Exhibit 4.2

                         SPECTRUM PHARMACEUTICALS, INC.

                                WARRANT AGREEMENT

                                 AMENDMENT NO. 1


        This Amendment No.1 to Warrant Agreement No. SPPI 233 (the "Warrant")
dated September 17, 2003, is made and entered into effective NOVEMBER 2, 2005
(the "Effective Date"), by and between Spectrum Pharmaceuticals, Inc. (the
"Company") located at 157 Technology Dr., Irvine California 92618, USA, and John
T. Moore ("Holder"), located at 618 Rolling Green Drive, Austin, TX 78734, and
hereby amends the Warrant as follows:

        The Warrant recital is hereby amended, in its entirety, to read as
        follows:

        "Spectrum Pharmaceuticals, Inc., a Delaware corporation (the "Company"),
        hereby certifies that, for value received, John T. Moore or his
        registered assigns ("Holder"), is entitled, subject to the terms set
        forth below, to purchase from the Company up to a total of 130,000
        shares of Common Stock, $.001 par value per share (the "Common Stock"),
        of the Company (each such share, a "Warrant Share" and all such shares,
        the "Warrant Shares") at an exercise price equal to $4.90 per share (as
        adjusted from time to time as provided in Section 7, the "Exercise
        Price"), at any time from and including September 17, 2004 (the
        "Effective Date") through and including September 16, 2011 (the
        "Expiration Date"), and subject to the following terms and
        conditions:..."

        Holder represents and warrants to the Company that the statements
        contained in Section 12 of the Warrant are correct and complete as of
        the Effective Date.

        All other terms and conditions of the Warrant remains unchanged and in
        full force and effect.

        IN WITNESS WHEREOF, the parties have executed this Amendment No. 1 as of
the Effective Date written above.



SPECTRUM PHARMACEUTICALS, INC.            HOLDER


By:   /s/ Rajesh C. Shrotriya             By:   /s/ John T. Moore
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      Rajesh C. Shrotriya, M.D.                 John T. Moore

Its:  Chairman, CEO & President           Its:  President
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