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                                                                    Exhibit 10.4


                             ASCENT PEDIATRICS, INC.



                               MAXIMUM $40,000,000
                  7.5% CONVERTIBLE SUBORDINATED NOTES DUE 2005


                                 LOAN AGREEMENT

                             DATE: FEBRUARY 16, 1999
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                                TABLE OF CONTENTS



                                                                                                                     Page

                                                                                                                   
ARTICLE I
         DEFINITIONS AND INCORPORATION BY REFERENCE...............................................................     1
         1.1      DEFINITIONS.....................................................................................     1
         1.2      RULES OF CONSTRUCTION..........................................................................     10
                                                                                                                      
ARTICLE II                                                                                                            
         AMOUNT AND TERMS OF SECURITIES..........................................................................     11
         2.1      COMMITMENT TO LEND; LOANS......................................................................     11
         2.2      EVIDENCE OF DEBT...............................................................................     11
         2.3      MAKING OF LOANS................................................................................     12
         2.4      INTEREST AND PRINCIPAL PAYMENTS................................................................     12
         2.5      MANDATORY PREPAYMENT UPON CHANGE IN CONTROL....................................................     13
         2.6      LENDER DISCRETIONARY BORROWING UNDER NOTE......................................................     14
         2.7      OPTIONAL PREPAYMENT............................................................................     14
                                                                                                                      
ARTICLE III                                                                                                           
         REPRESENTATIONS AND WARRANTIES OF THE COMPANY...........................................................     14
         3.1      ORGANIZATION AND EXISTENCE, ETC................................................................     14
         3.2      SUBSIDIARIES...................................................................................     15
         3.3      CAPITALIZATION.................................................................................     15
         3.4      AUTHORIZATION; BINDING OBLIGATIONS.............................................................     15
         3.5      COMPLIANCE WITH INSTRUMENTS, ETC...............................................................     16
         3.6      LITIGATION.....................................................................................     17
         3.7      FINANCIAL STATEMENTS; TAXES....................................................................     17
         3.8      OFFERING.......................................................................................     18
         3.9      PERMITS; GOVERNMENTAL AND OTHER APPROVALS......................................................     18
         3.10     SALES REPRESENTATIVES, CUSTOMERS AND KEY EMPLOYEES.............................................     18
         3.11     INTELLECTUAL PROPERTY..........................................................................     19
         3.12     FORM 10-K AND 10-Q.............................................................................     20
         3.13     REGULATORY STATUS..............................................................................     20
         3.14     REGISTRATION RIGHTS............................................................................     20
         3.15     NO RELATIONSHIP BETWEEN PARTIES................................................................     20
         3.16     ORDINARY COURSE................................................................................     21
         3.17     NO FINDERS.....................................................................................     21
                                                                                                                      
ARTICLE IV                                                                                                            
         CONDITIONS OF OBLIGATIONS OF THE LENDER.................................................................     21
         4.1      CONDITIONS TO LENDER'S OBLIGATIONS ON THE FIRST LOAN DATE......................................     21



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         4.2      CONDITIONS TO LENDER'S OBLIGATIONS TO MAKE THE FIRST UNRESTRICTED LOAN.........................   23
         4.3      CONDITIONS PRECEDENT TO EACH LOAN..............................................................   24
         4.4      COOPERATION....................................................................................   24
                                                                                                                    
ARTICLE V                                                                                                           
         CONDITIONS OF OBLIGATIONS OF THE COMPANY................................................................   25
         5.1      COMPANY'S OBLIGATION...........................................................................   25
         5.2      COOPERATION....................................................................................   25
                                                                                                                    
ARTICLE VI                                                                                                          
         AFFIRMATIVE COVENANTS OF THE COMPANY....................................................................   25
         6.1      REPORTS........................................................................................   25
         6.2      ACCOUNTS AND RECORDS...........................................................................   27
         6.3      INSPECTION.....................................................................................   27
         6.4      INDEPENDENT ACCOUNTANTS........................................................................   27
         6.5      BOARD MEMBERS AND MEETINGS.....................................................................   27
         6.6      USE OF PROCEEDS................................................................................   28
         6.7      INSURANCE......................................................................................   28
         6.8      RESEARCH AND DEVELOPMENT.......................................................................   28
         6.9      FURTHER ASSURANCES.............................................................................   28
         6.10     TERMINATION....................................................................................   28
                                                                                                                    
ARTICLE VII                                                                                                         
         NEGATIVE COVENANTS......................................................................................   29
         7.1      BORROWED MONEY INDEBTEDNESS....................................................................   29
         7.2      LIENS..........................................................................................   30
         7.3      CONTINGENT LIABILITIES.........................................................................   30
         7.4      MERGERS, CONSOLIDATIONS AND DISPOSITIONS AND ACQUISITIONS OF ASSETS............................   30
         7.5      REDEMPTION, DIVIDENDS AND DISTRIBUTIONS........................................................   31
         7.6      NATURE OF BUSINESS.............................................................................   31
         7.7      TRANSACTIONS WITH RELATED PARTIES..............................................................   31
         7.8      LOANS AND INVESTMENTS..........................................................................   31
         7.9      ORGANIZATIONAL DOCUMENTS.......................................................................   32
         7.10     LEASE EXPENSES; PURCHASE MONEY INDEBTEDNESS....................................................   32
         7.11     SALE/LEASEBACKS................................................................................   32
         7.12     ISSUANCE OF STOCK..............................................................................   32
         7.13     SUBSIDIARIES...................................................................................   32
         7.14     TERMINATION....................................................................................   32




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ARTICLE VIII
         DEFAULTS AND REMEDIES...................................................................................   33
         8.1      EVENTS OF DEFAULT..............................................................................   33
         8.2      ACCELERATION...................................................................................   34
         8.3      OTHER REMEDIES.................................................................................   34
         8.4      WAIVER OF PAST DEFAULTS........................................................................   35
                                                                                                                    
ARTICLE IX                                                                                                          
         CONVERSION..............................................................................................   35
         9.1      RIGHT OF CONVERSION............................................................................   35
         9.2      CONVERSION PRICE...............................................................................   35
         9.3      EXERCISE OF CONVERSION RIGHT...................................................................   35
         9.4      PROVISIONS IN CASE OF MERGER, ETC..............................................................   36
         9.5      TAXES ON CONVERSION............................................................................   36
         9.6      COMPANY TO PROVIDE STOCK.......................................................................   36
         9.7      REQUIRED ANTITRUST APPROVAL....................................................................   36
                                                                                                                    
ARTICLE X                                                                                                           
         SUBORDINATION...........................................................................................   37
         10.1     AGREEMENT TO SUBORDINATE.......................................................................   37
                                                                                                                    
ARTICLE XI                                                                                                          
         RESTRICTIONS ON TRANSFER................................................................................   37
         11.1     SECURITIES LAWS RESTRICTIONS ON TRANSFER.......................................................   37
         11.2     RESTRICTIVE LEGEND.............................................................................   37
         11.3     REGISTRATION RIGHTS AGREEMENT..................................................................   38
         11.4     ADDITIONAL RESTRICTIONS........................................................................   38
                                                                                                                    
ARTICLE XII                                                                                                         
         AMENDMENT, SUPPLEMENT AND WAIVER........................................................................   39
         12.1     WITH CONSENT OF HOLDERS OF THE NOTE............................................................   39
                                                                                                                    
ARTICLE XIII                                                                                                        
         MISCELLANEOUS...........................................................................................   40
         13.1     NOTICES........................................................................................   40
         13.2     DUPLICATE ORIGINALS............................................................................   41
         13.3     GOVERNING LAW..................................................................................   41
         13.4     NO ADVERSE INTERPRETATION OF OTHER AGREEMENTS..................................................   41
         13.5     SUCCESSORS AND ASSIGNS.........................................................................   41
         13.6     SEPARABILITY...................................................................................   41
         13.7     HEADINGS, ETC..................................................................................   41
         13.8     CONFIDENTIALITY................................................................................   41
         13.9     PARENT GUARANTEE...............................................................................   42




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         LOAN AGREEMENT (the "Agreement") dated as of February 16, 1999 among
ASCENT PEDIATRICS, Inc., a Delaware corporation (the "Company"), Alpharma USPD
Inc., a Maryland corporation (the "Lender"), and Alpharma Inc., a Delaware
corporation (the "Parent").

         WHEREAS, the Lender has agreed to loan to the Company an aggregate of
up to $40 million from time to time upon the terms and conditions set forth
herein;

         NOW, THEREFORE, in consideration of the premises, it is agreed by and
among the parties hereto as follows:


                                    ARTICLE I
                   DEFINITIONS AND INCORPORATION BY REFERENCE

1.1      DEFINITIONS.

         "Affiliate" shall have the meaning ascribed to it in Rule 405
         promulgated under the Securities Act.

         "Alpharma Director" has the meaning set forth in Section 6.5(a) of this
         Agreement.

         "Ancillary Agreements" shall mean the Depositary Agreement, the Master
         Agreement, the Merger Agreement and the Registration Rights Agreement.

         "Approved Accounting Firm" shall have the meaning set forth in Section
         6.1(a) of this Agreement.

         "Bankruptcy Law" means Title 11, U.S. Code or any similar Federal or
         State law for the relief of debtors. The term "Custodian" means any
         receiver trustee, assignee, liquidator or similar official under any
         Bankruptcy Law.

         "Board of Directors" means the Board of Directors of the Company or any
         committee of the Board authorized to act for it hereunder.

         "Borrowed Money Indebtedness" means, with respect to any Person,
         without duplication:

                           (a) all obligations of such Person for borrowed
                  money;

                           (b) all obligations of such Person evidenced by
                  bonds, debentures, notes or similar instruments;

                           (c) all obligations of such Person under conditional
                  sale or other title retention agreements relating to Property
                  purchased by such Person;
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                           (d) all obligations of such Person issued or assumed
                  as the deferred purchase price of Property or services
                  (excluding obligations of such Person to creditors for raw
                  materials, inventory, services and supplies and deferred
                  payment for services to employees and former employees
                  incurred in the ordinary course of such Person's business);

                           (e) all capital lease obligations;

                           (f) all obligations of others secured by any Lien on
                  Property or assets owned or acquired by such Person, whether
                  or not the obligations secured thereby have been assumed;

                           (g) all outstanding letters of credit, surety bonds
                  and currency swap or similar agreements issued for the account
                  of such Person; and

                           (h) all guarantees of such Person for obligations of
                  the type described above.

         "Business Day" means any day which is neither a Saturday nor a Sunday
         nor a legal holiday on which banks are authorized or required to be
         closed in Boston, Massachusetts, New York, New York or in any other
         city in which the Depositary's Office (as defined in the Depositary
         Agreement) is located.

         "Call Option" has the meaning set forth in the Depositary Agreement.

         "Capital Stock" means any and all shares, interests, participations or
         other equivalents of or interests in (however designated) equity of the
         Company, including any preferred stock, but excluding any debt
         securities convertible into such equity prior to such conversion.

         "Change in Control" of the Company means:

                           (a) the acquisition by any Person or "group" within
                  the meaning of Section 13(d)(3) or 14(d)(2) of the Exchange
                  Act (excluding, for this purpose, the Company or its
                  Subsidiaries, any employee benefit plan of the Company or its
                  Subsidiaries which acquires beneficial ownership of voting
                  securities of the Company, or the Lender or its Affiliates) of
                  beneficial ownership (within the meaning of Rule 13d-3
                  promulgated under the Exchange Act) of more than 50% of the
                  aggregate voting power of all classes of outstanding Voting
                  Capital Stock that are then outstanding or that are issuable
                  upon the conversion or exercise of convertible securities,
                  options, warrants or rights of the Company that are then
                  outstanding; provided that any voting securities acquired
                  directly from the Company by an underwriter of the Company as
                  part of an underwritten public offering of Capital Stock of
                  the Company shall not be deemed to be beneficially


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                  owned by such underwriter for purposes of determining whether
                  a Change in Control has occurred;

                           (b) Persons who, as of the Closing Date constitute
                  all of the Non- Alpharma Directors (the "Non-Alpharma
                  Incumbent Directors") cease for any reason to constitute at
                  least a majority of the Non-Alpharma Directors then in office,
                  provided that any Person becoming a director subsequent to the
                  Closing Date whose election, or nomination for election by the
                  Company's stockholders, was approved by a vote of at least a
                  majority of the Non-Alpharma Incumbent Directors shall be
                  considered as though such Person were one of the Non- Alpharma
                  Incumbent Directors as of the Closing Date, provided, however,
                  that there shall be excluded from this clause (b) any
                  individual whose initial assumption of office occurred as a
                  result of an actual or threatened election contest with
                  respect to the election or removal of directors or other
                  actual or threatened election contest with respect to the
                  election or removal of directors or other actual or threatened
                  solicitation of proxies or consents, by or on behalf of a
                  Person other than the Board of Directors;

                           (c) the consummation of a reorganization, merger or
                  consolidation involving the Company, if the stockholders of
                  the Company beneficially owning 100% of the aggregate voting
                  power of all classes of Voting Capital Stock that are then
                  outstanding or that are issuable upon conversion or exercise
                  of convertible securities, options, warrants or rights that
                  are then outstanding immediately prior to such reorganization,
                  merger, or consolidation do not, immediately thereafter,
                  beneficially own more than 50% of the aggregate voting power
                  of all classes of Voting Capital Stock that are then
                  outstanding or issuable upon conversion or exercise of
                  convertible securities, options, warrants or rights that are
                  then outstanding; or

                           (d) a liquidation or dissolution of the Company
                  (other than pursuant to the United States Bankruptcy Code) or
                  the conveyance, transfer or leasing of all or substantially
                  all of the assets of the Company to any Person.

         "Closing Date" has the meaning set forth in the Master Agreement.

         "Common Stock" means (i) prior to the Effective Time, the Old Common
         Stock, and (ii) at and after the Effective Time, the New Common Stock.

         "Company" means the party named as such above until a successor
         replaces it pursuant to the applicable provision hereof and thereafter
         means the successor to such party.

         "Company Intellectual Property" has the meaning set forth in Section
         3.11(a) of this Agreement.



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         "Conversion Date" has the meaning set forth in Section 9.3 of this
         Agreement.

         "Default" means any event which is, or after notice or passage of time
         or both would be, an Event of Default (as defined in Article VIII of
         this Agreement).

         "Depositary Agreement" means the Depositary Agreement dated as of the
         date hereof by and among the Company, the Lender and State Street Bank
         and Trust Company, as Depositary.

         "Depositary Share" has the meaning set forth in the Merger Agreement.

         "Derivative Securities" has the meaning set forth in Section 3.3(a) of
         this Agreement.

         "Effective Time" has the meaning set forth in the Merger Agreement.

         "Encumbrance" has the meaning set forth in Section 3.4(a) of this
         Agreement.

         "Event of Default" has the meaning set forth in Section 8.1 of this
         Agreement.

         "Exchange Act" means the Securities Exchange Act of 1934, as amended.

         "FDA" means the United States Food and Drug Administration.

