1 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A2 CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 April 7, 2000 (Date of earliest event reported) HYSEQ, INC. (Exact name of Registrant as specified in its charter) Nevada 0-22873 36-3855489 (State of (Commission File No.) (IRS Employer Incorporation) Identification No.) 670 Almanor Avenue Sunnyvale, California 94086 (Address of principal executive offices, including zip code) (408) 524-8100 (Registrant's telephone number, including area code) 2 This Form 8-K/A2 amends the Current Report on Form 8-K of Hyseq. Inc. as filed with the Securities and Exchange Commission on April 14, 2000 and as amended on April 20, 2000, to amend and restate paragraph 2 of Item 4 and to file an amended copy of the Former Accountants Letter. Item 4. Changes in Registrant's Certifying Accountant. During the fiscal years ended December 31, 1999 and 1998 and the subsequent interim period through April 7, 2000, there were no disagreements with the former accountants on any matter of accounting principles or practices, financial statement disclosures, or auditing scope or procedure which would have caused the former accountants to make reference in their report to such disagreements if not resolved to their satisfaction. Item 7. Financial Statements and Exhibits. (c) Exhibits 16 Amended copy of Former Accountants Letter 3 SIGNATURE Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. HYSEQ, INC. /s/ Mark E. Gitter --------------------------- Name: Mark E. Gitter Title: Chief Financial Officer Date: May 22, 2000 4 EXHIBIT INDEX Exhibit No. Description of Exhibit - ----------- ---------------------- 16 Amended Copy of Former Accountants Letter