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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549



                                    FORM 8-K
                                 CURRENT REPORT


                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934




                Date of Report (Date of earliest event reported):
                               DECEMBER 6, 1996




                               GENZYME CORPORATION
             (Exact name of registrant as specified in its charter)



     MASSACHUSETTS                  0-14680                   06-1047163
(State or other jurisdiction    (Commission File            (IRS Employer
     of incorporation)              Number)               Identification No.)




               ONE KENDALL SQUARE, CAMBRIDGE, MASSACHUSETTS 02139
              (Address of principal executive offices and zip code)



               Registrant's telephone number, including area code:
                                 (617) 252-7500



Total number of page in document - 26
Exhibit Index located on page - 4






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        ITEM 5.     OTHER.
                    ------

        On October 28, 1996, Genzyme Corporation ("Genzyme"), through Neozyme II
Acquisition Corp. ("Acquisition Corp."), its wholly-owned subsidiary, completed
its tender offer for the outstanding units (the "Units") of Neozyme II
Corporation ("Neozyme II"), each Unit consisting of (i) one share of the
Callable Common Stock (the "Callable Common Stock"), $1.00 par value per share,
of Neozyme II and (ii) one Callable Warrant (the "Callable Warrants") to
purchase two shares of General Division Common Stock ("General Division Stock"),
$0.01 par value per share, and .135 share of Tissue Repair Division Common Stock
("TR Stock"), $0.01 par value per share, of Genzyme, for $45 per Unit in cash.
2,385,686 Units, or 98.8%, were tendered and accepted for payment, resulting in
an aggregate tender offer price of $107.4 million.

        On December 6, 1996, Neozyme II was merged with and into Acquisition
Corp. and as a result of the merger, all outstanding shares of Callable Common  
Stock (other than shares held by Genzyme and its subsidiaries) were cancelled
and converted into the right to receive $29.00 in cash per share, for an
aggregate merger consideration of $0.9 million. The Callable Warrants included
in the untendered Units separated from the shares of Callable Common Stock
converted in the merger and became exercisable on December 6, 1996.  The
exercise price of the Callable Warrants is $44.202 per Callable Warrant and was
determined by the average closing price of two shares of General Division Stock
and .135 share of TR Stock for the 20 trading days prior to December 6, 1996. 
The Callable Warrants will expire in December 31, 1998.

        Funds for the tender offer and for the merger were provided as
follows: $80.0 million from borrowings under a revolving credit facility from
Fleet National Bank, and the balance from Genzyme General Division cash
balances.

        The nature and amount of the consideration paid pursuant to the tender
offer and the merger were determined by negotiation between Genzyme and a 
special committee of independent directors of Neozyme II who are neither 
executive officers nor directors of Genzyme.

        In order to update the information previously filed with the Securities
and Exchange Commission at pages F-2 to F-17 to the Current Report of Genzyme on
Form 8-K (Commission File No. 0-14680) filed on November 5, 1996, Genzyme hereby
files as Exhibit 99.1 unaudited pro forma financial statements and the related
notes thereto for both Genzyme and Genzyme General Division (the "General
Division") giving effect to the acquisition by Genzyme of Genetrix, Inc.
("Genetrix") on May 1, 1996 (the "Genetrix Acquisition"), the acquisition of
Deknatel Snowden Pencer, Inc. ("DSP") on July 1, 1996 (the "DSP Acquisition"),
and the acquisition of Neozyme II (the "Neozyme II Acquisition") (collectively,
the "Acquisitions"). Pro forma condensed statements of operations have been
presented for both Genzyme and the General Division assuming that the
Acquisitions occurred as of January 1, 1995, using the purchase accounting
method. Pro forma balance sheets have been presented for both Genzyme and the
General Division assuming that the Neozyme II Acquisition occurred as of
September 30, 1996. The historical Genzyme and General Division balances
included in the pro forma balance sheets reflect the effect of the Genetrix
Acquisition which was completed on May 1, 1996 and the DSP Acquisition which was
completed on July 1, 1996. In addition, historical financial statements and
notes thereto of Neozyme II are filed herewith as Exhibit 99.2.