         "Financial Statements" has the meaning set forth in Section 3.7(a) of
         this Agreement.

         "First Loan" has the meaning set forth in Section 2.3 of this
         Agreement.

         "First Loan Date" has the meaning set forth in Section 2.3 of this
         Agreement.

         "GAAP" means U.S. generally accepted accounting principles as in effect
         from time to time.

         "Historical Financial Statements" has the meaning set forth in Section
         3.7(a) of this Agreement.

         "Holder" means the Lender and any other Person to whom all or a portion
         of the Note is transferred in accordance with Article XI of this
         Agreement.

         "HSR Act" means the Hart Scott Rodino Antitrust Improvements Act of
         1976, as amended.

         "Impairment Event" means (i) the existence of a Negative Equity
         Position, provided, however, that notwithstanding the requirements of
         GAAP, any amounts outstanding under the 8% Subordinated Notes and any
         amounts outstanding under any debt securities issued



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         upon conversion or exchange of the Series G Preferred shall be
         considered to be equity for purposes of this clause only; (ii) the
         occurrence of an event which would make it reasonably probable that the
         Company's operating income as defined by GAAP for the 2001 fiscal year
         will be less than the amount set forth on Schedule I hereto; or (iii)
         the occurrence of an event described in Section 8.1(i) or (j) hereof.

         "Indebtedness" means and includes:

                           (a) all items which in accordance with GAAP would be
                  included on the liability side of a balance sheet on the date
                  as of which Indebtedness is to be determined (excluding
                  capital stock, surplus reserves and deferred credits);

                           (b) all guaranties, letter of credit, contingent
                  reimbursement obligations and other contingent obligations in
                  respect of, or any obligations to purchase or otherwise
                  acquire, indebtedness of others; and

                           (c) all indebtedness secured by any Lien existing on
                  any interest of the Person with respect to which indebtedness
                  is being determined in Property owned subject to such Lien
                  whether or not the indebtedness secured thereby shall been
                  assumed.

         "Intellectual Property" has the meaning set forth in Section 3.11(a) of
         this Agreement.

         "Investment" means the purchase or other acquisition of any
         Indebtedness of, or the making of any loan, advance or capital
         contribution to, or the incurring of any liability, contingent or
         otherwise, in respect of the Indebtedness of, any Person.

         "Lien" means any mortgage, pledge, charge, encumbrance, security
         interest, collateral assignment or other lien or restriction of any
         kind, whether based on common law, constitutional provision, statute or
         contract, and shall include reservations, exceptions, encroachments,
         easements, rights of way, covenants, conditions, restrictions and other
         title exceptions.

         "Loan" means any borrowing by the Company from the Lender of up to a
         maximum principal amount of $40,000,000 pursuant to Section 2.1 and the
         other terms and conditions of this Agreement.

         "Loan Date" has the meaning set forth in Section 2.3 of this Agreement.

         "Master Agreement" means the Master Agreement dated as of the date
         hereof by and between the Company and the Lender.

         "Material Adverse Effect" means, when used in connection with the
         Company, any development, change or effect that is materially adverse
         to the business, Properties


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         (including, without limitation, Intellectual Property), assets, net
         worth, financial condition, results of operations or future prospects
         (including, without limitation, future equity value) of the Company and
         its Subsidiaries taken as a whole.

         "May 1998 Securities Purchase Agreement" means the Series G Securities
         Purchase Agreement dated as of May 13, 1998 by and among the Company
         and the Purchasers named in Schedule I thereto.

         "Merger" means the merger of Merger Sub with and into the Company
         pursuant to the Merger Agreement.

         "Merger Agreement" means the Agreement and Plan of Merger dated as of
         the date hereof by and between the Company and Bird Merger Corporation,
         a Delaware corporation and wholly-owned subsidiary of the Company
         ("Merger Sub").

         "Merger Sub" has the meaning set forth in the definition of Merger
         Agreement.

         "Negative Equity Position" means the existence of a stockholders'
         deficit on the Company's balance sheet, determined in accordance with
         GAAP, as of the last day of any monthly fiscal period.

         "New Common Stock" has the meaning set forth in the Depositary
         Agreement.

         "Non-Alpharma Directors" has the meaning set forth in the Depositary
         Agreement.

         "Note" means the note to be issued by the Company to the Lender
         pursuant to Section 2.2(a) of this Agreement, substantially in the form
         attached hereto as Exhibit A, evidencing the maximum principal amount
         of the Loans; provided however, that in the event that the Lender
         exchanges all or a portion of the Note for one or more Notes in
         accordance with Section 2.2(c) of this Agreement or transfer all or a
         portion of the Note in accordance with Article XI, all references to
         the Note in this Agreement shall be deemed to include the Notes issued
         by the Company upon such exchange or transfer.

         "Note Conversion Shares" has the meaning set forth in Section 3.4(b) of
         this Agreement.

         "Notice of Borrowing" has the meaning set forth in Section 2.3 of this
         Agreement.

         "Officer" means the Chairman of the Board, the President, any Vice
         President, the Treasurer or the Secretary of the Company.

         "Old Common Stock" has the meaning set forth in the Depositary
         Agreement.

         "Option Determination Date" has the meaning set forth in the Depositary
         Agreement.



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         "Option Expiration Date" has the meaning set forth in the Depositary
         Agreement.

         "Permitted Investments" means:

                           (a) readily marketable securities issued or fully
                  guaranteed by the United States of America with maturities of
                  not more than one year;

                           (b) commercial paper rated "Prime 1" by Moody's
                  Investors Services, Inc. or "A-1" by Standard and Poor's
                  Rating Services with maturities of not more than 180 days;

                           (c) certificates of deposit or repurchase obligations
                  issued by any bank organized under the laws of the United
                  States of America or any state thereof having capital surplus
                  of at least $100,000,000 or by any other financial institution
                  acceptable to the Requisite Holders, all of the foregoing not
                  having a maturity of more than one year from the date of
                  issuance thereof; and

                           (d) other Investments not exceeding, in the
                  aggregate, $50,000 in any fiscal year.

         "Permitted Liens" means each of the following:

                           (a) artisans' or mechanics' Liens arising in the
                  ordinary course of business, and Liens for taxes, but only to
                  the extent that payment thereof shall not at the time be due
                  or if due, the payment thereof is being diligently contested
                  in good faith and adequate reserves computed in accordance
                  with GAAP have been set aside therefor;

                           (b) Liens in effect on the First Loan Date and
                  disclosed to the Lender in the Financial Statements, provided
                  that neither the Borrowed Money Indebtedness secured thereby
                  nor the Property covered thereby shall increase after the
                  First Loan Date without the prior written consent of the
                  Requisite Holders, provided that, for purposes of this clause
                  (b), the accrual of interest on such Borrowed Money
                  Indebtedness, so long as it is not converted to principal,
                  shall not be deemed to increase such Borrowed Money
                  Indebtedness;

                           (c) normal encumbrances and restrictions on title
                  which do not secure Borrowed Money Indebtedness and which do
                  not have a material adverse affect on the value or utility of
                  the applicable Property;

                           (d) Liens incurred or deposits made in the ordinary
                  course of business (i) in connection with workmen's
                  compensation, unemployment insurance, social security and
                  other like laws, or (ii) to secure insurance in the ordinary
                  course of business, the performance of bids, tenders,
                  contracts, leases, licenses, statutory


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                  obligations, surety, appeal and performance bonds and other
                  similar obligations incurred in the ordinary course of
                  business, but not, in any of the cases specified in this
                  clause (ii), incurred in connection with the borrowing of
                  money, the obtaining of advances or the payment of the
                  deferred purchase of Property;

                           (e) Liens in connection with or to secure Borrowed
                  Money Indebtedness permitted under Section 7.1(c);

                           (f) attachments, judgments and other similar Liens
                  arising in connection with the court proceedings, provided
                  that the execution and enforcement of such Liens are
                  effectively stayed and the claims secured thereby are being
                  actively contested in good faith with adequate reserve made
                  therefor in accordance with GAAP;

                           (g) Liens imposed by law, such as carriers',
                  warehousemen's, mechanics', materialmen's and vendors' liens
                  incurred in good faith in the ordinary course of business and
                  securing obligations which are not yet due or which are being
                  contested in good faith by appropriate proceedings if adequate
                  reserves with respect thereto are maintained in accordance
                  with GAAP;

                           (h) zoning restrictions, easements, licenses,
                  reservations, provisions, covenants, conditions, waivers, and
                  restrictions on the use of Property, and which do not in any
                  case singly or in the aggregate materially impair the present
                  use or value of Property subject to any such restriction or
                  materially interfere with the ordinary conduct of the business
                  of the Company and its Subsidiaries, if any;

                           (i) Liens securing purchase money Indebtedness
                  permitted under Section 7.1 hereof and covering only the
                  Property so purchased;

                           (j) capital leases and sale/leaseback transactions
                  permitted under the other provisions of this Agreement; and

                           (k) extensions, renewals and replacements of Liens
                  referred to in paragraphs (a) through (j) of this Section;
                  provided that any such extension, renewal or replacement Lien
                  shall be limited to the Property or assets (and, in the case
                  of clause (e), categories of Property or assets) covered by
                  the Lien extended, renewed or replaced and that the Borrowed
                  Money Indebtedness secured by any such extension, renewal or
                  replacement Lien shall be in an amount not greater than the
                  amount of the Indebtedness secured by the Lien extended,
                  renewed or replaced.

         "Person" means any individual, corporation, association, company,
         business trust, partnership, joint venture, joint-stock company,
         limited liability company, trust,


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         unincorporated organization or association or government or any agency
         or political subdivision thereof.

         "Project" means (i) the acquisition of all or a substantial part of the
         stock or assets of any Person engaged in the development, manufacture
         or sale of pharmaceuticals or other health care products principally
         for the pediatric market; (ii) the acquisition of a product or product
         line from, or the acquisition of the right to manufacture, distribute
         or sell any product or product line of any Person, in each case with
         applications in the pediatric pharmaceutical or pediatric health care
         market; or (iii) R&D Project.

         "Project Loans" has the meaning set forth in Section 2.1.

         "Property" means any interest in any kind of property or asset, whether
         real, personal or mixed, tangible or intangible.

         "R&D Project" means any project for the research and development of
         products or processes related to pediatric pharmaceuticals.

         "Registration Rights Agreement" means the Registration Rights Agreement
         between the Company and the Lender dated as of the date hereof.

         "Requisite Holders" means Holders of more than 50% of the aggregate
         principal amount of the Note outstanding at any time.

         "Screened Project" means a Project that meets the criteria set forth on
         Schedule II hereto.

         "Screened Project Loans" has the meaning set forth in Section 2.1.

         "Screened Project Indebtedness" means Borrowed Money Indebtedness
         (other than Loans under this Agreement) incurred for the purpose of
         funding a Screened Project.

         "SEC" means the United States Securities and Exchange Commission.

         "Second Amendment" means the Second Amendment to the May 1998
         Securities Purchase Agreement.

         "Securities" means the Note and the Note Conversion Shares.

         "Securities Act" means the Securities Act of 1933, as amended.

         "Series G Preferred" means the Series G Convertible Exchangeable
         Preferred Stock of the Company.



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         "Subordination Agreement" means the Subordination Agreement dated the
         date hereof by and among the Company, the Lender and the Original
         Lenders (as defined therein).

         "Subsidiary" of a Person means any corporation, association,
         partnership, joint venture or other business entity of which more than
         fifty percent (50%) of the voting stock or other equity interests (in
         the case of Persons other than corporations), is owned or controlled
         directly or indirectly by the Person, or one or more of the
         Subsidiaries of the Person, or a combination thereof.

         "Top-Off Notice" has the meaning set forth in Section 2.6 of this
         Agreement.

         The term "to the knowledge of" or derivatives thereof shall mean the
         actual knowledge of the Chief Executive Officer or the Vice President,
         Finance of the Company.

         "Type," when referring to a Loan, indicates whether such Loan is the
         First Loan, an Unrestricted Loan, a Project Loan or a Screened Project
         Loan.

         "Unrestricted Loans" means one or more Loans made on or after the
         Closing Date in an aggregate principal amount not to exceed $8,000,000.

         "Voting Capital Stock" means the Capital Stock entitled to vote
         generally in the election of directors.

         "1934 Act Filings" means the Annual Report on Form 10-K of the Company
         for the fiscal year ended December 31, 1997, the Quarterly Reports of
         the Company on Form 10-Q for each of the three months ended March 31,
         1998, June 30, 1998 and September 30, 1998 and any other reports or
         other documents filed by the Company with the SEC since December 31,
         1997 pursuant to the Exchange Act.

         "1998 Financial Statements" has the meaning set forth in Section 3.7(a)
         of this Agreement.

         "1999 Financial Statements" has the meaning set forth in Section 3.7(a)
         of this Agreement.

         "8% Subordinated Notes" means the Company's 8% Subordinated Notes in
         the aggregate principal amount of $9,000,000 issued pursuant to the May
         1998 Securities Purchase Agreement.

1.2      RULES OF CONSTRUCTION.

         Unless the context otherwise requires:

                  a.       a term has the meaning assigned to it;


                                       10
   15
                  b.       an accounting term not otherwise defined has the
                           meaning assigned to it in accordance with GAAP;

                  c.       "or" is not exclusive;

                  d.       words in the singular include the plural and in the
                           plural include the singular;

                  e.       provisions apply to successive events and
                           transactions; and

                  f.       "herein", "hereof" and other words of similar import
                           refer to this Agreement as a whole and not to any
                           particular Article, Section or other subdivision.


                                   ARTICLE II
                         AMOUNT AND TERMS OF SECURITIES

2.1      COMMITMENT TO LEND; LOANS. On the terms and subject to the conditions
         contained in this Agreement (including, without limitation, Section
         2.3(b) of this Agreement), the Lender agrees to make one or more Loans
         to the Company from time to time on any Business Day on or prior to
         December 31, 2001. Such Loans shall consist of (i) the First Loan, (ii)
         the Unrestricted Loans, (iii) Loans in addition to those referred to in
         clauses (i) and (ii) in the maximum principal amount of $8,000,000
         ("Project Loans") and (iv) Loans in addition to those referred to in
         clauses (i), (ii) and (iii) in the maximum principal amount of
         $20,000,000 ("Screened Project Loans"). The maximum principal amount of
         Loans outstanding at any time shall not exceed $4,000,000 prior to the
         Closing Date and $40,000,000 at any time thereafter. On the terms and
         subject to the conditions contained in this Agreement, on or prior to
         December 31, 2001 amounts repaid pursuant to the first sentence of
         Section 2.4(b) may be reborrowed by the Company and, if reborrowed, (A)
         shall be deemed to be a Loan of the same Type as the Loan that was
         repaid, if the aggregate amount of Loans made pursuant to this
         Agreement at the time of such reborrowing (whether or not repaid) is
         less than $20,000,000 and (B) shall be deemed to be a Screened Project
         Loan, in all other cases. The Lender shall (i) have no obligation to
         make more than one Loan in any one calendar month and (ii) have no
         obligation to make any Loans to the Company after December 31, 2001.

