1 AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JANUARY 30, 1997. REGISTRATION NO. 333- - -------------------------------------------------------------------------------- - -------------------------------------------------------------------------------- SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ------------------------ FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ------------------------ CAMBRIDGE NEUROSCIENCE, INC. (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER) DELAWARE 13-3319074 (STATE OR OTHER JURISDICTION (I.R.S. EMPLOYER OF INCORPORATION OR ORGANIZATION) IDENTIFICATION NUMBER) ONE KENDALL SQUARE, BUILDING 700, CAMBRIDGE, MASSACHUSETTS 02139 (617) 225-0600 (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES) ------------------------ ELKAN R. GAMZU PRESIDENT AND CHIEF EXECUTIVE OFFICER CAMBRIDGE NEUROSCIENCE, INC. ONE KENDALL SQUARE, BUILDING 700 CAMBRIDGE, MASSACHUSETTS 02139 (617) 225-0600 (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF AGENT FOR SERVICE) ------------------------ WITH COPIES TO: WILLIAM T. WHELAN, ESQ. LESLIE E. DAVIS, ESQ. PALMER & DODGE LLP TESTA, HURWITZ & THIBEAULT, LLP ONE BEACON STREET HIGH STREET TOWER BOSTON, MASSACHUSETTS 02108 125 HIGH STREET (617) 573-0100 BOSTON, MASSACHUSETTS 02110 (617) 248-7000 ------------------------ APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as practicable after this Registration Statement becomes effective. ------------------------ If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. [ ] If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box. [ ] If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [X] 333-18225 If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [ ] If delivery of the prospectus is expected to be made pursuant to Rule 434, please check the following box. [ ] ------------------------ CALCULATION OF REGISTRATION FEE ============================================================================================================ PROPOSED PROPOSED MAXIMUM AGGREGATE AMOUNT OF TITLE OF EACH CLASS OF AMOUNT TO BE MAXIMUM OFFERING OFFERING REGISTRATION SECURITIES TO BE REGISTERED REGISTERED(1) PRICE PER SHARE(2) PRICE(1)(2) FEE - ------------------------------------------------------------------------------------------------------------ Common Stock, $0.001 par value..... 460,000 shares $11.625 $5,347,500 $1,621 ============================================================================================================ <FN> (1) Includes 60,000 shares which the Underwriters may purchase to cover over-allotments, if any. (2) Estimated solely for the purpose of determining the registration fee and computed pursuant to Rule 457(c) and based on the average of the high and low sales prices on January 29, 1997, as reported on the Nasdaq National Market. ------------------------ THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A), MAY DETERMINE. - -------------------------------------------------------------------------------- - -------------------------------------------------------------------------------- 2 This Registration Statement is being filed with respect to the registration of additional shares of the common stock, $.001 par value per share, of Cambridge NeuroScience, Inc., a Delaware corporation, for an offering pursuant to Rule 462(b) under the Securities Act of 1933, as amended. The contents of the earlier effective registration statement (Registration No. 333-18225) (the "Earlier Registration Statement") are incorporated in this Registration Statement by reference. The required opinions and consents are listed on an Exhibit Index attached hereto and filed herewith. 3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on January 30, 1997. CAMBRIDGE NEUROSCIENCE, INC. By: /s/ Elkan R. Gamzu ------------------------------ Elkan R. Gamzu, Ph.D. President and Chief Executive Officer Pursuant to the requirements of the Securities Act of 1933, this Registration Statement thereto has been signed by the following persons in the capacities and on the dates indicated. SIGNATURE CAPACITY DATE - --------- -------- ---- /s/ Elkan R. Gamzu President, Chief Executive Officer January 30, 1997 - ------------------------------------- and Director (Principal Executive Elkan R. Gamzu, Ph.D. Officer) Harry W. Wilcox, III* Senior Vice President, Finance and January 30, 1997 - ------------------------------------- Business Development and Chief Harry W. Wilcox, III Financial Officer (Principal Financial and Accounting Officer) Nancy S. Amer* Director January 30, 1997 - ------------------------------------- Nancy S. Amer Burkhard Blank, M.D.* Director January 30, 1997 - ------------------------------------- Burkhard Blank, M.D. Ira A. Jackson* Director January 30, 1997 - ------------------------------------- Ira A. Jackson S. Joshua Lewis* Director January 30, 1997 - ------------------------------------- S. Joshua Lewis Joseph B. Martin* Director January 30, 1997 - ------------------------------------- Joseph B. Martin, M.D., Ph.D. Paul C. O'Brien* Director January 30, 1997 - ------------------------------------- Paul C. O'Brien Peter Stalker, III* Director January 30, 1997 - ------------------------------------- Peter Stalker, III *By: /s/ ELKAN R. GAMZU ------------------------------ Elkan R. Gamzu, Ph.D. Attorney-in-Fact 4 EXHIBIT INDEX EXHIBIT NO. DESCRIPTION - ------------ ----------- 5.1 Opinion of Palmer & Dodge LLP as to the legality of the securities registered hereunder. Filed herewith................................... 23.1 Consent of Ernst & Young LLP, independent auditors. Filed herewith..... 23.2 Consent of Palmer & Dodge LLP (included in Exhibit 5.1)................ 24.1* Power of Attorney...................................................... <FN> - --------------- * Filed with the Company's Registration Statement on Form S-3 (Registration No. 333-18225).