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                                                                     EXHIBIT 3.5

                                  AMENDMENT TO

                           AMENDED AND RESTATED BYLAWS

                                       OF

                                STERICYCLE, INC.



         The Amended and Restated Bylaws of Stericycle, Inc. (the "Bylaws") are
amended as follows:

         1. AMENDMENT OF SECTION 2.1. Section 2.1 ("Annual Meeting") of the
Bylaws is amended to read as follows:

           2.1 Annual Meeting. An annual meeting of stockholders for the
       election of directors and the transaction of any other business which
       properly comes before the meeting shall be held between March 31 and
       October 31 of each year, on the date fixed by the board of directors.

         2. AMENDMENT OF SECTION 2.2. The first sentence of Section 2.2
("Special Meetings") of the Bylaws is amended to read as follows:

       A special meeting of stockholders may be called for any purpose or
       purposes by the chairman of the board, the president, the board of
       directors or the holder or holders of at least 80% of the outstanding
       shares of Series A Preferred Stock.

         3. AMENDMENT OF SECTION 2.6. The first sentence of Section 2.6
("Voting") of the Bylaws is amended to read as follows:

       Each holder of Common Stock shall be entitled to one vote for each share
       of Common Stock that he holds of record, and each holder of Series A
       Preferred Stock shall be entitled to a number of votes for each share of
       Series A Preferred Stock that he holds of record equal to the number of
       shares of Common Stock into which such share of Series A Preferred Stock
       is convertible as of the record date (with any fractional voting rights
       that result, after aggregating the voting rights of all of the holder's
       shares of record of Series A Preferred Stock, rounded upwards or
       downwards to the nearest whole share, with one-half being rounded
       upwards).

         4. AMENDMENT OF SECTION 3.2. The first two sentences of Section 3.2
("Number and Term of Office") of the Bylaws are amended to read as follows:

       The number of directors constituting the board of directors shall be
       nine. Subject to any restrictions in the certificate of incorporation or
       the Corporate Governance Agreement prohibiting a reduction in the number
       of directors, the number of directors may be changed by a resolution of
       the board of directors or the stockholders, but if changed, no decrease
       in the number of directors shall affect the term of any incumbent.

         5. AMENDMENT OF SECTION 3.3. The first sentence of Section 3.3
("Regular Meetings") of the Bylaws is amended to read as follows:

       Regular meetings of the board of directors shall be held, at least once
       each fiscal quarter, at the times and places determined by the board of
       directors.


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       6. AMENDMENT OF SECTION 3.4. The first sentence of Section 3.4 ("Special
Meetings" of the Bylaws is amended to read as follows:

       Special meetings of the board of directors may be held at any time at the
       call of the chairman of the board, the president or any director.

       7. ADDITION OF NEW SECTION 4.8. Sections 4.8 through 4.12 of the Bylaws
are renumbered as Sections 4.9 through 4.13, and the following provision is
added as Section 4.8:

           4.8 CHIEF OPERATING OFFICER. The chief operating officer of the
       Corporation shall be responsible, under the president's direction, for
       overseeing the Corporation's day-to-day business operations. The chief
       operating officer shall have the powers and duties usually vested in the
       office of chief operating officer of a corporation and such other powers
       and duties as the president or the board of directors assigns.

       8. AMENDMENT OF SECTION 7.10. Section 7.10 ("Certificate of
Incorporation" of the Bylaws is deleted, and the following provision is
substituted in its place as Section 7.10:

           7.10 CERTAIN TERMS. As used in these Bylaws, the following
       terms have these meanings:

                CERTIFICATE OF DESIGNATION means the Certificate of Designation
           Relating to Series A Convertible Preferred Stock, Par Value $.01 Per
           Share, that the Corporation filed with the Secretary of State of the
           State of Delaware on November 5, 1999, as it may be amended.

                CERTIFICATE OF INCORPORATION means the Amended and Restated
           Certificate of Incorporation that the Corporation filed with the
           Secretary of State of the State of Delaware on August 19, 1996, as
           amended by the Certificate of Amendment that the Corporation filed on
           November 4, 1999, and as it may be further amended, and including the
           Certificate of Designation.

                COMMON STOCK means the Corporation's common stock, par value
           $.01 per share.

                CORPORATE GOVERNANCE AGREEMENT means the corporate governance
           agreement that the Company entered into pursuant to Section 2A(k) of
           the Series A Preferred Stock Purchase Agreement.

                SERIES A PREFERRED STOCK means the Corporation's Series A
           Convertible Preferred Stock, par value $.01 per share, issued
           pursuant to the Certificate of Designation.

                SERIES A PREFERRED STOCK PURCHASE AGREEMENT means the Amended
           and Restated Series A Convertible Preferred Stock Purchase Agreement,
           dated as of September 26, 1999, entered into by the Company and
           certain investors.

                STOCK means Common Stock or Series A Preferred Stock, or both,
           as the context requires.

                STOCKHOLDER means a holder of Common Stock or Series A Preferred
           Stock, or both, as the context requires.

       9. ADDITION OF NEW SECTION 8.3. The following provision is added as
Section 8.3 of the Bylaws.

                8.3 RESTRICTIONS ON AMENDMENTS. Notwithstanding anything to the
           contrary in Sections 8.1 and 8.2, no amendment of the following
           provisions of these bylaws shall be effective without the approval of
           the holders of a majority of the shares of Series A Preferred Stock
           that the Company issued and sold pursuant to the Series A Preferred
           Stock Purchase Agreement: (i)


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         the first sentence of Section 2.2; (ii) the first two sentences of
         Section 3.2; (iii) the first sentence of Section 3.3; and (iv) the
         first sentence of Section 3.4.



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