2.2      EVIDENCE OF DEBT.

         (a)      On the First Loan Date, Lender shall receive from the Company
                  the Note evidencing the maximum aggregate principal amount of
                  the Loans.

         (b)      There shall be attached to the Note, and maintained by the
                  Company, a register in which the Company shall, from time to
                  time, record (i) the date, amount and


                                       11
   16
                  Type of each Loan under the Note, (ii) the date and amount of
                  any interest payments due under the Note and (iii) the date
                  and amount of any principal and interest payments made by the
                  Company under the Note. The entries made in the register by
                  the Company shall be conclusive and binding for all purposes,
                  absent manifest error.

         (c)      At any time after the Option Expiration Date, the Lender may,
                  at its option, exchange the Note for one or more Notes of like
                  tenor, in such denominations as the Lender may determine,
                  payable to the order of the Lender evidencing in the aggregate
                  the principal amount of Loans outstanding on such date;
                  provided that the Lender may not transfer the Note or any
                  portion of the Note except in accordance with Article XI of
                  this Agreement.

2.3      MAKING OF LOANS.

         (a)      The Lender agrees to make each Loan upon receipt of a notice
                  of borrowing in the form of Exhibit B (a "Notice of
                  Borrowing") specifying the amount of the proposed Loan given
                  by the Company to the Lender not later than 10:00 am (New York
                  time) on the tenth Business Day prior to the date of the
                  proposed Loan, except with respect to the first Loan hereunder
                  which shall be in the principal amount of $4,000,000 (the
                  "First Loan") and which shall be made by the Lender to the
                  Company on the third Business Day after the date hereof (the
                  "First Loan Date") and shall be made without any requirement
                  that the Company deliver a Notice of Borrowing. Subject to the
                  terms and conditions of this Agreement, upon the date of a
                  proposed Loan (a "Loan Date"), the Lender shall make available
                  for the account of the Company in accordance with the bank
                  wire instructions contained in such Notice of Borrowing,
                  immediately available funds in the amount of the Loan. Each
                  Loan shall be in an aggregate amount of not less than
                  $1,000,000 or a multiple of $500,000 in excess thereof. Each
                  Notice of Borrowing shall be irrevocable and binding upon the
                  Company. The Company shall indemnify the Lender against any
                  loss, cost or expense including, without limitation, the cost
                  of Lender funds on its credit facilities, incurred by the
                  Lender if a proposed Loan requested in a Notice of Borrowing
                  (other than any Notice of Borrowing delivered pursuant to
                  Section 2.6) is not made by the Lender because the conditions
                  precedent to such Loan as set forth in Section 4.1, 4.2 or 4.3
                  of this Agreement were not satisfied or waived.

         (b)      Each Notice of Borrowing shall describe the proposed use of
                  proceeds, and shall provide sufficient information (including
                  a description of any Project, if applicable) to allow the
                  Lender to reasonably determine that the proceeds of the
                  requested Loan will be used as required by Section 6.6. The
                  Lender shall have the reasonable opportunity to review
                  information (including without limitation the Company's
                  financial projections) related to any Screened Project
                  proposed in a


                  
                                       12
   17
                  Notice of Borrowing and to discuss the proposed use of
                  proceeds with the Company.

2.4      INTEREST AND PRINCIPAL PAYMENTS.

         (a)      The Company shall pay interest on the unpaid principal amount
                  of each Loan from the date of the making thereof until the
                  principal amount thereof shall be paid in full at a rate of
                  7.5% per annum. Interest shall be due and payable by the
                  Company with respect to each Loan quarterly, in arrears on the
                  last Business Day of each calendar quarter. All amounts paid
                  shall first be applied to any accrued but unpaid interest. All
                  payments required to be made by the Company under this
                  Agreement shall be paid to the Lender to an account of the
                  Lender designated to the Company in writing.

         (b)      On or prior to June 30, 2001, the Company may repay all or a
                  portion of the outstanding principal amount of the Note in its
                  sole discretion (by approval of the Non-Alpharma Directors) on
                  no more than one occasion in each calendar quarter on the last
                  Business Day of such calendar quarter. Subject to the terms
                  and conditions of this Agreement, amounts so repaid may be
                  reborrowed pursuant to Section 2.1 on or prior to December 31,
                  2001. The Company shall repay the aggregate principal amount
                  of the Note outstanding as of December 31, 2001 in accordance
                  with the following schedule:


                                      % of Principal Amount of Note 
                  Date of Payment     Outstanding as of December 31, 2001
                  -------------------------------------------------------
                  March 30, 2004                               5%
                  June 30, 2004                                5%
                  September 30, 2004                           5%
                  December 31, 2004                            5%
                  March 30, 2005                               10%
                  June 30, 2005                                70%

                  provided that any then remaining principal and interest
                  outstanding with respect to the Note shall be paid in full on
                  June 30, 2005. Notwithstanding the foregoing, Loans made
                  pursuant to Section 2.6 may not be repaid by the Company.

         (c)      Notwithstanding the foregoing, if the Closing Date has not
                  occurred on or prior to September 30, 1999 (i) the Lender
                  shall have no further obligation to make Loans and (ii) all
                  unpaid principal and accrued interest on the Note shall be and
                  become immediately due and payable by the Company without any
                  declaration or other act on the part of any Holder.

         (d)      If any required payment of principal or interest is not paid
                  when due, whether at stated maturity, by acceleration or
                  otherwise, the interest rate applicable to the


                                       13
   18
                  amount of any such payment shall be the 7.5% per annum
                  provided above plus an additional 2% per annum, all payable on
                  demand.

2.5      MANDATORY PREPAYMENT UPON CHANGE IN CONTROL. The Company shall give all
         Holders notice of any Change in Control with respect to the Company
         within 10 days after the later of (i) the date of such Change in
         Control and (ii) the date on which the Company becomes aware of such
         Change in Control. Upon any such Change in Control, any Holder shall
         have the right at its option exercisable upon written notice to the
         Company within 15 days after the Holder receives notice of such Change
         in Control, (i) to convert all or a portion of the then outstanding
         principal of the Note into Common Stock (or such other security as may
         be provided under Section 9.4) pursuant to Article IX hereof, or (ii)
         to require the Company to repay all of the outstanding amounts
         principal and accrued and unpaid interest under the Note held by such
         Holder. Following a Change in Control with respect to the Company, the
         Lender shall have no further obligations to make Loans.

2.6      LENDER DISCRETIONARY BORROWING UNDER NOTE. So long as the Company has
         not exercised its right under Section 2.7 hereof, at any time after the
         close of business on December 31, 2002 and prior to the close of
         business on February 28, 2003, the Company shall, upon receipt of a
         written request from the Lender, deliver to the Lender a Notice of
         Borrowing (a "Top-Off Notice") requesting a Loan in an amount so that
         after giving effect to the Loan requested by such Notice of Borrowing
         the maximum principal amount of $40,000,000 is outstanding under the
         Note and the Lender shall make such Loan on the third Business Day
         following receipt of such Top-Off Notice. The Loan made pursuant to
         this Section is intended by the parties to provide for conversion of
         the maximum principal amount of the Note into Common Stock and may not
         be repaid by the Company. If a Loan is made pursuant to this Section,
         the Lender shall deliver a notice of conversion pursuant to Section 9.3
         with respect to the maximum principal amount of $40,000,000 within
         three Business Days of making such Loan. Notwithstanding Section 2.3(b)
         of this Agreement, any Top-Off Notice need not specify a Project for
         which the Company proposes to use the proceeds of the Loan being
         requested. Notwithstanding the foregoing, the Lender shall have no
         right to request a Top-Off Notice and no obligation to make a Loan
         pursuant to this Section if the Option Expiration Date has occurred due
         to the failure or refusal of Alpharma to make Loans, as set forth in
         the proviso to the definition of the term "Option Expiration Date" in
         the Depositary Agreement.

2.7      OPTIONAL PREPAYMENT. At any time beginning at the close of business on
         the Option Expiration Date and ending at the close of business on
         December 31, 2002, the Company may, at its option, upon five Business
         Days prior written notice to the Lender, prepay all, but not less than
         all, of the outstanding principal amount of the Note, together with any
         accrued and unpaid interest to the date of such prepayment. Concurrent
         with such prepayment, the Company shall pay to the Lender in cash a
         conversion termination fee equal to 25% of the principal amount of the
         Note outstanding as of the close of business on December 31, 2001.


                                       14
   19
                                   ARTICLE III
                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

The Company represents and warrants to the Lender as follows:

3.1      ORGANIZATION AND EXISTENCE, ETC. The Company (a) is duly incorporated,
         validly existing and in good standing under the laws of the State of
         Delaware, and has all requisite corporate power and authority to carry
         on its business as now conducted and as proposed to be conducted, and
         (b) is duly qualified to do business as a foreign corporation and is in
         good standing (or the equivalent thereof under applicable law) in each
         jurisdiction in which the conduct of its business requires such
         qualification by reason of the ownership or leasing of property or
         otherwise (except for those jurisdictions in which the failure so to
         qualify does not have a Material Adverse Effect).

3.2      SUBSIDIARIES. Other than Merger Sub, the Company has no Subsidiaries
         and owns no securities of other corporations or entities other than
         Permitted Investments.

3.3      CAPITALIZATION.

         (a)      As of the date hereof, (i) the Company's authorized capital
                  stock consists of: 60,000,000 shares of Common Stock, of which
                  7,026,445 shares are validly issued and outstanding, fully
                  paid and non-assessable, and 5,000,000 shares of "blank check"
                  preferred stock, $.01 par value per share, of which 7,000
                  shares have been designated Series G Convertible Exchangeable
                  Preferred Stock, all of which shares are validly issued and
                  outstanding, fully paid and non-assessable; and (ii) the
                  Company has outstanding the securities set forth on Schedule
                  3.3A which are convertible into or exercisable or exchangeable
                  for Common Stock (the "Derivative Securities").

         (b)      All the issued and outstanding shares of Capital Stock are
                  free of preemptive and similar rights and have been offered,
                  issued, sold and delivered by the Company in transactions in
                  compliance with the applicable federal, state and foreign
                  securities laws. Other than as set forth in Schedule 3.3A,
                  there are no outstanding agreements or commitments requiring
                  the Company to issue Capital Stock or Derivative Securities.

3.4      AUTHORIZATION; BINDING OBLIGATIONS.

         (a)      The Company has full power and authority to execute, deliver
                  and perform this Agreement, the Note, the Ancillary Agreements
                  and such other documents furnished or to be furnished by the
                  Company hereunder, subject to the approval by the stockholders
                  of the Company of the Merger Agreement and the transactions
                  contemplated thereby. This Agreement, the Note and the
                  Ancillary Agreements


                                       15
   20
                  have each been duly authorized, executed and delivered by the
                  Company, subject to the approval by the stockholders of the
                  Company of the Merger Agreement and the transactions
                  contemplated thereby, and each constitutes a legal, valid and
                  binding agreement of the Company, enforceable against the
                  Company in accordance with its terms, subject to bankruptcy,
                  insolvency, reorganization and other laws of general
                  applicability relating to or affecting creditors' rights and
                  to general principles of equity and subject to the approval by
                  the stockholders described above. Subject to the approval by
                  the stockholders of the Company of the Merger Agreement and
                  the transactions contemplated thereby, the issuance, offering
                  and sale of the Securities pursuant to this Agreement, the
                  compliance by the Company with the provisions of this
                  Agreement, the Securities and the Ancillary Agreements, and
                  the consummation of the other transactions contemplated hereby
                  or thereby will not result in the creation or imposition of
                  any lien, charge, security interest or encumbrance
                  (collectively "Encumbrance") upon any of the assets of the
                  Company pursuant to the terms or provisions of, or result in a
                  breach or violation of or conflict with any of the terms or
                  provisions of, or constitute a default under, or give any
                  other party a right to terminate any of its obligations under,
                  or result in the acceleration of any obligation under, (i) the
                  Certificate of Incorporation and Bylaws of the Company, (ii)
                  any contract or other agreement to which the Company is a
                  party or by which the Company or any of its respective
                  properties is bound, or (iii) any judgment, ruling, decree,
                  order, statute, rule or regulation of any court or other
                  governmental agency or body, domestic or foreign, applicable
                  to the business or properties of the Company, except, with
                  respect to clauses (ii) and (iii), in circumstances that would
                  not, individually or in the aggregate, reasonably be expected
                  to have a Material Adverse Effect.

         (b)      The Note has been duly authorized for issuance and, following
                  the issuance of the Note, the shares of Common Stock issuable
                  upon conversion of the Note (the "Note Conversion Shares")
                  will have been duly authorized and reserved for issuance. When
                  the Note has been duly executed and delivered by the Company
                  in accordance with this Agreement, (i) the Note will
                  constitute the valid and legally binding obligation of the
                  Company, enforceable against the Company in accordance with
                  its terms, subject to bankruptcy, insolvency, reorganization
                  and other laws of general applicability relating to or
                  affecting creditors' rights and to general principles of
                  equity, (ii) the principal amount outstanding under the Note
                  will be convertible into Note Conversion Shares in accordance
                  with the provisions of this Agreement and the Note, and (iii)
                  the Note Conversion Shares initially issuable upon such
                  conversion, when issued and delivered in accordance with the
                  provisions of this Agreement and the Note, will be validly
                  issued, fully paid and non-assessable.



                                       16
   21
3.5      COMPLIANCE WITH INSTRUMENTS, ETC. Except as set forth on Schedule 3.5
         hereto, the Company is not in breach or violation of, or in default
         under, any term or provision of (i) its Certificate of Incorporation
         and Bylaws, (ii) any indenture, mortgage, deed of trust, voting trust
         agreement, stockholders agreement, note agreement, debt instrument or
         other agreement or instrument to which it is a party or by which it is
         bound or to which any of its Property is subject, the effect of which
         breach, violation or default, individually or in the aggregate, would
         reasonably be expected to have a Material Adverse Effect, or (iii) any
         statute, judgment, decree, order, rule or regulation applicable to the
         Company or of any arbitrator, court, regulatory body, administrative
         agency or any other governmental agency or body, domestic or foreign,
         having jurisdiction over the Company or any of its respective
         activities or properties and the effect of which breach, violation or
         default, individually or in the aggregate, would reasonably be expected
         to have a Material Adverse Effect.

3.6      LITIGATION. Except as set forth on Schedule 3.6 hereto, there are no
         actions, suits, proceedings or investigations pending, or, to the
         knowledge of the Company, threatened, against the Company before or by
         any court, regulatory body or administrative agency or any other
         governmental agency or body, domestic or foreign, which would,
         individually or in the aggregate, reasonably be expected to have a
         Material Adverse Effect, or any actions, suits, proceedings or
         investigations pending, or, to the knowledge of the Company,
         threatened, which challenges the validity of any action taken or to be
         taken pursuant to or in connection with this Agreement or the issuance
         of the Note or the Note Conversion Shares, which would, individually or
         in the aggregate, reasonably be expected to have a Material Adverse
         Effect.

