<ARTICLE> 5 <RESTATED> <CIK> 0000356830 <NAME> GENOME THERAPEUTICS <MULTIPLIER> 1,000 <CURRENCY> U.S. DOLLAR <PERIOD-TYPE> 3-MOS <FISCAL-YEAR-END> AUG-31-1998 <PERIOD-START> SEP-01-1997 <PERIOD-END> FEB-28-1998 <EXCHANGE-RATE> 1 <CASH> 12,849 <SECURITIES> 28,192 <RECEIVABLES> 178 <ALLOWANCES> 0 <INVENTORY> 0 <CURRENT-ASSETS> 39,275 <PP&E> 21,864 <DEPRECIATION> 6,844 <TOTAL-ASSETS> 58,920 <CURRENT-LIABILITIES> 12,751 <BONDS> 0 <PREFERRED-MANDATORY> 0 <PREFERRED> 0 <COMMON> 1,821 <OTHER-SE> 35,078 <TOTAL-LIABILITY-AND-EQUITY> 58,920 <SALES> 0 <TOTAL-REVENUES> 9,650 <CGS> 0 <TOTAL-COSTS> 17,070 <OTHER-EXPENSES> 0 <LOSS-PROVISION> 0 <INTEREST-EXPENSE> 539 <INCOME-PRETAX> 0 <INCOME-TAX> 0 <INCOME-CONTINUING> 0 <DISCONTINUED> 0 <EXTRAORDINARY> 0 <CHANGES> 0 <NET-INCOME> (7,958) <EPS-PRIMARY> (.44) <EPS-DILUTED> (.44)