) redeem or purchase or otherwise acquire for
                   consideration any shares of Series A Preferred Stock, or any
                   shares of stock ranking on a parity with the Series A
                   Preferred Stock, except in accordance with a purchase offer
                   made in writing or by publication (as determined by the Board
                   of Directors) to all holders of such shares upon such terms
                   as the Board of Directors, after consideration of the
                   respective annual dividend rates and other relative rights
                   and preferences of the respective series and classes, shall
                   determine in good faith will result in fair and equitable
                   treatment among the respective series or classes.

                        (B) The Corporation shall not permit any subsidiary of
                   the Corporation to purchase or otherwise acquire for
                   consideration any shares of stock of the Corporation unless
                   the Corporation could, under paragraph (A) of this Section 4,
                   purchase or otherwise acquire such shares at such time and in
                   such manner.

              Section 5. REACQUIRED SHARES. Any shares of Series A Preferred
         Stock purchased or otherwise acquired by the Corporation in any manner
         whatsoever shall be retired and cancelled promptly after the
         acquisition thereof. All such shares shall upon their cancellation
         become authorized but unissued shares of Preferred Stock and may be
         reissued as part of a new series of Preferred Stock subject to the
         conditions and restrictions on issuance set forth herein, in the
         Certificate of Incorporation, or in any other Certificate of
         Designations creating a series of Preferred Stock or any similar stock
         or as otherwise required by law.

              Section 6.  LIQUIDATION, DISSOLUTION OR WINDING UP.

                        (A) Upon any liquidation, dissolution or winding up of
                   the Corporation, no distribution shall be made (1) to the
                   holders of shares of stock ranking junior (either as to
                   dividends or upon liquidation, dissolution or winding up) to
                   the Series A Preferred Stock unless, prior thereto, the
                   holders of shares of Series A Preferred Stock shall have
                   received $10 per share, plus



                                        -8-


   23


                   an amount equal to accrued and unpaid dividends and
                   distributions thereon, whether or not declared, to the date
                   of such payment, provided that the holders of shares of
                   Series A Preferred Stock shall be entitled to receive an
                   aggregate amount per share, subject to the provision for
                   adjustment hereinafter set forth, equal to 1,000 times the
                   aggregate amount to be distributed per share to holders of
                   shares of Common Stock, or (2) to the holders of shares of
                   stock ranking on a parity (either as to dividends or upon
                   liquidation, dissolution or winding up) with the Series A
                   Preferred Stock, except distributions made ratably on the
                   Series A Preferred Stock and all such parity stock in
                   proportion to the total amounts to which the holders of all
                   such shares are entitled upon such liquidation, dissolution
                   or winding up.

                        (B) Neither the consolidation, merger or other business
                   combination of the Corporation with or into any other
                   corporation nor the sale, lease, exchange or conveyance of
                   all or any part of the property, assets or business of the
                   Corporation shall be deemed to be a liquidation, dissolution
                   or winding up of the Corporation for purposes of this Section
                   6.

                        (C) In the event the Corporation shall at any time
                   declare or pay any dividend on the Common Stock payable in
                   shares of Common Stock, or effect a subdivision, combination
                   or consolidation of the outstanding shares of Common Stock
                   (by reclassification or otherwise than by payment of a
                   dividend in shares of Common Stock) into a greater or lesser
                   number of shares of Common Stock, then in each such case the
                   aggregate amount to which holders of shares of Series A
                   Preferred Stock were entitled immediately prior to such event
                   under the proviso in clause (1) of paragraph (A) of this
                   Section 6 shall be adjusted by multiplying such amount by a
                   fraction the numerator of which is the number of shares of
                   Common Stock outstanding immediately after such event and the
                   denominator of which is the number of shares of Common Stock
                   that were outstanding immediately prior to such event. In the
                   event the Corporation shall at any time declare or pay any
                   dividend on the Series A Preferred Stock payable in shares of
                   Series A Preferred Stock, or effect a subdivision,
                   combination or consolidation of the outstanding shares of
                   Series A



                                        -9-


   24



                   Preferred Stock (by reclassification or otherwise than by
                   payment of a dividend in shares of Series A Preferred Stock)
                   into a greater or lesser number of shares of Series A
                   Preferred Stock, then in each such case the aggregate amount
                   to which holders of shares of Series A Preferred Stock were
                   entitled immediately prior to such event under the proviso in
                   clause (1) of paragraph (A) of this Section 4 shall be
                   adjusted by multiplying such amount by a fraction, the
                   numerator of which is the number of shares of Series A
                   Preferred Stock that were outstanding immediately prior to
                   such event and the denominator of which is the number of
                   shares of Series A Preferred Stock outstanding immediately
                   after such event.