3.7      FINANCIAL STATEMENTS; TAXES.

         (a)      The Company has previously delivered to the Lender, true,
                  correct and complete copies of its financial statements for
                  the years ended December 31, 1995, 1996 and 1997 (the
                  "Historical Financial Statements") and for the nine months
                  ended September 30, 1998 (the "1998 Financial Statements").
                  The Company will deliver to the Lender true, correct and
                  complete copies of all financial statements filed with the SEC
                  from January 1, 1999 to the Closing Date (the "1999 Financial
                  Statements" and together with the Historical Financial
                  Statements and the 1998 Financial Statements, the "Financial
                  Statements"). The Financial Statements have been (and in the
                  case of 1999 Financial Statements will be) prepared in
                  accordance with GAAP (except for the absence of the footnotes
                  in any Financial Statements which do not cover a full fiscal
                  year) and fairly present (and in the case of the 1999
                  Financial Statements will present) in all material respects,
                  the financial position of the Company as of the respective
                  dates thereof and the results of operations and cash flows of
                  the Company for the periods then ended (subject to normal
                  year-end adjustments in the case of the 1998 Financial
                  Statements and in any other Financial Statements which do not
                  cover a full fiscal year). The Historical Financial Statements
                  have been (and the Company's financial statements


                                       17
   22
                  for the year ended December 31, 1998 will be) audited by
                  PricewaterhouseCoopers LLP who are independent public
                  accountants within the meaning of the Securities Act and they
                  have expressed (or in the case of the Company's financial
                  statements for the year ended December 31, 1998 will express)
                  an opinion thereon, which is unqualified with respect to the
                  Financial Statements for the years ended December 31, 1995 and
                  1996. As of the respective dates of the Financial Statements,
                  the Company had (and in the case of 1999 Financial Statements
                  will have) no material liabilities or obligations of any
                  nature (absolute, accrued, contingent or otherwise) whether or
                  not required by GAAP to be reflected on a balance sheet or
                  disclosed in the notes thereto except as were reflected on any
                  balance sheet or disclosed in any notes contained in the
                  Financial Statements.

         (b)      Except as set forth on Schedule 3.7B hereto, the Company has
                  filed or obtained extensions for all necessary income,
                  franchise and other material tax returns, domestic and
                  foreign, and has paid all taxes shown as due thereunder
                  (except in the case where the Company is contesting such
                  matter in good faith and except in such circumstances where
                  such failure would not reasonably be expected to have a
                  Material Adverse Effect), and the Company has no knowledge of
                  any tax deficiency which might be assessed against the Company
                  which would reasonably be expected to have a Material Adverse
                  Effect.

3.8      OFFERING. Subject to the Lender's representations and warranties in the
         Ancillary Agreements, the offer, sale and issuance of the Securities to
         the Lender as contemplated by this Agreement are not subject to the
         registration requirements of the Securities Act and neither the
         Company, nor anyone acting on its behalf, has taken or will take any
         action that would cause such registration requirements to be
         applicable.

3.9      PERMITS; GOVERNMENTAL AND OTHER APPROVALS. Except as set forth in
         Schedule 3.9 hereto, the Company has such licenses, permits, consents,
         orders, approvals and other authorizations necessary for the conduct of
         its business as now being conducted, except where the absence of such
         authorizations would not have a Material Adverse Effect and except with
         respect to the Company's products in development for which marketing
         and other approval from the FDA and similar regulatory authorities have
         not been obtained. No approval, consent, authorization or other order
         of, and no designation, filing, registration, qualification or
         recording with, any governmental authority, domestic or foreign, is
         required for the Company's performance of this Agreement or the
         consummation of the transactions contemplated hereby except for
         applicable filings with the Nasdaq Stock Market, the filing of Form D
         under the Securities Act, the filing of one or more Reports on Form 8-K
         under the Exchange Act, the filing of a Registration Statement on Form
         S-4 and a Registration Statement on Form 8-A in connection with the
         Merger, any filings required under the HSR Act and the filing of a
         Certificate of Merger and Certificate of Amendment to the Company's
         Certificate of Incorporation in connection with the Merger.


                                       18
   23
3.10     SALES REPRESENTATIVES, CUSTOMERS AND KEY EMPLOYEES. Except as set forth
         in Schedule 3.10A, to the knowledge of the Company, as of the date
         hereof, no independent sales representative or key employee or group of
         employees of, or party or Person providing services to, the Company has
         any intention to terminate his, her or its relationship with the
         Company or, in the case of employees, to leave the employ of the
         Company, which termination or departure would have a Material Adverse
         Effect. Except as set forth in Schedule 3.10B hereto, all personnel as
         of the date hereof are employed on an "at will" basis and may be
         terminated upon notice of not more than (30) days.

3.11     INTELLECTUAL PROPERTY.

         (a)      To the Company's knowledge, the Company has full and exclusive
                  right, title and interest in and to, or, to the extent set
                  forth on Schedule 3.11(a), license rights to, all (i) patents,
                  patent applications, registered or unregistered trademarks,
                  service marks, tradenames, and applications therefor,
                  registered or unregistered copyrights and applications
                  therefor, know-how, proprietary rights and processes, trade
                  secrets, customer lists, methodologies (to the extent
                  practicable), proprietary developments and marketing
                  information, (ii) know-how, inventions, inventors' notes (to
                  the extent such notes exist), drawings and designs associated
                  with the foregoing and (iii) other confidential information,
                  (all of the foregoing collectively, "Intellectual Property")
                  used in or necessary for the ongoing conduct of its business
                  and the development of the Pipeline Products ("Company
                  Intellectual Property"), free and clear of all Encumbrances of
                  any nature, except where the failure to have full and
                  exclusive right, title and interest in and to, or license
                  rights to, Intellectual Property would not reasonably be
                  expected to have a Material Adverse Effect; and except as set
                  forth on Schedule 3.11(a), the Company has no material
                  obligation to any other Person or entity with respect to
                  Company Intellectual Property or any developed or under
                  development product or process of the Company utilizing or
                  embodying any Company Intellectual Property. Schedule 3.11(a)
                  is a complete and accurate schedule of all patents, patent
                  applications, registered trademarks, service marks, tradenames
                  and applications therefor, registered copyrights and
                  applications therefor, and license agreements used in or
                  necessary for the ongoing conduct of Company's business.

         (b)      There is (i) to the Company's knowledge, no infringement,
                  misuse or misappropriation of any Intellectual Property owned,
                  licensed or controlled by any third party arising out of any
                  product or process (including without limitation any Pipeline
                  Product) now being used, manufactured, developed, under
                  development, or distributed, or ever having been used,
                  manufactured, developed, under development, or distributed at
                  any time previously, by or on behalf of the Company, except to
                  the extent such infringement, misuse or misappropriation would
                  not reasonably be expected to have a Material Adverse Effect,
                  (ii) no pending or, to the knowledge of the Company,
                  threatened claim or challenge of or proceeding for
                  infringement, misuse or misappropriation of or interference
                  with


                                       19
   24
                  any Intellectual Property owned, licensed or controlled by any
                  third party arising out of any product or process now being
                  used, manufactured, developed or distributed, or ever having
                  been used, manufactured, distributed or developed at any time
                  previously, by or on behalf of the Company, which would
                  reasonably be expected to have a Material Adverse Effect,
                  (iii) except as set forth in Schedule 3.11(b) hereto, no
                  pending or, to the knowledge of the Company, threatened claim,
                  challenge or proceeding by the Company against any third party
                  for infringement, misuse or misappropriation of or
                  interference with any Intellectual Property owned, licensed or
                  controlled by the Company or (iv) no notice from any another
                  party to the Company to the effect that, or, to the knowledge
                  of the Company, facts or information which, in the reasonable
                  opinion of the Company, would render any Company Intellectual
                  Property owned, invalid or unenforceable, nor, to the
                  knowledge of the Company, is there any allegation that any
                  such Company Intellectual Property is invalid or
                  unenforceable, except to the extent that the invalidity or
                  unenforceability of such Company Intellectual Property would
                  not reasonably be expected to have a Material Adverse Effect.

         (c)      Except as set forth in Schedule 3.11(c), the Company has not
                  disclosed any material confidential information developed or
                  utilized by the Company to any third party except on a
                  confidential basis and pursuant to a written confidentiality
                  agreement, nor, to the knowledge of the Company, has any third
                  party disclosed confidential information developed or utilized
                  by the Company to any Person in material breach of such
                  confidentiality agreement.

3.12     FORM 10-K AND 10-Q. The Annual Report on Form 10-K of the Company for
         the fiscal year ended December 31, 1997, the Quarterly Reports on Form
         10-Q for each of the three months ended March 31, 1998, June 30, 1998
         and September 30, 1998, and any reports filed with the SEC pursuant to
         the Exchange Act from the date hereof to the First Loan Date when filed
         by the Company, complied or will comply as to form in all material
         respects with the applicable requirements of the Exchange Act and did
         not or will not, as of the date of such filing, contain any untrue
         statement of a material fact or omit to state a material fact necessary
         in order to make the statements made therein, in the light of the
         circumstances under which they were made, not misleading.

3.13     REGULATORY STATUS. Schedule 3.13 sets forth a description of the
         development status of each of the Company's principal products not
         currently on the market as of the date hereof ("Pipeline Products"),
         including status with the FDA. The Company has made available to the
         Lender for its review all of its correspondence with the FDA related to
         the Pipeline Products and has had no oral communications with the FDA
         that are contrary to any such correspondence dated later than January
         1, 1998. With respect to any Pipeline Products not in commercial
         production, such description sets forth the remaining steps to be taken
         prior to commercial production and an estimate of the time required to
         reach commercial production. The Company makes no representation or
         warranty with respect to the estimated time to achieve such steps.


                                       20
   25
3.14     REGISTRATION RIGHTS. Except as provided for in this Agreement, the
         Ancillary Agreements, or in Schedule 3.14, the Company is not under any
         obligation to register under the Securities Act any of its currently
         outstanding securities or any of its securities which may hereunder be
         issued.

3.15     NO RELATIONSHIP BETWEEN PARTIES. The Company is not an owner of any
         shares of the stock or equity interest in the Lender. To the Company's
         knowledge, as of the date hereof no officer, director, or owner of more
         than 5% of the outstanding capital stock of the Company with which any
         officer or director of the Company is affiliated owns any shares of the
         capital stock of or equity interest in the Lender.

3.16     ORDINARY COURSE. Since September 30, 1998, the Company, except as set
         forth on Schedule 3.16 hereto, in the 1934 Act Filings or as explicitly
         contemplated by this Agreement, has conducted its business in the
         ordinary course, has not incurred any material obligation, absolute or
         contingent, or entered into any material transactions not in the
         ordinary course of business which, individually or in the aggregate,
         would reasonably be expected to have a Material Adverse Effect, and has
         not declared or paid any dividends or distributions on its Capital
         Stock or reacquired any shares of its Capital Stock.

3.17     NO FINDERS. The Company has not employed any broker or finder in
         connection with the transactions contemplated by this Agreement or the
         Ancillary Agreements.


                                   ARTICLE IV
                     CONDITIONS OF OBLIGATIONS OF THE LENDER

4.1      CONDITIONS TO LENDER'S OBLIGATIONS ON THE FIRST LOAN DATE. The
         obligation of the Lender to make the First Loan is subject to the
         fulfillment to its reasonable satisfaction, or the waiver by the
         Lender, on the First Loan Date of each of the following conditions:

         (a)      Representations and Warranties Correct. The representations
                  and warranties of the Company in Article III hereof shall be
                  (x) true and correct on and as of the date hereof and (y) true
                  and correct in all material respects on and as of the First
                  Loan Date with the same force and effect as if they had been
                  made on and as of the First Loan Date, except in the case of
                  clause (y) for (i) those representations and warranties which
                  address matters only as of a particular date (which shall be
                  true and correct as of such date), (ii) circumstances in which
                  the failure of such representations and warranties to be true
                  and correct would not, individually or in the aggregate,
                  reasonably be expected to have a Material Adverse Effect and
                  (iii) inaccuracies resulting from the failure to obtain
                  shareholder approval for the transactions contemplated by the
                  Ancillary Agreements.



                                       21
   26
         (b)      Compliance Certificate. The Company shall have delivered to
                  the Lender a certificate of the Company's President, dated the
                  First Loan Date, certifying to the fulfillment of the
                  conditions specified in subsections (a) and (e) of this
                  Section 4.1.

         (c)      No Impediments. No statute, judgment, order or decree of any
                  court, regulatory body, administrative agency or any other
                  governmental agency or body shall be in effect which would
                  impose any material limitation on the ability of the Lender to
                  exercise full rights of ownership of the Securities.

         (d)      No Defaults. The Company shall not be in default under any
                  indenture, mortgage, agreement, instrument or commitment
                  evidencing or under which there is at the time outstanding any
                  Indebtedness of the Company or any Subsidiary, in excess of
                  $200,000, or which results in such Indebtedness, in an
                  aggregate amount (with other defaulted Indebtedness) in excess
                  of $200,000 becoming due and payable prior to its due date.

         (e)      No Material Adverse Events. Except as set forth in the
                  schedules attached hereto pursuant to Article III hereof, as
                  disclosed in the 1934 Act Filings filed with the SEC prior to
                  the date hereof or as set forth in Schedule 4.1(e) hereto,
                  since September 30, 1998, there shall have been no Material
                  Adverse Effect with respect to the Company (other than the
                  continued incurrence of losses in the ordinary course of
                  business).

         (f)      Legal Investment. The purchase of the Note by the Lender
                  hereunder shall be legally permitted by all statutes, rules
                  and regulations to which the Lender and the Company are
                  subject.

         (g)      Qualifications. All authorizations, approvals or permits, if
                  any, of any governmental authority or regulatory body that are
                  now required in connection with the lawful issuance and sale
                  of the Note pursuant to this Agreement shall have been duly
                  obtained and shall be in full force and effect.

         (h)      Issuance Taxes. All taxes imposed by law in connection with
                  the initial issuance, sale and delivery of the Securities
                  shall have been fully paid by the Company, and all laws
                  imposing such taxes shall have been fully complied with at the
                  time of such issuance.

         (i)      Proceedings and Other Documents. All corporate and other
                  proceedings in connection with the transactions contemplated
                  by this Agreement and the Ancillary Agreements (other than
                  shareholder approval) shall have been taken, and the Lender
                  shall have received such other documents and instruments in
                  form and substance reasonably satisfactory to it and its
                  counsel, as to such other matters


                                       22
   27
                  incident to the transaction contemplated hereby as it may
                  reasonably request. The Ancillary Agreements shall be in full
                  force and effect.

         (j)      Opinion of Counsel. The Lender shall have received the opinion
                  of Hale and Dorr LLP, counsel for the Company, dated the First
                  Loan Date, substantially with respect to the matters set forth
                  on Exhibit C attached hereto.

