1
                                                                    Exhibit 10.8


                                                                  EXECUTION COPY







                                SECOND AMENDMENT

                             DATED FEBRUARY 16, 1999

                                     TO THE

                          SECURITIES PURCHASE AGREEMENT

                               DATED MAY 13, 1998

                                  BY AND AMONG

                          FURMAN SELZ INVESTORS II L.P.
                            FS EMPLOYEE INVESTORS LLC
                              FS PARALLEL FUND L.P.
                            BANCBOSTON VENTURES INC.
                                 FLYNN PARTNERS

                                       AND

                             ASCENT PEDIATRICS, INC.
   2
                  SECOND AMENDMENT dated as of the 16th day of February 1999
(the "Second Amendment") among Ascent Pediatrics, Inc. (the "Company"), Furman
Selz Investors II L.P. ("Investors"), FS Employee Investors LLC ("Employee"), FS
Parallel Fund L.P. ("Parallel"), BancBoston Ventures Inc. ("BancBoston") and
Flynn Partners ("Flynn"), (each of Investors, Employee, Parallel, BancBoston and
Flynn are herein referred to as "Purchaser", and collectively, the
"Purchasers").

                  WHEREAS, the Company and the Purchasers are parties to a
Securities Purchase Agreement dated as of May 13, 1998, as amended September 30,
1998 (the "Series G Purchase Agreement");

                  WHEREAS, the Company is negotiating a Loan Agreement (the
"Loan Agreement") with Alpharma, Inc., a Delaware corporation ("Parent"), and
Alpharma USPD Inc., a Maryland corporation and a wholly-owned subsidiary of
Parent ("Alpharma"), pursuant to which the Company proposes to issue and sell to
Alpharma a 7.5% Convertible Subordinated Note in an aggregate principal amount
of up to $40,000,000 (the "Alpharma Convertible Note");

                  WHEREAS, in connection with the Loan Agreement, the Company
and Alpharma will enter into a Registration Rights Agreement (the "Registration
Rights Agreement"), pursuant to which the Company will grant Alpharma certain
demand and incidental registration rights with respect to the shares of Common
Stock issued or issuable upon conversion of the Alpharma Convertible Note (the
"Alpharma Registrable Shares");

                  WHEREAS, in connection with the Loan Agreement, (i) the
Company and Bird Merger Corporation, a Delaware corporation and wholly-owned
subsidiary of the Company (the "Merger Subsidiary"), will enter into an
Agreement and Plan of Merger (the "Merger Agreement"), (ii) the Company,
Alpharma and Parent will enter into a Master Agreement (the "Master Agreement"),
and (iii) the Company, Alpharma and State Street Bank and Trust Company will
enter into a Depositary Agreement (the "Depositary Agreement" and together with
the Merger Agreement, the Registration Rights Agreement and the Master
Agreement, the "Ancillary Agreements"), pursuant to which, among other things
the Company will assign to Alpharma the right and option (the "Call Option"),
upon the terms and conditions set forth in the Depositary Agreement, to purchase
all of the outstanding shares of common stock, $.00004 par value per share, of
the Company (the "Common Stock"); and

                  WHEREAS, the Purchasers are the holders of all of (i) the
Preferred Stock and Preferred Conversion Shares issuable upon conversion of the
Preferred Stock, (ii) the principal amount of the Subordinated Notes, and (iii)
the Warrants and Warrant Shares issuable upon exercise of the Warrants.

                  NOW THEREFORE, in order to induce Alpharma to enter into the
Loan Agreement and the Ancillary Agreements and to consummate the transactions
contemplated thereby and in consideration of these premises, the mutual
covenants and agreements set forth

                                        1
   3
herein and other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, the parties hereto agree as follows:


                                    ARTICLE I
                         DEFINITIONS AND INTERPRETATION

         SECTION 1.1 Definitions and Interpretation.

         (a) All capitalized terms used herein which are not otherwise
specifically defined herein shall have the respective meaning as ascribed
thereto in the Series G Purchase Agreement.

         (b) For purposes of this Second Amendment and the Series G Purchase
Agreement:

                  "Alpharma Closing Date" shall mean the Closing Date as such
term is defined in the Master Agreement.

                  "Direct Purchase Shares" shall have the meaning ascribed to
such term in Section 5.1 of this Second Amendment.

                  "Second Amendment Closing Date" shall have the meaning
ascribed to such term in Section 5.3 of this Second Amendment.

         (c) Unless otherwise expressly indicated, all references contained
herein to SECTIONS or other subdivisions or SCHEDULES refer to the corresponding
SECTIONS and other subdivisions or SCHEDULES of the Series G Purchase Agreement.

         (d) The sections and the headings in the sections in this Second
Amendment are for convenience only. Said sections and headings shall not be
deemed to be part of this Second Amendment and in no way define, limit, extend
or describe the scope or intent of its provisions.


                                   ARTICLE II
                    CERTAIN AGREEMENTS, WAIVERS AND CONSENTS

         SECTION 2.1 Registration Rights. The Purchasers hereby consent to the
grant of registration rights to Alpharma pursuant to the Registration Rights
Agreement and agree that, in the event that (i) Alpharma initiates an
underwritten offering of shares of Common Stock pursuant to the Registration
Rights Agreement, (ii) the Holders (as defined in Section 10.2 of the Series G
Purchase Agreement) elect pursuant to Section 10.4 of the Series G Purchase
Agreement to include Registrable Securities (as defined in the Series G Purchase
Agreement) in such offering, and (iii) the managing underwriter of such offering
determines that the number of shares to be included in such offering needs to be
reduced, then the number of Registrable Securities to be included in the
offering shall be reduced or eliminated, as determined by the managing

                                        2
   4
underwriter of such offering, prior to any reduction in the number of Alpharma
Registrable Shares included in the offering. The Purchasers hereby waive
compliance with the requirements set forth in the last sentence of Section 10.9
of the Series G Purchase Agreement as such requirements apply to the
Registration Rights Agreement.

         SECTION 2.2 Waiver of Events of Default. The Purchasers hereby waive
any Events of Default under Section 13.1 of the Series G Purchase Agreement
arising on or before the date hereof, including without limitation, (i) any
Event of Default resulting from the formation of the Merger Subsidiary as a
wholly-owned subsidiary of the Company, and (ii) any Event of Default resulting
from any failure of the Company to provide to the Purchasers any of the
financial information or notices set forth in Section 7.1 of the Series G
Purchase Agreement and agree that the Company shall have no further obligation
to provide any of such financial information or notices to the extent such
financial information or notices were otherwise required to be provided prior to
the date hereof.

         SECTION 2.3 Right of First Refusal. The Purchasers hereby waive any
rights of first refusal held by the Purchasers under Section 7.7 of the Series G
Purchase Agreement which were, are or may be, applicable to (i) the issuance of
any shares of New Common Stock, Depositary Receipts or Depositary Shares (each
as defined in the Depositary Agreement) pursuant to the Merger Agreement or the
Depositary Agreement, (ii) the issuance of the Alpharma Convertible Note and the
shares of Common Stock issuable upon conversion of the Alpharma Convertible
Note.

         SECTION 2.4 Seniority of Notes. The Purchasers hereby agree that the
Alpharma Convertible Note issued pursuant to the Loan Agreement shall rank pari
passu in right of payment with the Subordinated Notes and any debt securities
issuable upon conversion or exchange of the shares of Preferred Stock of the
Company issued to the Purchasers pursuant to the Series G Purchase Agreement,
except as otherwise provided in the Subordination Agreement dated as of February
16, 1999 among the Company, the Purchasers and Alpharma.

         SECTION 2.5 Consent to Loan Agreement and Ancillary Agreements. The
Purchasers hereby consent, in all respects under the Series G Purchase
Agreement, to the execution of the Loan Agreement and the Ancillary Agreements
and to the consummation of the transactions contemplated thereby, including
without limitation the incurrence of additional Indebtedness (as defined in the
Series G Purchase Agreement) by the Company.

         SECTION 2.6 Consent to Letter Agreement. The Purchasers hereby consent,
in all respects under the Series G Purchase Agreement, to the letter agreement
dated February 16, 1999 among the Company and FS Private Investments LLC. The
parties agree that paragraph 2 of such letter agreement shall be an amendment to
Article X of the Series G Purchase Agreement.

