1 EXHIBIT 11.1 ARQULE, INC. STATEMENT RE COMPUTATION OF PER SHARE NET INCOME (LOSS) Basic Net Income (Loss) Per Share YEAR ENDED DECEMBER 31, ----------------------- 1995 1996 1997 ------------ ------------- ----------- Net income (loss) $(2,252,000) $(2,993,000) $ 291,000 ----------- ----------- ----------- Weighted average shares outstanding: Common Stock 284,000 2,272,000 11,282,000 Weighted average common shares outstanding 284,000 2,272,000 11,282,000 ----------- ----------- ----------- Basic net income (loss) per share $ (7.93) $ (1.32) $ 0.03 ----------- ----------- ----------- Diluted Net Income (Loss) Per Share YEAR ENDED DECEMBER 31, ----------------------- 1995 1996 1997 ------------- ------------- ------------- Net income (loss) $(2,252,000) $(2,993,000) $ 291,000 Weighted average shares outstanding: Common Stock 284,000 2,272,000 11,282,000 Stock option common stock equivalents -- -- 1,057,000 Unvested restricted common stock equivalents -- -- 55,000 ----------- ----------- ----------- Weighted average common shares and equivalents outstanding 284,000 2,272,000 12,394,000 ----------- ----------- ----------- Diluted net income (loss) per share $ (7.93) $ (1.32) $ 0.02 ----------- ----------- ----------- 39