Exhibit 10.1 AMENDMENT NO. 2 Dated as of June 22, 2006 to CREDIT AGREEMENT Dated as of September 29, 2005 REINSURANCE GROUP OF AMERICA, INCORPORATED, REINSURANCE COMPANY OF MISSOURI, INCORPORATED, RGA REINSURANCE COMPANY, RGA LIFE REINSURANCE COMPANY OF CANADA, RGA REINSURANCE COMPANY (BARBADOS) LTD., RGA AMERICAS REINSURANCE COMPANY, LTD., RGA WORLDWIDE REINSURANCE COMPANY, LTD., the BANKS party hereto and THE BANK OF NEW YORK, as Administrative Agent, agree as follows: 1. Existing Credit Agreement. This Amendment No. 2 (this "Amendment") relates to and amends that certain Credit Agreement, dated as of September 29, 2005, among Reinsurance Group of America, Incorporated, certain subsidiaries thereof, the banks and issuing banks party from time to time thereto, Bank of America, N.A., as Syndication Agent, KeyBank National Association, Wachovia Bank, National Association and Deutsche Bank AG New York Branch, as Co-Documentation Agents, and The Bank of New York, as Administrative Agent, as amended by Amendment No. 1 thereof, dated as of November 30, 2005 (as in effect immediately prior to the effectiveness of this Amendment, the "Existing Credit Agreement"). Terms used but not defined in this Amendment are used herein with the meaning ascribed to them in the Existing Credit Agreement. 2. Amendment. On and after the Effective Date (as defined below), the Existing Credit Agreement shall be amended as follows: (a) The definition of "Permitted Lien" in Section 11.01 of the Existing Credit Agreement shall be amended by (i) re-lettering the existing clause (n) as clause (o), (ii) replacing the reference therein to "clauses (f) through (m) of this definition" with "clauses (f) through (n) of this definition", and (iii) inserting the following new clause (n): "(n)any Lien on (i) Investments and cash balances of any Subsidiary formed in connection with an Alternative Reserve Agreement, and (ii) Investments and cash balances of any Captive Subsidiary (including the Capital Securities of such Captive Subsidiary) in each case, securing obligations of such Subsidiary and such Captive Subsidiary in connection with an Alternative Reserve Agreement; or" (b) The definition of "Permitted Restrictive Covenant" in Section 11.01 of the Existing Credit Agreement shall be amended by (i) re-lettering the existing clause (h) as clause (i), (ii) replacing the reference therein to "clause (b), (c), (d), (e), (f) or (g)" with "clauses (b) through (h)", and (iii) inserting the following new clause (h): "(h)any covenant or restriction of the type contained in Section 4.18, imposed on a Captive Subsidiary or any other Subsidiary formed in connection with an Alternative Reserve Agreement, that is contained in any such Alternative Reserve Agreement; provided that any Indebtedness incurred in connection with such Alternative Reserve Agreement is, and remains at all times, non-recourse to any Account Party, or" 3. Acknowledgment. For the avoidance of doubt, the Administrative Agent and the Banks hereby confirm and agree that the transactions with Affiliates in connection with the floating rate insured notes due 2036 to be issued by Timberlake Financial LLC shortly following the date hereof are permitted under Section 4.17 of the Credit Agreement. 4. Further Assurances. The Account Parties will execute, acknowledge and deliver all such instruments, amendments, documents, and take all such action, as the Administrative Agent deems necessary or advisable to carry out the intent and purpose of this Amendment and will, upon the Administrative Agent's reasonable request, furnish the Administrative Agent with proof thereof. 5. Continuing Effect of Existing Credit Agreement. The provisions of the Existing Credit Agreement, as amended hereby, are and shall remain in full force and effect and are hereby in all respects confirmed, approved and ratified. 6. Representations and Warranties. In order to induce the Administrative Agent and the Banks to agree to this Amendment, each Account Party hereby represents and warrants as follows: Each representation and warranty made by any Account Party in any Loan Document is, after giving effect to this Amendment, true and correct at and as of the Effective Date, and, after giving effect to this Amendment, no Default or Event of Default is continuing at and as of the Effective Date. 7. Conditions to Effectiveness. This Amendment shall be effective as of the date first written above, but shall not become effective as of such date until the date (the "Effective Date") that each of the following conditions shall have been satisfied in the sole determination of the Administrative Agent: (a) The Administrative Agent shall have received each of the following, in form and substance satisfactory to the Administrative Agent: (i) This Amendment duly executed by the Account Parties, the Administrative Agent and the Required Banks; and (ii) Such other information, documents or materials as the Administrative Agent may have requested pursuant to the Loan Documents; and (b) the Administrative Agent shall have received all fees and expenses payable pursuant to the Loan Documents and this Amendment including the fees and 2 disbursements of legal counsel retained by the Administrative Agent (if an invoice for such fees and disbursements of such counsel has been delivered to the Account Parties). 8. Governing Law. This Amendment shall, pursuant to New York General Obligations Law 5-1401, be construed in accordance with and governed by the laws of the State of New York. 9. Counterparts. This Amendment may be signed in any number of counterparts, each of which shall be an original, with the same effect as if the signatures thereon were upon the same instrument. 