Certification Pursuant to 18 U.S.C. 1350, as adopted pursuant to Section 906 of
the Sarbanes-Oxley Act of 2002; provided by the Chief Executive Officer and
Chief Financial Officer, based on each such officer's knowledge and belief.

The undersigned officers of Nuveen Multi-Strategy Income and Growth Fund (the
"Fund"), certify that, to the best of each such officer's knowledge and belief:

      1.    The Form N-CSR of the Fund for the period ended December 31, 2007
            (the "Report") fully complies with the requirements of Section 13(a)
            or 15(d) of the Securities Exchange Act of 1934; and

      2.    The information contained in the Report fairly presents, in all
            material respects, the financial condition and results of operations
            of the Fund.

Date: March 7, 2008

                                           s/ Gifford R. Zimmerman
                                              --------------------------
                                              Gifford R. Zimmerman
                                              Chief Administrative Officer
                                              (principal executive officer)

                                           s/ Stephen D. Foy
                                              --------------------------
                                              Stephen D. Foy
                                              Vice President, Controller
                                              (principal financial officer)