              Section 7. CONSOLIDATION, MERGER, ETC. Notwithstanding anything to
         the contrary contained herein, in case the Corporation shall enter into
         any consolidation, merger, combination or other transaction in which
         the shares of Common Stock are exchanged for or changed into other
         stock or securities, cash and/or any other property, then in any such
         case each share of Series A Preferred Stock shall at the same time be
         similarly exchanged or changed into an amount per share, subject to the
         provision for adjustment hereinafter set forth, equal to 1,000 times
         the aggregate amount of stock, securities, cash and/or any other
         property (payable in kind), as the case may be, into which or for which
         each share of Common Stock is changed or exchanged. In the event the
         Corporation shall at any time declare or pay any dividend on the Common
         Stock payable in shares of Common Stock, or effect a subdivision,
         combination or consolidation of the outstanding shares of Common Stock
         (by reclassification or otherwise than by payment of a dividend in
         shares of Common Stock) into a greater or lesser number of shares of
         Common Stock, then in each such case the amount set forth in the
         preceding sentence with respect to the exchange or change of shares of
         Series A Preferred Stock shall be adjusted by multiplying such amount
         by a fraction, the numerator of which is the number of shares of Common
         Stock outstanding immediately after such event and the denominator of
         which is the number of shares of Common Stock that were outstanding
         immediately prior to such event. In the event the Corporation shall at
         any time declare or pay any dividend on the Series A Preferred Stock
         payable in shares of Series A Preferred Stock, or effect a subdivision,
         combination or consolidation of the outstanding shares of Series A
         Preferred Stock (by reclassification or otherwise than by payment of a
         dividend in shares of Series A Preferred Stock) into a greater or
         lesser number of shares of



                                       -10-


   25





         Series A Preferred Stock, then in each such case the amount set forth
         in the first sentence of this Section 7 with respect to the exchange or
         change of shares of Series A Preferred Stock shall be adjusted by
         multiplying such amount by a fraction, the numerator of which is the
         number of shares of Series A Preferred Stock that were outstanding
         immediately prior to such event and the denominator of which is the
         number of shares of Series A Preferred Stock outstanding immediately
         after such event.

              Section 8. NO REDEMPTION.  The shares of Series A Preferred
         Stock shall not be redeemable.

              Section 9. RANK. The Series A Preferred Stock shall rank, with
         respect to the payment of dividends and the distribution of assets,
         junior to all series of any other class of the Preferred Stock issued
         either before or after the issuance of the Series A Preferred Stock,
         unless the terms of any such series shall provide otherwise.

              Section 10. AMENDMENT. The Restated Certificate of Incorporation,
         as amended, of the Corporation shall not be amended in any manner which
         would materially alter or change the powers, preferences or special
         rights of the Series A Preferred Stock so as to affect them adversely
         without the affirmative vote of the holders of at least two-thirds of
         the outstanding shares of Series A Preferred Stock, voting together as
         a single class.

              Section 11. FRACTIONAL SHARES. Series A Preferred Stock may be
         issued in fractions of a share which shall entitle the holder, in
         proportion to such holder's fractional shares, to exercise voting
         rights, receive dividends, participate in distributions and have the
         benefit of all other rights of holders of Series A Preferred Stock.
















                                       -11-


   26




              IN WITNESS WHEREOF, this Certificate of Designations is executed
         on behalf of the Corporation by its President and Chief Executive
         Officer and attested by its Secretary this 11th day of July, 1995.


                                          IMMULOGIC PHARMACEUTICAL
                                            CORPORATION


                                          /s/ Robert J. Gerety
                                          -------------------------------------
                                          Robert J. Gerety, M.D., Ph.D.
                                          President and Chief Executive
                                          Officer


         Attest:


          /s/ Stacey L. Channing
         --------------------------------  
         Stacey L. Channing,
         Secretary



























                                       -12-
   27








                            CERTIFICATE OF AMENDMENT

                                       OF

                        RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                      IMMULOGIC PHARMACEUTICAL CORPORATION

              ImmuLogic Pharmaceutical Corporation, a corporation organized

         and existing under and by virtue of the General Corporation Law of

         the State of Delaware (the "Corporation"), DOES HEREBY CERTIFY:

              FIRST:  That the Board of Directors of said Corporation at a

         meeting on March 21, 1996 duly adopted a resolution pursuant to

         Section 242 of the General Corporation Law of the State of

         Delaware ("Delaware Law") proposing and declaring advisable the

         following amendment to the Amended and Restated Certificate of

         Incorporation of the Corporation:

              RESOLVED:    That the first paragraph of Article FOURTH of
                           the Amended and Restated Certificate of
                           Incorporation, as amended, be amended to read in
                           its entirety as follows:

                           FOURTH:  The total number of shares of all classes of
                           stock which the Corporation has authority to issue is
                           forty-one million shares (41,000,000) consisting of
                           forty million (40,000,000) shares of common stock,
                           $.01 par value per share ("Common Stock"), and one
                           million (1,000,000) shares of Preferred Stock, $.01
                           par value per share ("Preferred Stock").



   28







              SECOND:  That the foregoing Amendment to the Corporation's

         Amended and Restated Certificate of Incorporation, as amended, was

         adopted by the holders of a majority of the outstanding shares of

         Common Stock at the Corporation's Annual Meeting of Stockholders

         held on May 23, 1996 pursuant to notice duly given.

              IN WITNESS WHEREOF, ImmuLogic Pharmaceutical Corporation has

         caused this Certificate to be signed by Stacey L. Channing, its

         Vice President, General Counsel this 24th day of May, 1996.


                                    IMMULOGIC PHARMACEUTICAL CORPORATION



                                       By: /s/ Stacey L. Channing
                                           ----------------------------- 
                                           Stacey L. Channing
                                      Its: Vice President,
                                           General Counsel
































                                        -2-