                                        3
   5
                                   ARTICLE III
                  AMENDMENTS TO THE SERIES G PURCHASE AGREEMENT

         SECTION 3.1 Amendment to Section 3.1. Section 3.1 of the Series G
Purchase Agreement is hereby amended by deleting in its entirely the text of the
penultimate sentence thereof and inserting in lieu thereof the following:

                  "Material Adverse Effect" means, when used in connection with
                  the Company, any development, change or effect that is
                  materially adverse to the business, properties (including,
                  without limitation, Intellectual Property (as defined in
                  Section 3.11), assets, net worth, financial conditions,
                  results of operations or future prospects (including, without
                  limitation, future equity value) of the Company and its
                  Subsidiaries taken as a whole."

         SECTION 3.2 Amendment to Sections 7.1 through 7.4. Section 7.1 through
7.4 of the Series G Purchase Agreement are hereby amended by deleting in its
entirety the text thereof and inserting in lieu thereof the following:

                  "7.1 Reports. The Company will deliver to each Purchaser the
following:

                  (a)      within thirty (30) days after the end of each of the
                           twelve (12) monthly accounting periods in each fiscal
                           year (or when furnished to the Board of Directors, if
                           earlier), unaudited consolidated statements of income
                           and retained earnings and cash flows of the Company
                           and its Subsidiaries, if any, for each monthly period
                           and for the period from the beginning of such fiscal
                           year to the end of such monthly period, together with
                           consolidated balance sheets of the Company and its
                           Subsidiaries, if any, as at the end of each monthly
                           period, setting forth in each case comparisons to
                           budget and to corresponding periods in the preceding
                           fiscal year which statements will be prepared in
                           accordance with GAAP, consistently applied subject to
                           the absence of footnotes and year-end adjustments;

                  (b)      within ninety (90) days after the end of each fiscal
                           year, consolidated statements of income and retained
                           earnings and cash flow of the Company and its
                           Subsidiaries, if any, for the period from the
                           beginning of each fiscal year to the end of such
                           fiscal year, and consolidated balance sheets as at
                           the end of such fiscal year, setting forth in each
                           case in comparative form corresponding figures for
                           the preceding fiscal year, which statements will be
                           prepared in accordance with GAAP, consistently
                           applied (except as approved by the accounting firm
                           examining such statements and disclosed by the
                           Company) and will be accompanied by a report on the
                           consolidated statements of a public accounting firm
                           reasonably acceptable to the Purchasers or one of the
                           public accounting firms currently known as the "Big
                           Five" (either, an "Approved Accounting Firm");

                                        4
   6
                  (c)      within ten (10) days after transmission thereof,
                           copies of all financial statements, proxy statements,
                           reports and other communications which the Company
                           sends to its stockholders, copies of all registration
                           statements and all regular, special or periodic
                           reports which it files with the SEC or with any
                           securities exchange on which any of the securities of
                           the Company are then listed or proposed to be listed,
                           and copies of all press releases made generally
                           available by the Company to the public concerning
                           material developments in the business of the Company
                           and its Subsidiaries, if any;

                  (d)      promptly after the occurrence thereof (but in any
                           event within seven (7) days after such occurrence is
                           known to the Company) notice of any condition or
                           event which constitutes, or the occurrence of (i) an
                           event which would lead the Company to believe that
                           the Company is not in compliance in material respects
                           with the covenants in this Agreement or (ii) the
                           institution or threatened institution of an action,
                           suit or proceeding against the Company or any of its
                           Subsidiaries by or before any court, regulatory
                           authority, administrative agency or any other
                           governmental agency or body, domestic or foreign,
                           which, if adversely decided, could have a Material
                           Adverse Effect; and

                  (e)      at least thirty (30) days prior to the end of each
                           fiscal year, a detailed annual operating budget and
                           business plan for the Company and its Subsidiaries,
                           if any, for such fiscal year. Such budgets shall be
                           prepared on a monthly basis, displaying consolidated
                           statements of anticipated cash flow and projected
                           consolidated balance sheets, setting forth in each
                           case the assumption (which assumptions and
                           projections shall represent and be based upon the
                           good faith best judgment in respect thereof of the
                           Chief Executive Officer of the Company) behind the
                           projections contained in such financial statements,
                           and which budgets shall have been approved by the
                           Board of Directors of the Company or prior to the
                           beginning of each twelve-month period to which they
                           pertain and, promptly upon preparation thereof, any
                           other budgets that the Company may prepare and any
                           revisions of such annual or other budgets.


                  7.2 Accounts and Records. The Company shall keep true records
         and books of account in which entries will be made of all dealings or
         transactions in relation to the business and affairs of the Company and
         its Subsidiaries, if any, in accordance with GAAP, to the extent
         applicable, applied on a consistent basis.

                  7.3 Inspection. The Company shall permit Furman Selz
         Investments LLC, BancBoston Ventures Inc. or any of their respective
         officers, employees, representatives or such other Person as Furman
         Selz Investments LLC or BancBoston Ventures Inc. may designate, during
         regular business hours of the Company, upon reasonable prior notice,

                                        5
   7
         to visit and inspect the offices and properties of the Company and to
         (i) review and make extracts or copies of the books, accounts and
         records of the Company, and (ii) discuss the affairs, finances and
         accounts of the Company, with the Company's Officers, members of the
         Board of Directors, Approved Accounting Firm, consultants and
         attorneys.

                  7.4 Independent Accountants. The Company will retain an
         Approved Accounting Firm to audit the Company's financial statements at
         the end of each fiscal year. In the event the services of the Approved
         Accounting Firm shall be terminated, the Company shall promptly
         thereafter seek to engage another Approved Accounting Firm.

         SECTION 3.3 Amendments to Sections 7.5.

         (a) Section 7.5(a) of the Series G Purchase Agreement is hereby amended
by deleting in its entirety the text thereof and inserting in lieu thereof the
following:

                  "From and after the Alpharma Closing Date and prior to the
         Option Expiration Date, the Company's Board of Directors shall consist
         of a minimum of seven and a maximum of eleven directors. The Company
         agrees to hold meetings of its Board of Directors at least four times a
         year, at least once per calendar quarter. The Purchasers shall have the
         right to have two (2) nominees included on the Board of Directors'
         slate of nominees to stand for election to the Board of Directors. The
         directors of the Company designated by the Purchasers pursuant to this
         Section 7.5(a) shall be referred to hereinafter as the "Purchaser
         Directors."'

         (b) Section 7.5(b) of the Series G Purchase Agreement is hereby amended
by deleting in its entirety the text thereof and inserting in lieu thereof the
following:

                  "If at any time the Board of Directors designates a committee
         or committees to act on behalf of the Board, at least one (1) of the
         Purchaser Directors shall be a member of such committee or committees."

         (c) Section 7.5(d) of the Series G Purchase Agreement is hereby amended
by deleting the word "the" before the term "Purchaser Director" in the first
line thereof and inserting the word "each" in lieu thereof.

         SECTION 3.4 Addition of Section 7.10. Article VII of the Series G
Purchase Agreement is hereby amended by adding the following immediately after
Section 7.9:

                  "7.10 Insurance. The Company shall keep in force with
         responsible insurers, policies of insurance providing coverage, limits
         and deductibles customary in the Company's industry."

         SECTION 3.5 Amendment to Section 7.10. Section 7.10 of the Series G
Purchase Agreement is hereby amended by renumbering the same as Section 7.11.

