1 EXHIBIT 11.1 ARQULE, INC. STATEMENT RE COMPUTATION OF PER SHARE NET INCOME (LOSS) PER SHARE Basic Net Income (Loss) Per Share YEAR ENDED DECEMBER 31, ----------------------- 1995 1996 1997 ------------ ------------- ----------- Net income (loss) $(2,252,000) $(2,993,000) $ 291,000 ----------- ----------- ----------- Weighted average shares outstanding: Common Stock 599,000 2,430,000 11,337,000 Weighted average common shares outstanding 599,000 2,430,000 11,337,000 ----------- ----------- ----------- Basic net income (loss) per share $ (3.76) $ (1.23) $ 0.03 ----------- ----------- ----------- Diluted Net Income (Loss) Per Share YEAR ENDED DECEMBER 31, ----------------------- 1995 1996 1997 ------------- ------------- ------------- Net income (loss) $(2,252,000) $(2,993,000) $ 291,000 Weighted average shares outstanding: Common Stock 599,000 2,430,000 11,337,000 Stock option common stock equivalents -- -- 1,057,000 ----------- ----------- ----------- Weighted average common shares and equivalents outstanding 599,000 2,430,000 12,394,000 ----------- ----------- ----------- Diluted net income (loss) per share $ (3.76) $ (1.23) $ 0.02 ----------- ----------- ----------- 39