         (k)      Consents, Waivers, Etc. The Company shall have obtained all
                  consents or waivers necessary to execute and deliver this
                  Agreement and the Ancillary Agreements, issue the Securities
                  and carry out the transactions contemplated hereby and
                  thereby, and all such consents and waivers shall be in full
                  force and effect except for shareholder approval.

         (l)      Delivery. The Company shall have delivered to the Lender (i)
                  the Note and (ii) the following:

                  (A)      A certified copy of the Company's certificate of
                           incorporation and all amendments thereto,
                           appropriately authenticated;

                  (B)      A copy of the Company's bylaws, as amended to date,
                           certified as being true by a principal Officer of the
                           Company; and

                  (C)      A certificate of good standing of the Company as a
                           foreign corporation certified as of a recent date by
                           the Secretary of State of the Commonwealth of
                           Massachusetts, and from every jurisdiction in which
                           the Company is qualified to do business.

4.2      CONDITIONS TO LENDER'S OBLIGATIONS TO MAKE THE FIRST UNRESTRICTED LOAN.
         The obligation of the Lender to make the first Unrestricted Loan is
         subject to the fulfillment to its reasonable satisfaction, or the
         waiver by the Lender, on or prior to the Closing Date of each of the
         following conditions:

         (a)      Representations and Warranties Correct. The representations
                  and warranties of the Company in Article III hereof shall be
                  (x) true and correct on and as of the date hereof and (y) true
                  and correct in all material respects on and as of the Closing
                  Date with the same force and effect as if they had been made
                  on and as of the Closing Date, except in the case of clause
                  (y) for (i) those representations and warranties which address
                  matters only as of a particular date (which shall be true and
                  correct as of such date) and (ii) circumstances in which the
                  failure of such representations and warranties to be true and
                  correct would not, individually or in the aggregate,
                  reasonably be expected to have a Material Adverse Effect.

         (b)      Performance. All covenants, agreements and conditions
                  contained in this Agreement to be performed or complied with
                  on or prior to the Closing Date by


                                       23
   28
                  the Company shall have been performed or complied with by the
                  Company in all material respects on or prior to the Closing
                  Date.

         (c)      Conditions in Section 4.1. The conditions set forth in Section
                  4.1 remain fulfilled or waived by the Lender on or prior to
                  the Closing Date, provided that any exceptions therein for
                  shareholder approval shall not be given effect.

         (d)      Proceedings and Other Documents. All corporate and other
                  proceedings in connection with the transactions contemplated
                  by this Agreement and the Ancillary Agreements shall have been
                  taken, and the Lender shall have received such other documents
                  and instruments in form and substance reasonably satisfactory
                  to it and its counsel, as to such other matters incident to
                  the transaction contemplated hereby as it may reasonably
                  request. The Ancillary Agreements shall be in full force and
                  effect. The Merger shall have occurred as contemplated by the
                  Merger Agreement and the other transactions required by the
                  Ancillary Agreements (including the satisfaction or waiver of
                  the conditions set forth in Section 5.1, 5.2 and 5.3 of the
                  Master Agreement) to have occurred at or prior to the
                  Effective Time shall have occurred. The Second Amendment shall
                  be in full force and effect. The Second Amendment Closing Date
                  (as defined in the Second Amendment) shall have occurred and
                  all the other transactions required by the Second Amendment to
                  have occurred at or prior to the Second Amendment Closing Date
                  shall have occurred.

         (e)      No Defaults. No event has occurred and is continuing or would
                  result from the first Unrestricted Loan being made on such
                  date, which constitutes a Default or an Event of Default.

         (f)      Use of Proceeds. The Lender shall be reasonably satisfied that
                  the proceeds of the Loan being made will be used as set forth
                  in Section 6.6.

4.3      CONDITIONS PRECEDENT TO EACH LOAN. The obligation of the Lender to make
         any Loan other than the First Loan or the first Unrestricted Loan is
         subject to the fulfillment to its reasonable satisfaction, or the
         waiver by the Lender, on or prior to the applicable Loan Date of each
         of the following conditions:

         (a)      The conditions set forth in subsections (c), (d), (f) and (g)
                  of Section 4.1 remain fulfilled or waived by Lender.

         (b)      No event has occurred and is continuing, or would result from
                  the Loan being made on such date, which constitutes a Default
                  or an Event of Default.

         (c)      No Impairment Event has occurred and is continuing since
                  September 30, 1998.



                                       24
   29
         (d)      The Lender shall be reasonably satisfied that the proceeds of
                  the Loan being made will be used as set forth in Section 6.6.

4.4      COOPERATION. The Lender shall take all reasonable steps and use all
         reasonable efforts necessary or desirable, and shall cooperate with the
         Company to enable it, to obtain, as promptly as practicable, all
         approvals, authorizations, certificates, consents and clearances
         required to consummate the transactions contemplated hereby and satisfy
         the conditions set forth in Sections 4.1, 4.2 and 4.3.


                                    ARTICLE V
                    CONDITIONS OF OBLIGATIONS OF THE COMPANY

5.1      COMPANY'S OBLIGATION. The Company's obligations under this Agreement
         are subject to the fulfillment to its reasonable satisfaction, or the
         waiver by the Company, on or prior to the First Loan Date of each of
         the following conditions:

         (a)      Performance. All covenants, agreements and conditions
                  contained in this Agreement to be performed or complied with
                  on or prior to the First Loan Date by the Lender shall have
                  been performed or complied with in all respects on or prior to
                  the First Loan Date.

         (b)      Compliance Certificate. The Lender shall have delivered to the
                  Company a certificate of an Officer of the Lender, dated the
                  First Loan Date, certifying to the fulfillment of the
                  condition specified in subsection (a) of this Section 5.1.

5.2      COOPERATION. The Company shall take all reasonable steps and use all
         reasonable efforts necessary or desirable, and shall cooperate with the
         Lender to enable it, to obtain, as promptly as practicable, all
         approvals, authorizations, certificates, consents and clearances
         required to consummate the transactions contemplated hereby and satisfy
         the conditions set forth in Section 5.1.


                                   ARTICLE VI
                      AFFIRMATIVE COVENANTS OF THE COMPANY

         Subject to Section 6.10 hereof, the Company hereby covenants and
agrees:

6.1      REPORTS.

         The Company will deliver to each Holder the following:

         (a)      within thirty (30) days after the end of each of the twelve
                  (12) monthly accounting periods in each fiscal year (or when
                  furnished to the Board of Directors, if


                                       25
   30
                  earlier), unaudited consolidated statements of income and
                  retained earnings and cash flows of the Company and its
                  Subsidiaries, if any, for each monthly period and for the
                  period from the beginning of such fiscal year to the end of
                  such monthly period, together with consolidated balance sheets
                  of the Company and its Subsidiaries, if any, as at the end of
                  each monthly period, setting forth in each case comparisons to
                  budget and to corresponding periods in the preceding fiscal
                  year which statements will be prepared in accordance with
                  GAAP, consistently applied subject to the absence of footnotes
                  and year-end adjustments;

         (b)      within ninety (90) days after the end of each fiscal year,
                  consolidated statements of income and retained earnings and
                  cash flow of the Company and its Subsidiaries, if any, for the
                  period from the beginning of each fiscal year to the end of
                  such fiscal year, and consolidated balance sheets as at the
                  end of such fiscal year, setting forth in each case in
                  comparative form corresponding figures for the preceding
                  fiscal year, which statements will be prepared in accordance
                  with GAAP, consistently applied (except as approved by the
                  accounting firm examining such statements and disclosed by the
                  Company) and will be accompanied by a report on the
                  consolidated statements of a public accounting firm reasonably
                  acceptable to the Requisite Holders or one of the public
                  accounting firms currently known as the "Big Five" (either, an
                  "Approved Accounting Firm");

         (c)      within ten (10) days after transmission thereof, copies of all
                  financial statements, proxy statements, reports and other
                  communications which the Company sends to its stockholders,
                  copies of all registration statements and all regular, special
                  or periodic reports which it files with the SEC or with any
                  securities exchange on which any of the securities of the
                  Company are then listed or proposed to be listed, and copies
                  of all press releases made generally available by the Company
                  to the public concerning material developments in the business
                  of the Company and its Subsidiaries, if any; and

         (d)      promptly after the occurrence thereof (but in any event within
                  seven (7) days after such occurrence is known to the Company)
                  notice of any condition or event which constitutes, or the
                  occurrence of (i) an event which would lead the Company to
                  believe that the Company is not in compliance in material
                  respects with the covenants in this Agreement or (ii) the
                  institution or threatened institution of an action, suit or
                  proceeding against the Company or any of its Subsidiaries by
                  or before any court, regulatory authority, administrative
                  agency or any other governmental agency or body, domestic or
                  foreign, which, if adversely decided, could have a Material
                  Adverse Effect.

         (e)      at least thirty (30) days prior to the end of each fiscal
                  year, a detailed annual operating budget and business plan for
                  the Company and its subsidiaries, if any, for such fiscal
                  year. Such budgets shall be prepared on a monthly basis,
                  displaying consolidated statements of anticipated income and
                  retained earnings,


                                       26
   31
                  consolidated statements of anticipated cash flow and projected
                  consolidated balance sheets, setting forth in each case the
                  assumption (which assumptions and projections shall represent
                  and be based upon the good faith best judgment in respect
                  thereof of the Chief Executive Officer of the Company) behind
                  the projections contained in such financial statements, and
                  which budgets shall have been approved by the Board of
                  Directors of the Company or prior to the beginning of each
                  twelve-month period to which they pertain and, promptly upon
                  preparation thereof, any other budgets that the Company may
                  prepare and any revisions of such annual or other budgets.


6.2      ACCOUNTS AND RECORDS. The Company shall keep true records and books of
         account in which entries will be made of all dealings or transactions
         in relation to the business and affairs of the Company and its
         Subsidiaries, if any, in accordance with GAAP, to the extent
         applicable, applied on a consistent basis.

6.3      INSPECTION. For so long as the Lender has not transferred any portion
         of the Note, the Company shall permit the Lender or any of its
         officers, employees, representatives or such other Person as the Lender
         may designate, during regular business hours of the Company, upon
         reasonable prior notice, to visit and inspect the offices and
         properties of the Company and to (i) review and make extracts or copies
         of the books, accounts and records of the Company, and (ii) discuss the
         affairs, finances and accounts of the Company, with the Company's
         Officers, members of the Board of Directors, Approved Accounting Firm,
         consultants and attorneys.

6.4      INDEPENDENT ACCOUNTANTS. The Company will retain an Approved Accounting
         Firm to audit the Company's financial statements at the end of each
         fiscal year. In the event the services of the Approved Accounting Firm
         shall be terminated, the Company shall promptly thereafter seek to
         engage another Approved Accounting Firm.

6.5      BOARD MEMBERS AND MEETINGS. From and after the Closing Date and prior
         to the Option Expiration Date,

         (a)      The Company's Board of Directors may not consist of more than
                  eleven or less than seven directors without the consent of the
                  Requisite Holders. The Company agrees to hold meetings of its
                  Board of Directors at least four times a year, at least once
                  per calendar quarter. The Lender shall have the right to have
                  one (1) nominee included on the Board of Directors' slate of
                  nominees to stand for election to the Board of Directors. The
                  director of the Company designated by the Lender pursuant to
                  this Section 6.5(a) shall be referred to hereinafter as the
                  "Alpharma Director".

         (b)      If at any time the Board of Directors designates a committee
                  or committees to act on behalf of the Board, (other than any
                  special committee or committees of Non- 


                                       27
   32
                  Alpharma Directors constituted for the purpose of making any
                  determination that is to be made by such committee under the
                  terms of this Agreement or any Ancillary Agreement or that
                  otherwise relates to any matter with respect to which the
                  Company and the Lender have a potential conflict of interest,
                  if counsel to the Company advises the Board of Directors that
                  the exclusion of the Alpharma Director from such committee is
                  appropriate given such potential conflict of interest) the
                  Alpharma Director shall be given an option to be a member of
                  such committee or committees. Prior to the Closing Date, the
                  Alpharma Director shall have been appointed to the
                  Compensation Committee and the Audit Committee of the
                  Company's Board of Directors.

         (c)      No more than three (3) of the members of the Company's Board
                  of Directors shall be employed, or otherwise be compensated
                  (other than normal director's compensation (i.e., meeting
                  fees, expense reimbursements and stock options), by the
                  Company.

         (d)      The Company shall pay fees to the Alpharma Director in an
                  amount not less than the fees paid to any other director of
                  the Company who is not an executive officer of the Company,
                  and shall reimburse such Alpharma Director for his or her
                  reasonable expenses incurred in attending each Board or
                  committee meeting or otherwise serving as a director.

6.6      USE OF PROCEEDS. The Company shall use all the proceeds received from
         the First Loan and the Unrestricted Loans for (a) general corporate
         purposes, including capital expenditures and working capital, (b) the
         payment of legal fees and disbursements, accounting fees, investment
         banking fees, SEC filing fees and other fees and expenses incurred in
         connection with the transactions contemplated by this Agreement and the
         Ancillary Agreements, and (c) any Projects. The Company shall use all
         of the proceeds of Project Loans (other than Loans made pursuant to
         Section 2.6 hereof) only for Projects and the payment of fees and
         expenses related thereto. The Company shall use all the proceeds
         received from Screened Project Loans (other than any Loans made
         pursuant to Section 2.6 hereof) for Screened Projects and the payment
         of fees and expenses related thereto. Pending the Company's use of the
         proceeds as set forth herein, the Company shall invest all Loan
         proceeds in Permitted Investments consisting exclusively of such
         proceeds.

6.7      INSURANCE. The Company shall keep in force with responsible insurers,
         policies of insurance providing coverage, limits and deductibles
         customary in the Company's industry.

6.8      RESEARCH AND DEVELOPMENT. The Company shall not incur expenses of, or
         make commitments with respect to, more than an aggregate of $7,500,000
         in the 2001 fiscal year in R&D Projects.



                                       28
   33
6.9      FURTHER ASSURANCES. From time to time the Company shall execute and
         deliver to Lender such other instruments, certificates, agreements and
         documents and take such other action and do all other things as may be
         reasonably requested by Lender in order to implement or effectuate the
         terms and provisions of this Agreement.

6.10     TERMINATION. The covenants and agreements of the Company set forth in
         this Article VI (other than Section 6.9) shall terminate and be of no
         further force or effect at such time as no principal or interest on the
         Note is outstanding or payable (whether as a result of the payment of
         all outstanding principal and accrued interest on the Note or the
         conversion of the Note) and no amounts may be borrowed pursuant to this
         Agreement.