                                        6
   8
         SECTION 3.6 Amendment to Sections 8.1 Through 8.12. Sections 8.1
through 8.12 of the Series G Purchase Agreement are hereby amended by deleting
in its entirety the text thereof and inserting in lieu thereof the following:

                           "8.1 Borrowed Money Indebtedness. Create, incur,
         suffer or permit to exist, or assume or guarantee, or become or remain
         liable with respect to any Borrowed Money Indebtedness, except the
         following:

         (a)      the Alpharma Convertible Note;

         (b)      the Borrowed Money Indebtedness existing on the date of the
                  Second Amendment and disclosed in the Financial Statements,
                  and all renewals, extensions and replacements (but not
                  increases) of any of the foregoing, provided that the accrual
                  of interest on such liabilities, so long as it is not
                  converted to principal, shall not be deemed to increase such
                  liabilities;

         (c)      principal of up to $50,000,000 of Borrowed Money Indebtedness
                  in the aggregate outstanding at any time (which (i) prior to
                  or on the Option Expiration Date must consist solely of
                  Screened Project Indebtedness and (ii) thereafter, may include
                  up to $10,000,000 of Borrowed Money Indebtedness that is not
                  Screened Project Indebtedness), plus any accrued interest
                  thereon;

         (d)      purchase money Indebtedness permitted by Section 8.10 to the
                  extent liens securing the same are allowed by the other
                  provisions of this Agreement;

         (e)      capitalized lease obligations to the extent leases with
                  respect thereto are allowed by the other provisions of this
                  Agreement;

         (f)      the Convertible Notes;

         (g)      on or prior to the Option Expiration Date, any Screened
                  Project Indebtedness that is convertible directly or
                  indirectly into Common Stock; and

         (h)      after the Option Expiration Date, any Borrowed Money
                  Indebtedness that is convertible directly or indirectly into
                  Common Stock.

                  8.2 Liens. Create or suffer to exist any Lien upon any of its
         Property now owned or hereafter acquired, or acquire any Property upon
         any conditional sale or other title retention device or arrangement or
         any purchase money security agreement; provided, however, that the
         Company and any Subsidiaries of the Company may create or suffer to
         exist Permitted Liens.

                  8.3 Contingent Liabilities. Directly or indirectly guarantee
         the performance or

                                        7
   9
         payment of, or purchase or agree to purchase, or assume or contingently
         agree to become or be secondarily liable in respect of, any obligation
         or liability of any other Person except for:

         (a)      the endorsement of checks or other negotiable instruments in
                  the ordinary course of business;

         (b)      obligations disclosed to the Purchasers in the Financial
                  Statements (but not increases of such obligations after the
                  First Loan Date, provided that the accrual of interest on such
                  obligations, so long as it is not converted to principal,
                  shall not be deemed to increase such obligations);

         (c)      obligations in respect of employees which shall not exceed an
                  aggregate amount equal to $200,000 at any time outstanding;
                  and

         (d)      those liabilities permitted under Section 8.1 hereof.

                  8.4 Mergers, Consolidations and Dispositions and Acquisitions
         of Assets. In any single transaction or series of related transactions,
         directly or indirectly:

         (a)      liquidate or dissolve;

         (b)      be a party to any merger or consolidation unless (i) no
                  Default or Event of Default has occurred that is then
                  continuing; (ii) immediately thereafter and giving effect
                  thereto, no event will occur and be continuing which
                  constitutes a Default; (iii) the Company, or the Subsidiary,
                  if any, is the surviving Person; and (iv) the Purchasers are
                  given at least twenty (20) days prior notice of such merger or
                  consolidation or such lesser number of days as is practicable;

         (c)      sell, convey or lease all or substantially all of its assets,
                  except for the sale of property in the ordinary course of
                  business;

         (d)      acquire all or a substantial portion of the assets or stock of
                  any person whether by merger or otherwise other than in a
                  transaction or series of transactions that constitute a
                  Screened Project, provided that this subsection shall not
                  prevent any Project funded with the proceeds of the First
                  Loan, any Unrestricted Loan or Project Loans; or

         (e)      pledge, transfer or otherwise dispose of any equity interest
                  in any of its Subsidiaries, if any exist, or issue or permit
                  any of its Subsidiaries, if any exist, to issue any additional
                  equity interests except to the Company or another of its
                  Subsidiaries. Nothing in this Agreement shall prohibit the
                  Company from selling obsolete equipment or from replacing used
                  equipment in the ordinary course of business.

                                        8
   10
                  8.5 Redemption, Dividends and Distributions. At any time,
         except as contemplated by this Agreement and the Securities and by the
         terms of the Alpharma Convertible Note, by the Loan Agreement and, by
         the Ancillary Agreements: (a) redeem, retire or otherwise acquire,
         directly or indirectly, any equity interest of the Company or any of
         its Subsidiaries (other than $250,000 in any fiscal year to be used to
         effectuate the repurchase of restricted stock issued to employees,
         directors or consultants of the Company pursuant to a restricted stock
         agreement) or (b) make any distributions of any property or cash in
         respect of any of its Capital Stock.

                  8.6 Nature of Business. Change the nature of its business or
         enter into any business which is substantially different from the
         development, manufacture and sale of pharmaceuticals principally for
         the pediatric market.

                  8.7 Transactions with Related Parties. Enter into any
         transaction or agreement any Officer, director or beneficial owner of
         five percent (5%) or more of the outstanding Capital Stock in the
         Company or any of its Subsidiaries (or any Affiliate of any such
         Person) unless the transaction is upon no less favorable terms than
         those that are obtainable from wholly unrelated sources. The provisions
         of this Section 8.7 shall not apply to (a) fees and compensation
         (including options and equity compensation) paid to or indemnity
         provided on behalf of Officers, directors, employees or consultants of
         the Company and any of its Subsidiaries, as determined by the Board of
         Directors of the Company or any of such Subsidiaries or the Chief
         Executive Officer thereof in good faith and (b) transactions
         exclusively between or among the Company's Subsidiaries, provided such
         transactions are not otherwise prohibited by this Agreement.
         Notwithstanding the prior two sentences, the Company may not pay
         management or consulting fees to such related person in excess of an
         aggregate of $50,000 per year.

                  8.8 Loans and Investments. Make any loan, advance, extension
         of credit or capital contribution to, or make or have any Investment
         in, any Person, or make any commitment to make any such extension of
         credit or investment, except (a) Permitted Investments, (b) normal and
         reasonable advances in the ordinary course of business to Officers and
         employees and (c) capital contributions or Investments used to fund a
         Project permitted by Section 6.6 of the Loan Agreement, provided in the
         case of clause (c) that the making of such capital contribution or
         Investment does not cause a Default under any other provision hereof.

                  8.9 Organizational Documents. Amend, modify, restate or
         supplement its Certificate of Incorporation or Bylaws if such action
         could reasonably be expected to adversely affect the rights of the
         Purchasers under this Agreement.

                  8.10 Lease Expenses; Purchase Money Indebtedness. Permit
         aggregate operating lease expenses (excluding lease payments under
         capital leases), for the Company and its Subsidiaries in the aggregate
         in any fiscal year, to exceed $500,000. Incur or create new capital
         lease obligations or purchase money Indebtedness in any fiscal year in
         excess of

                                        9
   11
         $200,000 in the aggregate for the Company and its Subsidiaries. Permit
         aggregate capital lease obligations and purchase money Indebtedness
         outstanding at any one time to exceed $2,000,000 in the aggregate for
         the Company and its Subsidiaries.

                  8.11 Sale/Leasebacks. Enter into any sale/leaseback
         transactions except as permitted under the provisions of Section 8.10.

                  8.12 Issuance of Stock. On or prior to the Option Expiration
         Date, issue, or become obligated to issue shares of Capital Stock or
         securities convertible into Capital Stock, except for (i) shares of
         Common Stock, (ii) rights, warrants or options to purchase shares of
         Common Stock granted prior to March 31, 2002 and rights, warrants or
         options to purchase up to 100,000 shares of Common Stock on or after
         March 31, 2002 (such number to be adjusted for stock splits or
         reclassifications), (iii) securities permitted by Section 7.1(g) of the
         Loan Agreement. Prior to the Option Expiration Date, establish a
         "Shareholders Rights Plan" or "Poison Pill" or issue any securities in
         connection therewith.

                  8.13 Subsidiaries. Form, create or acquire any Subsidiary
         other than Merger Subsidiary or permit any Person other than the
         Company or a wholly owned Subsidiary to hold an equity interest in any
         Subsidiary."

         SECTION 3.7 Amendment to Section 8.13. Section 8.13 of the Series G
Purchase Agreement is hereby amended by renumbering the same as Section 8.14.

         SECTION 3.8 Amendments to Section 8.14.

         (a) Section 8.14 of the Series G Purchase Agreement is hereby amended
by renumbering the same as Section 8.15.

         (b) Section 8.15 of the Series G Purchase Agreement (as renumbered) is
hereby amended by deleting in its entirety the text thereof and inserting in
lieu thereof the following:

                  "8.15 Definitions. For purposes of this Article VIII, the
         following terms shall have the meanings set forth in this Section 8.15.