10. Headings. Section headings in this Amendment are included herein for convenience and reference only and shall not constitute a part of this Amendment for any other purpose. 3 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed by their duly authorized officers all as of the date first above written. REINSURANCE GROUP OF AMERICA, INCORPORATED By: /s/ Todd C. Larson ------------------------------------ Name: Todd C. Larson Title: Senior Vice President, Controller & Treasurer REINSURANCE COMPANY OF MISSOURI INCORPORATED By: /s/ Todd C. Larson ------------------------------------ Name: Todd C. Larson Title: Senior Vice President, Controller & Treasurer RGA REINSURANCE COMPANY By: /s/ Todd C. Larson ------------------------------------ Name: Todd C. Larson Title: Senior Vice President, Controller & Treasurer RGA LIFE REINSURANCE COMPANY OF CANADA By: /s/ Alain Neemeh ------------------------------------ Name: Alain Neemeh Title: President & CEO By: /s/ Alka Gautam ------------------------------------ Name: Alka Gautam Title: Vice President & CFO RGA CREDIT AGREEMENT (AMENDMENT NO. 2) RGA REINSURANCE COMPANY (BARBADOS) LTD. By: /s/ Todd C. Larson ------------------------------------ Name: Todd C. Larson Title: Senior Vice President, Controller & Treasurer RGA AMERICAS REINSURANCE COMPANY, LTD. By: /s/ Todd C. Larson ------------------------------------ Name: Todd C. Larson Title: Senior Vice President, Controller & Treasurer RGA WORLDWIDE REINSURANCE COMPANY, LTD. By: /s/ Todd C. Larson ------------------------------------ Name: Todd C. Larson Title: Senior Vice President, Controller & Treasurer THE BANK OF NEW YORK, as Administrative Agent and as a Bank By: /s/ Lizanne T. Eberle ------------------------------------ Name: Lizanne T. Eberle Title: Vice President BANK OF AMERICA, N.A., as a Bank By: /s/ Jeffrey M. Shaver ------------------------------------ Name: Jeffrey M. Shaver Title: Vice President RGA CREDIT AGREEMENT (AMENDMENT NO. 2) KEYBANK NATIONAL ASSOCIATION, as a Bank By: /s/ Suzannah Harris ------------------------------------ Name: Suzannah Harris Title: Vice President WACHOVIA BANK, NATIONAL ASSOCIATION, as a Bank By: /s/ Karen Hanke ------------------------------------ Name: Karen Hanke Title: Director DEUTSCHE BANK AG NEW YORK BRANCH, as a Bank By: /s/ Ruth Leung ------------------------------------ Name: Ruth Leung Title: Director By: /s/ Brett Hanmer ------------------------------------ Name: Brett Hanmer Title: Vice President THE BANK OF TOKYO-MITSUBISHI, LTD., CHICAGO BRANCH, as a Bank By: /s/ Tsuguyuki Umene ------------------------------------ Name: Tsuguyuki Umene Title: Deputy General Manager RGA CREDIT AGREEMENT (AMENDMENT NO. 2) HSBC BANK USA, N.A., as a Bank By: /s/ Dennis Cogan ------------------------------------ Name: Dennis Cogan Title: Senior Vice President ABN AMRO BANK, N.V., as a Bank By: /s/ Neil R. Stein ------------------------------------ Name: Neil R. Stein Title: Director By: /s/ Michael DeMarco ------------------------------------ Name: Michael DeMarco Title: Vice President BAYERISCHE HYPO-UND VEREINSBANK AG, as a Bank By: /s/ Michael Imperiale ------------------------------------ Name: Michael Imperiale Title: Director By: /s/ Michael F. Davis ------------------------------------ Name: Michael F. Davis Title: Director RGA CREDIT AGREEMENT (AMENDMENT NO. 2) CALYON NEW YORK BRANCH, as a Bank By: /s/ Sebastian Rocco ------------------------------------ Name: Sebastian Rocco Title: Managing Director By: /s/ Charles Kornberger ------------------------------------ Name: Charles Kornberger Title: Managing Director SOCIETE GENERALE, as a Bank By: /s/ William Aishton ------------------------------------ Name: William Aishton Title: Vice President BAYERISCHE LANDESBANK, NEW YORK BRANCH, as a Bank By: /s/ Steven Fielitz ------------------------------------ Name: Steven Fielitz Title: Second Vice President By: /s/ Norman McClave ------------------------------------ Name: Norman McClave Title: First Vice President RGA CREDIT AGREEMENT (AMENDMENT NO. 2) ROYAL BANK OF CANADA, as a Bank By: /s/ Evan Glass ------------------------------------ Name: Evan Glass Title: Authorized Signatory WILLIAM STREET CREDIT CORPORATION, as a Bank By: /s/ Mark Walton ------------------------------------ Name: Mark Walton Title: Assistant Vice President LANDESBANK HESSEN-THURINGEN GIROZENTRALE NEW YORK BRANCH, as a Bank By: /s/ Samuel W. Bridges ------------------------------------ Name: Samuel W. Bridges Title: Senior Vice President Financial Institutions Public Finance By: /s/ John A. Sarno ------------------------------------ Name: John A. Sarno Title: Vice President Financial Institutions Public Finance LEHMAN COMMERCIAL PAPER INC., as a Bank By: /s/ Janine M. Shugan ------------------------------------ Name: Janine M. Shugan Title: Authorized Signatory RGA CREDIT AGREEMENT (AMENDMENT NO. 2) SOUTHWEST BANK OF ST. LOUIS, as a Bank By: /s/ Roy C. Postel ------------------------------------ Name: Roy C. Postel Title: Senior Vice President MIZUHO CORPORATE BANK (USA), as a Bank By: /s/ Robert Gallagher ------------------------------------ Name: Robert Gallagher Title: Senior Vice President STATE STREET BANK AND TRUST COMPANY, as a Bank By: /s/ Lise Anne Boutiette ------------------------------------ Name: Lise Anne Boutiette Title: Vice President WELLS FARGO BANK, NATIONAL ASSOCIATION, as a Bank By: /s/ Robert P. Fialkowski ------------------------------------ Name: Robert P. Fialkowski Title: Vice President RGA CREDIT AGREEMENT (AMENDMENT NO. 2)