                                   ARTICLE VII
                               NEGATIVE COVENANTS

         Subject to Section 7.14 hereof, the Company hereby covenants and agrees
that it will not, will not agree to and will not suffer or permit any Subsidiary
of the Company to, do any of the following without the consent of the Requisite
Holders:

7.1      BORROWED MONEY INDEBTEDNESS. Create, incur, suffer or permit to exist,
         or assume or guarantee, or become or remain liable with respect to any
         Borrowed Money Indebtedness, except the following:

         (a)      the Note;

         (b)      the Borrowed Money Indebtedness existing on the date of this
                  Agreement and disclosed in the Financial Statements, and all
                  renewals, extensions and replacements (but not increases) of
                  any of the foregoing, provided that the accrual of interest on
                  such liabilities, so long as it is not converted to principal,
                  shall not be deemed to increase such liabilities;

         (c)      principal of up to $50,000,000 of Borrowed Money Indebtedness
                  in the aggregate outstanding at any time (which (i) prior to
                  or on the Option Expiration Date must consist solely of
                  Screened Project Indebtedness and (ii) thereafter, may include
                  up to $10,000,000 of Borrowed Money Indebtedness that is not
                  Screened Project Indebtedness), plus any accrued interest
                  thereon; provided, that all such Screened Project Indebtedness
                  outstanding on the Option Exercise Date must be repayable at
                  the option of the Company in full with aggregate penalties not
                  in excess of $1,000,000 in connection with the Lender's
                  purchase of the Common Stock pursuant to its exercise of the
                  Call Option;

         (d)      purchase money Indebtedness permitted by Section 7.10 to the
                  extent liens securing the same are allowed by the other
                  provisions of this Agreement;



                                       29
   34
         (e)      capitalized lease obligations to the extent leases with
                  respect thereto are allowed by the other provisions of this
                  Agreement;

         (f)      the convertible notes issuable pursuant to the May 1998
                  Securities Purchase Agreement;

         (g)      on or prior to the Option Expiration Date, any Screened
                  Project Indebtedness that is convertible directly or
                  indirectly into Common Stock provided that (i) the aggregate
                  annual interest expense (including, without limitation the
                  full effect of both cash and non-cash accrued interest) with
                  respect to such Indebtedness shall not exceed $1,500,000; (ii)
                  such Indebtedness by its terms is automatically converted into
                  Common Stock on or prior to the Option Closing Date; and (iii)
                  such Indebtedness may not be repaid by the Company prior to
                  the Option Closing Date; and

         (h)      after the Option Expiration Date, any Borrowed Money
                  Indebtedness that is convertible directly or indirectly into
                  Common Stock.

7.2      LIENS. Create or suffer to exist any Lien upon any of its Property now
         owned or hereafter acquired, or acquire any Property upon any
         conditional sale or other title retention device or arrangement or any
         purchase money security agreement; provided, however, that the Company
         any Subsidiaries of the Company may create or suffer to exist Permitted
         Liens.

7.3      CONTINGENT LIABILITIES. Directly or indirectly guarantee the
         performance or payment or, or purchase or agree to purchase, or assume
         or contingently agree to become or be secondarily liable in respect of,
         any obligation or liability of any other Person except for:

         (a)      the endorsement of checks or other negotiable instruments in
                  the ordinary course of business;

         (b)      obligations disclosed to Lender in the Financial Statements
                  (but not increases of such obligations after the First Loan
                  Date, provided that the accrual of interest on such
                  obligations, so long as it is not converted to principal,
                  shall not be deemed to increase such obligations);

         (c)      obligations in respect of employees which shall not exceed an
                  aggregate amount equal to $200,000 at any time outstanding;
                  and

         (d)      those liabilities permitted under Section 7.1 hereof.

7.4      MERGERS, CONSOLIDATIONS AND DISPOSITIONS AND ACQUISITIONS OF ASSETS. In
         any single transaction or series of related transactions, directly or
         indirectly:



                                       30
   35
         (a)      liquidate or dissolve;

         (b)      be a party to any merger or consolidation unless (i) no
                  Default or Event of Default has occurred that is then
                  continuing; (ii) immediately thereafter and giving effect
                  thereto, no event will occur and be continuing which
                  constitutes a Default; (iii) the Company, or the Subsidiary,
                  if any, is the surviving Person; and (iv) the Holders are
                  given at least twenty (20) days prior notice of such merger or
                  consolidation or such lesser number of days as is practicable;

         (c)      sell, convey or lease all or substantially all of its assets,
                  except for the sale of property in the ordinary course of
                  business;

         (d)      acquire all or a substantial portion of the assets or stock of
                  any person whether by merger or otherwise other than in a
                  transaction or series of transactions that constitute a
                  Screened Project, provided that this subsection shall not
                  prevent any Project funded with the proceeds of the First
                  Loan, any Unrestricted Loan or Project Loans; or

         (e)      pledge, transfer or otherwise dispose of any equity interest
                  in any of its Subsidiaries, if any exist, or issue or permit
                  any of its Subsidiaries, if any exist, to issue any additional
                  equity interests except to the Company or another of its
                  Subsidiaries. Nothing in this Agreement shall prohibit the
                  Company from selling obsolete equipment or from replacing used
                  equipment in the ordinary course of business.

7.5      REDEMPTION, DIVIDENDS AND DISTRIBUTIONS. At any time, except as
         contemplated by this Agreement and the terms of the Note, by the
         Ancillary Agreements and by the Series G Preferred: (a) redeem, retire
         or otherwise acquire, directly or indirectly, any equity interest of
         the Company or any of its Subsidiaries (other than $250,000 in any
         fiscal year to be used to effectuate the repurchase of restricted stock
         issued to employees, directors or consultants of the Company pursuant
         to a restricted stock agreement) or (b) make any distributions of any
         property or cash in respect of any of its Capital Stock.

7.6      NATURE OF BUSINESS. Change the nature of its business or enter into any
         business which is substantially different from the development,
         manufacture and sale of pharmaceuticals principally for the pediatric
         market.

7.7      TRANSACTIONS WITH RELATED PARTIES. Enter into any transaction or
         agreement with any Officer, director or beneficial owner of five
         percent (5%) or more of the outstanding Capital Stock in the Company or
         any of its Subsidiaries (or any Affiliate of any such Person) unless
         the transaction is upon no less favorable terms than those that are
         obtainable from wholly unrelated sources. The provisions of this
         Section 7.7 shall not apply to (a) fees and compensation (including
         options and equity compensation) paid to or indemnity provided on
         behalf of Officers, directors, employees or consultants of the


                                       31
   36
         Company and any of its Subsidiaries, as determined by the Board of
         Directors of the Company or any of such Subsidiaries or the Chief
         Executive Officer thereof in good faith and (b) transactions
         exclusively between or among the Company's Subsidiaries, provided such
         transactions are not otherwise prohibited by this Agreement.
         Notwithstanding the prior two sentences, the Company may not pay
         management or consulting fees to such related parties in excess of an
         aggregate of $50,000 per year.

7.8      LOANS AND INVESTMENTS. Make any loan, advance, extension of credit or
         capital contribution to, or make or have any Investment in, any Person,
         or make any commitment to make any such extension of credit or
         investment, except (a) Permitted Investments, (b) normal and reasonable
         advances in the ordinary course of business to Officers and employees
         and (c) capital contributions or Investments used to fund a Project
         permitted by Section 6.6, provided in the case of clause (c) that the
         making of such capital contribution or Investment does not cause a
         Default under any other provision hereof.

7.9      ORGANIZATIONAL DOCUMENTS. Amend, modify, restate or supplement its
         Certificate of Incorporation or Bylaws if such action could reasonably
         be expected to adversely affect the rights of the Lender under this
         Agreement or any Ancillary Agreement.

7.10     LEASE EXPENSES; PURCHASE MONEY INDEBTEDNESS. Permit aggregate operating
         lease expenses (excluding lease payments under capital leases), for the
         Company and its Subsidiaries in the aggregate in any fiscal year, to
         exceed $500,000. Incur or create new capital lease obligations or
         purchase money Indebtedness in any fiscal year in excess of $200,000 in
         the aggregate for the Company and its Subsidiaries. Permit aggregate
         capital lease obligations and purchase money Indebtedness outstanding
         at any one time to exceed $2,000,000 in the aggregate for the Company
         and its Subsidiaries.

7.11     SALE/LEASEBACKS. Enter into any sale/leaseback transactions except as
         permitted under the provisions of Section 7.10.

7.12     ISSUANCE OF STOCK. On or prior to the Option Expiration Date, issue, or
         become obligated to issue shares of Capital Stock or securities
         convertible into Capital Stock, except for (i) shares of Common Stock,
         (ii) rights, warrants or options to purchase shares of Common Stock
         granted prior to March 31, 2002 and rights, warrants or options to
         purchase up to 100,000 shares of Common Stock on or after March 31,
         2002 (such number to be adjusted for stock splits or
         reclassifications), (iii) securities evidencing Screened Project
         Indebtedness permitted by Section 7.1(g). On or prior to the Option
         Expiration Date, use the proceeds of any issuances of securities (other
         than pursuant to the exercise of options granted to officers,
         directors, consultants, employees and advisors and other than the First
         Loan, the Unrestricted Loans and the Project Loans) to fund Screened
         Projects and the payment of fees and expenses related thereto. Prior to
         the Option Expiration Date, establish a "Shareholders Rights Plan" or
         "Poison Pill" or issue any securities in connection therewith.



                                       32
   37
7.13     SUBSIDIARIES. Form, create or acquire any Subsidiary other than Merger
         Sub or permit any Person other than the Company or a wholly owned
         Subsidiary to hold an equity interest in any Subsidiary.

7.14     TERMINATION. The covenants and agreements of the Company set forth in
         this Article VII shall terminate and be of no further force or effect
         at such time as no principal or interest on the Note is outstanding or
         payable (whether a result of the payment of all outstanding principal
         and accrued interest on the Note or the conversion of the Note) and no
         amounts may be borrowed pursuant to this Agreement.


                                  ARTICLE VIII
                              DEFAULTS AND REMEDIES

8.1 EVENTS OF DEFAULT. An "Event of Default" occurs if:

         (a)      the Company defaults in the payment of interest on the Note
                  when the same becomes due and payable and such default
                  continues for a period of 5 Business Days;

         (b)      the Company defaults in the payment of the principal of the
                  Note when the same becomes due and payable at maturity, upon
                  acceleration or otherwise;

         (c)      the Company defaults in the performance of any covenants under
                  Article VII of this Agreement;

         (d)      the Company fails to comply with any of the provisions of this
                  Agreement (other than Article VII) and such failure continues
                  for 20 Business Days after notice from the Requisite Holders;

         (e)      the Company defaults in payment on Borrowed Money Indebtedness
                  (giving effect to any applicable grace periods and any
                  extensions thereof) of at least $700,000 principal amount;

         (f)      there has been an acceleration of the final stated maturity of
                  any Borrowed Money Indebtedness of the Company (which
                  acceleration shall not have been cured, waived, rescinded or
                  annulled for 10 Business Days) if the aggregate principal
                  amount of such Borrowed Money Indebtedness, together with the
                  principal amount of any other such Borrowed Money Indebtedness
                  in default for failure to pay principal at maturity or which
                  has been accelerated, aggregates $700,000 or more at any time;

         (g)      any representation or warranty of the Company under this
                  Agreement shall prove to have been incorrect in any material
                  respect when made;


                                       33
   38
         (h)      there exists an outstanding unsatisfied final judgment which,
                  either alone or together with other outstanding unsatisfied
                  final judgments against the Company, exceeds an aggregate of
                  $200,000 (to the extent not covered by insurance) and such
                  judgment shall have continued undischarged or unstayed for 20
                  Business Days after entry thereof;

         (i)      the Company pursuant to or within the meaning of any
                  Bankruptcy Law:

                  (i)      commenced a voluntary case,

                  (ii)     consents to the entry of an order for relief against
                           it in an involuntary case,

                  (iii)    consents to the appointment of a custodian of it or
                           for all or substantially all of its property, or

                  (iv)     makes a general assignment for the benefit of its
                           creditors; or

         (j)      a court of competent jurisdiction enters an order or decree
                  under any Bankruptcy Law that:

                  (i)      is for relief against the Company in an involuntary
                           case,

                  (ii)     appoints a custodian of the Company for all or
                           substantially all of its property, or

                  (iii)    orders the liquidation of the Company, and the order
                           or decree remains unstayed and in effect for 90
                           consecutive days.

8.2      ACCELERATION. If an Event of Default occurs and is continuing, the
         Requisite Holders by notice to the Company, may declare the principal
         of and any accrued interest on the Note to be due and payable. Upon
         such declaration such principal and interest shall be due and payable
         immediately. If an Event of Default specified in Section 8.1(i) or (j)
         occurs, all unpaid principal and accrued interest on the Note then
         outstanding shall ipso facto become and be immediately due and payable
         without any declaration or other act on the part of any Holder.

8.3      OTHER REMEDIES. Notwithstanding any other provision of this Agreement,
         if an Event of Default occurs and is continuing, any Holder may pursue
         any available remedy by proceeding at law or in equity to collect the
         principal of or interest then due on the Note held by such Holder.
         Without limiting the foregoing, the Company, the Parent and the Lender
         acknowledge and agree that the respective remedies of the Company, the
         Parent, the Lender and any other Holder at law for a breach or
         threatened breach of any of the provisions of this Agreement or the
         Subordination Agreement would be inadequate and, in recognition of that
         fact, agree that, in the event of a breach or threatened breach by the


                                       34
   39
         Company, the Parent, the Lender or any Holder of any of the provisions
         of this Agreement, or the Subordination Agreement, in addition to any
         remedies specified herein, at law or otherwise, any party hereto and
         any Holder, without posting any bond shall be entitled to seek
         equitable relief in the form of specific performance, a temporary
         restraining order, a temporary or permanent injunction or any other
         equitable remedy which may then be available, provided that no Holder
         shall be entitled to specific performance of the provisions of Section
         6.5 hereof.

         A delay or omission by any Holder in exercising any right or remedy
         accruing upon an Event of Default shall not impair the right or remedy
         or constitute a waiver of or acquiescence in the Event of Default. All
         remedies are cumulative.

8.4      WAIVER OF PAST DEFAULTS. Any past Default or Event of Default and its
         consequences may be waived in accordance with Section 12.2. When a
         Default or an Event of Default is waived, it is cured and ceases.


                                   ARTICLE IX
                                   CONVERSION

9.1      RIGHT OF CONVERSION. A Holder may convert all or a portion of the then
         outstanding principal of the Note into Common Stock of the Company (i)
         on one occasion on or after any Change in Control with respect to the
         Company in accordance with Section 2.5 and (ii) at any time after the
         close of business on December 31, 2002.

9.2      CONVERSION PRICE. The conversion price per share of Common Stock for
         the Note shall be $7.125 per share. The number of shares of Common
         Stock issuable upon conversion of the Note shall be determined by
         dividing the dollar amount of the outstanding principal of the Note to
         be converted, by $7.125. Except as set forth in Section 9.4, no payment
         or adjustment to the conversion price shall be made with respect to
         dividends or other distributions declared on shares of Common Stock
         prior to the Conversion Date. The Company will pay the Lender in cash
         any accrued and unpaid interest with respect to the principal amount of
         the Note being converted on the Conversion Date. No fractional shares
         of Common Stock shall be issuable upon conversion of the Note, but a
         payment in cash will be made in respect of any fraction of a share
         which would otherwise be issuable upon such conversion. Such payment
         shall be based on the fair market value of the Common Stock at the time
         of conversion of the Note, as determined in good faith by the Board of
         Directors.