                  "Affiliate" has the meaning ascribed to it in Rule 405
         promulgated under the Securities Act.

                  "Alpharma Closing Date" means the "Closing Date" as such term
         is defined in the Master Agreement.

                  "Alpharma Convertible Note" has the meaning set forth in the
         Preamble to the Second Amendment.

                                       10
   12
                  "Ancillary Agreements" shall mean the Depositary Agreement,
         the Master Agreement, the Merger Agreement and the Registration Rights
         Agreement.

                  "Board of Directors" means the Board of Directors of the
         Company or any committee of the Board authorized to act for it
         hereunder.

                  "Borrowed Money Indebtedness" means, with respect to any
         Person, without duplication:

                           (a) all obligations of such Person for borrowed
                  money;

                           (b) all obligations of such Person evidenced by
                  bonds, debentures, notes or similar instruments;

                           (c) all obligations of such Person under conditional
                  sale or other title retention agreements relating to Property
                  purchased by such Person;

                           (d) all obligations of such Person issued or assumed
                  as the deferred purchase price of Property or services
                  (excluding obligations of such Person to creditors for raw
                  materials, inventory, services and supplies and deferred
                  payment for services to employees and former employees
                  incurred in the ordinary course of such Person's business);

                           (e) all capital lease obligations;

                           (f) all obligations of others secured by any Lien on
                  Property or assets owned or acquired by such Person, whether
                  or not the obligations secured thereby have been assumed;

                           (g) all outstanding letters of credit, surety bonds
                  and currency swap or similar agreements issued for the account
                  of such Person; and

                           (h) all guarantees of such Person for obligations of
                  the type described above.

                  "Business Day" means any day which is neither a Saturday nor a
         Sunday nor a legal holiday on which banks are authorized or required to
         close in Boston, Massachusetts, New York, New York or in any other city
         in which the Depositary's Office (as defined in the Depositary
         Agreement) is located.

                  "Capital Stock" means any and all shares, interests, rights to
         purchase, warrants, options, participations or other equivalents of or
         interests in (however designated) equity of the Company, including any
         preferred stock, but excluding any debt securities convertible into
         such equity prior to such conversion.

                                       11
   13
                  "Common Stock" means (i) prior to the Effective Time, the Old
         Common Stock, and (ii) at and after the Effective Time, the New Common
         Stock.

                  "Company" means the party named as such in the Preamble hereof
         until a successor replaces it pursuant to the applicable provision
         hereof and thereafter means the successor to such party.

                  "Default" means any event which is, or after notice or passage
         of time or both would be, an Event of Default (as defined in Article
         XIII this Agreement).

                  "Depositary Agreement" means the Depositary Agreement dated as
         of the date hereof by and among the Company, the Lender and State
         Street Bank and Trust Company, as Depositary.

                  "Effective Time" has the meaning set forth in the Merger
         Agreement.

                  "Event of Default" has the meaning set forth in Article XIII
         of this Agreement.

                  "Financial Statements" has the meaning set forth in Section
         3.7(a) of the Loan Agreement.

                  "First Loan" has the meaning set forth in Section 2.3 of the
         Loan Agreement.

                  "First Loan Date" has the meaning set forth in Section 2.3 of
         the Loan Agreement.

                  "GAAP" means U.S. generally accepted accounting principles as
         in effect from time to time.

                  "Indebtedness" means and includes:

                           (a) all items which in accordance with GAAP would be
                  included on the liability side of a balance sheet on the date
                  as of which Indebtedness is to be determined (excluding
                  capital stock, surplus reserves and deferred credits);

                           (b) all guaranties, letter of credit, contingent
                  reimbursement obligations and other contingent obligations in
                  respect of, or any obligations to purchase or otherwise
                  acquire, indebtedness of others; and

                           (c) all indebtedness secured by any Lien existing on
                  any interest of the Person with respect to which indebtedness
                  is being determined in Property owned subject to such Lien
                  whether or not the indebtedness secured thereby shall been
                  assumed.

                  "Investment" means the purchase or other acquisition of any
         Indebtedness of, or

                                       12
   14
         the making of any loan, advance or capital contribution to, or the
         incurring of any liability, contingent or otherwise, in respect of the
         Indebtedness of, any Person.

                  "Lender" means Alpharma USPD Inc., a Maryland corporation, the
         Lender under the Loan Agreement.

                  "Lien" means any mortgage, pledge, charge, encumbrance,
         security interest, collateral assignment or other lien or restriction
         of any kind, whether based on common law, constitutional provision,
         statute or contract, and shall include reservations, exceptions,
         encroachments, easements, rights of way, covenants, conditions,
         restrictions and other title exceptions.

                  "Loan" means any borrowing by the Company from the Lender of
         up to a maximum principal amount of $40,000,000 pursuant to Section 2.1
         of the Loan Agreement and the other terms and conditions of the Loan
         Agreement.

                  "Loan Agreement" has the meaning set forth in the Preamble to
         the Second Amendment.

                  "Master Agreement" has the meaning set forth in the Preamble
         to the Second Amendment.

                  "Merger Agreement" has the meaning set forth in the Preamble
         to the Second Amendment.

                  "Merger Subsidiary" has the meaning set forth in the Preamble
         to the Second Amendment.

                  "New Common Stock" has the meaning set forth in the Depositary
         Agreement.

                  "Officer" means the Chairman of the Board, the President, any
         Vice President, the Treasurer or the Secretary of the Company.

                  "Old Common Stock" has the meaning set forth in the Depositary
         Agreement.

                  "Option Closing Date" has the meaning set forth in the
         Depositary Agreement.

                  "Option Expiration Date" has the meaning set forth in the
         Depositary Agreement.

                  "Permitted Investments" means:

                           (a) readily marketable securities issued or fully
                  guaranteed by the United States of America with maturities of
                  not more than one year;

                                       13
   15
                           (b) commercial paper rated "Prime 1" by Moody's
                  Investors Services, Inc. or "A-1" by Standard and Poor's
                  Rating Services with maturities of not more than 180 days;

                           (c) certificates of deposit or repurchase obligations
                  issued by any bank organized under the laws of the United
                  States of America or any state thereof having capital surplus
                  of at least $100,000,000 or by any other financial institution
                  acceptable to the Purchasers (and permitted assignees of the
                  Purchasers) in accordance with Article XIV hereof, all of the
                  foregoing not having a maturity of more than one year from the
                  date of issuance thereof; and

                           (d) other Investments not exceeding, in the
                  aggregate, $50,000 in any fiscal year.

                  "Permitted Liens" means each of the following:

                           (a) artisans' or mechanics' Liens arising in the
                  ordinary course of business, and Liens for taxes, but only to
                  the extent that payment thereof shall not at the time be due
                  or if due, the payment thereof is being diligently contested
                  in good faith and adequate reserves computed in accordance
                  with GAAP have been set aside therefor;

                           (b) Liens in effect on the First Loan Date and
                  disclosed to the Purchasers in the Financial Statements,
                  provided that neither the Borrowed Money Indebtedness secured
                  thereby nor the Property covered thereby shall increase after
                  the First Loan Date without the prior written consent of the
                  Purchasers (and permitted assignees of the Purchasers) in
                  accordance with Article XIV hereof, provided that, for
                  purposes of this clause (b), the accrual of interest on such
                  Borrowed Money Indebtedness, so long as it is not converted to
                  principal, shall not be deemed to increase such Borrowed Money
                  Indebtedness;

                           (c) normal encumbrances and restrictions on title
                  which do not secure Borrowed Money Indebtedness and which do
                  not have a material adverse affect on the value or utility of
                  the applicable Property;

                           (d) Liens incurred or deposits made in the ordinary
                  course of business (i) in connection with workmen's
                  compensation, unemployment insurance, social security and
                  other like laws, or (ii) to secure insurance in the ordinary
                  course of business, the performance of bids, tenders,
                  contracts, leases, licenses, statutory obligations, surety,
                  appeal and performance bonds and other similar obligations
                  incurred in the ordinary course of business, but not, in any
                  of the cases specified in this clause (ii), incurred in
                  connection with the borrowing of money, the obtaining of
                  advances or the payment of the deferred purchase of Property;