ITEM 7.     FINANCIAL STATEMENTS AND EXHIBITS.
            ---------------------------------


           (c)  Exhibits.
                
                EXHIBIT NO.                     DESCRIPTION
                -----------                     -----------
                              
                  
                99.1             Unaudited pro forma balance sheets as of 
                                 September 30, 1996 and statements of operations
                                 (and related notes) for the year ended December
                                 31, 1995 and for the nine-months ended
                                 September 30, 1996 for Genzyme and the General
                                 Division, giving effect to the Acquisitions.
                                 Filed herewith.

                99.2             Historical unaudited financial statements 
                                 (and related notes) of Neozyme II Corporation
                                 including statements of operations for the nine
                                 months ended September 30, 1995 and 1996 and
                                 cumulative from March 2, 1992 (date of
                                 inception) to September 30, 1996; balance
                                 sheets as of September 30, 1996 and December
                                 31, 1995; and statements of cash flows for the
                                 nine months ended September 30, 1996 and 1995
                                 and cumulative from March 2, 1992 (date of
                                 inception) to September 30, 1996. Filed
                                 herewith.


                                 
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                                   SIGNATURES

      Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


Date: February 4, 1996              GENZYME CORPORATION

                                    By:/s/ David J. McLachlan
                                       ------------------------------------
                                       David J. McLachlan
                                        Executive Vice President, Finance;
                                        Chief Financial Officer





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                                  EXHIBIT INDEX

EXHIBIT                                                               SEQUENTIAL
  NO.            DESCRIPTION                                           PAGE NO.
  ---            -----------                                           --------

99.1         Unaudited pro forma balance sheets as of September 30,        7
             1996 and statements of operations (and related notes) 
             for the year ended December 31, 1995 and for the 
             nine-months ended September 30, 1996 for Genzyme and 
             the General Division, giving effect to the Acquisitions. 
             Filed herewith.

99.2         Historical unaudited financial statements (and related       22
             notes) of Neozyme II Corporation including statements 
             of operations for the three and nine months ended 
             September 30, 1995 and 1996 and cumulative from 
             March 2, 1992 (date of inception) to September 30,
             1996; balance sheets as of September 30, 1996 and 
             December 31, 1995; and statements of cash flows for the 
             nine months ended September 30, 1996 and cumulative from 
             March 2, 1992 (date of inception) to September 30, 1996. 
             Filed herewith.





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                         INDEX TO FINANCIAL STATEMENTS


                                                                                       PAGE(S)
                                                                                       -------
                                                                                      
EXHIBIT 99.1
- ------------
 PRO FORMA FINANCIAL STATEMENTS:
 Introduction to Unaudited Pro Forma Financial Statements .........................       F-2
 GENZYME CORPORATION:
  Pro Forma Consolidated Balance Sheets as of September 30, 1996..................        F-3
  Pro Forma Consolidated Statements of Operations for the Nine Months
     Ended September 30, 1996.....................................................        F-4
  Pro Forma Consolidated Statements of Operations for the Year Ended
     December 31, 1995............................................................        F-6
 GENZYME GENERAL DIVISION:
  Pro Forma Combined Balance Sheets as of September 30, 1996......................        F-8
  Pro Forma Combined Statements of Operations for the Nine Months Ended 
     September 30, 1996...........................................................        F-9
  Pro Forma Combined Statements of Operations for the Year Ended
     December 31, 1995............................................................       F-11
 Notes to Unaudited Pro Forma Financial Statements................................       F-13
                                                                      
EXHIBIT 99.2
- ------------
 NEOZYME II UNAUDITED FINANCIAL STATEMENTS:
  Statements of Operations for the Three and Nine Months Ended 
     September 30, 1995 and 1996 and Cumulative from March 2, 1992 (date of 
     inception) through September 30, 1996........................................       F-18
  Balance Sheets as of December 31, 1995 and September 30, 1996 ..................       F-19
  Statements of Cash Flows for the Nine Months Ended September 30, 1995 
     and 1996 and Cumulative from March 2, 1992 (date of inception) through
     September 30, 1996...........................................................       F-20
  Notes to Unaudited Condensed Financial Statements...............................       F-21


 
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