9.3      EXERCISE OF CONVERSION RIGHT. A Holder may exercise the conversion
         right set forth in this Article IX by giving written notice to the
         Company at the time or times specified in Section 9.1, which notice
         shall be accompanied by the Note being surrendered for cancellation and
         shall state the portion of the principal amount of the Note being
         converted. As promptly as practicable after receipt of the Holder's
         notice of conversion


                                       35
   40
         and the Note being surrendered, the Company shall deliver or cause to
         be delivered at its principal executive office to the Holder a
         certificate or certificates for the number of full shares issuable upon
         the conversion of the Note, or portion thereof, in accordance with the
         provisions hereof. Such conversion shall be deemed to have been made at
         the time the Note was surrendered for conversion and the notice
         specified above shall have been received by the Company at its
         principal executive office (the "Conversion Date"), and the Holder upon
         such conversion shall be deemed to have become on the Conversion Date
         the holder of record of the shares represented thereby. If less than
         the entire outstanding principal amount of the Note is being converted,
         a new Note shall promptly be delivered to the Holder for the
         unconverted principal balance and shall be of like tenor as to all
         terms as the Note surrendered. Upon the Conversion Date, the Note or
         the portion of the Note being converted shall be deemed to be retired
         and canceled.

9.4      PROVISIONS IN CASE OF MERGER, ETC. In the case of any reorganization or
         reclassification of the outstanding shares of Common Stock (other than
         a change in par value, or from par value to no par value) or as a
         result of a subdivision, combination or stock split or in the case of
         any consolidation of the Company into, or the merger of the Company
         with another entity in which the Company is not the surviving entity
         (or it is the surviving entity, but its shares of Common Stock become
         shares of another entity), or in the case of a sale, lease or
         conveyance of all or substantially all of the assets of the Company as
         an entity, a Holder shall thereafter have the right to convert the Note
         held by such Holder into the kind and amount of securities, cash or
         other property that would have otherwise been receivable by such Holder
         upon such reorganization, reclassification, consolidation, merger or
         disposition if such Holder had converted the Note into shares of Common
         Stock immediately prior to such reorganization, reclassification,
         consolidation, merger or disposition. Notwithstanding the foregoing,
         nothing in this Section shall alter or affect any covenant in this
         Agreement which would limit or prevent the Company from entering into
         any transaction described in this Section.

9.5      TAXES ON CONVERSION. If a Holder converts the Note, the Company shall
         pay any documentary, stamp or similar issue or transfer tax due on the
         issue of shares of Common Stock upon such conversion.

9.6      COMPANY TO PROVIDE STOCK. The Company shall reserve out of its
         authorized but unissued Common Stock or its Common Stock held in
         treasury enough shares of Common Stock to permit the conversion of the
         maximum principal amount of the Note.

         All shares of Common Stock which may be issued upon conversion of the
         Note in accordance with the terms hereof shall be validly issued, fully
         paid and non-assessable.

         The Company will endeavor to comply with all securities laws regulating
         the offer and delivery of shares of Common Stock upon conversion of the
         Note and will endeavor to list or qualify such shares for trading on
         each national securities exchange or market on which the Common Stock
         is then listed or traded.


                                       36
   41
9.7      REQUIRED ANTITRUST APPROVAL. Notwithstanding anything in this Article
         IX to the contrary, the Note may not be converted at any time if such
         conversion and the issuance of shares of Common Stock upon such
         conversion require governmental approval under applicable antitrust
         laws, including without limitation the HSR Act, until such approval is
         obtained. If such approval is required and a Holder wishes to convert
         all or a portion of the Note, the Company shall at the request of such
         Holder:

         (a)      take all actions necessary to make the filings required of the
                  Holder or the Company under the HSR Act, relating to the
                  possible conversion of the Note, which filings shall comply in
                  all respects with the requirements of the HSR Act;

         (b)      comply at the earliest practicable date with any formal or
                  informal request for additional information received by the
                  Holder or the Company from the Federal Trade Commission or
                  Antitrust Division of the Department of Justice pursuant to
                  the HSR Act;

         (c)      consult and cooperate with the Holder and consider in good
                  faith the views of the Holder, in connection with any
                  analyses, appearances, presentations, memoranda, briefs,
                  arguments, opinions and proposals made or submitted by or on
                  behalf of any party in connection with proceedings under or
                  relating to the required approvals;

         (d)      request early termination of the applicable waiting period
                  under the HSR Act; and

         (e)      take any and all other commercially reasonable actions in
                  order to obtain the approval of the governmental entity with
                  the jurisdiction of enforcing applicable antitrust laws,
                  including without limitation complying with the HSR Act and
                  obtaining termination or expiration of the applicable waiting
                  period under the HSR Act.


                                    ARTICLE X
                                  SUBORDINATION

10.1     AGREEMENT TO SUBORDINATE. The Company shall perform and comply with the
         covenants and other obligations for the benefit of the Lender set forth
         in the Subordination Agreement, which covenants and other obligations
         are incorporated by reference herein, as if such covenants and other
         obligations were included herein.



                                       37
   42
                                   ARTICLE XI
                            RESTRICTIONS ON TRANSFER

11.1     SECURITIES LAWS RESTRICTIONS ON TRANSFER. Neither the Note or the Note
         Conversion Shares shall be sold or transferred unless either (a) they
         first shall have been registered under the Securities Act or (b) the
         Company shall have been furnished with an opinion of legal counsel,
         reasonably satisfactory to the Company, to the effect that such a
         transfer is exempt from the registration requirements of the Securities
         Act.

11.2     RESTRICTIVE LEGEND. Each Note or certificate representing Note
         Conversion Shares and any other securities issued in respect of such
         securities shall be stamped or otherwise imprinted with a legend in the
         following form (in addition to any legend required under applicable
         state securities laws):

         "THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE UNITED STATES
         SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR ANY STATE SECURITIES
         LAWS AND MAY NOT BE TRANSFERRED, SOLD OR OFFERED FOR SALE EXCEPT
         PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT AS TO THE SECURITIES
         UNDER THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS OR AN OPINION OF
         COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION
         IS NOT REQUIRED."

         The foregoing legend may be removed after the second anniversary of the
         later of (a) the issue date of the Conversion Shares and (b) the last
         date upon which the Company or any Affiliate of the Company was the
         owner of such Security (or such shorter period of time as permitted by
         Rule 144(k) under the Securities Act or any successor provision).

11.3     REGISTRATION RIGHTS AGREEMENT. The rights and obligations of the
         Company and the Lender with respect to Securities Act registration are
         set forth in the Registration Rights Agreement.

11.4     ADDITIONAL RESTRICTIONS.

         (a)      Notwithstanding the foregoing, none of this Agreement, the
                  Note or the rights and obligations hereunder and thereunder
                  may be transferred by the Lender on or prior to the Option
                  Expiration Date except in the event of a Change in Control.
                  Following the Option Expiration Date or such Change in
                  Control, this Agreement, the Note and the rights and
                  obligations hereunder and thereunder may be transferred or
                  assigned by a Holder to an affiliate of such Holder, to
                  another Holder, if any, or to any Person acquiring a Note
                  having a principal amount equal to at least 25% of the
                  aggregate principal amount of the Note or Notes then
                  outstanding; provided, however, that the transferee provides
                  written notice of such assignment to the Company stating its
                  name and address and the principal amount


                                       38
   43
                  of the Note with respect to which such rights are being
                  assigned; and provided further, that the Company receives the
                  written instrument provided in subparagraph (b) below. Any
                  transferee to whom a transfer is made in accordance with the
                  immediately preceding sentence shall be deemed a Holder for
                  purposes of this Agreement.

         (b)      Any transferee (other than a Holder) to whom rights hereunder
                  are transferred shall, as a condition to such transfer,
                  deliver to the Company a written instrument by which such
                  transferee agrees to be bound by the obligations imposed upon
                  Holders under this Agreement to the same extent as if such
                  transferee were a party hereto, including without limitation
                  the obligations imposed upon Holders pursuant to Section 13.8.

         (c)      A transferee to whom such rights are transferred pursuant to
                  this Section 11.4 may not again transfer such rights to any
                  other Person, other than as provided in this Section 11.4.


                                   ARTICLE XII
                        AMENDMENT, SUPPLEMENT AND WAIVER

12.1     WITH CONSENT OF HOLDERS OF THE NOTE. Except as provided below in this
         Section 12.1, no provision of this Agreement or the Note may be
         amended, supplemented or waived without the consent of the Requisite
         Holders voting as a single class (including consents obtained in
         connection with a tender offer or exchange offer for, or purchase of,
         the Note) and the Company, and no existing Default or Event of Default
         (other than a Default or Event of Default in the payment of the
         principal of, premium, if any, or interest on the Note, other than a
         payment default resulting from an acceleration that has been rescinded)
         and no compliance with any provision of this Agreement or the Note may
         be waived without the consent of the Requisite Holders voting as a
         single class (including consents obtained in connection with a tender
         offer or exchange offer for, or purchase, of the Note). Except as
         provided below in this Section 12.1, without the consent of the Holders
         holding at least 75% in principal amount of the Note then outstanding
         (including consents obtained in connection with a tender offer or
         exchange offer for, or purchase of, such Note) and the Company, no
         provisions of Article II hereof may be amended, supplemented or waived
         in a manner that adversely affects the rights of any Holder.

         It shall not be necessary for the consent of the Holders of the Note
         under this Section 12.1 to approve the particular form of any proposed
         amendment, supplement or waiver, but it shall be sufficient if such
         consent approves the substance thereof.

         After an amendment, supplement or waiver under this Section becomes
         effective, the Company shall mail to the Holders of the Note a notice
         briefly describing the amendment, supplement or waiver. Any failure of
         the Company to mail such notice, or any defect


                                       39
   44
         therein, shall not, however, in any way impair or affect the validity
         of any such amendment, supplement or waiver. Notwithstanding the
         foregoing, without the consent of each Holder affected, an amendment,
         supplement or waiver under this Section 12.1 may not (with respect to
         the Note held by a non-consenting Holder):

         (a)      reduce the principal amount of the Note;

         (b)      reduce the principal of or change the fixed maturity of the
                  Note or alter or waive any of the provisions with respect to
                  the conversion of the Note;

         (c)      reduce the rate of or change the time for payment of interest,
                  including default interest, on the Note;

         (d)      waive a Default or Event of Default in the payment of
                  principal of or premium, if any, or interest on the Note
                  (except a rescission of acceleration of the Note by the
                  Requisite Holders and a waiver of the payment default that
                  resulted from such acceleration);

         (e)      make any Note payable in money other than that stated in the
                  Note;

         (f)      make any change in the provisions of this Agreement relating
                  to waivers of past Defaults or the rights of the Holders of
                  the Note to receive payments of principal of or interest on
                  the Note; or

         (g)      make any changes in the foregoing amendment and waiver
                  provisions.


                                  ARTICLE XIII
                                  MISCELLANEOUS

13.1     NOTICES. All notices, requests, demands, claims, and other
         communications to any party hereunder or pursuant to the terms hereof
         shall be in writing. Any such notice, request, demand, claim, or other
         communication to any party hereunder shall be deemed duly delivered
         three Business Days after it is sent by registered or certified mail,
         return receipt requested, postage prepaid, or one Business Day after it
         is sent via a reputable nationwide overnight courier service, in each
         case to the intended recipient as set forth below:

         if to the Lender, to:

                  Alpharma, Inc.
                  One Executive Drive
                  Fort Lee, New Jersey  07024
                  Attention:  President



                                       40
   45
         with a copy to:

                  Alpharma, Inc.
                  One Executive Drive
                  Fort Lee, New Jersey  07024
                  Attention:  Chief Legal Officer

If to the Company, to:

                  Ascent Pediatrics, Inc.
                  187 Ballardvale Street, Suite B125
                  Wilmington, Massachusetts  01887
                  Attention:  Alan R. Fox

         with a copy to:

                  Hale and Dorr LLP
                  60 State Street
                  Boston, Massachusetts  02109
                  Attention: David E. Redlick, Esq.

         If to a Holder other than the Lender, to the address provided to the
Company pursuant to Section 11.4.

Any party may give any such notice, request, demand, claim, or other
communication using any other means (including personal delivery, expedited
courier, messenger service, telecopy, telex, ordinary mail, or electronic mail),
but no such notice, request, demand, claim, or other communication shall be
deemed to have been duly given unless and until it actually is received by the
party for whom it is intended. Any party may change the address to which
notices, requests, demands, claims, and other communications hereunder are to be
delivered by giving the other parties notice in the manner herein set forth.

13.2     DUPLICATE ORIGINALS. The parties may sign any number of copies of this
         Agreement. Each signed copy shall be an original, but all of them
         together represent the same agreement.

13.3     GOVERNING LAW. The laws of the State of New York, without regard to
         principles of conflicts of law, shall govern this Agreement and the
         Securities.

13.4     NO ADVERSE INTERPRETATION OF OTHER AGREEMENTS. This Agreement may not
         be used to interpret another indenture, loan or debt agreement of the
         Company or a subsidiary. Any such indenture, loan or debt agreement may
         not be used to interpret this Agreement.



                                       41
   46
13.5     SUCCESSORS AND ASSIGNS. All agreements of the Company in this Agreement
         and the Securities shall bind its successors and assigns. All
         agreements of the Lender in this Agreement shall bind its successors
         and assigns.

13.6     SEPARABILITY. In case any provision in this Agreement or in the
         Securities shall be invalid, illegal or unenforceable, the validity,
         legality and enforceability of the remaining provisions shall not in
         any way be affected or impaired thereby.

13.7     HEADINGS, ETC. The Headings of the Articles and Sections of this
         Agreement have been inserted for convenience of reference only, are not
         to be considered a part hereof and shall in no way modify or restrict
         any of the terms or provisions hereof.

13.8     CONFIDENTIALITY. The Lender and each other Holder agree that he, she or
         it will keep confidential and will not disclose, divulge or use for any
         purpose other than to monitor his, her or its investment in the Company
         any confidential, proprietary or secret information which such Holder
         may obtain from the Company pursuant to financial statements, reports
         and other materials submitted by the Company to such Holder pursuant to
         this Agreement, or pursuant to visitation or inspection rights granted
         hereunder, unless such information is known, or until such information
         becomes known, to the public (other than as a result of a breach of
         this Section 13.8 by such Holder); provided, however that a Holder may
         disclose such information if required by law, provided that the Holder
         provides prior written notice to the Company of such proposed
         disclosure and takes reasonable steps to avoid and/or minimize the
         extent of any such required disclosure. The Lender and each other
         Holder further acknowledge and agree that certain of the confidential,
         proprietary or secret information which it may obtain hereunder may be
         material non-public information and that neither it nor any of its
         Affiliates shall engage in any acquisition, disposition or other
         similar transaction involving the Company's securities on the basis of,
         or at such time as such Holder possesses, such material non-public
         information.