                           (e) Liens in connection with or to secure Borrowed
                  Money

                                       14
   16
                  Indebtedness permitted under Section 8.1(c) hereof;

                           (f) attachments, judgments and other similar Liens
                  arising in connection with court proceedings, provided that
                  the execution and enforcement of such Liens are effectively
                  stayed and the claims secured thereby are being actively
                  contested in good faith with adequate reserve made therefor in
                  accordance with GAAP;

                           (g) Liens imposed by law, such as carriers',
                  warehousemen's, mechanics', materialmen's and vendors' liens
                  incurred in good faith in the ordinary course of business and
                  securing obligations which are not yet due or which are being
                  contested in good faith by appropriate proceedings if adequate
                  reserves with respect thereto are maintained in accordance
                  with GAAP;

                           (h) zoning restrictions, easements, licenses,
                  reservations, provisions, covenants, conditions, waivers, and
                  restrictions on the use of Property, and which do not in any
                  case singly or in the aggregate materially impair the present
                  use or value of Property subject to any such restriction or
                  materially interfere with the ordinary conduct of the business
                  of the Company and its Subsidiaries, if any;

                           (i) Liens securing purchase money Indebtedness
                  permitted under Section 8.1 hereof and covering only the
                  Property so purchased;

                           (j) capital leases and sale/leaseback transactions
                  permitted under the other provisions of the Series G Purchase
                  Agreement; and

                           (k) extensions, renewals and replacements of Liens
                  referred to in paragraphs (a) through (j) of this definition;
                  provided that any such extension, renewal or replacement Lien
                  shall be limited to the Property or assets (and, in the case
                  of clause (e), categories of Property or assets) covered by
                  the Lien extended, renewed or replaced and that the Borrowed
                  Money Indebtedness secured by any such extension, renewal or
                  replacement Lien shall be in an amount not greater than the
                  amount of the Indebtedness secured by the Lien extended,
                  renewed or replaced.

                  "Person" means any individual, corporation, association,
         company, business trust, partnership, joint venture, joint-stock
         company, limited liability company, trust, unincorporated organization
         or association or government or any agency or political subdivision
         thereof.

                  "Project" means (i) the acquisition of all or a substantial
         part of the stock or assets of any Person engaged in the development,
         manufacture or sale of pharmaceuticals or other health care products
         principally for the pediatric market; (ii) the acquisition of a product
         or product line from, or the acquisition of the right to manufacture,
         distribute or sell any product or product line of any Person, in each
         case with applications in the

                                       15
   17
         pediatric pharmaceutical health care market; or (iii) any R&D Project.

                  "Project Loans" has the meaning set forth in Section 2.1of the
         Loan Agreement.

                  "Property" means any interest in any kind of property or
         asset, whether real, personal or mixed, tangible or intangible.

                  "R&D Project" means any project for the research and
         development of products or processes related to pediatric
         pharmaceuticals

                  "Registration Rights Agreement" has the meaning set forth in
         the Preamble to the Second Amendment.

                  "Screened Project" means a Project that meets the criteria set
         forth on Schedule II to the Loan Agreement.

                  "Screened Project Loans" has the meaning set forth in Section
         2.1 of the Loan Agreement.

                  "Screened Project Indebtedness" means Borrowed Money
         Indebtedness (other than Loans under the Loan Agreement) incurred for
         the purpose of funding a Screened Project.

                  "Second Amendment" means the Second Amendment dated February
         16, 1999 to the Securities Purchase Agreement date May 13, 1998 by and
         among Furman Selz Investors II L.P., FS Employee Investors LLC, FS
         Parallel Fund L.P., BancBoston Ventures Inc., Flynn Partners and the
         Company.

                  "Subsidiary" of a Person means any corporation, association,
         partnership, joint venture or other business entity of which more than
         fifty percent (50%) of the voting stock or other equity interests (in
         the case of Persons other than corporations), is owned or controlled
         directly or indirectly by the Person, or one or more of the
         Subsidiaries of the Person, or a combination thereof.

                  "Unrestricted Loans" means one or more Loans made on or after
         the Alpharma Closing Date in an aggregate principal amount not to
         exceed $8,000,000."

         SECTION 3.9 Amendment to Section 10.2. Section 10.2 of the Series G
Purchase Agreement is amended by deleting the definition of "Registrable Warrant
Shares" included thereon and inserting in lieu thereof the following:

                                    ""Registrable Warrant Shares" shall mean the
         Warrant Shares and the Direct Purchase Shares and any other securities
         issued in respect of the Warrant Shares or the Direct Purchase Shares
         upon any stock split, stock dividend, recapitalization, merger,
         consolidation or similar event, provided, however, that shares of
         Common Stock which are Registrable

                                       16
   18
         Warrant Shares shall cease to be Registrable Warrant Shares upon any
         sale pursuant to a Registration Statement, Section 4(1) of the
         Securities Act or Rule 144 under the Securities Act, or any sale in any
         manner to a person or entity which, by virtue of Section 17.3 of this
         Agreement is not entitled to the rights provided by this Article X or
         at such time as the Holder of such shares may sell under Rule 144 under
         the Securities Act in a three-month period all Registrable Securities
         then held by such Holder. For purposes of this definition, Direct
         Purchase Shares shall have the meaning ascribed to such term in the
         Second Amendment, as such term is defined in Section 8.15."

         SECTION 3.10 Amendment to Article XI. Article XI of the Series G
Purchase Agreement is amended by adding thereto the following:

                                    "11.9 Senior Indebtedness Under the Alpharma
         Loan. If any indebtedness of the Company would constitute both "Senior
         Indebtedness" as defined in Section 11.1 and "Senior Indebtedness" as
         defined in the Loan Agreement, as such term is defined in Section 8.15,
         the terms of subordination of the Notes relating to such indebtedness
         shall be as set forth in the Subordination Agreement dated as of
         February 16, 1999 among the Company, the Purchasers and Alpharma USPD,
         Inc., a Maryland corporation without reference to this Article XI."

         SECTION 3.11 Amendment to Section 12.11. Section 12.11 of the Series G
Purchase Agreement is amended by deleting in its entirety the second sentence of
the first paragraph thereof and inserting in lieu thereof the following:

                  "Notwithstanding any additional or contrary rights of the
         Purchasers contained in Section 9.3 hereof, the Convertible Notes shall
         be automatically converted into shares of Common Stock at the
         applicable Conversion Price in accordance with this Article XII
         immediately prior to the Option Closing on the Option Closing Date, as
         such terms are defined in the Depository Agreement (as such term is
         defined in Section 8.15). The date on which either of the foregoing
         conditions is first satisfied is hereinafter referred to as the
         "Mandatory Conversion Date""

         SECTION 3.12 Amendment to Section 13.1. Section 13.1 of the Series G
Purchase Agreement is amended by deleting the text thereof and inserting in lieu
thereof the following:

                  "13.1    Events of Default. An "Event of Default" occurs if:

                  (a)      the Company defaults in the payment of interest on
                           any Note when the same becomes due and payable and
                           such default continues for a period of 5 Business
                           Days;

                  (b)      the Company defaults in the payment of the principal
                           of any Note when the same becomes due and payable at
                           maturity, upon acceleration or otherwise;

                                       17
   19
                  (c)      the Company defaults in the performance of any
                           covenants under Article VIII of this Agreement;

                  (d)      the Company fails to comply with any of the
                           provisions of this Agreement (other than Article
                           VIII) and such failure continues for 20 Business Days
                           after notice specified in the penultimate paragraph
                           of this Section 13.1 (the "Default Notice") without
                           cure (the Company to give forthwith to all other
                           holders of the Notes at the time outstanding written
                           notice of the receipt of such Default Notice,
                           specifying the default referred to therein); or

                  (e)      the Company defaults in payment on Borrowed Money
                           Indebtedness (giving effect to any applicable grace
                           periods and any extensions thereof) of at least
                           $700,000 principal amount;

                  (f)      there has been an acceleration of the final stated
                           maturity of any Borrowed Money Indebtedness of the
                           Company (which acceleration shall not have been
                           cured, waived, rescinded or annulled for 10 Business
                           Days) if the aggregate principal amount of such
                           Borrowed Money Indebtedness, together with the
                           principal amount of any other such Borrowed Money
                           Indebtedness in default for failure to pay principal
                           at maturity or which has been accelerated, aggregates
                           $700,000 or more at any time;

