1 As filed with the Securities and Exchange Commission on July 23, 1999 REGISTRATION NO. 333-33291 ================================================================================ SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ---------------------------------- POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ---------------------------------- GENZYME CORPORATION (Exact name of registrant as specified in its charter) MASSACHUSETTS 06-1047163 (State or other jurisdiction of (I.R.S. Employer Identification No.) incorporation) ONE KENDALL SQUARE, CAMBRIDGE, MASSACHUSETTS 02139 (Address of Principal Executive Offices) ---------------------------------- 1990 EMPLOYEE STOCK PURCHASE PLAN 1999 EMPLOYEE STOCK PURCHASE PLAN (Full Title of the Plan) PETER WIRTH, ESQ. Genzyme Corporation One Kendall Square Cambridge, Massachusetts 02139 (617) 252-7500 (Name, address and telephone number of agent for service) with copies to: PAUL M. KINSELLA, ESQ. Palmer & Dodge LLP One Beacon Street Boston, Massachusetts 02108 (617) 573-0100 ---------------------------------- - -------------------------------------------------------------------------------- 2 EXPLANATORY STATEMENT The Registrant hereby amends its Registration Statement on Form S-8 (File No. 333-33291) filed with the Securities and Exchange Commission on August 8, 1997, to reflect the merger of the Registrant's 1990 Employee Stock Purchase Plan (the "1990 Plan") with and into the Registrant's 1999 Employee Stock Purchase Plan (the "1999 Plan"). As of the date of termination of the 1990 Plan, 89,929 shares of Genzyme General Division Common Stock, 1 share of Genzyme Tissue Repair Division Common Stock and 500,000 shares of Genzyme Molecular Division Common Stock that had been previously registered had not been issued under the 1990 Plan. The 1999 Plan was effective as of March 24, 1999, the date on which it was approved by the Registrant's Board of Directors. 3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Post-Effective Amendment No. 1 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on this 23rd day of July, 1999. GENZYME CORPORATION By: /s/ Michael S. Wyzga ---------------------------------------- Michael S. Wyzga Senior Vice President and Chief Financial Officer Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on the dates indicated: SIGNATURE TITLE DATE --------- ----- ---- * Principal Executive July 23, 1999 - ---------------------------------------- Officer and Director Henri A. Termeer /s/ Michael S. Wyzga Principal Financial and July 23, 1999 - ---------------------------------------- Accounting Officer Michael S. Wyzga * Director July 23, 1999 - ---------------------------------------- Constantine E. Anagnostopoulos * Director July 23, 1999 - ---------------------------------------- Douglas A. Berthiaume * Director July 23, 1999 - ---------------------------------------- Henry E. Blair * Director July 23, 1999 - ---------------------------------------- Robert J. Carpenter * Director July 23, 1999 - ---------------------------------------- Charles L. Cooney * Director July 23, 1999 - ---------------------------------------- Henry R. Lewis *By: /s/ Peter Wirth July 23, 1999 ------------------------------------ Peter Wirth Attorney-in-Fact