13.9     PARENT GUARANTEE. The Parent agrees to enter into a guaranty agreement
         with the Company with respect to all obligations of the Lender,
         monetary or otherwise, under this Agreement.
   47
IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement as of
the day and year first above set forth.


                              ASCENT PEDIATRICS, INC.



                              By:      /s/ Emmett Clemente           
                                       ------------------------
                                       Name: Emmett Clemente
                                       Title: Chairman


                              ALPHARMA USPD, INC.



                              By:      /s/ Thomas L. Anderson               
                                       ------------------------
                                       Name: Thomas L. Anderson
                                       Title: President


                              ALPHARMA INC.



                              By:      /s/ Jeffrey E. Smith                     
                                       ------------------------
                                       Name: Jeffrey E. Smith
                                       Title: Vice President Finance and
                                                Chief Financial Officer



                                       43
   48
                                                                       EXHIBIT A

                                      NOTE


                                                       Wilmington, Massachusetts
                                                               February 19, 1999

up to $40,000,000

         FOR VALUE RECEIVED, the undersigned, ASCENT PEDIATRICS, INC., a
Delaware corporation (the "Company"), HEREBY PROMISES TO PAY to the order of
ALPHARMA USPD INC., a Maryland corporation (the "Lender") in lawful money of the
United States of America in immediately available funds, the amount of
$40,000,000 or, if less, the aggregate unpaid amount of all Loans made to the
undersigned under the "Loan Agreement" (as hereinafter defined). Schedule A
attached hereto and incorporated herein by reference records (i) the date,
amount and Type of each Loan hereunder, (ii) the date and amount of any interest
payments due hereunder and (iii) the date and amount of any principal and
interest payments made by the Company hereunder; provided, however, that any
failure to endorse such information on such schedule or continuation thereof
shall not in any manner affect the obligation of the Company to make payments of
principal and interest in accordance with the terms of this Note. All
capitalized terms used but not otherwise defined herein have the meanings given
to them in the Loan Agreement.

         This Note is issued pursuant to that certain Loan Agreement dated as of
February 16, 1999 by and between the Company, the Lender and Alpharma Inc., a
Delaware corporation (including all annexes, exhibits and schedules thereto and
as amended, modified, restated or supplemented from time to time (the "Loan
Agreement")), and is entitled to the benefit and security of the Loan Agreement.
Reference is hereby made to the Loan Agreement for a statement of all of the
terms and conditions under which the Loans evidenced hereby are made and are to
be repaid.

         1. Interest and Principal Payments. The principal amount of the
indebtedness evidenced hereby shall be payable in the amounts and on the dates
specified in the Loan Agreement, the terms of which are hereby incorporated
herein by reference. Interest thereon shall be paid until such principal amount
is paid in full at such interest rates and at such times, and pursuant to such
calculations, as are specified in the Loan Agreement.

         2.  Default and Remedies. Subject to the requirements of Section 8.2 of
the Loan Agreement, upon and after the occurrence of any Event of Default, this
Note may, as provided in the Loan Agreement, be declared, and immediately shall
become, due and payable.

         3. Conversion. A Holder has the right to convert this Note under the
circumstances and at a Conversion Price as provided in the Loan Agreement. A
Holder may exercise the conversion right by following the procedures set forth
in the Loan Agreement.

         4. Subordination. This Note is subordinated in right of payment, in the
manner and to the extent set forth in the Subordination Agreement dated as
of February 16, 1999 among the


                                       A-1
   49
Company, the Lender and the Original Lenders named therein (the "Subordination
Agreement"), to the prior payment in full of the Senior Indebtedness in
accordance with the terms set forth in the Loan Agreement.

         5. Legends.

                   "THIS NOTE AND THE SECURITIES ISSUED UPON CONVERSION OF THIS
                  NOTE HAVE NOT BEEN REGISTERED UNDER THE UNITED STATES
                  SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR ANY STATE
                  SECURITIES LAWS AND MAY NOT BE TRANSFERRED, SOLD OR OFFERED
                  FOR SALE EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
                  STATEMENT AS TO THIS NOTE AND THE SECURITIES ISSUED UPON
                  CONVERSION OF THIS NOTE UNDER THE ACT AND ANY APPLICABLE STATE
                  SECURITIES LAWS OR AN OPINION OF COUNSEL REASONABLY
                  SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT
                  REQUIRED."

                  The foregoing legend may be removed after the second
         anniversary of the later of (a) the issue date of the Conversion Shares
         and (b) the last date upon which the Company or any Affiliate of the
         Company was the owner of such Security (or such shorter period of time
         as permitted by Rule 144(k) under the Securities Act or any successor
         provision).

                  "THIS INSTRUMENT IS SUBJECT TO THE TERMS OF A SUBORDINATION
                  AGREEMENT DATED AS OF FEBRUARY 16, 1999, AMONG ASCENT
                  PEDIATRICS, INC., ALPHARMA USPD, INC. AND THE ORIGINAL LENDERS
                  NAMED THEREIN, WHICH AGREEMENT IS INCORPORATED HEREIN BY
                  REFERENCE. NOTWITHSTANDING ANY STATEMENT TO THE CONTRARY
                  CONTAINED IN THIS INSTRUMENT, NO PAYMENT OF ANY NATURE ON
                  ACCOUNT OF THE OBLIGATIONS HEREUNDER, WHETHER PRINCIPAL OR
                  INTEREST, SHALL BE MADE, PAID, RECEIVED OR ACCEPTED EXCEPT IN
                  ACCORDANCE WITH THE EXPRESS TERMS OF SUCH AGREEMENT."

                  The foregoing legend may be removed upon termination of the
         Subordination Agreement.

                  "THIS INSTRUMENT HAS BEEN ISSUED WITH ORIGINAL ISSUE DISCOUNT,
                  AS SUCH TERM IS DEFINED IN SECTION 1271 ET SEQ. OF THE
                  INTERNAL REVENUE CODE OF 1986, AS AMENDED. FROM AND AFTER THE
                  CLOSING DATE (AS DEFINED IN THE LOAN AGREEMENT DATED AS OF
                  FEBRUARY 16, 1999 BY AND BETWEEN ASCENT PEDIATRICS, INC.,
                  ALPHARMA USPD INC. AND ALPHARMA, INC.) UPON INQUIRY MADE BY
                  ANY HOLDER HEREOF, ADDRESSED TO ASCENT PEDIATRICS, INC. AT 187
                  BALLARDVALE STREET, SUITE B125, WILMINGTON, MASSACHUSETTS,
                  ATTENTION: ALAN R. FOX, ASCENT PEDIATRICS, INC. WILL PROVIDE A
                  STATEMENT SETTING


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   50
                  FORTH THE ISSUE PRICE, THE AMOUNT OF ORIGINAL ISSUE DISCOUNT,
                  THE ISSUE DATE AND THE YIELD TO MATURITY WITH RESPECT TO THE
                  INSTRUMENT HELD BY SUCH HOLDER."

         6. Registration Rights. The rights and obligations of the Company and
the Lender with respect to Securities Act registration are set forth in the
Registration Rights Agreement.

         7.  Additional Restrictions.

                  (a) None of this Note or the rights and obligations hereunder
may be transferred by the Lender on or prior to the Option Expiration Date
except in the event of a Change in Control. Following the Option Expiration Date
or such Change in Control, this Note and the rights and obligations hereunder
may be transferred or assigned by a Holder to an affiliate of such Holder, to
another Holder, if any, or to any Person acquiring a Note having a principal
amount equal to at least 25% of the aggregate principal amount of the Note or
Notes then outstanding; provided, however, that the transferee provides written
notice of such assignment to the Company stating its name and address and the
principal amount of the Note with respect to which such rights are being
assigned; and provided further, that the Company receives the written instrument
provided in subparagraph (b) below. Any transferee to whom a transfer is made in
accordance with the immediately preceding sentence shall be deemed a Holder of
the Loan Agreement.

                  (b) Any transferee (other than a Holder) to whom rights
hereunder are transferred shall, as a condition to such transfer, deliver to the
Company a written instrument by which such transferee agrees to be bound by the
obligations imposed upon Holders under the Loan Agreement to the same extent as
if such transferee were a party hereto, including without limitation the
obligations imposed upon Holders pursuant to the Loan Agreement.

                  (c) A transferee to whom such rights are transferred pursuant
to the Loan Agreement may not again transfer such rights to any other Person,
other than as provided in the Loan Agreement.

         8.      Governing Law.  THIS NOTE SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK APPLICABLE TO
CONTRACTS MADE AND PERFORMED IN THAT STATE.


                                                  ASCENT PEDIATRICS, INC.



                                                  By: 
                                                    -------------------------
                                                  Title:                  
                                                    -------------------------



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   51
                                             SCHEDULE A TO THE NOTE OF
                                              ASCENT PEDIATRICS, INC.
                                              DATED FEBRUARY 19, 1999





                                                                                            Unpaid             Name of
                        Type                                       Payments                 Principal          Person
                         of             Interest                                            Balance            Making
     Date               Loan             Period       Principal                             of Note           Notation
     ----               ----             ------       ---------                             -------           --------
                                                      Interest
                                                      --------
                                                                                            







                                      A-4
   52
                                                                       EXHIBIT B


                           FORM OF NOTICE OF BORROWING

         Reference is made to that certain Loan Agreement dated as February 16,
1999 by and among Ascent Pediatrics, Inc. (the "Company"), Alpharma USPD Inc.
(the "Lender") and Alpharma Inc. (including all annexes, exhibits and schedules
thereto, and as from time to time amended, restated, supplemented or otherwise
modified, the "Loan Agreement"). Capitalized terms used herein without
definition are so used as defined in the Loan Agreement.

         The Company hereby gives irrevocable notice, pursuant to Section 2.3(a)
of the Loan Agreement, that it requests a Loan under the Loan Agreement and in
that connection sets forth below the terms on which such Loan is requested to be
made:

(A)   Date of Borrowing
      (which is a Business Day)______________________________________________ 



(B)   Principal Amount of Loan(1)____________________________________________ 



(C)   Funds are requested to be disbursed to the Company's account with______

                                 Account No._________________________________



(D)   Project Information and Use of Proceeds:







- --------

(1) Not less than $1,000,000 or a multiple of $500,000 in excess thereof.


                                       B-1
   53
         The Company shall indemnify the Lender against any loss, cost or
expense including, without limitation, the cost of Lender funds on its credit
facilities, incurred by the Lender as a result of the Loan requested in this
Notice of Borrowing (other than any Notice of Borrowing delivered pursuant to
Section 2.6 of the Loan Agreement) not being made if such Loan is not made by
the Lender because the conditions precedent to such Loan as set forth in Section
4.1, 4.2 or 4.3 of the Loan Agreement were not satisfied or waived.

         IN WITNESS WHEREOF, the Company has caused this Notice of Borrowing to
be executed and delivered by its duly authorized officer as of the date first
set above.


                                    ASCENT PEDIATRICS, INC.

                                    By: ---------------------------------------


                                    Title:-------------------------------------




                                       B-2
   54
                                                                       EXHIBIT C

                          OPINION OF HALE AND DORR LLP

1.       Each of the Company and Merger Sub is a corporation existing and in
         good standing under the General Corporation Law of the State of
         Delaware.

2.       The Company has the requisite corporate power and authority to execute,
         deliver and, subject to the approval of the stockholders of the Company
         of the Merger Agreement (including the exhibits thereto) and the
         transactions contemplated thereby, perform the Merger Agreement and the
         Transaction Agreements. The Merger Sub has the requisite corporate
         power and authority to execute, deliver and perform the Merger
         Agreement.

3.       The Board of Directors of the Company has adopted by requisite vote
         the resolutions necessary to authorize the execution, delivery and,
         subject to the approval of the stockholders of the Company of the
         Merger Agreement (including the exhibits thereto) and the transactions
         contemplated thereby, performance by the Company of the Merger
         Agreement and the Transaction Agreements.  The Board of Directors of
         the Merger Sub has adopted by requisite vote the resolutions necessary
         to authorize the execution, delivery and performance by the Merger Sub
         of the Merger Agreement.

4.       The Company has duly executed and delivered the Merger Agreement and
         the Transaction Agreements. The Merger Sub has duly executed and
         delivered the Merger Agreement.

5.       Subject to the approval of the stockholders of the Company of the
         Merger Agreement (including the exhibits thereto) and the transactions
         contemplated thereby, each of the Merger Agreement and the
         Transaction Agreements is a valid and binding obligation of the
         Company and is enforceable against the Company in accordance with
         its respective terms.  The Merger Agreement is a valid and binding
         obligation of the Merger Sub and is enforceable against the Merger Sub
         in accordance with its terms.

6.       The Note has been duly authorized, executed, issued and delivered by
         the Company and constitutes a valid and binding obligation of the
         Company enforceable against the Company in accordance with its terms.



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   55
7.       Subject to the approval of the stockholders of the Company of the
         Merger Agreement (including the exhibits thereto) and the transactions
         contemplated thereby, the execution and delivery by the Company of the
         Merger Agreement and the Transaction Agreements and the performance of
         its obligations thereunder will not (a) constitute a violation of the
         certificate of incorporation or bylaws of the Company, (b) constitute a
         material violation by the Company of any statutory law or governmental
         regulation covered by this Opinion, or (c) breach, or result in a
         default under any existing obligation of the Company under any of its
         Other Specified Agreements. The execution and delivery by the Merger
         Sub of the Merger Agreement and the performance of its obligations
         thereunder will not (a) constitute a violation of the certificate of
         incorporation or bylaws of the Merger Sub or (b) constitute a material
         violation by the Merger Sub of any statutory law or governmental
         regulation covered by this Opinion. The term Other Specified Agreements
         means those agreements set forth on Schedule A attached hereto.

8.       Except as provided on the schedule of Governmental Filings attached
         hereto as Schedule B, to our knowledge and based in part upon the
         representations of Alpharma in the Master Agreement, neither the
         Company nor Merger Sub was required to obtain any consent, approval,
         authorization or order of, or make any filings or registrations with,
         any United States federal court or governmental agency in order to
         obtain the right to enter into or perform under the Merger Agreement
         or, in the case of the Company, any of the Transaction Agreements, or
         to take any of the actions taken by it on or prior to this date to
         consummate the transactions contemplated thereby, except for (i) such
         consents, authorizations, approvals, orders, registrations or filings
         as have been obtained or made prior to the date hereof, or as permitted
         to be made or obtained on or after the date hereof pursuant to the
         Merger Agreement, the Transaction Agreements and the exhibits and
         schedules thereto, respectively; and (ii) such consents,
         authorizations, approvals, orders, registrations or filings as could
         not individually or in the aggregate reasonably be expected to have a
         Material Adverse Effect.

9.       Neither the Company nor Merger Sub is an "investment company" within
         the meaning of the Investment Company Act of 1940, as amended.



                                       C-2