                  (g)      any representation or warranty of the Company under
                           this Agreement shall prove to have been incorrect in
                           any material respect when made;

                  (h)      there exists an outstanding unsatisfied final
                           judgment which, either alone or together with other
                           outstanding unsatisfied final judgments against the
                           Company, exceeds an aggregate of $200,000 (to the
                           extent not covered by insurance) and such judgment
                           shall have continued undischarged or unstayed for 20
                           Business Days after entry thereof;

                  (i)      the Company pursuant to or within the meaning of any
                           Bankruptcy Law:

                                    (i)      commenced a voluntary case,

                                    (ii)     consents to the entry of an order
                                             for relief against it in an
                                             involuntary case,

                                    (iii)    consents to the appointment of a
                                             custodian of it or for all or
                                             substantially all of its property,
                                             or

                                    (iv)     makes a general assignment for the
                                             benefit of its creditors; or

                  (j)      a court of competent jurisdiction enters an order or
                           decree under any

                                       18
   20
                           Bankruptcy Law that:

                                    (i)      is for relief against the Company
                                             in an involuntary case,

                                    (ii)     appoints a custodian of the Company
                                             for all or substantially all of its
                                             property, or

                                    (iii)    orders the liquidation of the
                                             Company, and the order or decree
                                             remains unstayed and in effect for
                                             90 consecutive days.

                  A default under paragraph (d) of this Section 13.1 is not a
         default unless the holders of at least eighty percent (80%) of the
         aggregate principal amount then outstanding under the Notes notify the
         Company of the default and the Company does not cure the default within
         twenty (20) days after receipt of such notice. The notice must specify
         the default and demand that it be remedied.

                  A "Business Day" means any day which is neither a Saturday nor
         a Sunday nor a legal holiday on which banks are authorized or required
         to close in Boston, Massachusetts or New York, New York. A "Default"
         means any of the events specified in this Section 13.1, regardless of
         whether there shall have occurred any passage of time or giving of
         notice or both that would be necessary in order to constitute such
         event an Event of Default."

         SECTION 3.13 Effectiveness of Amendments.

                  (a) The amendments to the Series G Purchase Agreement set
forth in this Article III shall be effective on and after the Second Amendment
Closing Date.

                  (b) If the average closing price of the Common Stock is not
greater than $12.00 per share as traded on the Nasdaq Stock Market or a
registered national securities exchange over the 60 trading days prior to the
Option Expiration Date, as such term is defined in the Depositary Agreement,
then the amendments to the Series G Purchase Agreement set forth in this Article
III shall cease to be effective, and the terms of the Series G Purchase
Agreement amended hereby shall be as if such amendments had never been made, as
of the Option Expiration Date; provided, however, that (i) Section 7.5 (a) of
the Series G Purchase Agreement shall be amended by deleting the word "nine" in
the first sentence thereof and inserting in lieu thereof the word "ten" and (ii)
the Amendment to Article XI set forth in Section 3.10 of this Second Amendment
shall remain in effect so long as the Subordination Agreement dated as of
February 16, 1999 among the Company, the Purchasers and Alpharma remains in
effect. In such event, any Default or Event of Default due to the existence of
circumstances which would not have constituted a Default or Event of Default
immediately prior to the Option Expiration Date are hereby waived.


                                   ARTICLE IV
                              AMENDMENT TO WARRANTS

                                       19
   21
         SECTION 4.1 Amendment to the Definition of "Warrant Price" in the
Warrants. The definition of "Warrant Price" in Section 1.1(m) of each
outstanding Warrant is amended by deleting the phrase "four dollars and seventy
five cents ($4.75)" and inserting in lieu thereof the phrase "three dollars
($3.00)."

         SECTION 4.2 Effectiveness of the Amendment. The amendment to the
Warrants set forth in this Article IV shall be effective on and after the Second
Amendment Closing Date.


                                    ARTICLE V
        AUTHORIZATION AND SALE AND PURCHASE OF THE DIRECT PURCHASE SHARES

         SECTION 5.1 Authorization of the Direct Purchase Shares. The Company
has, or before the Second Amendment Closing Date will have, authorized the
issuance and sale of 300,000 shares of Common Stock (the "Direct Purchase
Shares").

         SECTION 5.2 Sale and Purchase of the Direct Purchase Shares. Subject to
the terms and conditions hereof and in reliance on the representations and
warranties contained herein, the Company will issue and sell to each Purchaser,
and such Purchaser will purchase from the Company, on the Second Amendment
Closing Date (as defined below), the number of Direct Purchase Shares set forth
opposite the name of such Purchaser on Schedule 1 attached hereto, for a
purchase price per share of Direct Purchase Shares of $3.00, with the aggregate
purchase price for all the Direct Purchase Shares being $900,000.

         SECTION 5.3 Closing. The closing of the purchase and sale of the Direct
Purchase Shares (the "Second Amendment Closing") will take place at the offices
of Hale and Dorr LLP, 60 State Street, Boston, Massachusetts 02109 at 1:00 p.m.,
local time, on the Alpharma Closing Date or such other time and date, or place
as shall be mutually agreed to by the Company and FS Private Investments LLC, on
behalf of the Purchasers. Such time and date are hereinafter referred to as the
"Second Amendment Closing Date." If the Second Amendment Closing shall not have
occurred on or before September 30, 1999, this Second Amendment shall
automatically terminate.

         At the Second Amendment Closing, the Company will deliver to each
Purchaser a certificate or certificates (in definitive form) in the
denominations specified in Schedule 1 and registered in the name of such
Purchaser (or in the name of such Purchaser's nominee) representing the Direct
Purchase Shares to be purchased by such Purchaser against payment to the Company
of the purchase price of such Direct Purchase Shares, by delivery to the Company
of Subordinated Notes in an aggregate principal amount equal to the purchase
price to be paid by each Purchaser. Accrued interest on the Subordinated Notes
so delivered shall be paid to the Purchasers on the Second Amendment Closing
Date.

                                       20
   22
                                   ARTICLE VI
                           EXCHANGE OF PREFERRED STOCK
                            AND EXERCISE OF WARRANTS

         SECTION 6.1 Exchange of Preferred Stock. Pursuant to the terms of the
Preferred Stock, the Company shall exchange all outstanding shares of the
Preferred Stock for Convertible Notes on the Second Amendment Closing Date. The
Exchange Date, as defined in the Certificate of Designation shall be the Second
Amendment Closing Date.

         SECTION 6.2 Exercise of Warrants. Pursuant to the terms of the
Warrants, each Purchaser agrees to exercise all Warrants held by such Purchaser
on the Second Amendment Closing Date. The Warrant Price, as such term is defined
in the Warrants, shall be paid by delivery to the Company of Subordinated Notes
in an aggregate principal amount equal to the Warrant Price to be paid by each
Purchaser. Accrued interest on the Subordinated Notes so delivered shall be paid
to the Purchasers on the Second Amendment Closing Date.


                                   ARTICLE VII
                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

         The Company represents and warrants to the Purchasers as follows:

         SECTION 7.1 Organization and Existence, etc. The Company (a) is duly
incorporated, validly existing and in good standing under the laws of the State
of Delaware, and has all requisite power and authority to carry on its business
as now conducted and as proposed to be conducted, and (b) is duly qualified to
do business as a foreign corporation and is in good standing (or the equivalent
thereof under applicable law) in each jurisdiction in which the conduct of its
business requires such qualification by reason of the ownership or leasing of
property or otherwise (except for those jurisdictions in which the failure so to
qualify does not have a Material Adverse Effect). "Material Adverse Effect"
means, when used in connection with the Company, any development, change or
effect that is materially adverse to the business, properties, assets, net
worth, financial condition, results of operations or future prospects (including
without limitation, future equity value) of the Company and its Subsidiaries
taken as a whole.

         SECTION 7.2 Capitalization of the Company.

                  (a) As of the date hereof, (i) the Company's authorized
capital stock consists of: 60,000,000 shares of Common Stock, of which 7,026,445
shares are validly issued and outstanding, fully paid and non-assessable, and
5,000,000 shares of "blank check" preferred stock, $.01 par value per share, of
which 7,000 shares have been designated Series G Convertible Exchangeable
Preferred Stock, all of which shares are validly issued and outstanding, fully
paid and non-assessable; and (ii) the Company has outstanding the securities set
forth on Schedule 7.2 attached hereto which are convertible into or exercisable
or exchangeable for Common Stock (the "Derivative Securities").

