1
                                                                     Exhibit 4.5

           
                                                              
                                                            SCHEDULE 3(A)

                                  Subsidiaries

ABT Securities Corp., a Massachusetts corporation
MycoTox, Inc., a Massachusetts corporation













   2

                                                            SCHEDULE 3(C)

                                 Capitalization

Pursuant to the terms of the Shareholder Rights Agreement, dated as of February
2, 1997, as amended on November 13, 1997, between the Company and BankBoston,
N.A. f/k/a The First National Bank of Boston, the Company has outstanding rights
exercisable for one one-thousandth of a share of Series A Junior Participating
Cumulative Preferred Stock upon the occurrence of certain events.

The Company has agreed to issue World Capital Funding, LLC and Reedland Capital
Partners the following securities: (i) 22,500 shares of restricted Common Stock,
(ii) warrants exercisable for 25,000 shares of Common Stock at an exercise price
equal to 125% of the fair market value of the Common Stock on the Initial
Closing Date and (iii) warrants exercisable for 25,000 shares of Common Stock at
an exercise price equal to 150% of the fair market value of the Common Stock on
the Initial Closing Date.

Pursuant to the Stock Purchase Agreement dated as of November 18, 1998 by and
between the Company and Ross Financial Corporation ("Ross"), Ross has (i)
certain preemptive rights (subject to certain exceptions and limitations) with
respect to the Company's issuance of shares of Common Stock or securities
convertible into or exercisable for shares of Common Stock, and (ii) piggy-back
and demand registration rights with respect to the shares of Common Stock it
holds.

The Company has options and warrants outstanding pursuant to the terms of its
1988 Stock Option and Grant Plan and 1997 Stock Option and Grant Plan.

In connection with the waiver of certain obligations under its lease, the
Company has offered the landlord of its Worcester, Massachusetts facility a
warrant exercisable for 12,000 shares of Common Stock (a definitive agreement
has not yet been executed).

The Company has the following outstanding debt securities in excess of $25,000:

         $30,330,000 letter of credit with Sumitomo Bank Limited
         $341,000 debt obligation to ClinTrials
         $184,967 note in favor of Flagship Bank
         $125,000 debt obligation to John Brown (due upon product approval)





   3


                                                             SCHEDULE 3(E)

                                    Conflicts

The Shareholder Rights Agreement, dated as of February 2, 1997, as amended on
November 13, 1997, between the Company and BankBoston, N.A. f/k/a The First
National Bank of Boston.












   4


                                                             SCHEDULE 3(G)

                                Material Changes


None.












   5


                                                             SCHEDULE 3(H)

                                   Litigation

None.












   6


                                                             SCHEDULE 3(N)

                              Intellectual Property

None.












   7


                                                             SCHEDULE 3(P)

                                      Liens

Fleet National Bank, as trustee, has a first priority mortgage on the real
property and fixtures located at the Company's Smithfield, Rhode Island
facility.

Flagship Bank has a first priority purchase money security interest in certain
assets at the Company's Worcester, Massachusetts and Smithfield, Rhode Island
facilities.












   8


                                                             SCHEDULE 3(T)



                                   Tax Status

None.












   9


                                                             SCHEDULE 3(U)


                              Certain Transactions

None.












   10


                                                             SCHEDULE 4(D)

                                 Use of Proceeds


Operations and working capital.