                                       21
   23
                  (b) All the issued and outstanding shares of capital stock of
the Company are free of preemptive and similar rights and have been offered,
issued, sold and delivered by the Company in transactions in compliance with the
applicable federal, state and foreign securities laws. Other than as set forth
in Schedule 7.2 attached hereto, there are no outstanding agreements or
commitments requiring the Company to issue capital stock or Derivative
Securities as of the date hereof.

         SECTION 7.3  Authorization; Binding Obligations.

                  (a) The Company has full power and authority to execute and
deliver this Second Amendment and such other documents furnished or to be
furnished by the Company hereunder, subject to the approval by the stockholders
of the Company of this Second Amendment and the transactions contemplated
hereby. This Second Amendment, subject to the approval by the stockholders of
the Company of this Second Amendment and the transactions contemplated hereby,
has been duly authorized, executed and delivered by the Company and, subject to
the approval by the stockholders of the Company of this Second Amendment and the
transactions contemplated hereby, constitutes a legal, valid and binding
agreement of the Company, enforceable against the Company in accordance with its
terms, subject to bankruptcy, insolvency, reorganization and other laws of
general applicability relating to or affecting creditors' rights and to general
principles of equity. Subject to the approval by the stockholders of the Company
of this Second Amendment and the transactions contemplated hereby, the issuance,
offering and sale of the Direct Purchase Shares pursuant to this Second
Amendment, the compliance by the Company with the provisions of this Second
Amendment, and the consummation of the other transactions herein contemplated
will not result in the creation or imposition of any lien, charge, security
interest or encumbrance upon any of the assets of the Company pursuant to the
terms or provisions of, or result in a breach or violation of or conflict with
any of the terms or provisions of, or constitute a default under, or give any
other party a right to terminate any of its obligations under, or result in the
acceleration of any obligation under, (i) the Certificate of Incorporation and
Bylaws of the Company, (ii) any contract or other agreement to which the Company
is a party or by which the Company or any of its respective properties is bound
or (iii) any judgment, ruling, decree, order, statute, rule or regulation of any
court or other governmental agency or body, domestic or foreign, applicable to
the business or properties of the Company, except, with respect to clauses (ii)
and (iii), circumstances that would not, individually or in the aggregate,
reasonably be expected to have a Material Adverse Effect.

                  (b) Subject to the approval by the stockholders of the Company
of this Second Amendment and the transactions contemplated hereby, the Direct
Purchase Shares have been duly authorized for issuance and, when issued and
delivered in accordance with the provisions of this Second Amendment, will be
validly issued, fully paid and nonassessable.

         SECTION 7.4 Compliance with Instruments, etc. Except as set forth on
Schedule 7.4 hereto, the Company is not in breach or violation of, or in default
under, any term or provision of (i) its Certificate of Incorporation and Bylaws,
(ii) any indenture, mortgage, deed of trust, voting trust agreement,
stockholders agreement, note agreement, debt instrument or other agreement or
instrument to which it is a party or by which it is bound or to which any of its
property is subject, the effect

                                       22
   24
of which breach, violation or default, individually or in the aggregate, would
reasonably be expected to have a Material Adverse Effect, or (iii) any statute,
judgment, decree, order, rule or regulation applicable to the Company or of any
arbitrator, court, regulatory body, administrative agency or any other
governmental agency or body, domestic or foreign, having jurisdiction over the
Company or any of its respective activities or properties and the effect of
which breach, violation or default, individually or in the aggregate, would
reasonably be expected to have a Material Adverse Effect.

         SECTION 7.5 Litigation. Except as set forth on Schedule 7.5 hereto,
there are no actions, suits, proceedings or investigations pending, or, to the
knowledge of the Company, threatened, against the Company before or by any
court, regulatory body or administrative agency or any other governmental agency
or body, domestic or foreign, which would, individually or in the aggregate,
reasonably be expected to have a Material Adverse Effect, or any actions, suits,
proceedings or investigations pending, or, to the knowledge of the Company,
threatened, which challenges the validity of any action taken or to be taken
pursuant to or in connection with this Second Amendment or the issuance of the
Direct Purchase Shares which would, individually or in the aggregate, reasonably
be expected to have a Material Adverse Effect. As it pertains to the Company,
when used herein, the phrases "to the knowledge of" or derivatives thereof shall
mean the actual knowledge of the Chief Executive Officer or Vice President,
Finance of the Company.

         SECTION 7.6 Offering. Subject to the Purchasers' representations and
warranties in Article VIII of this Second Amendment, the offer, sale and
issuance of the Direct Purchase Shares as contemplated by this Second Amendment
are not subject to the registration requirements of the Securities Act of 1933,
as amended (the "Securities Act") and neither the Company nor anyone acting on
its behalf, has taken or will take any action that would cause such registration
requirements to be applicable.

         SECTION 7.7 Permits; Governmental and Other Approvals. No approval,
consent, authorization or other order of, and no designation, filing,
registration, qualification or recording with, any governmental authority,
domestic or foreign, is required for the Company's performance of this Second
Amendment or the consummation of the transactions contemplated hereby except for
applicable filings with the Nasdaq Stock Market, the filing of a Form D under
the Securities Act and the filing of a Form 8-K under the Securities Exchange
Act of 1934, as amended (the "Exchange Act").

                                       23
   25
                                  ARTICLE VIII
                REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS

                  Each Purchaser, severally and not jointly, hereby represents
and warrants to the Company that (i) it is an "accredited investor" as that term
is defined in Rule 501(a) promulgated under the Securities Act, (ii) it has the
requisite knowledge and experience in financial and business matters to be
capable of evaluating the merits and risks of an investment in the Company,
(iii) it has had an opportunity to discuss the Company's business, management
and financial affairs with the Company's management, (iv) it is acquiring the
Direct Purchase Shares for investment for its own account and not with a view
to, or for resale in connection with, any distribution thereof; nor with any
present intention of distributing or selling the same; and, except as
contemplated by the Series G Purchase Agreement, such Purchaser has no present
or contemplated agreement, undertaking, arrangement, obligation, indebtedness or
commitment providing for the disposition thereof, (v) it is not in material
breach or violation of, or in default under, any term or provision of (A) its
organizational and governing documents, (B) any indenture, mortgage, deed of
trust, voting trust agreement, stockholders, partners or members agreement, note
agreement or other agreement or instrument to which it is a party or by which it
is or may be bound or to which any of its property is or may be subject, or (C)
any statute, judgment, decree, order, rule or regulation applicable to such
Purchaser or of any arbitrator, court, regulatory body, administrative agency or
any other governmental agency or body, domestic or foreign, having jurisdiction
over such Purchaser or any of its activities or properties, (vi) any Purchaser
which is a corporation, partnership, limited liability company or trust
represents that it has not been organized, reorganized or recapitalized
specifically for the purpose of investing in the Company, (vii) it understands
that the Direct Purchase Shares have not been registered under the Securities
Act and it will not offer, sell, transfer, pledge, hypothecate or otherwise
dispose of any Direct Purchase Shares except pursuant to an exemption from, or
otherwise in a transaction not subject to, the registration requirements of the
Securities Act or pursuant to an effective registration statement under the
Securities Act, and, in each case, in accordance with any applicable state
securities or "blue sky" laws and (viii) it understands that any certificates
representing the Shares and any other securities issued in respect of such
securities upon any stock split, stock dividend, recapitalization, merger,
consolidation or similar event, shall be stamped or otherwise imprinted with a
legend in the following form (in addition to any legend required under other
applicable securities laws):

                  "THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE UNITED
                  STATES SECURITIES ACT OF 1933, AS AMENDED (THE 'ACT'), OR ANY
                  STATE SECURITIES LAWS AND MAY NOT BE TRANSFERRED, SOLD OR
                  OFFERED FOR SALE EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
                  STATEMENT AS TO THE SECURITIES UNDER THE ACT AND ANY
                  APPLICABLE STATE SECURITIES LAWS OR AN OPINION OF COUNSEL
                  REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION
                  IS NOT REQUIRED."

                                       24
   26
Each Purchaser further represents that (i) it has full power and authority to
execute, deliver and perform this Second Amendment, (ii) the person executing
this Second Amendment on behalf of such Purchaser has the appropriate authority
to act on behalf of such Purchaser, and (iii) this Second Amendment has been
duly authorized, executed and delivered by such Purchaser and constitutes a
legal, valid and binding agreement of such Purchaser, enforceable against such
Purchaser in accordance with its terms, subject to bankruptcy, insolvency,
reorganization and other laws of general applicability relating to or affecting
creditors' rights and to general principles of equity, and (iv) it has not
employed any broker or finder in connection with the transactions contemplated
by this Second Amendment. To the best of its knowledge, each Purchaser
acknowledges receipt of, and the opportunity to review, the information that it
believes necessary to make an investment in the Direct Purchase Shares.


                                   ARTICLE IX
                   CONDITIONS OF OBLIGATIONS OF THE PURCHASERS

         The obligations of each of the Purchasers under this Second Amendment
are subject to the fulfillment to their reasonable satisfaction, or the waiver
by the Purchasers, on or prior to the Second Amendment Closing Date of each of
the following conditions:

         SECTION 9.1 Representations and Warranties Correct. The representations
and warranties of the Company in Article VII hereof shall be true and correct on
and as of the date hereof, and shall be true and correct in all material
respects on and as of the Second Amendment Closing Date with the same force and
effect as if they had been made on and as of the Second Amendment Closing Date.

         SECTION 9.2 Performance. All covenants, agreements and conditions
contained in this Second Amendment to be performed or complied with on or prior
to the Second Amendment Closing Date by the Company shall have been performed or
complied with by the Company in all material respects on or prior to the Second
Amendment Closing Date.

         SECTION 9.3 Compliance Certificate. The Company shall have delivered to
the Purchasers a certificate of the Company's President, dated the Second
Amendment Closing Date, certifying to the fulfillment of the conditions
specified in Sections 9.1, 9.2 and 9.5 of this Second Amendment and such other
matters as the Purchasers shall reasonably request.

         SECTION 9.4 No Impediments. No statute, judgment, order, decree of any
court, regulatory body, administrative agency or any other governmental agency
or body shall be in effect which would impose any material limitation on the
ability of the Purchasers to exercise full rights of ownership of the Direct
Purchase Shares.

         SECTION 9.5 No Material Adverse Change. Except as set forth in the
Schedules attached to the Loan Agreement pursuant to Article III thereof, as
disclosed in the 1934 Act Filings (as defined in the Loan Agreement) filed with
the SEC prior to the date of the Master Agreement or as set forth in Schedule
4.1(e) to the Loan Agreement, since September 30, 1998, there shall have been

                                       25
   27
no Material Adverse Effect with respect to the Company (other than the continued
incurrence of losses in the ordinary course of business).

         SECTION 9.6 Legal Investment. The purchase of the Direct Purchase
Shares by the Purchasers hereunder shall be legally permitted by all statutes,
rules and regulations to which the Purchasers and the Company are subject.

         SECTION 9.7 Qualifications. All authorizations, approvals or permits,
if any, of any governmental authority or regulatory body that are now required
in connection with the lawful issuance and sale of the Direct Purchase Shares
pursuant to this Second Amendment shall have been duly obtained and shall be in
full force and effect on and as of the Second Amendment Closing Date.

         SECTION 9.8 Proceedings and Other Documents. All corporate and other
proceedings in connection with the transactions contemplated by this Second
Amendment shall have been taken and the Purchasers shall have received such
other documents and instruments in form and substance reasonably satisfactory to
them and their counsel, as to such other matters incident to the transaction
contemplated hereby as they may reasonably request.

         SECTION 9.9 Opinion of Counsel. The Purchasers shall have received the
opinion of Hale and Dorr LLP, counsel for the Company, dated the Second
Amendment Closing Date, substantially in the form delivered in connection with
the original issuance of the Securities, but limited to matters relating to the
Second Amendment and the Direct Purchase Shares.

         SECTION 9.10 Other Matters. The Company shall have delivered to the
Purchasers certificates (in definitive form) in the denominations specified by
the respective Purchasers and registered in their respective names (or in the
names of their respective nominees) representing the Direct Purchase Shares.


                                    ARTICLE X
                    CONDITIONS OF OBLIGATIONS OF THE COMPANY

         The Company's obligations under this Second Amendment are subject to
the fulfillment to its reasonable satisfaction, or the waiver by the Company, on
or prior to the Second Amendment Closing Date of each of the following
conditions:

         SECTION 10.1 Representations and Warranties Correct. The
representations and warranties of the Purchasers in Article VIII hereof shall be
true and correct on and as of the date hereof and shall be true and correct in
all material respects on and as of the Second Amendment Closing Date with the
same force and effect as if they had been made on and as of the Second Amendment
Closing Date.

                                       26
   28
         SECTION 10.2 Legal Investment. The purchase of the Direct Purchase
Shares by the Purchasers hereunder shall be legally permitted by all statutes,
rules and regulations to which the Purchasers and the Company are subject.

         SECTION 10.3 Stockholder Approval. The stockholders of the Company
shall have approved this Second Amendment and the transactions contemplated
hereby.

         SECTION 10.4 Payment of Purchase Price. The Company shall have received
payment in full of the aggregate purchase price required to be paid under
Article V.


                                   ARTICLE XI
                                  MISCELLANEOUS

         SECTION 11.1 The Series G Purchase Agreement. Except as amended by this
Second Amendment, the Series G Purchase Agreement shall remain in full force and
effect in accordance with its terms. This Second Amendment shall be deemed to be
part of the Series G Purchase Agreement.

         SECTION 11.2 Governing Law. The rights and obligations of the parties
under or pursuant to this Second Amendment shall be governed by and construed in
accordance with the laws of the State of New York.

         SECTION 11.3 Representation and Warranty. Each party hereto hereby
represents and warrants that this Second Amendment is a legal, valid and binding
obligation of such party and is enforceable against such party in accordance
with its terms.

         SECTION 11.4 References to Series G Purchase Agreement. Whenever in any
certificate, letter, notice or other instrument reference is made to the Series
G Purchase Agreement, such reference without more shall include this Second
Amendment.

         SECTION 11.5 Amendments to Alpharma Agreements.

                  (a) No amendment to the Loan Agreement or any of the Ancillary
Agreements shall have the effect of changing the meaning of any provision of
this Second Amendment or the Series G Purchase Agreement without the consent of
the Purchasers (and permitted assignees of the Purchasers) in accordance with
Article XIV of the Series G Purchase Agreement.

                  (b) The Company shall not consent to any amendment to the
proviso to the definition of "Option Exercise Price" in the Depositary Agreement
without the consent of the Purchasers (and permitted assignees of the
Purchasers) in accordance with Article XIV of the Series G Purchase Agreement.

                                       27
   29
         SECTION 11.6 Counterparts. This Second Amendment may be executed
simultaneously in counterparts, each of which shall be deemed an original, and
it shall not be necessary in making proof of the contents of this Second
Amendment to produce or account for more than one such counterpart.

                                       28
   30
         IN WITNESS WHEREOF this Second Amendment has been executed by duly
authorized representatives of the parties hereto on the day, month and year
first above written.


                                  ASCENT PEDIATRICS, INC.


                                  By: /s/ Alan R. Fox
                                      -----------------------------------------
                                      Name:  Alan R. Fox
                                      Title: President and
                                             Chief Executive Officer

                                  FURMAN SELZ INVESTORS II L.P.
                                  FS EMPLOYEE INVESTORS LLC
                                  FS PARALLEL FUND L.P.

                                  By:  FS PRIVATE INVESTMENTS LLC,
                                           MANAGER


                                  By: /s/ James L. Luikart
                                      -----------------------------------------
                                      Name:  James L. Luikart
                                      Title: Managing Member


                                  BANCBOSTON VENTURES INC.


                                  By: /s/ Marcia T. Bates
                                      -----------------------------------------
                                      Name:  Marcia T. Bates
                                      Title: Managing Director


                                  FLYNN PARTNERS


                                  By: /s/ James E. Flynn
                                      -----------------------------------------
                                      Name:  James E. Flynn, General Partner
                                             Flynn Partners

                                       29